Patents Examined by Sharon E. Kennedy
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Patent number: 7413746Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a self-assembled monolayer.Type: GrantFiled: May 15, 2007Date of Patent: August 19, 2008Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Ni Ding
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Patent number: 7415306Abstract: The present invention provides a transdermal delivery system for hydrophilic anti-emetic agents and methods of using thereof. The system includes an anti-emetic hydrophilic adhesive composition of a hydrophilic polymer and hydrophilic anti-emetic agent, a patch containing at least one hydrophilic layer of the composition, and an apparatus that generates hydrophilic micro-channels in skin of a subject using the patch or composition. The system preferably avoids the use of penetration enhancers and is particularly useful for transdermal delivery of hydrophilic anti-emetic agents.Type: GrantFiled: April 27, 2005Date of Patent: August 19, 2008Assignee: TransPharma Medical Ltd.Inventors: Galit Levin, Dorit Daniel
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Patent number: 7407511Abstract: This invention is generally directed to methods and materials for connective tissue repair. The invention is more specifically related to methods and materials for the repair of tendons and ligaments, especially in the hand. Methods and materials for rotator cuff repair are also disclosed. The use of extraoperatively obtained scaffolding matrices is promoted when reapproximating the connective tissue.Type: GrantFiled: May 13, 2004Date of Patent: August 5, 2008Assignee: Wright Medical Technology IncInventors: Cary P. Hagan, Rick P. Swaim, Kelly W. Schlachter, James J. Chao, Hungnan Lo
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Patent number: 7402320Abstract: This invention relates to occlusion of a hollow anatomical structure by inserting an occluding device or occluding material into a hollow anatomical structure or surrounding native tissue.Type: GrantFiled: August 26, 2005Date of Patent: July 22, 2008Assignee: VNUS Medical Technologies, Inc.Inventors: Michael Stephan Mirizzi, Halil Ibrahim Karabey, Anna Grace Prestezog, Bob McRae
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Patent number: 7399482Abstract: A thin layer medication device and kit for various therapeutic uses are disclosed. The device includes at least one support sheet and at least one application strip attached to the support sheet, wherein the strip includes a polymer base and a therapeutic agent admixed with the polymer base. The kit includes a plurality of support sheets, a plurality of application strips attached to each support sheet; and a case containing the plurality of support sheets.Type: GrantFiled: May 7, 2004Date of Patent: July 15, 2008Inventors: Christine Horner Biernacki, Carolyn Horner Palank
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Patent number: 7399295Abstract: A medical syringe employs a capsule containing multiple doses of medication within a sealed storage chamber formed between concentric inner and outer walls. The inner wall forms a cavity including a delivery chamber from which a single dose of medication is ejected. The syringe includes an ejection port, an axial moveable plunger extending into the cavity and delivery chamber, and a body with a compartment that holds the capsule. With the plunger in a first position, the capsule is closed. With the plunger in a second position, the delivery chamber is filled with a single dose of medication. With the plunger in a third position, the single dose of medication is ejected from the delivery chamber though the injection port.Type: GrantFiled: September 22, 2006Date of Patent: July 15, 2008Inventor: Ottfried Waldenburg
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Patent number: 7399484Abstract: The present invention relates to a patch and method for providing therapy to an individual. The patch and method provide a user or therapist with the flexibility to apply a patch to highly contoured areas on the individual's body. In some embodiments, the patch includes a body that applies therapy to the individual when the patch is placed on the individual. The patch further includes at least one cut in the body of the patch. In other example embodiments, the present invention relates to a method of providing therapy to an individual. The method includes selecting a patch that provides therapy to an individual. The patch includes a body and at least one cut in the body. The method further includes applying the patch to the individual where the cut in the body allows the patch to conform to the individual as the patch is applied to the individual.Type: GrantFiled: June 30, 2004Date of Patent: July 15, 2008Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Kimberly L. Ellefson, James D. Milner, MeeWha Lee
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Patent number: 7399480Abstract: A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature.Type: GrantFiled: October 29, 2004Date of Patent: July 15, 2008Assignee: Abbott LaboratoriesInventors: Karl W. Mollison, Angela M. LeCaptain, Sandra E. Burke, Keith R. Cromack, Peter J. Tarcha
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Patent number: 7399486Abstract: Disclosed is a method for preparing a mixed formulation of sustained release microspheres with various compositions by a continuous one-step process. The present method is characterized by preparing the mixed formulation of sustained release microspheres with different compositions by a continuous one-step process by continuously introducing the mixed fluids into a dryer from the two or more different fluids for preparation of sustained release microspheres containing a biodegradable polymer, a drug, an additive and a solvent with different types of contents or both of the components, by controlling the mixing ratios of the fluids according to the time, unlike a conventional method including spray-drying a mixture of microspheres containing a biodegradable polymer, a drug, an additive and a solvent with a single composition.Type: GrantFiled: June 25, 2004Date of Patent: July 15, 2008Assignee: Peptron Co., Ltd.Inventors: Hee Yong Lee, Sung Kyu Kim, Jung Soo Kim, Ji Suk Lee, Young Hwan Jung, Jung In Kim, Yun Mi Seo, Ho-Il Choi, Seung Gu Chang, Kee Don Park
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Patent number: 7396541Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.Type: GrantFiled: September 15, 2005Date of Patent: July 8, 2008Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Ni Ding
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Patent number: 7396539Abstract: Coatings and methods of forming coatings for implantable medical devices, such as stents, are described. The coatings are used for the sustained release of a therapeutic agent or drug.Type: GrantFiled: June 21, 2002Date of Patent: July 8, 2008Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F A. Hossainy, Gordon Stewart
