Patents Examined by Sharmila G. Landau
  • Patent number: 11193142
    Abstract: The present invention relates to an anaerobic process for biogas upgrading and hydrogen utilization comprising the use of acidic waste as co-substrate. In this process, H2 and CO2 will be converted to CH4, which will result in lower CO2 content in the biogas. The invention relates to both in situ and ex situ methods of biogas upgrading. The invention further relates to a bioreactor comprising hollow fibre membranes.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: December 7, 2021
    Assignee: AgorFora ApS
    Inventors: Irini Angelidaki, Poul Lyhne, Gang Luo
  • Patent number: 11155851
    Abstract: Methods are provided for detecting enzymatic activity of various lysosomal storage enzymes using substrates that include: a sugar moiety; a linker moiety allowing the conjugation of sugar moiety with the remaining structure of the substrate; and two or more fatty acid chains or derivatives thereof at least one of which is sufficiently structured to provide improved solubility in aqueous or organic solvent systems. Also provided are internal standards, and inhibitors for use in detecting or reducing enzymatic activity using the inventive substrates.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: October 26, 2021
    Assignees: University of Washington through its Center for Commercialization, PerkinElmer Health Sciences, Inc.
    Inventors: Alexander Cherkassky, Jason Coumoyer, Michael Gelb
  • Patent number: 11092600
    Abstract: A method for detecting at least one microorganism that may be present in a sample, comprising the steps of: a) bringing into contact, in a container: a culture medium that enables the growth and/or detection of microorganisms, said sample and a sensitized solid support; b) subjecting the whole to a temperature that promotes the growth and/or detection of microorganisms; and c) observing, in real time, the appearance of an agglutination indicating the presence of the microorganism(s) or confirming said presence when said microorganisms are detected in said culture medium, when step b) has been completed, and a method for detecting and identifying at least one target microorganism that may be present in a sample.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: August 17, 2021
    Assignee: BIOMERIEUX
    Inventors: Bruno Colin, David Mosticone, Jean-Claude Raymond, Thierry Sofia, Antoine Vimont
  • Patent number: 11083190
    Abstract: This invention provides gels and matrices having a rigidity in the range of 150-750 Pa, methods of manufacturing same, and method of preserving a mesenchymal stem cell population or studying mesenchymal stem cells, comprising same.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: August 10, 2021
    Inventors: Makoto Funaki, Paul A. Janmey, Jessamine Winer
  • Patent number: 11020358
    Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: June 1, 2021
    Inventors: Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin, Karthyayani Rajamani, Yi-Chun Lin
  • Patent number: 11013228
    Abstract: The present invention relates to a method of processing allograft skin for transplantation and a cryopreserved allograft skin produced thereby. More specifically, the present invention relates to a method in which a cryoprotectant is prepared by adding sucrose to basic constituents comprising dimethyl sulfoxide, an animal cell culture medium and fetal bovine serum, and then the resulting solution is used to subject skin tissue for transplantation to a freezing process.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: May 25, 2021
    Inventors: Weon Ik Choi, Wook Chun, Jae Deuk Jung
  • Patent number: 10995024
    Abstract: The present invention relates to apparatus, methods, and applications for treating wastewater, and more particularly to biological processes for removing pollutants from wastewater. This invention further relates to apparatus and methods for growing microbes on-site at a wastewater treatment facility, and for economically inoculating sufficient microbes to solve various treatment problems rapidly.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: May 4, 2021
    Assignee: Advanced Biological Services, Inc.
    Inventor: G. Robert Whiteman
  • Patent number: 10983104
    Abstract: The present invention relates to a device and method for the detection of mastitis or other disease from a body fluid of a mammal for example from cow's milk. The device and method relates to a wedge microfluidic chamber for using a minimal amount of fluid and being able to use the device to observe leukocytes in a mono-layer for the purpose of disease detection, cell counts or the like.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: April 20, 2021
    Assignee: Advanced Animal Diagnostics, Inc.
    Inventors: Rodolfo R. Rodriguez, Charles F. Galanaugh
  • Patent number: 10966421
    Abstract: The claimed subject matter comprises a device to collect and preserve cells comprising of: (1) a collection container comprised of a tube having an open end and a closed end, a closure in the open end of the tube, a vacuum drawn to a predetermined level inside the container; and (2) compounds including an anticoagulant agent and a fixative agent, wherein the compounds are in a sufficient amount to preserve said cells' original morphology and antigenic sites without significant dilution of said cells, and thereby allowing said cells to be directly analyzed by a flow cytometer without further treatment.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: April 6, 2021
    Assignee: Streck, Inc.
