Abstract: Tissue anchoring devices in the form of microanchors that partially penetrate tissue, thereby avoiding full thickness penetration of the tissue, yet are secure enough to enable reliable device fixation and easy removal of the device while maintaining normal GI tract functions.

Abstract: Devices can generally include a fan portion for occluding an aneurysm neck, a channel orifice opening in the fan portion, and an agent channel for delivering a coagulating agent through the orifice into the aneurysm. Devices can be delivered through a catheter to the aneurysm, the fan portion can expand to occlude the aneurysm neck, and coagulating agent can be injected into the aneurysm. During injection of the coagulating agent, the fan portion can inhibit the coagulating agent from exiting the aneurysm. After injection of the coagulation agent, the fan portion can collapse and the device can be extracted from the patient.

Abstract: Certain embodiments of the present disclosure provide a prosthetic valve (e.g., prosthetic heart valve) and a valve delivery apparatus for delivery of the prosthetic valve to a native valve site via the human vasculature. The prosthetic valve comprises a frame or stent that comprises multiple cells arranged in unique ways. The prosthetic valve also comprises a leaflet assembly coupled to the frame and having a plurality of leaflets, wherein the leaflets are configured to allow blood to flow through the prosthetic heart valve in one direction from an inflow end portion to an outflow end portion of the frame or stent.

Abstract: A tonsillectomy suction dissector apparatus (100) having a proximal handle (101) and a distal curved tip (102) which has a suction channel (103) within and along the tip connecting at least one suction inlet port (105) to a vacuum port. The apparatus has a flexible cutting blade member (106) slidably retained and orientated widthwise within a corresponding slot (107) and configurable by hand operable locking mechanism (108) between an extended position wherein a distal cutting end (109) of the cutting blade member extends from the end of the tip and a retracted position. The shape and orientation of the blade allows the blade to bend within the slot when being extended for cutting.

Abstract: The present disclosure describes treatment of the vasculature of a patient with an expandable implant. The implant is constrained to a reduced delivery diameter for delivery within the vasculature by at least one sleeve. The implant can be constrained to other diameters, such as an intermediate diameter. The sleeves can be expanded, allowing for expansion of the diameter of the expandable implant, by disengaging a coupling member from the sleeve or sleeves from outside of the body of the patient. The expandable implant can comprise a steering line or lines which facilitate bending and steering of the expandable implant through the vasculature of a patient.

Abstract: A method for treating a patient includes a surgical instrument having a handle assembly, a shaft assembly, and an end effector. The end effector includes an upper jaw and a lower jaw configured to pivot to receive a tissue of the patient therebetween. The upper and lower jaws respectively have upper and lower crush surfaces, which extends generally parallel with a centerline and are configured to receive the tissue thereagainst. The upper jaw also includes an anvil, whereas the lower jaw includes a staple cartridge and a deck facing the anvil. In addition, the lower jaw has a plurality of staple opening formed through the deck with a plurality of staples received therein. The upper and lower crush surfaces are configured to compress the tissue therebetween with a crush pressure configured to sever the tissue along the upper and lower crush surfaces.

Abstract: Abdominal closure reinforcement methods and tissue anchoring devices for reducing the rate of abdominal wall closure dehiscence are described. The tissue anchors avoid a permanent footprint of foreign material and precluding materials spanning the interior layer of the abdominal closure where risk to visceral structures exists.

Abstract: An assembly and method are provided for incorporation into suture anchor designs to facilitate the locking of a slidable working suture after it has been tensioned. The assembly can be utilized on multiple anchors in a pre-strung chain on a single working suture to create continuous, individually tensioned suture bridges between anchors in series, without knot tying. Further, the bridges are independently locked with selected tension for the particular application. An anchor body having at least one suture receiving passage therethrough is threaded with a working suture wherein the working suture flosses through the passage when tension is applied to the working suture. A locking cord extends through a second passage through the anchor body, the locking cord having a collapsible loop extending out the second passage and encircling a portion of the working suture, wherein collapsing the loop locks the working suture after tensioning.

Abstract: Methods of printing a bio-ink on a substrate are provided comprising at least one bio ink layer, said method comprising: i) positioning a printhead comprising a two-dimensional array of print nozzles within proximity of or in contact with a substrate; and ii) ejecting a bio-ink through the print nozzles onto the substrate, forming a bio ink layer, wherein the bio-ink construct comprises at least one bio-ink layer. The methods further encompass methods of printing a live tissue and methods of treating tissue defects.

