Patents Examined by Sharon M Papciak
  • Prevention of progressive heart failure
    Patent number: 11491188
    Abstract: The present disclosure relates to methods for preventing progressive heart failure in subjects with persistent left ventricular (LV) dysfunction. Such methods may also be used for treating or preventing progressive heart failure in subjects with a proximal left anterior descending (LAD) lesion and persistent left ventricular dysfunction.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: November 8, 2022
    Assignee: MESOBLAST INTERNATIONAL SARL
    Inventors: Silviu Itescu, Lee Golden
  • Method for producing whey protein hydrolysate
    Patent number: 11477999
    Abstract: The present invention relates to a method for producing a whey protein hydrolysate, the method comprising subjecting a whey protein-containing starting material having (a) a lipid content of less than 1 mass % and/or (b) a lactose content of less than 1 mass % to hydrolysis treatment. According to the present invention, a whey protein hydrolysate having excellent flavor with reduced odor is produced by reducing the problems involving rough taste, bitterness, or an unpleasant odor caused by hydrolysis of whey proteins. It is also possible to produce a whey protein hydrolysate that is not easily discolored, and that is prevented from being degraded in quality during the production process and storage thereof.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: October 25, 2022
    Assignee: MEIJI CO., LTD.
    Inventors: Kenji Toyota, Nobutaka Yahiro
  • Method for promoting growth of using ferments
    Patent number: 11478525
    Abstract: Provided is a method of promoting the growth of Akkermansia muciniphila, including contacting A. muciniphila with an effective amount of a prebiotic composition including a Musa ferment. Also provided is a prebiotic composition including a Musa ferment. The prebiotic composition promotes the growth of A. muciniphila in the intestine, and reduces the body weight, fat percentage, waist circumference, and hip circumference of obese individuals.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: October 25, 2022
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, Chu-Han Huang, Cheng-Yu Ho
  • Method for obtaining a biomass of a microalga of the species enriched in superoxide dismutase (SOD)
    Patent number: 11473065
    Abstract: The invention relates to a method for enriching a biomass of a microalga of the species Tetraselmis chuii in superoxide dismutase (SOD) by placing said microalga under abiotic stress conditions. The invention also relates to a biomass enriched in SOD as well as to an extract of the microalga and to the uses thereof as a pharmaceutical composition, as a cosmetic or in foodstuff.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: October 18, 2022
    Assignee: FITOPLANCTON MARINO, S.L.
    Inventors: Carlos Unamunzaga Escosura, Eulalia Mantecón Gálvez
  • Methods of treating spinal cord injury
    Patent number: 11439690
    Abstract: The invention is directed to a method of treating a spinal cord injury, a neurodegenerative disease or a neuronal injury in an individual in need thereof comprising administering an effective amount of superoxide dismutase (SOD) and catalase to the individual, wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that release the SOD and catalase upon administration. Another aspect of the invention is directed to compositions comprising superoxide dismutase (SOD) and catalase encapsulated in one or more nanoparticles.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: September 13, 2022
    Assignee: The Cleveland Clinic Foundation
    Inventors: Vinod Labhasetwar, Hayder H. Jaffer
  • Vasoconstrictive and antibacterial combination treatment for rosacea
    Patent number: 11439693
    Abstract: The invention relates to the field of medicine, specifically to the field of treatment of rosacea. The invention relates to a novel composition and a novel kit of parts, both comprising a vasoconstrictive compound and a compound specifically targeting a bacterial cell, preferably a gram positive bacterial cell. The invention further relates to said composition and/or kit of parts for medical use, preferably for treating an individual suffering from rosacea.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: September 13, 2022
    Assignee: MIGREOS HUMAN HEALTH B.V.
    Inventors: Mark Leonard Offerhaus, Bjorn Lars Herpers
  • Lactic acid bacteria and its applications
    Patent number: 11434468
    Abstract: The invention relates to a lactic acid bacterium (LAB), Lactobacillus fermentum PS150, and a bioactive protein produced by the LAB, which has an advantageous effect in improving mood disorder, enhancing cognitive functions in brain and treating or preventing a neurodegenerative disease.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: September 6, 2022
    Assignee: Bened Biomedical Co., Ltd.
