Abstract: A method for safe radioisotope preparation and injection of H215O for use in Positron Emission Tomography (PET). The disclosure also relates to a safety valve for controlling a flow of H215O for use in PET, to a use of said safety valve and to a method for preparing and injecting H215O.

Abstract: A system and method of using machine learning to predict the pharmacokinetics of a therapeutic radiopharmaceutical on a subject patient using the biodistribution data of the patient in order to dynamically treat the patient using the radiopharmaceutical.

Abstract: An unshielded, non-invasive, ambulatory neural activity sensing device includes an array of alternating H-field and E-field sensors and a processor configured to localize an electromagnetic signal using a combination of H-field and E-field sensor outputs from the H-field and E-field sensors.

Abstract: Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

Abstract: The present disclosure solves many problems. The main problem solved by the present disclosure is the problem of showing veins for patients whose veins may be hard to find. The present disclosure will greatly improve the venipuncture experiences for millions of people every day. The present invention discloses a system and method imaging objects in or behind a turbid medium comprising a light source adapted to illuminate an imaged area, an imaging device arranged to optically capture and relay an image, an electronic display to receive and display the image, and a control unit to control at least one spectral and polarization properties of the light source. Also disclosed is a camera module within an embodiment of the imaging device that provides for an alternative operation of the imaging device, without a control unit, and relaying of the image to the electronic display, which may be a tablet.

Abstract: A hybrid NIRF/IVUS imaging probe containing i) a spatially-truncated optical lens a substantially-planar surface of which is inclined with respect to an axis to reflect light, transmitted between proximal and distal ends of the probe, internally into a body of the lens, and ii) an acoustic transducer disposed sequentially with the optical lens on the axis of the probe while, at the same time, the optical and electrical members of the probe transmitting the radiative and mechanical energies (which the probe exchanges with a target bodily vessel) are parallel to one another within the housing of the probe. A method for operating the probe resulting in formation of spatially co-registered optical and acoustic images of the target. Related imaging system and computer-program product.

Abstract: Systems and methods for anatomical identification using ultrasonic imaging and acoustic shadow detection methods are provided. At least some embodiments of the disclosure comprise the following steps: acquiring ultrasound image; detecting shadow region; extracting shadow profile; filtering shadow profile with matched filter; identifying anatomical landmarks within shadow; extracting features of anatomical landmarks; classifying anatomy, and determining with a high degree of confidence that the target anatomy is depicted in the image. A determination is made as to the degree of confidence that the target anatomy is depicted in the image. Conditionally, graphics indicating presence and position of target anatomy is displayed including disposition, location and orientation thereof.

Abstract: An arthroplasty trial assembly for a human shoulder can include a first implant securable to a first bone and a second implant securable to a second bone. The second implant can include a body, a stem, an articulation component, and a sensor. The stem can extend from the body, and the stem can be insertable into the second bone. The articulation component can be coupled to the body opposite the stem, and the articulation component can be articulable with the first implant. The sensor can be connected to the articulation component and can be configured to monitor a condition of the second implant and can produce a sensor signal as a function of the condition that is indicative of stability of the shoulder.

Abstract: An apparatus includes a handle, a catheter, extending distally from the handle, an end effector extending distally from the catheter, a deflection assembly, and a load limiting assembly. The deflection assembly is configured to deflect the end effector away from a longitudinal axis of the catheter. The deflection assembly includes an input member and a translating assembly. The input member is configured to drive the translating assembly to deflect the end effector away from the longitudinal axis. The load limiting assembly is configured to decouple the input member from the translating assembly at a predetermined load such that the input member is inhibited from driving the translating assembly when the input member is decoupled by the load limiting assembly.

Abstract: A system, method, and apparatus for performing intraocular lens implantation using real-time surgical reference indicium are disclosed. An example method includes recording a patient specific pre-operative still image of an eye prior to cyclorotation of the eye when a patient lies down for surgery and generating at least one real-time multidimensional visualization of at least a portion of the eye for display. The method further includes using the patient specific pre-operative still image to at least produce at least one virtual surgical reference indicium including an ocular natural vertical axis of the eye and align the at least one virtual surgical reference indicium to the eye in conjunction with the real-time multidimensional visualization of at least a portion of the eye. The patient specific pre-operative still image is captured under a dilation condition selected from the group consisting of natural dilation, chemical dilation, and no dilation.

