Patents Examined by Sharon Rose
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Patent number: 5104378Abstract: A cost effective, disposable, safety syringe having a conventional single ended hypodermic needle cannula retained in an axially extended position at the distall end of a cylinder by an epoxy bond formed with the central core of a needle carrying hub. A locking and retracting probe extends proximally into the syringe cylinder from the central core of the needle hub. A piston assembly, having an offset locking bore formed therein, is advanced distally through the cylinder to expulse fluid therefrom via the cannula and to receive the locking and retracting probe within the locking bore. A continued distal advancement of the piston assembly through the cylinder causes the central core and the cannula supported thereby to be broken away from the needle hub. Therefore, when the piston assembly is withdrawn proximally through the cylinder, the cannula is correspondingly retracted within and shielded by the cylinder to avoid an accidental needle stick and the spread of disease.Type: GrantFiled: October 13, 1989Date of Patent: April 14, 1992Assignee: Habley Medical Technology CorporationInventors: Terry M. Haber, William H. Smedley, Clark B. Foster
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Patent number: 5100401Abstract: A flexible plastic container made from a flexible, autoclavable, non-PVC polymer composition capable of suppressing the hemolysis of red blood cells. The polymer contains a material selected from the group consisting of either triethylhexyltrimellitate (TEHTM) and citrate ester. In the preferred embodiment, the non-PVC plastic is comprised of a polyolefin copolymer containing a central block of ethylene and butylene units with terminal blocks of polystyrene.Type: GrantFiled: March 15, 1990Date of Patent: March 31, 1992Assignee: Baxter International Inc.Inventor: Indrajit Patel
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Patent number: 5088978Abstract: An apparatus and method for iontophoretic transdermal delivery of exercise simulating agents includes an electrode having disposed therein a drug reservoir comprising a viscosity-control agent comprising an aqueous sol with an antioxidant, a preservative, a chelator and a buffer. A silver/silver chloride conducive element is preferably situated in the electrode adjacent the drug reservoir to conduct an electric charge across the reservoir.Type: GrantFiled: January 26, 1990Date of Patent: February 18, 1992Assignee: Gensia Pharmaceuticals, Inc.Inventors: Robert S. Hillman, John M. Pawelchak
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Patent number: 5071415Abstract: Novel adhesive system for releasably fastening or securing superposed portions of a disposable diaper or other articles, comprising a sheet material carrying different adhesive layers on its respective surfaces, the adhesive layer on one side being characterized as having a high peel strength adapted for permanently securing the sheet material to a first portion of the diaper or other article of apparel, the adhesive layer on the other side comprising a pressure-sensitive adhesive having appreciably less peel strength and being adapted for releasably engaging an opposed portion of said article in order to secure the article on the person.Type: GrantFiled: October 30, 1987Date of Patent: December 10, 1991Assignee: Kendall CompanyInventor: Shiro G. Takemoto
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Patent number: 5050609Abstract: A nuclear magnetic resonance method is provided for monitoring and imaging the exchange of magnetization between protons in free water and protons in a relatively immobilized pool of protons in a sample. The method provides a new form of contrast for nuclear magnetic resonance imaging of samples such as biological tissues, polymers, and geological samples.Type: GrantFiled: April 14, 1989Date of Patent: September 24, 1991Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Robert S. Balaban, Steven D. Wolff
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Patent number: 5041078Abstract: The present invention demonstrates a method of photodynamic inactivation of viruses having a membranous envelope, such as Herpes simplex type 1 and Human immunodeficiency type 1 viruses. The method uses substituted sapphyrin compounds to effect viral deactivation during radiation with light at or near the absorption wavelength of the sapphyrin compound. A highly reactive species selectively toxic to infectious agents is produced.One particular sapphyrin compound useful for the practice of the invention is 8,17-bis(carboxymethyl)-3,12,13,22-tetraethyl-2,7,18,23-tetramethylsapphyr in (Sapphyrin 2). The most preferred sapphyrin sapphyrin compound for the practice of the invention is 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 1).The method is particularly suitable for inactivation of viruses in blood and blood products.Type: GrantFiled: December 21, 1989Date of Patent: August 20, 1991Assignees: Baylor Research Foundation, a nonprofit corporation of the State of Texas, Board of Regents, The University of Texas SystemInventors: J. Lester Matthews, Millard M. Judy, Joseph T. Newman, Frank Sogandares-Bernal, Jonathan L. Sessler, Anthony Harriman, Bhaskar G. Maiya
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Patent number: 5037400Abstract: An apparatus for resheathing hypodermic needles having a hollow cylindrical sheathguard to encompass a needle sheath inserted therein; a means of retaining the needle sheath within the sheathguard; a horizontal protective barrier below the aperture of the sheathguard and parallel thereto; a means for supporting the barrel of a hypodermic syringe engaged in the device; a means of guiding the syringe with hypodermic needle during resheathing; and a vertical protective barrier adjacent to the aperture of said sheathguard and perpendicular thereto.Type: GrantFiled: March 30, 1988Date of Patent: August 6, 1991Assignee: Oakleaf Enterprises, Inc.Inventor: Robert L. Curry
