Abstract: A needle protective housing is fitted to the neck of a medicament container, for example a glass vial, that has a circumferential notch formed at a proximal portion of the neck. The needle protective device has a needle protective housing pivotally connected to a cup-shaped collar. The collar has a base that is formed by a plurality of coplanar extensions, that in turn form an aperture that allows the base to be press-fitted onto the neck of the vial. The extensions are each separated by a space, so that the extensions would give way when the collar is slidedly fitted along the length of the neck of the vial, until the extensions reach the notch at the proximal end of the neck of the vial where the extensions return to the original shape to thereby couple the collar to the vial. The circular wall upraised from the base of the collar is internally threaded for accepting the luer of a needle assembly, when the needle assembly is mated to the neck of the syringe.

Abstract: The present invention describes DNA coated stents and methods of using the same to treat or prevent vascular diseases, such as restenosis.

Abstract: A dialysis catheter comprising a catheter body having a proximal portion, a distal portion, a first longitudinally extending central lumen configured to deliver blood, and at least three longitudinally extending lumens positioned radially of the central lumen and configured to withdraw blood from a patient. At least one blood delivery opening is formed in the distal portion of the catheter body and in fluid communication with the first lumen and configured for passage of blood therethrough. At least three blood withdrawal openings are formed in the outer wall of the catheter body, wherein each of the openings is in fluid communication with one of the at least three lumens and is configured for passage of blood from a patient.

Abstract: An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid. The dermal-access member extends at least 1 mm from the protrusion. A mechanism drives the device against the skin at a calculated speed of about 6 m/s to about 18 m/s.

Abstract: Embodiments of the present invention generally relate to devices and processes related to estrus synchronization. Particular embodiments of devices and processes of the present invention slowly release progesterone over a period of time for estrus synchronization.

Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.

Abstract: A fluid handling device comprises a barrel for containing fluid to be delivered through a needle, a needle-mounting hub at one end of the barrel, a biasing element arranged to urge the hub inwardly of the barrel, a stop element blocking inward movement of the hub into the barrel, and a hollow plunger which is movable within the barrel to deliver fluid from the barrel via the needle and has at its forward end a portion which is severable in response to movement of the plunger over the final part of, or at the conclusion of, its delivery stroke to allow retraction of the needle-mounting hub into the hollow plunger, the hub and the stop element being formed as plastics mouldings in such a way that the stop element is axially captive with the hub and the plunger being arranged to disengage the stop element and the hub during said final part of, or at the conclusion of, the delivery stroke to allow the biasing element to drive the needle into the hollow plunger.

Abstract: Many conventional pharmaceutical articles contain seemingly inert components that come into contact with a pharmaceutically active material during use, which contact substantially reduces the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to these incompatible components, which are effective to diminish the reduction in pharmaceutical effectiveness.

Abstract: Distal protection filter assembly and methods for coupling a filter to an elongate shaft. A filter assembly may include a tubular adaptor having a distal holding receptacle. The filter may include struts adapted and configured for being coupled to the holding receptacle.

Abstract: This relates to an improved delivery system for accurately loading and controlling the delivery of flowable material to a patient. Particularly, the system may be used in the injection of hard tissue implant materials such as PMMA under pressures up to about 4000 psi. The system includes an applicator with a first column having an implant material introduction section adapted to provide for effective loading of the implant material and a second column housing a piston. The introduction section has a larger size than that of a vessel section or bore in which the requisite pressure seal between the piston and bore wall is formed. The first column may include an introduction section flared open to an included larger funnel-like opening or a separate funnel may be used that interfaces with the introduction section to facilitate the introduction of implant material.

Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a housing assembly having an interior chamber, a filter assembly, an activation assembly and a needle assembly. In accordance with the present invention, the interior chamber may include a dry compartment for storing a predetermined dry charge of dry medicament therein, and a wet compartment for storing a predetermined amount of liquid injection solution therein. The filter assembly enhances the laminar flow of fluid between the wet compartment to the dry compartment prior to the pressurization of the liquid injection solution within the wet compartment.