Abstract: An intraluminal device is provided. In on embodiment, an intraluminal device includes a flexible elongate member including a proximal portion and a distal portion; an imaging component coupled to the distal portion of the flexible elongate member; and a plurality of radiopaque markers positioned at the distal portion of the flexible elongate member, wherein the plurality of radiopaque markers are separated from each other, wherein the plurality of radiopaque markers are arranged on the flexible elongate member at two different orientations with respect to the imaging component, and wherein at least a first radiopaque marker of the plurality of radiopaque markers includes an arc-shaped portion and an extended portion extending from the arc-shaped portion.

Abstract: An elongated medical catheter includes a marker band with sidebands. The elongated medical catheter and the marker band have a radiopacity being different from the radiopacity of the sidebands.

Abstract: A system and method for positioning a sensor on a subject. In some embodiments, the system includes an instrument holder, the instrument holder being configured to be secured to a subject, and to hold an instrument temporarily.

Abstract: The Biomechanical Integrity Score and its five components are calculated as a result of vaginal tactile probe insertion, elevation, rotation, Valsalva maneuver, voluntary pelvic muscle contraction, reflex contraction, and relaxation while the probe is in contact with vaginal walls for a comprehensive biomechanical characterization of the pelvic floor. The probe is equipped with a plurality of tactile sensors recording various static and dynamic pressure patterns during a vaginal examination.

Abstract: Systems and methods for image-based guidance for facilitating navigation of tubular networks. A region of interest in three-dimensional image data may first be segmented. An endoscopic instrument may be detected in two-dimensional intraoperative image data of the region of interest. A centerline of the detected endoscopic instrument may then be determined. The endoscopic instrument and the centerline may be backprojected to generate a three-dimensional backprojected volume. A device path of the endoscopic instrument may be generated based at least in part on the three-dimensional backprojected volume and the three-dimensional image data.

Abstract: A system and method enabling the receipt of image data of a patient, identification of one or more locations within the image data depicting symptoms of COPD, analyzing airways and vasculature proximate the identified locations; planning a pathway to the one or more locations, navigating an extended working channel to one of the locations, positioning a microwave ablation catheter proximate the location, and energizing the microwave ablation catheter to treat the locations depicting symptoms of COPD.

Abstract: Ultrasound image devices, systems, and methods are provided. In one embodiment, an intraluminal ultrasound imaging system includes a patient interface module (PIM) in communication with an intraluminal imaging device comprising an ultrasound imaging component, the PIM comprising a processing component configured to detect information associated with the intraluminal imaging device; and determine a waveform characteristic for ultrasound wave emissions at the ultrasound imaging component based on the detected information; and a trigger signal generation component in communication with the processing component and configured to generate a trigger signal based on the determined waveform characteristic to control the ultrasound wave emissions at the ultrasound imaging component.

Abstract: The system includes an instrument for determining the anatomical, biomechanical, and physiological properties of a body segment that includes one or more force sensitive probes is provided. A human operator actuates one or more force sensitive probes, wherein the force sensitive probes are positioned at the surface of the body segment. The operator pushes on the force sensitive probes with varying force applied on the body segment to measure tissue deflection forces. The instrument may include one or more of gyroscopes, accelerometers, and magnetometers capable of measuring changes in tissue deflection caused by the force sensitive probes relative to a grounded reference frame in 3-D space, wherein the tissue deflection force data and the change in tissue deflection data are used to compute segment tissue viscoelastic properties. The instrument may also be untethered or wireless.

Abstract: A method of operating a shape sensing apparatus comprises receiving shape data from a first shape sensor. The first shape sensor includes a first plurality of optical cores extending between a first section and a second section of an elongated optical fiber. The method further comprises receiving shape data from a second shape sensor. The second shape sensor includes a second plurality of optical cores extending between the first and second sections of the elongated optical fiber. The method further comprises determining a shape of the elongated optical fiber between the first and second sections by combining the shape data from the first and second shape sensors.

Abstract: A method for quantifying viscoelasticity of a medium includes: obtaining a position-time graph of vibration propagation after the medium is subjected to a vibration excitation, determining an angle with maximum signal energy in the position-time graph by using angle projection, where the angle with the maximum signal energy corresponds to a slope of the position-time graph and the slope of the position-time graph is the propagation velocity of the vibration in the medium. Since the propagation velocity of the vibration in the medium is related to the viscoelasticity of the medium, a viscoelasticity parameter of the medium can be quantitatively calculated after the slope of the position-time graph is obtained. The method does not need to select a feature point from the position-time graph to calculate the slope of the position-time graph, and can efficiently and accurately quantifies viscoelasticity of the medium.