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Patent number: 5037402Abstract: A hypodermic syringe incorporating a post-injection safety sheath for enclosing the sharpened needle tip. The hypodermic syringe incorporates parallel main and sheath chambers, the main chamber being to store fluid being injected or withdrawn, the parallel sheath chamber positioning the protective sheath. An axially aligned slot is disposed in the wall of the protective needle sheath and is aligned in communication with the ingress of the arcuate needle. A helical compression spring is coaxially aligned within the sheath chamber against the needle sheath biasing the sheath to enclosure the needle tip. When compressed, the needle sheath is withdrawn from the needle tip held in place through a detachable tab extending through the chamber wall.Type: GrantFiled: May 29, 1990Date of Patent: August 6, 1991Inventor: Thomas F. Bartman
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Patent number: 5037430Abstract: A clamping device for positioning and holding gynecological instruments, such as uterine instruments, or the like. The device is illustrated in the form of a forceps having handles located at one end, and clamps located at the opposite end for selectively clamping onto at least a portion of the cervix. A second clamp is located intermediate the ends of the forceps for releasably clamping onto the gynecological instrument to hold the instrument in proper position relative to the uterus.Type: GrantFiled: July 17, 1987Date of Patent: August 6, 1991Inventor: Harrith M. Hasson
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Patent number: 5034008Abstract: An elasticized absorbent article, illustrated as an elastic waistband disposable diaper, includes an absorbent panel, a backsheet underlying the absorbent panel, and a liquid-permeable topsheet which overlies the absorbent panel. Each of the backsheet and topsheet includes at least one longitudinal end marginal portion which extends beyond an end edge of the absorbent panel. A waist elastic element is provided which is positioned between the end marginal portions of the topsheet and backsheet for forming an elastic waistband region. Notably, the elastic waistband element is provided with a substantially overall adhesive coating, preferably in either slot-coated or spray-coated filament form, for securement to the associated topsheet. The topsheet is thereby elastically gathered to provide a textured and cushioned surface at the inside region of the waistband for enhanced comfort.Type: GrantFiled: November 7, 1989Date of Patent: July 23, 1991Assignee: ChicopeeInventor: Stephen Breitkopf
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Patent number: 5030216Abstract: An implantable osmotically driven syringe is disclosed which can be used to deliver a beneficial agent, such as a drug, at a predetermined rate over an extended period of time. A movable piston divides the syringe into a beneficial agent-containing compartment and a driving compartment. The piston is movable into a position wherein the driving compartment has a volume of essentially zero. The syringe is driven by an osmotic engine which has a shaped wall surrounding, and in contact with, an osmotic solute. The wall is comprised of a semipermeable and/or microporous material which is permeable to the external fluid (e.g., water) but is impermeable to the solute. The engine also has a passageway forming a fluid flow path between the osmotic solute and the driving compartment. A portion of the wall is exposed to a fluid-containing external environment. At least about 30% of the wall which contacts the solute also is exposed to the fluid in the external environment.Type: GrantFiled: December 15, 1989Date of Patent: July 9, 1991Assignee: ALZA CorporationInventors: Felix Theeuwes, Patrick S. L. Wong
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Patent number: 5026365Abstract: A unique method and apparatus for therapeutically treating immunological disorders and disease states which are characterized by the present of immunologically abnormal leukocytes in the body of the afflicted subject is provided. The apparatus and methodology utilized a sealed diffusion chamber which may be surgically implanted in-vivo or may be extracorporeally joined to the circulatory system of the afflicted subject. In either mode of use, the diffusion chamber utilizes immunologically normal leukocytes of various types and concentration which are able to provide cell functions and cellular secretory products which therapeutically counterbalance the effects of the immunological abnormality within the afflicted subject.Type: GrantFiled: April 29, 1987Date of Patent: June 25, 1991Assignee: The University of MassachusettsInventors: Aldo A. Rossini, John P. Mordes, Eugene S. Handler
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Patent number: 5026347Abstract: A plastic composition is disclosed which has particular application in the manufacture of blood bags and other medical products. The composition has anti-hemolytic effects when used in the storage of red blood cells. In connection with one aspect of the present invention, the plastic composition comprises the combination of a non-PVC plastic and a selected quantity citrate ester sufficient to suppress hemolysis of red blood cells. The non-PVC material is preferably a polyolefin copolymer. Materials other than citrate ester may also be used with polyolefin as a hemolysis suppressant.Type: GrantFiled: November 14, 1988Date of Patent: June 25, 1991Assignee: Baxter International Inc.Inventor: Indrajit Patel
