Patents Examined by Sharon M Papciak
  • Method for preparing rebaudioside A from stevioside
    Patent number: 10472660
    Abstract: The present invention relates to an in-situ method for preparing rebaudioside A from sucrose and stevioside by sucrose synthase and glycosyltransferase.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: November 12, 2019
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Sung Hee Park, Jung Eun Kim, Ran Young Yoon, Young Ho Hong, Seong Bo Kim, Seung Won Park
  • Rare cell concentration
    Patent number: 10444240
    Abstract: A ratio of rare cells to non-rare cells in a blood sample suspected of containing rare cells and non-rare cells is enhanced. A treated blood sample is prepared by providing in combination the blood sample, a platelet deactivation agent, a fibrin-formation-arresting agent and fibrin in an amount sufficient to cause a predetermined level of agglutination of the rare cells. The treated blood sample is then contacted with a porous matrix such that agglutinated rare cells are preferentially retained on the porous matrix. The rare cells may then be identified.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: October 15, 2019
    Assignee: SIEMENS HEALTHCARE DIAGNOSTICS, INC.
    Inventor: Michael Pugia
  • Aqueous solution for preserving an organ and uses during hypothermic ischemia
    Patent number: 10440947
    Abstract: The present invention relates to an aqueous solution for organ preservation, in particular for the myocardium, the solution comprising: 100 mM to 130 mM of Na+; 12 mM to 15 mM of K+; 0.25 mM to 1.3 mM of Ca++; 0.5 ?M to 1.5 ?M of cyclosporin A; and 0.5 ?M to 1.5 ?M of taxol, and it also relates to the joint use of cyclosporin A and taxol in a solution for in vitro preservation of an organ, in particular the myocardium.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: October 15, 2019
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE CLAUDE BERNARD LYON I
    Inventor: Rene Ferrera
  • Method of determining consumption of decayed drug through drug taggants
    Patent number: 10408849
    Abstract: We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: September 10, 2019
    Inventors: David R. Hall, Dan Allen, Conrad Rosenbrock, Daniel Hendricks, Andrew Nguyen, Steven J. M. Butala, Travis Niederhauser, Terrece Pearman, Joe Fox
  • Effervescent compositions and uses thereof
    Patent number: 10378041
    Abstract: A latent effervescent body comprising a selective agent is disclosed. A method of using the latent effervescent body in a method to selectively enrich a target microorganism is also disclosed. The method comprises providing a sample, a culture medium, and the latent effervescent body. The method further comprises contacting the sample, the culture medium, and the latent effervescent body under conditions to facilitate growth of the target microorganism. The method further comprises releasing the selective agent from the latent effervescent body. Optionally, the method includes detecting a microorganism.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: August 13, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Wensheng Xia, Patrick A. Mach, Joseph M. Beaurline, Jason W. Bjork, Jie J. Liu
  • Micronized placental tissue compositions and methods of making and using the same
    Patent number: 10376546
    Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: August 13, 2019
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • Treatment method and product for uterine fibroids using purified collagenase
    Patent number: 10369110
    Abstract: The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 6, 2019
    Assignees: BioSpecifics Technologies Corporation, Duke University
    Inventors: Phyllis Carolyn Leppert, Thomas L. Wegman
  • Methods of processing municipal solid waste (MSW) using microbial hydrolysis and fermentation
    Patent number: 10358370
    Abstract: The invention provides a method of processing MSW comprising the steps of —providing a stream of unsorted MSW to a microbial fermentation reactor in which the MSW is fermented with agitation at a non-water content of between 10 and 50% by weight and at a temperature of between 35 and 75 degrees for a period of between 1 and 72 hours under conditions sufficient to maintain a live lactic acid bacteria concentration of at least 10.000.000.000 CFU/L, and —removing a stream of fermented unsorted MSW from the reactor and subjecting it to a separation step whereby non-degradable solids are removed to provide a slurry of bio-degradable components. Further, a slurry of bio-degradable components prepared according to said method is provided.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: July 23, 2019
    Assignee: RENESCIENCE A/S
    Inventors: Georg Ornskov Ronsch, Jacob Wagner Jensen, Sebastian Buch Antonsen
  • Method for the industrial production of flour from lipid-rich microalga biomass with no “off-notes” by controlling the oxygen availability
    Patent number: 10351814
    Abstract: The invention relates to a method for fermentative production, on an industrial scale, of lipid-rich biomass of microalgae of the Chlorella genus having acceptable sensory properties, characterized in that the dissolved oxygen availability in the fermenter is controlled by tracking the respiratory quotient of said microalgae.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: July 16, 2019
    Assignee: CORBION BIOTECH, INC.
    Inventors: Sylvain Delaroche, Marie Le Ruyet, Laurent Segueilha, Heike Jerosch, Amandine Druon
  • Advanced macromolecule transduction domain (aMTD) sequences for improvement of cell-permeability, polynucleotides encoding the same, method to identify the unique features of aMTDs comprising the same, method to develop the aMTD sequences comprising the same
    Patent number: 10323063
    Abstract: The present invention is to execute macromolecule intracellular transduction technology (MITT) for delivering biologically active macromolecules into the cells; specifically, by exploiting well-enhanced hydrophobic cell penetrating peptide (CPP)—advanced macromolecule transduction domain (aMTD)—to effectively transduce biologically active molecules into the plasma membrane, polynucleotides encoding the same, methods of identifying the same, systems of genetically engineering a biologically active molecule with much enhanced cell-permeability by using the same, methods of importing a biologically active molecule into a cell by using the same, and uses thereof.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: June 18, 2019
    Assignee: CELLIVERY THERAPEUTICS, INC.
