Patents Examined by Sharon E. Kennedy
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Patent number: 7323162Abstract: There is provided an aqueous cosmetic composition. The composition has an amount of a water-resistant film former and an amount of an oil-resistant film former effective to impart resistance to both water and oil when applied to the lip and/or skin. A preferred composition is a lip coloring and gloss product.Type: GrantFiled: December 27, 2002Date of Patent: January 29, 2008Assignee: Avon Products, Inc.Inventors: Shari R. Martin, Giovana A. Sandstrom, Jason N. Rothouse, Glen T. Anderson, Alan Letton, Hung-Ta Lin, Tao Zheng
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Patent number: 7320799Abstract: A multi-layer coating is particularly useful for the coating of implants such as orthopedic and dental implants, particularly metallic implants. The multi-layer coating has both high bond strength to implants and excellent bioactivity with the surrounding body tissue. A method of making a coated implant includes depositing a first layer on a metallic substrate, wherein the first layer comprises a material selected from the group consisting of nitride compounds, boride compounds, carbide compounds, and mixtures of two or more of the foregoing materials; forming at least one slurry comprising an apatite and a binder, wherein the apatite has greater than about 90% crystallinity, and wherein the binder is inert in body fluids; depositing the slurry on the first layer to form a green coating; and sintering the green coating to form a second layer.Type: GrantFiled: May 5, 2006Date of Patent: January 22, 2008Assignee: Inframat CorporationInventors: Zongtao Zhang, Tongsan D. Xiao
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Patent number: 7320798Abstract: A multi-layer coating is particularly useful for the coating of implants such as orthopedic and dental implants, particularly metallic implants. The first layer comprises a dense material insoluble and inert in body fluids. The second layer comprises apatite and a binder. The first layer protects the metallic implants from corrosion, apatite dissolution, and interfacial reaction with apatite and the binder. The binder allows adjustment of the thermal expansion coefficient between the coating and the metallic substrate. This multi-layer coating has both high bond strength to implants and excellent bioactivity with the surrounding body tissue.Type: GrantFiled: May 5, 2006Date of Patent: January 22, 2008Assignee: Inframat CorporationInventors: Zongtao Zhang, Tongsan D. Xiao
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Patent number: 7311731Abstract: A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying a target region of the myocardium and applying material directly and substantially only to at least a portion of the myocardial tissue of the target region through transseptal delivery. The material applied results in a physically modification the mechanical properties, including stiffness, of said tissue. Various devices and modes of practicing the method are disclosed for stiffening, restraining and constraining myocardial tissue for the treatment of conditions including myocardial infarction or mitral valve regurgitation. The novel treatment may be combined with prior art diagnostic and therapeutic techniques employing transseptal delivery methods.Type: GrantFiled: October 24, 2002Date of Patent: December 25, 2007Inventors: Jeanne M. Lesniak, Bonnie H. Weiner, William P. Santamore
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Patent number: 7306812Abstract: A dissolvable backing layer for use with transmucosal drug delivery devices includes a dissolvable hydrophilic region and a non-hydrophilic region that inhibits or slows migration of water, drugs, other active agents, or other molecules through the backing layer. The non-hydrophilic region can be a disperse phase of gaseous voids, droplets of a hydrophobic liquid, solid particles of a hydrophobic material, or water insoluble particles that are not necessarily hydrophobic. In the alternative, the non-hydrophilic region may comprise a continuous layer or component that is readily dispersible upon dissolving of the hydrophilic region. The backing layers may be used within any transmucosal delivery device used to delivery drugs or other active agents across a mucosal surface.Type: GrantFiled: May 7, 2004Date of Patent: December 11, 2007Assignee: Cephalon, Inc.Inventor: Hao Zhang
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Patent number: 7303758Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.Type: GrantFiled: January 20, 2004Date of Patent: December 4, 2007Assignee: Cordis CorporationInventors: Robert Falotico, Tom Jay Parry, Jonathon Z. Zhao
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Patent number: 7303549Abstract: A device for delivering fluid to a person including a reservoir for containing a fluid to be delivered to the person, a fluid transport device for dispensing fluid from said reservoir to the person, said fluid transport device including a proximal end in fluid communication with said reservoir and a distal end having a penetrating member for piercing the skin of the person to facilitate the delivery of fluid to the person through the fluid transport device, a housing containing said reservoir and said fluid transport device, said housing including an exit port for receiving said distal end of said fluid transport device upon injection of said distal end into said person and means for securing a first wall of said housing to the skin of the person, a injection activation device including a driving mechanism contacting said fluid transport device for driving said penetrating member from a first position within said housing, through said exit port to a second position, external to said housing and into the skinType: GrantFiled: March 21, 2005Date of Patent: December 4, 2007Assignee: Insulet CorporationInventors: J. Christopher Flaherty, William Gorman, John Garibotto, Timothy Wood, Patick Gutelius
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Patent number: 7300661Abstract: A vasoocclusive microcoil for therapeutic treatment of a patient's vasculature includes a surface with a plurality of voids or pores therein, and a therapeutic or bioactive material disposed within the plurality of voids or pores. The therapeutic or bioactive material within the plurality of voids or pores operates to accelerate a healing process in the patient's vasculature when the microcoil is introduced into the patient's vasculature.Type: GrantFiled: May 16, 2006Date of Patent: November 27, 2007Assignee: Micrus Endovascular CorporationInventors: Michael Henson, Robert A. Stern
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Patent number: 7300662Abstract: A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.Type: GrantFiled: April 21, 2004Date of Patent: November 27, 2007Assignee: Cordis CorporationInventors: Robert Falotico, Gregory A. Kopia, Gerard H. Llanos
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Patent number: 7294347Abstract: The present invention discloses coating compositions with taste masking property, comprising a blend of pH sensitive polymers and optionally a pH independent polymer or a blend of the pH sensitive polymer and pH independent polymer used for taste masking of highly bitter drugs. The pH sensitive polymers used comprise the acid soluble polymers and the enteric polymers. The process for the preparation of taste masked pharmaceutical compositions of the bitter drugs comprising the said coating compositions is disclosed. The concomitant use of the polymers inhibits the release of the bitter drug at the pH of saliva. The said coating compositions deliver substantial amount of the bitter drug immediately with improved palatability.Type: GrantFiled: June 21, 2004Date of Patent: November 13, 2007Assignee: Council of Scientific and Industrial ResearchInventors: Anupa R. Menjoge, Mohan G. Kulkarni
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Patent number: 7294344Abstract: The present invention is to provide a sustained-release preparation which comprises a compound having angiotensin II antagonistic activity, its pro-drug or their salt, and a biodegradable polymer, and if necessary, a polyvalent metal, and which is highly stable and active and shows angiotensin II antagonistic activity while maintaining circadian rhythm of blood pressure for a long time.Type: GrantFiled: May 22, 2003Date of Patent: November 13, 2007Assignee: Takeda Pharmaceutical Company LimitedInventors: Yasutaka Igari, Akira Saikawa, Yoshiyuki Inada, Shigeru Kamei
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Patent number: 7288570Abstract: The invention relates to a formulation in the form of a pharmaceutical composition, a food product, a feed product or a dietary supplement, comprising leucine and protein in specific amounts. Consumption of a formulation according to the invention has a very positive effect on the generation of muscle tissue and is therefore particularly useful for organisms wherein an anabolic response is desired.Type: GrantFiled: December 20, 2002Date of Patent: October 30, 2007Assignee: Nutricia N.V.Inventors: George Verlaan, Rudolf Leonardus Lodewijk Smeets, Robert Reese Wolfe
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Patent number: 7285520Abstract: Cleansing wipes comprising a film forming polymeric material and a cleansing agent stored in dry form are disclosed. The cleansing wipes are water disintegratable such that upon contact with water, the cleansing wipes release the cleansing agent and begin to dissolve/disperse into the water. Full dissolution/dispersion of the cleansing wipes occurs in about 60 seconds or less after contact with water to allow for a sufficient time for cleansing of the hands or other skin area.Type: GrantFiled: December 1, 2003Date of Patent: October 23, 2007Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Duane G. Krzysik, Stephen Baldwin, Bernard J. Minerath, III, Beth A. Lange, David J. Tyrrell
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Patent number: 7282216Abstract: The present invention relates to a novel series of polymers which have been prepared by blending hydrophobic biocompatible, biodegradable polymers or copolymers, such as poly(lactide-co-glycolide), and a biocompatible, amphipathic copolymer having a water absorption ratio of about 2 or less. A process for the preparation of the novel polymer blends and sustained release compositions comprising the novel polymer blends are also part of the invention described herein. Further the sustained release compositions can be used to deliver a biologically active with a desirable release profile and in a sustained fashion to a patient in need thereof.Type: GrantFiled: November 12, 2002Date of Patent: October 16, 2007Assignee: Alkermes Controlled Therapeutics, Inc.Inventors: Henry R. Costantino, Mark A. Tracy, Kevin L. Ward, Wendy W. Nelson
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Patent number: 7282218Abstract: The present invention discloses a substantially amorphous pharmaceutical composition comprising a drug that can exist in a variety of polymorphic forms and a pH sensitive polymer, which inhibits the crystallization of the drug during formulation and reconstitution. Polymers of higher molecular weight are more effective at lower loading, especially when the drug polymer matrix is prepared by the solvent evaporation or solvent extraction technique. The compositions used as dry syrups maintain bioavailability of the drug and effectively mask the taste of the drug when the composition is reconstituted.Type: GrantFiled: December 19, 2003Date of Patent: October 16, 2007Assignee: Council of Scientific and Industrial ResearchInventors: Mohan Gopalkrishna Kulkarni, Anupa Ramesh Menjoge
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Patent number: 7282217Abstract: The invention provides a rapidly disintegrating tablet comprising an active ingredient, a water soluble, directly compressible carbohydrate, and a water soluble, directly compressible filler. Also provided is a method of producing a rapidly disintegrating tablet, which method comprises wet granulating a mixture comprising a directly compressible, water soluble carbohydrate, a directly compressible, water insoluble filler, a beneficial ingredient, and a solvent, and compressing the granulate to produce the tablet.Type: GrantFiled: August 30, 2004Date of Patent: October 16, 2007Assignee: KV Pharmaceutical CompanyInventors: Michael N. Grimshaw, Donald J. Barbieri, Louise M. Vizzini, Steve F. Marsh
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Patent number: 7282219Abstract: A powdery preparation for transmucosal administration comprising a medicine of high molecular weight, a cationic polymer and, as needed, a viscous polymer, further comprising an effective amount of a basic amino acid. The powdery preparation for transmucosal administration has an improved storage stability for the medicine of high molecular weight while maintaining an improved mucosal absorption of the medicine.Type: GrantFiled: March 28, 2001Date of Patent: October 16, 2007Assignee: Kirin Beer Kabushiki KaishaInventors: Hideaki Nomura, Yosuke Ueki
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Patent number: 7279174Abstract: A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein the hydrophobic polymer and the hydrophilic additive form a physically entangled or interpenetrating system.Type: GrantFiled: May 8, 2003Date of Patent: October 9, 2007Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Stephen D. Pacetti, Yiwen Tang
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Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions
Patent number: 7279181Abstract: The present invention provides a method of producing particles from solution-in-supercritical fluid or compressed gas emulsions. In accordance with the method of the invention, a solution that includes a solute dissolved in a solvent is contacted with supercritical fluid or compressed gas to form a solution-in-supercritical fluid or compressed gas emulsion. The emulsion is sprayed through an orifice to create spray droplets. The supercritical fluid or compressed gas and the solvent are removed from the spray droplets resulting in the formation of particles that include the solute. In one embodiment of the invention, the solvent is removed from the spray droplets by lyophilization. In another embodiment of the invention, the solvent is removed from the spray droplets by evaporation.Type: GrantFiled: June 2, 2004Date of Patent: October 9, 2007Assignee: Ferro CorporationInventors: Pratibhash Chattopadhyay, Boris Y. Shekunov, Jeffrey S. Seitzinger -
Patent number: 7279175Abstract: An intraluminal medical device comprises a stent having a coating applied to at least part of an interior surface, an exterior surface, or both. The coating comprises a sustained release formulation of a combination of pharmaceutical compounds dispersed within a biologically tolerated polymer composition. The choice of the combination of pharmaceutical compounds are intended to reduce neointimal hyperplasia restenosis.Type: GrantFiled: September 17, 2002Date of Patent: October 9, 2007Assignee: Psivida Inc.Inventors: Jianbing Chen, Paul Ashton