    Inventors: Mintze Liong, Ying-Chieh Tsai, Matthew Cheeyuen Gan, Sawibah Yahya, Sybing Choi, Jiasin Ong, Waiyee Low, Chih-Chieh Hsu, Yi-Shan Lee
  • Serum-free medium containing PDGF for DS cells
    Patent number: 11427807
    Abstract: The present disclosure relates to a serum-free medium for culturing of DS cells containing platelet derived growth factor (PDGF), or to a method for culturing of dermal sheath (DS) cells, using serum-free medium comprising PDGF.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: August 30, 2022
    Assignee: Shiseido Company, Ltd.
    Inventors: Haruyo Yamanishi, Tsutomu Soma, Yuzo Yoshida
  • Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
    Patent number: 11413300
    Abstract: Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising a synergistic combination of thermolysin and at least one aminoglycoside antibacterial agent.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: August 16, 2022
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Aleksa Jovanovic, Lei Shi, Eric Roche, Paul Renick
  • Compositions and methods for augmenting the nasal microbiome
    Patent number: 11406671
    Abstract: Embodiments of the invention provide a method of reducing colonization of a subject's anterior nares and/or nasal cavity by a microorganism (e.g., Staphylococcus aureus). In some aspects, the method may include administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of at least one probiotic.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: August 9, 2022
    Assignee: The Translational Genomics Research Institute
    Inventors: Cindy Liu, Lance B. Price
  • RNA affinity purification
    Patent number: 11384352
    Abstract: Provided herein, in some embodiments, are methods of purifying a nucleic acid preparation. The methods may comprise contacting a nucleic acid preparation comprising messenger ribonucleic acid with an RNase III enzyme that is immobilized on a solid support and binds to double-stranded RNA contaminants.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: July 12, 2022
    Assignee: ModernaTX, Inc.
    Inventor: Edward J. Miracco
  • Amplification technology using dual enzyme cascade detection
    Patent number: 11385229
    Abstract: Diagnostic assays and methods employ a dual-enzyme cascade system comprised of two enzymatic amplifiers and two molecular probes, by (a) incubating a target enzyme with a target enzyme substrate to liberate a thiol; (b) incubating the thiol with a disulfide inactivated amplification enzyme to activate the amplification enzyme in an interchange reaction of the thiol and the disulfide; and (c) incubating the activated amplification enzyme with an amplification enzyme substrate to generate an amplified signal.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: July 12, 2022
    Assignee: The Regents of the University of California
    Inventors: Niren Murthy, Lee W. Riley, Tara Renee BeBoer
  • Lilac ginkgo brick tea and method of preparing the same
    Patent number: 11376299
    Abstract: A method of preparing a Lilac Ginkgo Brick Tea includes the following steps: (1) mixing and drying fresh Lilac leaves and Ginkgo leaves to obtain a Lilac Ginkgo Tea; (2) fermenting the Lilac Ginkgo Tea to obtain a Fermented Lilac Ginkgo Tea; (3) mixing the Fermented Lilac Ginkgo Tea with a black tea to obtain a Fermented Lilac Ginkgo Tea Mixture; and (4) processing the Fermented Lilac Ginkgo Tea Mixture to obtain the Lilac Ginkgo Brick Tea.
    Type: Grant
    Filed: October 20, 2019
    Date of Patent: July 5, 2022
    Assignee: XI'AN KANGYUANSHENG BIOMEDICAL TECHNOLOGY CO., LTD.