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Patent number: 5025800Abstract: This invention relates to contraceptive devices. More particularly, this invention relates to novel contraceptive devices for males and females which provide immunological barriers to the spread of sexually transmitted diseases along with related methods to prevent the spread of these diseases.Type: GrantFiled: January 26, 1988Date of Patent: June 25, 1991Inventor: Steve T. Zelson
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Patent number: 5024672Abstract: A disposable diaper put on by means of pressure-adhesive tape, has a liquid-permeable inner layer closest to the user during use of the diaper, a liquid-tight outer layer, and an absorbent layer disposed between the inner and outer layers. Tape tabs at one end of the diaper close to the corners of the diaper have a portion permanently joined to the liquid-tight outer layer at that diaper end. A plastic strip for fastening the tape tabs when putting the diaper on the user is disposed on the opposite end of the diaper and consists of a material which is inelastic and has suitable properties for fastening the tape tabs as well as removing and refastening the tape tabs. The plastic strip is elongated transversely of the diaper to permit adjustment of the tension of the diaper around the user by loosening and refastening the tape tabs. The strip extends across the width of the diaper on the outside of the liquid-tight outer layer. The tabs are also fastened to the same side of the liquidtight outer layer.Type: GrantFiled: December 8, 1988Date of Patent: June 18, 1991Inventor: Leif U. R. Widlund
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Patent number: 5022413Abstract: Cataracts are treated for removal by introducing a lenticular tissue dispersing agent into the opacified lens through a small opening in the lens capsule so that the capsule remains substantially intact. The tissue dispersing agent is contained in the lens by a gel-forming substance which functions to block the opening in the lens capsule, preventing its escape. This treatment is preferably carried out in conjunction with laser induced phacofracture.Type: GrantFiled: April 21, 1988Date of Patent: June 11, 1991Inventors: Joseph Spina, Jr., Michael K. Weibel
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Patent number: 5021053Abstract: An osmotic device for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device comprises a wall surrounding a compartment housing a layer of an agent that is insoluble to very soluble in aqueous biological fluid, e.g., saliva, and a layer of a fluid swellable, hydrophilic polymer. A passageway in the wall connects the agent with the exterior of the device. The wall is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer. In one embodiment the beneficial agent has a different color than the hydrophilic polymer. The wall is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent remaining to be delivered.Type: GrantFiled: July 14, 1989Date of Patent: June 4, 1991Assignee: Alza CorporationInventors: Brian L. Barclay, Jerry D. Childers, Jeri Wright, Virgil A. Place, Patrick S. L. Wong
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Patent number: 5019070Abstract: A disposable and anatomically reversible undergarment shield for removable attachment to the inside of underpants. The undergarment shield is shaped like an hourglass and has a thick portion which is reversible between a front side and a rear side, depending upon whether the wearer is a girl or a body. Words, colors, or other appropriate symbols are placed upon the end borders of the shield to indicate which side forms the front for a girl and likewise for a body. For more rapid and effective absorption, a generally Y-shaped trough is formed in the thick side of the shield. Gathers at the periphery of the crotch region ensure a close fit, thereby preventing leaks. Adhesive strips are used to attach the shield to the undergarment.Type: GrantFiled: March 1, 1988Date of Patent: May 28, 1991Inventor: Margaret Ruben
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Patent number: 5019723Abstract: A self-regulated system and method for controllably administering a therapeutic agent to a patient is disclosed. A therapeutic agent is driven by unidirectional electrostatic diffusion across a rate-controlling electret membrane. The diffused therapeutic agent is then delivered to a patient. The preparation of the electret membrane and therapeutic agent delivery apparatus are also disclosed.Type: GrantFiled: October 2, 1989Date of Patent: May 28, 1991Assignee: Controlled Release Technologies, Inc.Inventor: Loi H. Tran
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Patent number: 5017191Abstract: An injector pre-filled with a radiopharmaceutical liquid, which comprises (1) a syringe containing a radiopharmaceutical liquid with a stopper made of an elastic material fitted at the top opening, (2) a holder having a hole at thee central part fitted on the stopper to keep it firmly at such position, (3) an adaptor having a body portion of which the lower part forms a cap portion, a passage for the radiopharmaceutical liquid penetrating the body portion and a hollow needle portion continuously extending from the passage to the lower direction, detachably fitted on the syringe, and (4) a disposable needle head comprising a needle having a passage for the radiopharmaceutical liquid therein and a cap portion, detachably fitted on the body portion of said adaptor to make a gap at the top part of the cap portion of the needle head, the cap portion of the needle head being at least partly made of an inside observable material.Type: GrantFiled: March 8, 1989Date of Patent: May 21, 1991Assignee: Nihon Medi-Physics Co., Ltd.Inventors: Hideo Yamada, Shozo Nakayama, Mitsuhisa Iinuma, Hisao Tobiki