    Inventor: Daewoong Jo
  • Methods and kits for assessing heparanase procoagulant activity, compositions comprising heparanase, and methods for the treatment of coagulation related disorders
    Patent number: 10302662
    Abstract: Methods and kits for determining heparanase procoagulant activity in a biological sample are provided. Diagnostic methods for the detection and/or monitoring of a coagulation-related pathological disorder in a mammalian subject are further provided. In addition, compositions comprising heparanase and at least one tissue factor, uses and methods based thereon in the treatment, amelioration and prevention of coagulation-related pathologic conditions are provided. Also provided are methods for screening a coagulation modulatory compound, methods and uses based thereon in the treatment, amelioration and prevention of coagulation-related pathologic conditions.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: May 28, 2019
    Assignee: RAMBAM MED-TECH
    Inventors: Yona Nadir, Benjamin Brenner, Israel Vlodavsky
  • Proteolytic extract from bromelain for the treatment of connective tissue disorders
    Patent number: 10293033
    Abstract: The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present invention relates to a pharmaceutical composition comprising a proteolytic extract obtained from bromelain for the treatment of diseases such as Dupuytren's disease and Peyronie's disease.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: May 21, 2019
    Assignee: MediWound Ltd.
    Inventors: Lior Rosenberg, Guy Rubin, Eilon Asculai
  • Method for in vitro proliferation of cell population containing cells suitable for treatment of ischemic disease
    Patent number: 10286014
    Abstract: Simplification of a preparation step of a cell population used for the treatment of ischemic diseases, and provision of a cell population that shows more effective treatment are shown. A method of producing a cell population wherein a vascular endothelial progenitor cell and/or an anti-inflammatory macrophage are/is enriched, including cultivating a mononuclear cell derived from bone marrow, cord blood or peripheral blood in a serum-free medium containing stem cell factor, interleukin-6, FMS-like tyrosine kinase 3 ligand, thrombopoietin and vascular endothelial cell growth factor, and proliferating vascular endothelial progenitor cell from the cell; and a cell population obtained by the method are shown.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: May 14, 2019
    Assignees: FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE, TOKAI UNIVERSITY EDUCATIONAL SYSTEM, STEMMED INC., JUNTENDO EDUCATIONAL FOUNDATION
    Inventors: Takayuki Asahara, Haruchika Masuda, Rika Tanaka
  • Glycan sample preparation
    Patent number: 10247745
    Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol that can enable full automation and reduced sample preparation time relative to current methods of glycoanalysis. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method without requiring time-consuming sample preparation steps such as centrifugation or vacuum-centrifugation.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: April 2, 2019
    Assignee: Beckman Coulter, Inc.
    Inventors: Andras Guttman, Clarence Lew, Marton Szigeti, Csaba Varadi
  • Bovine milk oligosaccharides
    Patent number: 10238674
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: March 26, 2019
    Assignee: The Regents of the University of California
    Inventors: J. Bruce German, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
  • Treatment for mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)
    Patent number: 10213492
    Abstract: The invention provides a method of treating mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) in a patient, comprising administering to the patient autologous erythrocytes that contain thymidine phosphorylase and are free of animal proteins other than proteins derived from the patient. The erythrocytes generally contain a low amount of endotoxin.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: February 26, 2019
    Assignee: St. George's Hospital Medical School
    Inventors: Bridget Bax, Murray Bain
  • Method of detecting drug taggants in biological samples to assess drug decay
    Patent number: 10209264
    Abstract: We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, moisture, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: February 19, 2019
    Inventors: David R. Hall, Dan Allen, Conrad Rosenbrock, Daniel Hendricks, Andrew Nguyen, Steven J. M. Butala, Travis Niederhauser, Terrece Pearman, Joe Fox
  • Method for cycling biomasses between mushroom cultivation and anaerobic biogas fermentation, and for separating and drying a degassed biomass
    Patent number: 10196654
    Abstract: The present invention is related to recycling of fermentable and metabolizable biomass materials for sequentially performing a cultivation of fungal cells and for producing biogas by anaerobic fermentation of said biomass materials.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: February 5, 2019
    Assignee: ADVANCED SUBSTRATE TECHNOLOGIES A/S
    Inventors: Svend Kristian Hoff, Lars Jørgen Pedersen
  • High density cell banking methods
    Patent number: 10188099
    Abstract: The current disclosure provides a method for the creation of a high-density cryopreserved cell bank using perfusion culture techniques and non-centrifugal concentration of cells. Methods of production using this high-density cryopreserved cell bank are also provided.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 29, 2019
    Assignee: GENZYME CORPORATION
    Inventors: Xiaoxia Jin, Haodi Dong, Claudia Buser
  • Temperature-sensitive fluorescent probe for introduction into cell
    Patent number: 10191035
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: January 29, 2019
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto