Abstract: Apparatus for intracardiac drug administration, including a catheter which is inserted into a chamber of the heart and brought into engagement with a site in the heart wall. The catheter includes at least one position sensor, which generates signals responsive to the position of the catheter within the heart, and a drug delivery device, which administers a desired dose of a therapeutic drug at the site determined responsive to the signals from the position sensor.

Abstract: An injector pack has a box which houses in separate positions a firing mechanism and a syringe housing. The firing mechanism has safe and cocked conditions and as it is located in the box it is constrained to adopt the safe condition by a sleeve grip being held against rotation while a protruding barrel co-operates with cams to rotate it. The firing mechanism when removed can be screwed by its barrel to the rear end of the syringe housing while that is held by the box, and then the whole injector can be withdrawn for use. The syringe is made operable by rotating the barrel to the cocked condition. Pressing the grip forwards then releases a plunger to act on the syringe. The previous retraction of the plunger can be done using a pillar formation upstanding within the box and over which the barrel can be sleeved.

Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

Abstract: An intraluminal balloon catheter with an elongated shaft, and an inflatable balloon on the shaft which has an inner layer and a discontinuous outer layer formed at least in part of an elastomeric polymeric material. In a presently preferred embodiment, the catheter is a stent delivery catheter with a stent disposed on the balloon in contact with at least a section of the discontinuous outer layer of the balloon. The discontinuous outer layer of the balloon may comprise fibers or strands of the elastomeric material woven into a braided, webbed, meshed, wrapped or wound outer layer of the balloon.

Abstract: A device for delivering fluid to a patient including an exit port assembly adapted to connect to a transcutaneous patient access tool, a flow path extending from the exit port assembly, and a flow condition sensor assembly including a resilient diaphragm having opposing first and second surfaces. The first surface of the diaphragm is positioned against the flow path, and a chamber wall is positioned adjacent the second surface of the diaphragm and defines a sensor chamber against the second surface of the diaphragm. At least one sensor is arranged to provide a threshold signal when the second surface of the diaphragm expands into the chamber in response to at least one predetermined fluid flow condition occurring in the flow path.

Abstract: A skin cleansing device for cleansing facial skin includes electrode pairs attached to a facial mask and a cleansing signal generator for generating an alternating electric cleansing signal, the electrode pairs being operatively connected to the signal generator to apply the cleansing signal to charged molecules of the cleansing solution located at mask absorbent areas to create alternate backward and forward motion of the facial skin surface.

Abstract: A catheter is formed with a layered wall construction including an inside tube formed of a low friction polymer, a polymeric outside tube, and a metallic reinforcement braid embedded in the wall between the inside and outside tubes. The braid is composed of multiple elongate flexible strands preferably of stainless steel, wound in two opposite directions and interbraided with one another. Each strand has a rectangular transverse profile, with a profile width at least three times the profile thickness. The strands are wound with their thicknesses directed radially of the catheter wall, permitting the catheter wall to be formed at a reduced thickness while maintaining favorable structural characteristics including pushability, torqueability, flexibility and resistance to kinking. As a result, the catheter's outside diameter can be reduced without reducing its interior lumen, or alternatively a larger interior lumen can be provided in a catheter of a given size.

Abstract: A securement device includes a simply-structured retention mechanism that permits a portion of a catheter hub or a similar medical article to be easily anchored to a patient, without the use of tape or needles and suturing. A unitary retainer desirably includes a base defining a locator mechanism. The locator mechanism interacts with a fitting of the medical device so as to position the medical device relative to the retainer. The locator mechanism also desirably guides the medical device fitting into contact with an adhesive member mounted on an outer surface of the retainer. In one form, the locator mechanism includes one or more posts that engage mating holes defined in the medical device fitting. In other forms, the locator mechanism includes a cradle defining an arcuate channel to receive a convex surface of the medical device, or a recess shaped to matingly receive the fitting.

Abstract: A needle guiding apparatus includes a base, a guide assembly, and an imaging sight. The base defines an opening that extends through the base. The guide assembly includes at least one passage, and the guide assembly is disposed within the opening of the base. The guide assembly also is rotatable about at least one axis. The imaging sight is disposed adjacent the passage. An entry needle can be inserted through the needle guiding apparatus and into a body. Devices and methods according to the present invention allow a medical professional to accurately and rapidly place a probe, such as a needle, in a patient.

Abstract: An infusion hub assembly, comprising: a hub received in a hole in a wing, the hub having a bore passing therethrough, with an upper portion of the circular hub having an attachment surface thereon; an infusion cannula extending downwardly away from the wing, the infusion cannula being in fluid communication with the bore passing through the hub; a cover having a bore passing therethrough and having an inner attachment surface adapted to mate with the attachment surface on the upper portion of the hub; and a septum positioned in alignment with the bore passing through the cover.

