Patents Examined by Sharon M Papciak
  • Patent number: 11898192
    Abstract: A method for quantifying at least one microorganism group via at least one mass spectrometry analysis. The method includes at least one separation and fragmentation step. The method moreover includes a step that involves measuring the amount of at least one representative peptide or at least one protein representing the microorganism group. The at least one representative peptide or the at least one protein is obtained after the at least one separation and fragmentation step and serves as a quantification marker(s). The amount of the quantification marker(s) is directly correlatable to the amount of the at least one microorganism group.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: February 13, 2024
    Assignee: BIOMÉRIEUX
    Inventors: Chloé Bardet, Tiphaine Cecchini, Yannick Charretier, Jean-Philippe Charrier, Christelle Compagnon, Tanguy Fortin
  • Patent number: 11891626
    Abstract: The present disclosure relates to discogenic cell populations, methods of deriving, and methods of using them. The presently described discogenic cell populations may be used to restore or regenerate damaged, diseased, or missing intervertebral discs of a subject. The presently described discogenic cell populations can be derived from and administered or implanted into a subject, or may be derived from an unrelated donor.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 6, 2024
    Assignee: DiscGenics, Inc.
    Inventors: Lara Ionescu Silverman, Kevin T. Foley
  • Patent number: 11891622
    Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: February 6, 2024
    Assignee: CELL CURE NEUROSCIENCES LTD.
    Inventors: Osnat Bohana-Kashtan, Lior Ann Rosenberg Belmaker, Ofer Wiser
  • Patent number: 11884958
    Abstract: This document provides methods and materials involved in assessing and/or treating a mammal having a functional gastrointestinal disorder (FGID) such as irritable bowel syndrome (IBS). For example, methods and materials provided herein can be used for determining if a mammal having a FGID is likely to respond to a particular FGID treatment. This document also provides methods and materials for treating a mammal having a FGID.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: January 30, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Purna C. Kashyap
  • Patent number: 11865163
    Abstract: This document provides methods and materials for using butyrylcholinesterases (BChE) to treat cancer (e.g., triple negative breast cancer or prostate cancer). For example, methods and materials for using nucleic acid vectors (e.g., viral vectors) to express BChE polypeptides under conditions that reduce the number of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) and/or reduce the growth rate of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) are provided.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: January 9, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: William S. Brimijoin, Liewei Wang, Yang Gao, Ping Chen, Liyi Geng, Jia Yu, Judy C. Boughey, Matthew P. Goetz
  • Patent number: 11865146
    Abstract: This document provides biomarkers of gut microbiota dysbiosis. Bacteria that are increased or decreased in gut microbiota dysbiosis can be used as biomarkers to predict dysbiosis in patients with diarrhea and/or to predict susceptibility to Clostridium difficile infection (CDI). In addition, provided herein are compositions including at least three bacteria that are decreased in gut microbiota dysbiosis which can be used, for example, to restore heathy gut microbiota (e.g., by probiotic or by fecal microbiota transplant) to treat CDI.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: January 9, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Purna C. Kashyap, Eric J. Battaglioli, Vanessa L. Hale
  • Patent number: 11866690
    Abstract: A method includes containing an algae media within a contactor, introducing a stream of natural gas comprising up to 80 wt % carbon dioxide (CO2) into the contactor, contacting the natural gas on the algae media and thereby allowing the algae media to consume CO2 from the natural gas, and discharging a stream of natural gas comprising 2 wt % or less CO2 from the contactor.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: January 9, 2024
    Assignee: ExxonMobil Technology and Engineering Company
    Inventors: Vinit Choudhary, Everett J. O'Neal, Sarah E. Feicht, Patrick L. Hanks, Samantha J. Reuter, Rachel G. Munson
  • Patent number: 11857685
    Abstract: Compositions and methods for treating uterine fibroids are described, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: January 2, 2024
    Assignees: BioSpecifics Technologies LLC, Duke University
    Inventors: Phyllis Carolyn Leppert, Thomas L. Wegman
  • Patent number: 11859022
    Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising an alpha-1,3-glucan ether or ester compound, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in various applications.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: January 2, 2024
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Rong Guan, Michael D. Gagnon, Nikita Iltchenko, Yefim Brun, Laurie A. Howe
  • Patent number: 11857580
    Abstract: The present invention relates to a Lactobacillus strain having antimicrobial activity against Gardnerella vaginalis and Candida albicans, a culture medium of the strain, and a cell-free supernatant of the strain, and to an antimicrobial composition containing the same, a pharmaceutical composition for preventing or treating Gardnerella vaginalis infection or Candida albicans infection containing the same, a pharmaceutical composition for prevention or treatment of vaginitis containing the same, a health functional food for prevention or ameliorating of vaginitis containing the same, and a quasi-drug composition for prevention or amelioration of vaginitis containing the same.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: January 2, 2024
    Assignee: Mediogen Co., Ltd.
