Abstract: Devices, systems, reagents, and methods for the performance of multi-spectrum super resolution microscopy are disclosed.

Abstract: A spectroscope includes a first substrate and a second substrate opposite to each other; a light introducing assembly on a side of the first substrate facing away from the second substrate; a temperature adjusting assembly between the first substrate and the second substrate; a liquid crystal dimming assembly between the first substrate and the second substrate, wherein the temperature adjusting assembly is configured to adjust a temperature of the liquid crystal dimming assembly, so as to adjust spectrum of light passing through the liquid crystal dimming assembly; a spectroscopic grating on the first substrate; a reflector on the second substrate and configured to reflect incident light introduced by the light introducing assembly to the spectroscopic grating; and a plurality of sensors configured to receive the incident light after being subjected a light splitting by the spectroscopic grating. A wavelength of the incident light received by each sensor is different.

Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.

Abstract: The present invention provides a position detection apparatus including a detection unit configured to detect moire caused by overlap between a first diffraction grating including patterns arrayed in a first direction and a second diffraction grating including patterns arrayed in the first direction, and a processing unit configured to obtain a relative position of the first diffraction grating and the second diffraction grating based on the moire, wherein a width of an end pattern of patterns included in at least one of the first diffraction grating and the second diffraction grating in the first direction is smaller than widths of remaining patterns of the at least one diffraction grating in the first direction.

Abstract: The present disclosure provides for an apparatus for measuring optical properties of liquid samples. The apparatus includes a sample chamber and a spectrometer optically coupled with the sample chamber. One or multiple sources of electromagnetic radiation are positioned relative to the sample chamber to direct electromagnetic radiation through the sample chamber to measure the color, haze, and/or clarity of the sample. Also provided is a method for measuring optical properties of liquid samples, including inserting a cuvette containing a liquid sample into the sample chamber of the apparatus, and directing electromagnetic radiation from the one or more sources and through the sample to measure the color, haze, and/or clarity of the sample. The apparatus and methods may be used to analyze various samples, such as petroleum-based fluids, including fuels and lubricants.

Abstract: A sensing substrate including a substrate, a quantum well structure, a sensing surface and metal nanoparticles is provided. The quantum well structure is disposed on the substrate, and the quantum well structure includes at least one first metal nitride layer and second metal nitride layers. The first metal nitride layers and the second metal nitride layers are stacked on the substrate in alternation manner. The quantum well structure is located between the sensing surface and the substrate. The metal nanoparticles are disposed on the sensing surface, and the sensing surface is a rough surface. A manufacturing method of the sensing substrate and a sensor are also provided.

Abstract: A fiber includes M primary cores and N redundant cores, where M an integer is greater than two and N is an integer greater than one. Interferometric circuitry detects interferometric pattern data associated with the M primary cores and the N redundant cores when the optical fiber is placed into a sensing position. Data processing circuitry calculates a primary core fiber bend value for the M primary cores and a redundant core fiber bend value for the N redundant cores based on a predetermined geometry of the M primary cores and the N redundant cores in the fiber and detected interferometric pattern data associated with the M primary cores and the N redundant cores. The primary core fiber bend value and the redundant core fiber bend value are compared in a comparison. The detected data for the M primary cores is determined reliable or unreliable based on the comparison. A signal is generated in response to an unreliable determination.

Abstract: A device and method for guided insertion of microelectrodes into tissue is provided. The device includes a flexible optical fiber for optical coherence tomography imaging, a metal layer coating the optical fiber for recording electrical signals and an outer insulation layer coating the metal layer along the optical fiber length. The method includes inserting an optical fiber coated with a metal layer and further coated with an insulation layer into a tissue, collecting intraoperative image data through the optical fiber by optical coherence tomography, receiving the image data on a computer and displaying the image on a monitor, using the image data to determine a location in the tissue, receiving an electrical nerve signal through the metal layer and measuring the electrical nerve signal on a electrophysiological recording system.

Abstract: Disclosed is a laser-driven photon source comprising drive optics which focus drive radiation so as to maintain a plasma. The point spread function of the drive optics has a point spread function (75) which is configured such that a spectral position of a peak output wavelength of a black body portion of output radiation emitted by said plasma within a desired wavelength band.