Abstract: Continuous flow catheters, diffusers for catheters, catheters having a diffuser, and methods for continuous flow peritoneal dialysis are provided. The continuous flow catheter includes at least two lumens, of which one is short and the other is long. The long lumen is coiled and contains a plurality of openings. Another similar continuous flow catheter also includes a diffuser for the dispensing of fluid in a diffused manner. The catheters are used for peritoneal dialysis. The diffuser, for use with a catheter, has a plurality of openings for the dispensing of matter in a diffused manner. One method for continuous flow peritoneal dialysis includes creating an incision in the body of the user and separating the anatomical layers, making a circular suture in the peritoneal membrane, making an incision in the peritoneal membrane, inserting the catheter, and tightening the parietal peritoneum.

Abstract: A dual port syringe has an upper port for connection to a fluid reservoir and a lower port for delivery of the medical fluid under pressure to a patient. A first valve is connected between the fluid reservoir and the upper port, and second valve is connected between the lower port and the patient. During a fill operation, a piston is moved within the syringe to drawn fluid from the reservoir into the syringe through the upper port. During injection operation, the piston moves in an opposite direction to force fluid out of the syringe through the lower port.

Abstract: A probe that facilitates the creation of circumferential lesions in body tissue. The probe includes a probe body and a helical or loop structure that supports electrodes or other operative elements against the body tissue.

Abstract: A reusable cannula that supports minimally invasive surgical procedures, such as endoscopic and thorascopic procedures, fabricated from a composition including polyarylsulfone material that is non-conductive, radiolucent, and sterilizable. The cannula is compatible with endoscopic devices as well as standard housing/seal and trocar systems.

Abstract: An apparatus for the delivery of a biological composite and a method, kit, and system for preparing a biological composite is described herein. The biological composite includes both inorganic and biological materials.

Abstract: Spray-coated pharmaceutical powder compositions for transdermal administration using a needleless syringe comprise seed particles coated with a pharmaceutical composition, the said coated seed particles having an average size of about 10 to 100 &mgr;m and having an envelope density ranging from about 0.1 to about 25 g/cm3.

Abstract: The invention relates to a cannula support having a needle covering function, which may be connected to an injection or infusion device and forms a receptacle for a cannula, including at least two pivoting side portions which project from said receptacle which may be pivoted towards each other, to form a needle cover covering a proximal end of said cannula. The invention also encompasses a packaging structure for storing and transporting the cannula support.

Abstract: A catheter having one or more radio-opaque bands near the distal end is designed to be inserted into the renal artery so that the distal end of the catheter is adjacent to the origin of the renal artery. An X-ray image of the bands is used to position the X-ray head relative to the aorta and renal artery so that a useful, unobstructed radiological image perpendicular to the axis of the renal artery at its origin is obtained. This facilitates the positioning of a stent in the renal artery so that the stent encompasses the origin and extends no more than about three millimeters into the aorta. Two radio-opaque bands placed close to one another define a narrow radio-translucent band such that when the X-ray head is rotated to a position where parallax is reduced and the radio-translucent band can be imaged, the renal artery can be appropriately imaged without being obscured by the aorta.

Abstract: The present invention provides a transthoracic drug delivery device that utilizes pressure to determine the precise location of the distal tip of the delivery tube of the device to insure that therapeutic substances are ejected into the myocardium and not dissipated in unintended tissue locations. In one embodiment the drug delivery device comprises a pressure sensing tube mounted in parallel to a drug delivery tube wherein the tubes are staggered so that the pressure tube extends beyond the delivery tube. When the myocardium is penetrated by the tubes, advancement into the heart and penetration into the left ventricle by the pressure sensing tube results in a pressure increase that indicates to the physician that the drug delivery tube, by its placement relative to the pressure sensing tube is still in the myocardium and, thus, prepared to deliver the drug.