    Inventors: Jia Wan, Chunchun Kong, Chengyuan Liang, Nan Hui, Chunyang Shi, Han Li, Bin Tian, Gennian Mao, Qianqian Zhao, Qiao Zeng
  • Compositions and methods for the treatment of diseases involving mucin
    Patent number: 11364286
    Abstract: The present invention relates to synergistic compositions comprising bromelain, or a proteolytic fraction thereof, and cysteamine or a metabolite, pharmaceutically acceptable salt, solvate or prodrug thereof The invention also relates to methods and uses of such compositions for the treatment of diseases involving mucin.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: June 21, 2022
    Inventors: David L. Morris, Roger Aston, Javed Akhter, Krishna Pillai
  • Acaricides
    Patent number: 11344031
    Abstract: The present invention relates to a method of treating or preventing a house dust mite infestation, said method comprising applying an acaricidal infectious agent at a site of a house dust mite infestation, or at a site proximal thereto, or at a site at risk of such infestation. Also encompassed are uses of acaricidal infectious agents, methods of isolating acaricidal infectious agents, acaricidal infectious agents obtainable by said methods, acaricidal infectious agent formulations, foodstuffs and mite attractants comprising the same.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: May 31, 2022
    Assignee: Evolution Biotechnologies Ltd.
    Inventor: David R. Harper
  • Squalene epoxidase in the diagnosis and treatment of non-alcoholic fatty liver diseases
    Patent number: 11340226
    Abstract: The present invention provides a method for providing a diagnosis or prognosis of a non-alcoholic fatty liver disease (NAFLD) in a subject by detecting expression level of the Squalene Epoxidase (SQLE) gene. A kit and device useful for such methods are also provided. In addition, the present invention provides a method for treating NAFLD by suppressing SQLE gene expression or activity.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: May 24, 2022
    Assignee: The Chinese University of Hong Kong
    Inventors: Jun Yu, Dabin Liu, Chi-Chun Wong
  • Cell analysis method, cell analyzer and sample screening method
    Patent number: 11280720
    Abstract: Disclosed is a cell analysis method comprising: extracting target cells from a population of cells derived from an epithelial tissue on the basis of N/C ratio representing a relative size of a nucleus to a cytoplasm; classifying the target cells into at least a first group and a second group by difference of amount of DNA; and evaluating a pathology of the epithelial tissue by comparing a ratio of numbers of cells between the first and second groups with a threshold; wherein the threshold varies according to a proportion of the target cells in the population.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: March 22, 2022
    Assignee: SYSMEX CORPORATION
    Inventors: Kei Shirasuna, Ryuichiro Ebi, Shigeki Abe
  • Substrate for a three-dimensional cell culture, its preparation and use
    Patent number: 11280017
    Abstract: A layered material suitable as substrate for a three-dimensional cell culture includes a transparent carrier layer and a transparent conductive layer as well as a photoconductive layer comprising titanium oxide phthalocyanine. A method for producing the layered material and an article comprising it and a receiving unit are disclosed. A mold-free method is provided for forming a three-dimensional hydrogel as well as for forming a three-dimensional cell culture by using the layered material or article. Uses of the layered material and of the three-dimensional hydrogel and three-dimensional cell culture are also disclosed.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: March 22, 2022
    Assignee: City University of Hong Kong
    Inventors: Yajing Shen, Gaole Dai, Wenfeng Wan
  • Compositions and methods for treating immune disorders using immune modulating bacteria strains
    Patent number: 11266700
    Abstract: Provided herein are methods and compositions related to immune modulating Lactococcus strains useful as therapeutic agents. In certain embodiments, provided herein are methods of treating an immune disorder in a subject comprising administering to the subject a bacterial composition comprising Lactococcus lactis cremoris Strain A (ATCC Deposit Number PTA-125368).
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: March 8, 2022
    Assignee: Evelo Biosciences, Inc.
    Inventors: Brian Goodman, Holly Ponichtera, Andrea Itano, Mark Bodmer, Taylor A. Cormack, Maria Sizova, Carolina Baez-Giangreco, Duncan McHale, Kritika Ramani
  • Glycan sample preparation
    Patent number: 11249098
    Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method using magnetic beads containing negatively charged carboxyl groups extending from the surface of the magnetic beads.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: February 15, 2022
    Assignee: Beckman Coulter, Inc.
    Inventors: Andras Guttman, Clarence Lew, Marton Szigeti, Csaba Varadi