    Inventor: Wayne L. Ryan
  • Patent number: 10953133
    Abstract: A process providing a method to create 3D scaffolds using nano-scale fibers, comprising: deposition and alignment of a plurality of electrospun fiber layers on a substrate; application of a photosensitive biomedical polymer liquid to each fiber layer deposited on said substrate; deposition and cross-alignment of a plurality of electrospun fiber layers on said substrate; retaining said polymer liquid in place using said cross-aligned fiber layers; curing said polymer liquid on top of each fiber layer using UV light.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: March 23, 2021
    Assignee: University of Central Oklahoma
    Inventors: Morshed Khandaker, Shahram Riahinezhad
  • Patent number: 10935542
    Abstract: Variations in the differentiation and lineage potential of stem cells, including mesenchymal stem cells, currently limit their therapeutic use. The ability to identify, isolate, and specifically amplify stem cell populations with desired differentiation potential would contribute the use of stem cells in research and therapy. The present invention discloses a method of assessing differentiation potential of stem cells by measuring the differential expression of antigens CD 146 and NG2 on the stem cells. The correlation between CD 146 and NG2 expression and differentiation and trilineage potential is explored. The invention also discloses methods to specifically amplify or enrich stem cells with desired differentiation potential, monitor the differentiation potential of a heterogeneous stem cell population, quantify the heterogeneity in differentiation potential of a stem cell culture, and remove stem cells with specific differentiation potentials from a heterogeneous cell culture.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: March 2, 2021
    Inventors: Kim O'Connor, Katie Russell
  • Patent number: 10849858
    Abstract: The present invention relates to a process for preparing erythrocytes loaded with one or more substance of pharmaceutical interest. The present invention is also directed to loaded erythrocytes thus obtained and pharmaceutical compositions comprising said population of loaded erythrocytes as well as therapeutic application thereof, in particular in the treatment of Ataxia telangiectasia.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: December 1, 2020
    Assignee: ERYDEL S.P.A.
    Inventors: Giovanni Mambrini, Luca Benatti, Giovanni Capogrossi, Marco Mandolini
  • Patent number: 10851396
    Abstract: The present invention provides isolated acidophilic Fusarium oxysporum strains, such as MK7, and their progeny, compositions comprising such strains and their progeny, methods of producing such strains and their progeny, and methods of using such strains and their progeny.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: December 1, 2020
    Assignee: THE FYNDER GROUP, INC.
    Inventors: Mark A. Kozubal, Richard E. Macur, William P. Inskeep
  • Patent number: 10845369
    Abstract: Sample-collecting devices, articles and methods of use are disclosed. Premoistened sample-collecting devices comprise 1,2-propanediol as a humectant, which promotes the retention of a liquid solution on the sample-collecting device during storage. 1,2-propanediol as humectant can be compatible with proteins and other reagents used to detect an analyte.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: November 24, 2020
    Inventors: Nerys Bennion, James Watkin, Russell M. I. Thomas, William J. Simpson
  • Patent number: 10828165
    Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to TMJ implantation materials and implants (e.g., temporomandi bular joint (TMJ) methods of making TMJ implantation materials and implants, methods of forming a TMJ implantation material or an implant, and the like.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: November 10, 2020
    Assignee: University of Florida Research Foundation, Incorporated
    Inventor: Peter S. McFetridge
  • Patent number: 10793892
    Abstract: The present invention relates to a method for detecting the presence of expanded-spectrum ß-lactamase (ß-lactamase hydrolyzing expanded-spectrum cephalosporin)-producing bacteria in a sample, said method comprising the steps of: a) performing cell lysis on a test sample in order to obtain an enzymatic suspension; b) reacting a fraction of the enzymatic suspension obtained in step a) with a reagent kit, said reagent kit comprising —expanded-spectrum ß-lactamase substrate selected from the group consisting of cephalosporins, aztreonam, and cephamycins, —a pH color indicator which will change color when the pH of the reaction mixture is comprised between 6.4 and 8.4, wherein a color change after step b) indicates the presence of expanded-spectrum ß-lactamase-producing bacteria in the test sample. The invention also relates to a reagent kit, to a microtiter plate and to their uses in detecting the presence of expanded-spectrum ß-lactamase producers in a test sample.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: October 6, 2020
    Inventors: Patrice Nordmann, Laurent Dortet, Laurent Poirel
  • Patent number: 10786539
    Abstract: This invention relates to the use of Lactobacillus delbrueckii to elicit a plant cell of an Iridaceae and the use of these elicited cells in treating sensitive skins.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: September 29, 2020
    Assignee: L'OREAL
    Inventors: Richard Martin, Pascal Hilaire
  • Patent number: 10711215
    Abstract: A method to generate dioxolanes from renewable feedstocks, and more specifically, these oxygenated hydrocarbons can be used as gasoline-range fuels and diesel additives.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: July 14, 2020
    Assignee: The Government of the United States of America as represented by the Secretary of the Navy
    Inventors: Benjamin G. Harvey, Heather A. Meylemans
  • Patent number: 10696944
    Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: June 30, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Armon R. Sharei, Andrea Adamo, Robert S. Langer, Klavs F. Jensen
  • Patent number: 10653729
    Abstract: Probiotic compositions that comprise one or more bacteria species in spore form, a thickener to form a stabilized suspension and to preferably act as a prebiotic, one or more acids or salts of acids, and optionally a water activity reducer. A system for delivering probiotic compositions by gravity feed or non-contact pump to a point of consumption by a plant or animal, preferably in conjunction with acidified drinking water, comprising a collapsible container with attachable tubing that prevent contamination of the probiotic composition within the container. Delivery may be actuated in response to a timer, motion detector, fluid level sensor, RFID tag, or other mechanism to periodically or continuously dispense a dosage of probiotic composition directly to the soil surrounding a plant or to the water or feed for an animal. A method for increasing beneficial bacteria in an animal's GIT comprises adding probiotics to acidified drinking water.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: May 19, 2020
    Assignee: NCH Corporation
    Inventors: Scott Martell Boyette, Judith Gayle Pruitt, John Knope, Adrian Denvir, Charles Greenwald, Alex Erdman