Abstract: A mitral valve prosthesis is percutaneously and/or transapically deployed in at least two stages. In a first stage, a mitral annular ring platform adapted for percutaneous delivery is delivered to and anchored in the mitral valve annulus. In the second stage, a valved-stent mitral valve prosthetic device adapted for percutaneously delivery is delivered to the mitral valve annulus for mounting in the mitral annular ring platform. This approach provides a consistent platform for accepting valved-stent mitral valve prosthetic devices from different vendors to be used.

Abstract: The present invention relates generally to a closure system for use in surgical procedures.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device including a flexible portion that is suited to access target anatomy. The flexibility of an elongate portion of the delivery device can be varied. Additionally, the delivery device can include structure that maintains the positioning of the delivery device in patient anatomy.

Abstract: A device for reducing pulsatile pressure within a vessel to treat heart disease, such as pulmonary hypertension, includes a compliant body structured to expand and contract upon changes in pressure within the vessel, a reservoir structured for holding a fluid therein, and a conduit extending between and fluidly coupling the reservoir and the compliant body, wherein the device includes a graphene-polymer composite designed to resist diffusion of the fluid through the device.

Abstract: The present disclosure describes treatment of the vasculature of a patient with an expandable implant. The implant is constrained to a reduced delivery diameter for delivery within the vasculature by at least one sleeve. The implant can be constrained to other diameters, such as an intermediate diameter. The sleeves can be expanded, allowing for expansion of the diameter of the expandable implant, by disengaging a coupling member from the sleeve or sleeves from outside of the body of the patient. The expandable implant can comprise a steering line or lines which facilitate bending and steering of the expandable implant through the vasculature of a patient.

Abstract: An hemostatic device, the hemostatic device comprising: a bracelet configurable between an open configuration and a closed configuration, wherein, in the closed configuration, the bracelet forms a loop and in the open configuration, the bracelet is linear; a compression element mounted to the bracelet and defining a compression surface for compressing against a patient, the compression element being movable relative thereto the bracelet so that a distance between the bracelet and the compression surface is varied when the bracelet and compression element are moved relative to each other, the compression element including a lock for selectively locking the compression element and bracelet relative to each other.

Abstract: A clip includes a first side portion and a second side portion fastenable together and configured to attach to a broad suture. The first side portion has a first aperture sized to permit passage of the broad suture therethrough. The second side portion has a second aperture sized to permit passage of the broad suture therethrough, and at least one prong in the second aperture configured to penetrate the broad suture. A stopper surface is provided on the first side portion, wherein the prong contacts the stopper surface when the first side portion and the second side portion are fastened together so as to maintain the prong in the broad suture to thereby attach the clip to the broad suture.

Abstract: A clip treatment tool includes a clip body that has two clip-pieces, the two clip-pieces each having a body-portion and an arm-portion, the body-portion having a fixing-hole formed on a proximal end side and a movement hole formed on a distal end side relative to the fixing-hole, the movement hole extending so as to be inclined from a side part in a width direction of the body-portion on the proximal end side toward a middle in the width direction of the body-portion on the distal end side; a container tube that contains the body-portions of the two clip-pieces therein; a stopper that extends through the fixing-holes of the two clip-pieces and that is attached to the clip body; and a fixing pin that extends through the movement holes of the two clip-pieces and whose both end portions are fixed to positions in the container tube that face each other.

Abstract: A tissue repair apparatus includes a housing, a rotatable shaft at least partially disposed within the housing, and first and second curved needles coupled to the shaft. The housing defines a gap between a first edge of the housing and a second edge of the housing, the gap adapted to receive tissue. The first and second needles curved needles being articulable within the housing from a delivery position, at which the first and second needles are spaced from the gap, to a deployed position, at which the first and second needles extend through the gap. Actuation of the shaft simultaneously articulates the first and second needles and the first needle enters the gap before the second needle enters the gap.

Abstract: A device for cardiac surgery is disclosed. The device for cardiac surgery includes an aortic root retractor frame, an introducer, and one or more suture locking apparatuses. The device for cardiac surgery also includes an actuator for releasing the aortic root retractor frame, as well as a deployment mechanism for fully expanding the aortic root retractor frame. Multiple suture locking apparatuses used for releasable locking and unlocking of suture during a cardiac surgery procedure may be included in the device for cardiac surgery.

Abstract: A delivery system for an implantable medical device includes an outer shaft and an inner shaft translatable within the outer shaft. An internally exposed coil is disposed within the inner shaft and is electrically coupled to an externally exposed coil that can be used to inductively transmit a current flowing through the internally exposed coil. An actuation member extends within the inner shaft and includes a coupler, a force translation rod that extends proximally from the coupler and a plurality of push pull rods that extend distally from the coupler and that releasably couple to the implantable medical device. As the force translation rod moves relative to the internally exposed coil, an impedance varies in accordance with relative position.