Abstract: A disposable pant-like garment for absorbing human discharge is provided, and comprises an absorbent assembly comprising a liquid-impervious outer cover, a liquid-pervious liner, and an absorbent medium therebetween. The absorbent assembly also has generally opposite side edges and generally opposite end edges. A pair of stretchable side panels are joined to each one of the side edges to form with the absorbent assembly a waist opening and a pair of leg openings. A gathering means is joined along at least a portion of each leg opening for gathering that portion. The stretchable side panels provide generally inwardly directed force vectors against a wearer to maintain the garment snugly against the wearer's body and the absorbent assembly snugly in place against the crotch area both before and after a discharge.

Abstract: A dispenser is enclosed for delivering a beneficial agent to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first means in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.

Abstract: An integral disposable absorbent article such as a diaper provided with an absorbent core; a liquid impervious backsheet; a first barrier cuff disposed adjacent each longitudinal edge of the absorbent article and each having a first proximal edge and a first distal edge; a spacing means for spacing the first distal edge of each of the first barrier cuffs away from the liquid-receiving surface of the absorbent article; and a second barrier cuff disposed adjacent at least one and preferably adjacent each of the end edges of the absorbent article and having a second proximal edge and a second distal edge, the distal edges of the barrier cuffs overlapping at corner points to form a containment pocket. The spacing means preferably comprises a spacing elastic member that extends longitudinally along the first distal edge beyond the second distal edges.

Abstract: A disposable pant-like garment for absorbing human discharge comprises an absorbent assembly including a liquid impervious outer cover, a liquid pervious liner, and an absorbent medium therebetween. A pair of stretchable side panels are joined to the absorbent assembly to form a waist opening and a pair of leg openings, and an intermediate portion of each stretchable side panel is generally peripherally disposed about a respective leg opening. The stretchable side panels provide generally inwardly directed force vectors against a wearer to maintain the garment snugly against the wearer's body and the absorbent assembly snugly in place against the crotch area both before and after a discharge.

Abstract: Elastomeric bladders having improved resistance to spontaneous rupture when inflated are made by vulcanizing a homogeneous mixture of synthetic polyisoprene having 90% to 98% cis-1,4 linkages, 3 to 10 phr fumed silicon dioxide, and vulcanizing agent while simultaneously forming the mixture into hollow cylindrical bodies. After being formed the bodies are solvent extracted to remove unreacted vulcanizing agent and the degradation products of the vulcanizing agent. Following the solvent extraction about 0.2 to 2 phr of a nontoxic, nonleachable antioxidant are imbibed into the bodies by contacting the bodies with a liquid solution of the antioxidant.

Abstract: A transdermal delivery device having a release-rate controlling-adhesive is disclosed having improved delivery characteristics. The device employs a polyisobutylene/mineral oil adhesive formulation and an ethylene/viny acetate (EVA) drug reservoir formulation. The device is useful in delivering a wide variety of transdermally administrable drugs, particularly those which are moderately soluble in mineral oil. Preferred embodiments deliver timolol base and atropine base from an EVA (40% VA) reservoir formulation.

Abstract: A process for detecting accidental contact body fluid samples includes the addition of a small amount of a fluorescent chemical to the body fluid sample, the fluorescent chemical serving as a marker detectable upon exposure to ultraviolet light, Accordingly, any spills of the body fluid sample on exposed surfaces can be readily visually detected upon illuminating those surfaces with an ultraviolet light. Likewise, a process for detecting accidental exposure to a body fluid by skin surface protected by gloves or another substantially fluid impervious covering comprises submerging the gloved or otherwise covered skin surface into a fluorescent fluid, removing the glove or other covering and then illuminating the skin surface with an ultraviolet light to visually detect any fluorescent spots caused by holes or other leaks through the glove or other covering.

Abstract: A seam construction for an absorbent article comprises a layered composite portion of the absorbent article including a liquid pervious liner, a liquid impervious outer cover, and an absorbent medium therebetween. A pair of stretchable members are joined to the layered composite portion between respective side portions of the outer cover and the liner. The stretchable side members also extend outwardly beyond the opposite side portions of the outer cover and liner. The layered composite portion and each stretchable member form a seam construction that is resistant to liquid leakage and that provides a gentle transition between the layered composite portion and the stretchable members.

Abstract: A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

Abstract: An auxiliary absorbent article for use atop a primary absorbent article such as a diaper, said auxiliary absorbent article comprising an upper facing layer, a superabsorbent layer and an undersurface, said superabsorbent layer comprising a superabsorbent material dispersed at a matrix such that fluid passes through said auxiliary absorbent article and may be absorbed by the primary absorbent article and subsequently absorbed by the auxiliary absorbent article in the regions remote from the initial wetting.