    Inventors: Nam-Soo Paek, Chang Ho Kang
  • Patent number: 11844816
    Abstract: Embodiments of the invention provide a method of reducing colonization of a subject's anterior nares and/or nasal cavity by a microorganism (e.g., Staphylococcus aureus). In some aspects, the method may include administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of at least one probiotic.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: December 19, 2023
    Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on behalf of Northern Arizona University
    Inventors: Cindy Liu, Lance B. Price
  • Patent number: 11814616
    Abstract: The present disclosure relates to methods of culturing algae that overcomes catabolic repression of photosynthesis in mixotrophic growth.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: November 14, 2023
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Peter Lammers, Mark Seger, Wonkun Park, Nicholas Csakan
  • Patent number: 11779654
    Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PCSK9 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of hypercholesterolemia or a condition associated therewith.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: October 10, 2023
    Assignee: 2SEVENTY BIO, INC.
    Inventors: Jordan Jarjour, Kyle Havens, Michael Certo, Max Echterling
  • Patent number: 11712452
    Abstract: The present disclosure relates to methods for treating or preventing heart failure in subjects with elevated left ventricular end systolic volume (LVESV). In particular, the present disclosure relates to methods for treating or preventing heart failure in subjects with a LVESV of greater than 70 ml (>70 ml).
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: August 1, 2023
    Assignee: MESOBLAST INTERNATIONAL SÀRL
    Inventors: Silviu Itescu, Lee Golden
  • Patent number: 11701410
    Abstract: The invention relates to the use of deoxyribonuclease (DNase) enzyme for inhibiting progression and for prevention and treatment of neurodegeneration.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: July 18, 2023
    Assignee: CLS THERAPEUTICS LIMITED
    Inventors: Dmitry Dmitrievich Genkin, Georgy Viktorovich Tets, Viktor Veniaminovich Tets
  • Patent number: 11691436
    Abstract: A method for printing materials by: providing a receiving substrate; providing a target substrate having a photon-transparent support, a photon absorbent interlayer coated on the support, and a transfer material of a solid-phase environmental sample coated on top of the interlayer opposite to the support; and directing photon energy through the transparent support so that the photon energy strikes the interlayer is described. The environmental sample includes living organisms. A portion of the interlayer is energized by absorption of the photon energy, and the energized interlayer causes a transfer of a portion of the environmental sample including the microorganisms across a gap between the target substrate and the receiving substrate and onto the receiving substrate.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: July 4, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Bradley R. Ringeisen, Peter K. Wu
  • Patent number: 11686726
    Abstract: A separation system, a method in a separation system and an elution arrangement to be provided in a separation system for separating a biomolecule from a cell culture are provided. The method comprises the steps of: —providing a feed from a cell culture (3; 103; 203) comprising said biomolecule to a magnetic separator (5; 105; 205) and providing to the magnetic separator magnetic beads comprising ligands capable of binding this biomolecule; —separating by the magnetic separator said magnetic beads with bound biomolecules from the rest of the feed; —forwarding said magnetic beads as a slurry with an added buffer to an elution cell (7; 107; 207); —eluting the bound biomolecules in the elution cell.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: June 27, 2023
    Assignee: Cytiva Sweden AB
    Inventors: Ola Lind, Johan Fredrik Avallin, Andreas Torbjorn Lundin, Nils Norrman, Ronnie Palmgren, Gustav Jose Rodrigo
  • Patent number: 11684645
    Abstract: The present invention provides an Actinidia chinensis Planch ferment and the use thereof in a composition for increasing the antioxidant activity, increasing the anti-glycation activity, increasing the activity of proteolytic enzymes, improving the gastrointestinal dyspepsia, and increasing the gastrointestinal flora diversity. The Actinidia chinensis Planch ferment is prepared by fermenting Actinidia chinensis Planch extract with yeast, lactic acid bacteria and acetic acid bacteria in a three-staged fermentation.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: June 27, 2023
    Assignee: TCI CO., LTD.
    Inventor: Yung-Hsiang Lin
  • Patent number: 11672839
    Abstract: The present invention is directed to the field of phage therapy for the treatment and control of bacterial infections, in particular respiratory bacterial infections such as bacterial pneumonia. More specifically, the present invention is directed to novel bacteriophage strains, and products and cocktails thereof, including F99/10, F110/10, F27/12, Psa_F83/13, Psa_F95/13, F391/08, Kle_F92/15, Kle_F105/15, Kle_F134/15, Kle_F141/15, as well as variants thereof; and methods of using same in the treatment and prevention of bacterial infections, including respiratory infections caused by, e.g., Pseudomonas aeruginosa and/or Klebsiella pneumoniae. The cocktails are used as pharmaceutical compositions either alone or in further combination with other therapies, e.g., antibiotics or other standard and non-standard therapies for respiratory infections.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: June 13, 2023
    Assignees: TECHNECHNOPHAGE, INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA, SA, TECNIFAR—INDUSTRIA TECNICA FARMACEUTICA, SA
    Inventors: Sofia Valker Córte-Real, Miguel Ângelo Costa Garcia, Clara Isabel Rodrigues Leandro, Ana Raquel Martins Barbosa
  • Patent number: 11674958
    Abstract: This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: June 13, 2023
    Assignee: Academia Sinica
    Inventors: Ying-Chih Chang, Han-Chung Wu, Po-Yuan Tseng, Jen-Chia Wu