Abstract: In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

Abstract: A surgical handpiece having at least two lumens or tubes mounted to a body. At least one tube is used for aspiration and at least one other tube is used to inject heated surgical fluid for liquefying a cataractous lens. A portion of the second tube is enlarged to form a pumping chamber. The pumping chamber works by boiling a small volume of the surgical fluid. As the fluid boils, it expands rapidly, thereby propelling the liquid downstream of the pumping chamber out of the second tube. The pumping chamber may use a pair of electrodes.

Abstract: An improved breastshield for breastpumps has a tubular extension with a non-circular internal contour such as an oval, polygonal or fluted shape, among others. In another aspect of the invention, the non-circular contour is provided in the main breast-receiving part of the breastshield. Surface features, such as protuberances, are further provided for the breastshield which yield a non-smooth tactile feel to the breastshield.

Abstract: A needless connector is provided which utilizes a resealable preslit septum valve. The valve is resiliently restrained relative to a housing with the valve and housing configured to accept a standard male luer lock having a luer tip which penetrates the valve through the opening to extend within the housing and a luer locking flange of the luer lock extending about the housing. The valve includes a disk shaped upper portion covering the opening, a lower portion spaced from the housing and extending downward from the disk shaped portion into a passageway defined by the housing, and an annular skirt to attach the septum to the housing. The connector exhibits satisfactory leak pressure after multiple connections and disconnects to the luer lock fitting and long periods of indwell of the luer tip.

Abstract: A catheter assembly comprising a elongated, flexible support structure having an axis. The assembly also includes an elongated porous electrode assembly carried by the support structure along the axis for contact with tissue. The elongated porous electrode assembly comprises a wall having an exterior peripherally surrounding an interior area, a lumen to convey a medium containing ions into the interior area, and an element coupling the medium within the interior area to a source of electrical energy. At least a portion of the wall comprising a porous material is sized to allow passage of ions contained in the medium to thereby enable ionic transport of electrical energy through the porous material to the exterior of the wall to form a continuous elongated lesion pattern in tissue contacted by the wall. The support structure can have a curvilinear geometry, e.g., a loop shape, and the elongated porous electrode assembly conforms to the curvilinear geometry.

Abstract: A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.

Abstract: A disposable syringe has a plunger rupture device and a washer-guide sealing barrel nozzle which make it safe against re-use, since the plunger breaks up and the piston is stuck at the bottom of the barrel, thereby making impossible reloading of the syringe. The syringe is assembled by fitting the pressure washer onto the plunger, fitting the rubber to the piston base, fitting the plunger to the piston, inserting the support bolt to the fitting of the set plunger/piston, fitting the assembled set plunger/piston into the barrel, and, finally, seating the screening washer inside the top of the barrel, thereby sealing the syringe entirely.

Abstract: Locking device that is mounted on an endoscope or the like for selectively securing the position of a guide wire and/or catheter relative to the endoscope or the like. The locking device preferably includes a side wall with an opening therein for receiving the proximal end of a guide wire or catheter. The opening is preferably J-shaped or boot shaped, and has an entry end and a locking end. Once a guide wire or catheter is in a desired position within a body cavity, the portion of the guide wire or catheter that extends outside of the endoscope or the like may be moved into the opening. More particularly, a portion of the guide wire or catheter may be inserted by an operator through the entry end of the opening and into the locking end, wherein the locking end frictionally secures the position of the guide wire or catheter relative to the endoscope or the like.

Abstract: An adhesive “block” device is provided which can be used to grip to removable caps of single-use, disposable, hypodermic needles. Adhesive is provided on four sides of the block allowing for the block to be attached at one side to a tray or other supporting surface, with at least one of the surfaces configured to easily deform, retain said deformation, and adhesively grip and immobilize the caps to allow for safe, “one-hand” removal and subsequent replacement of the needle in the cap.

Abstract: A portable iontophoresis apparatus for facilitating delivery of medication across the cutaneous membrane into adjacent underlying tissues and blood vessels. The apparatus employs a modular, detachable non-reusable medicament-containing applicator electrode which is adapted to attach to a base assembly. The apparatus is designed to be hand-held and includes a circumferential tactile electrode band on the base assembly which provides electrical connection between the skin of the user's hand and one pole of a bipolar power source housed within the base assembly. The opposing pole of the power source is connected to the applicator electrode. The user's body completes the electrical circuit between the applicator and tactile electrodes. A method for using the device for the treatment of Herpes simplex infection and related viral infections which produce similar cutaneous lesions is presented.