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Patent number: 7396540Abstract: Treatment of aneurysmal blood vessels with local delivery of therapeutic agents thereby reduces or lessens the severity of an aneurysm, and, where used in conjunction with the placement of an excluding device, provides for more rapid recovery of the blood vessel from any disturbance occurring during placement of the excluding device. Therapeutic agents are placed in the aneurysmal site in a time-release carrier medium, such that the therapeutic agent is released into the aneurysmal site over a period of time without the need to provide systemic introduction of the therapeutic agent. The carrier may be introduced through the patient's dermis, such as with the use of a laparoscope, or intravacularly, through the use of a catheter. The carrier may be in a solid matrix, viscous liquid or liquid form.Type: GrantFiled: April 25, 2003Date of Patent: July 8, 2008Assignee: Medtronic Vascular, Inc.Inventors: Jack Chu, Brian Raze
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Patent number: 7395111Abstract: The present invention provides a system for transdermal delivery of water insoluble drugs and methods using the same. The system includes a pharmaceutical composition of a water insoluble drug and a carrier molecule that enhances the solubility of the drug in aqueous solution, a medical patch containing the same and an apparatus that generates hydrophilic micro-channels in an area of skin of a subject using the composition or patch. The system preferably avoids the use of penetration enhancers and is particularly useful for transdermal delivery of steroids.Type: GrantFiled: April 27, 2005Date of Patent: July 1, 2008Assignee: TransPharma Medical Ltd.Inventors: Galit Levin, Meir Stern, Dorit Daniel
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Patent number: 7390500Abstract: The invention relates to a transdermal therapeutic systems with fentanyl or an analogous fentanyl derivative as active ingredient. In order to prevent inadvertent overdosage by uncontrolled release of active ingredient as a result of damage, the active ingredient is contained in fluid-filled micro-reservoirs in the layer containing the active ingredient. The layer containing the active ingredient can optionally be provided with a membrane.Type: GrantFiled: July 10, 2002Date of Patent: June 24, 2008Assignee: LTS Lohmann Therapie-Systeme AGInventor: Walter Müller
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Patent number: 7387785Abstract: The present invention refers to an considerably improved medicinal preparation and its synthesizing method, in particular for allowing to affect the osteoreparative process due to stimulation of the prolific and functional activity of osteoblasts without risk of development of the immunologic conflict reactions. According to the invention it is provided a medicinal combined preparation for treating diseases of bone tissue containing at least a medicinal component, especially having anti-inflammatory and/or anti-bacterial properties and nano-sized crystalline hydroxyapatite having average dimensions with a length equal to 0.06 ?m±50%, a width equal to 0.015 ?m±50% and a thickness equal to a single transmission of crystalline lattice of the hydroxyapatite, in particular to 0.00068 ?m or 0.000814 ?m depending on direction of the symmetry axis of the crystalline cell.Type: GrantFiled: September 12, 2000Date of Patent: June 17, 2008Assignee: Zakrytogo Aktsionernoe Obschestvo “Ostim”Inventors: Vsevolod Nikolatvich Rudin, Vladimir Fedorovich Komarov, Igor Vitallevich Melikhov, Vladimir Vasillievich Minaev, Andrei Yurievich Orlov, Viktor Eygenievich Bozhevolnov, Aleksander Sergievich Pankratov
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Patent number: 7384649Abstract: This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, Applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (?) is greater than 2, optimally greater than 3.Type: GrantFiled: December 5, 2006Date of Patent: June 10, 2008Assignee: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, David A. Edwards, Michael M. Lipp
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Patent number: 7381419Abstract: Optimum compounding composition of a local injection preparation for treating rectal submucous lesioned abnormal tissue with local anesthetic is decided to provide a medical composition kit. In a composition kit for the treatment where respective containers are unsealed upon being used and respective contents are mixed to obtain a preparation for injection, a medical composition kit which is characterized in that respective single doses of a therapeutic preparation and local anesthetic are fractionally charged in containers, the said therapeutic preparation contains 1˜10% of a water-soluble aluminum compound and 0.01˜2% of tannic acid and the said local anesthetic contains 0.1˜1% of lidocaine hydrochloride or 0.5˜5% of procaine hydrochloride.Type: GrantFiled: June 5, 2001Date of Patent: June 3, 2008Assignees: Lequio Pharma Co., Ltd., Mitsubishi Pharma CorporationInventors: Kinuko Oku, Takako Iwamoto, Takashi Ono
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Patent number: 7381418Abstract: An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymeric release region comprises a radiation-crosslinked polymer, and the polymeric release region is crosslinked with a radiation dose of at least 10,000 rads. The radiation-crosslinked polymer can be, for example, a radiation-crosslinked methylene-containing polymer. The polymeric release region can be, for example, (a) a carrier region that comprises the therapeutic agent or (b) a barrier region that is disposed over a therapeutic-agent-containing region that comprises the therapeutic agent. The present invention is further directed to methods of forming such medical devices, methods of releasing a therapeutic agent within a patient using such medical devices, and methods of modulating the release of a therapeutic agent from such medical devices.Type: GrantFiled: July 5, 2007Date of Patent: June 3, 2008Assignee: Boston Scientific Scimed, Inc.Inventor: Robert E. Richard
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Patent number: 7378106Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.Type: GrantFiled: December 18, 2006Date of Patent: May 27, 2008Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Eugene T. Michal, Yiwen Tang
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Patent number: 7378105Abstract: A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature.Type: GrantFiled: August 15, 2006Date of Patent: May 27, 2008Assignee: Abbott LaboratoriesInventors: Sandra E. Burke, Keith R. Cromack, Matthew Mack, John L. Toner