Abstract: A method and composition of regenerating tissue. More specifically, a method for regenerating pancreatic islet tissue having the histological and insulin-containing properties of islets typically found in neonatal or adult animals is described. The regenerated islet tissue is produced by fetal mesenchyme acting upon an epithelium such that an inductive message causes the epithelium to differentiate into islet tissue.

Abstract: An improved safety device is provided for protecting medical personnel and the like against needle stick injuries and/or exposure to communicable diseases or other harmful agents. The safety device comprises an elongated protective sleeve supported by front and rear bearing members for sliding movement about a medical needle and its associated support structure, such as a support hub or barrel. The protective sleeve is slidable in a stable manner from a first position with the pointed end of the needle safely retracted within and shielded by the front bearing member to a second position with the needle projecting through and beyond the front bearing member for normal use. After use, the sleeve is slidable to a third position derailing the pointed needle end from the front bearing member, and exposing a visual indicator to indicate that the needle has been used.

Abstract: The present invention is directed to an improved method for the control of coccidiosis, in which both ionophore chemotherapy and immunology are employed.

Abstract: The present invention provides absorbent articles, such as disposable diapers, which utilize a particular type of stiffened cellulose fibers and a particlar type and form of polymeric gelling agent particles to enhance the absorbency characteristics of such articles. In these articles, the gelling agent material, combined in particulate form of a certain size with stiffened cellulose fiber material, is primarily placed in a lower fluid storage layer of the absorbent core of the article. Such a fluid storage lower layer of the absorbent core is placed underneath an upper, generally larger, fluid acquisition/distribution layer which also contains stiffened cellulose fibers and gelling agent particles of a certain size. This lower fluid storage layer is generally positioned toward the front of the absorbent article. Absorbent articles of this type can be fashioned into especially thin, compact, nonbulky diapers.

Abstract: Methods are provided for short-range intraoperative and endoscopic detection and therapy of tumors using radiolabeled antibodies and, in some cases, techniques for reducing or correcting for non-specific background radiation to improve resolution. Therapy using external radiation and/or laser or mechanical endoscopically introduced tumor removal means can be combined with the detection methods to increase precision of the tumor removal operations.

Abstract: A method and apparatus for pharmacological control of spastic urethral sphincters, particularly in patients with spinal cord injuries, includes a special monopolar electrode/needle (30) adapted for insertion through a cystoscope (46) in electrical isolation therewith but connection with an electromyograph (12) for precise determination of injection sites so that a toxin, such as botulinum A, can be injected directly into skeletal muscle tissue, rather than connective tissue, to denervate and thus relax the sphincter.

Abstract: A fiber comprised of chitin having a single yarn denier of 0.5 to 20 and a dry tensile strength of 2 g/d or more, and a process for the production thereof are described. The use of such chitin fibers permits the production of surgical sutures having high tensile strength and flexibility, and good absorption properties.

Abstract: A wetness indicator used on absorbent pads such as diapers for visually signalling the presence of water. The wetness indicator preferably comprises a hydratable salt mixture applied to a water permeable membrane and visible from an external observation of the absrobent pad. The hydratable salt has the characteristic of changing from the color it exhibits in its normal, anhydrous state to a contrasting color when it becomes hydrated. The wetness indicator is physically disposed within the pad so that it contacts water as it reaches the absorbent layers of the pad. The wetness indicator is constructed so that the hydratable salt mixture does not leach back into the absorbent layer or into contact with the wearer of the pad. The hydratable salt may be arranged to combine with a binder upon hydration to reduct toxicity.

Abstract: A disposable diaper with an integral wiping cloth and disposal container forming an integrated baby changing system is disclosed. The disposable diaper has a skin contacting moisture absorbing inner surface and a waterproof environment interfacing outer surface. A storage container means is mounted to the outer surface of the diaper and includes a liquid impermeable membrance formed so as to define a sulable pocket for retaining a towelette therein in the moistened state until such time as the towelette is needed for wiping the skin. The pocket is expandable to form a disposal container for the soiled diaper and the spent towelette. A moist towelette is adapted to be stored within the storage container means.

Abstract: Indwelling sustained release reservoirs for dispensing bloat-controlling agents to the rumens of grazing livestock. A plurality of osmotic dispensing devices with varying release patterns generate by bioerodible deposits on their osmotic membranes. The devices are linked together by bioerodible means so that they may be released and pass from the rumen when their contents are exhausted.