Abstract: A camera system for providing multispectral imaging of an object, the camera system having a longitudinal axis. The camera system comprises a quasi-collimating lens capable of receiving light from the object and separating wavelengths of the light. Each wavelength is projected to one of a plurality of intermediate image locations which are separated along the longitudinal axis. The system also comprises an achromatic imaging lens to receive the projected wavelengths of light from the quasi-collimating lens, and a pixelated detector positioned to receive the light from the achromatic imaging lens. The achromatic imaging lens and the pixelated detector are movable relative to one another in the direction of the longitudinal axis. The system is configured such that the projected wavelengths of light each form a corresponding image, the images formed on the detector when different distances within the range are achieved.

Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.

Abstract: An apparatus and method for die defect detection are disclosed. The apparatus includes: a light source unit (10) for emitting light of at least two wavelengths; a beam splitter (40) for receiving the light emitted by the light source unit (10) and splitting it into a first portion and a second portion, the first portion of the light reflected by a die (60) surface under inspection and thereby forming a detection beam; a reference unit (70) for receiving the second portion of the light and processing it into a reference beam; and a detection unit (90) for receiving the detection beam and the reference beam. The reference beam crosses the detection beam at an angle and thus produces interference fringes on a sensing surface of the detection unit (90), based on which a defect parameter of the die (60) surface under inspection is determined. This apparatus is capable of measuring a die with improved accuracy and efficiency and is suitable for the measurement of large dies.

Abstract: A storage unit stores first and second calibration curves. The first calibration curve represents a relationship between an absorbance of a first standard sample for light at a wavelength ?1 and a concentration of a target composition in the first standard sample. The second calibration curve represents a relationship between an absorbance of a second standard sample for light at a wavelength ?2 and a concentration of the target composition in the second standard sample. The second standard sample has a higher concentration than that of the first standard sample. When the absorbance of the unknown sample for the light at the wavelength ?1 is less than a threshold, a concentration measurement processing unit measures a concentration of the target composition in the unknown sample, based on the absorbance of the unknown sample for the light at the wavelength ?1 and the first calibration curve.

Abstract: The present invention relates to a method for detecting the presence of gas hydrates and/or ice in a medium. The method comprises at least the following steps: measuring at least at one measurement point in said medium two characteristic values of Raman spectra corresponding to two distinct vibration modes of the OH bonds of water, and determining the ratio ? of said two characteristic values, determining the temperature T in said medium at said measurement point of said spectra, comparing ratio ? with a value ?0 corresponding to a predetermined threshold of formation of said crystals for said temperature T, and determining the presence or not of hydrate and/or ice crystals from said comparison.

Abstract: Measurement system comprising a radiation source configured to generate a measurement radiation beam, a polarizer and a grating to receive the measurement radiation beam and provide a polarized measurement radiation beam patterned by the grating, optics to form an image of the grating at a target location on a substrate. The image comprises a first part having a first polarization and a second part having a second polarization, detection optics to receive radiation from the target location of the substrate and form an image of the grating image at a second grating, and a detector to receive radiation transmitted through the second grating and produce a two output signal indicative of the intensity of the transmitted radiation for the first and second parts of the grating image respectively. Topography of the substrate can be determined from the signals.

Abstract: The invention relates to a device and method for measuring the concentration, size and zeta potential of nanoparticles in liquids in scattered light mode and fluorescence mode, comprising the following features: a) a sample (28) is irradiated from above by a laser (1) via a beamsplitter (14) and an adjustable-focus liquid lens (9), and the reflected beam of light is deflected by the same beamsplitter (14) and a further liquid lens (8) onto a detector (5), and analysed; b) to observe the fluorescent light, a fluorescence filter (19) is connected in the convergent beam path between the liquid lens (8) and the detector (5), to increase the distance between the scattered light plane (31) and the fluorescence plane (30); and c) to control the measurement process, a particle tracking program, an optical control unit (15) and a display (2) with a touch screen are used.

Abstract: Systems and methods for measuring the isotope ratio of one or more gaseous oxides produced during combustion of drugs, pharmaceuticals, or medicines aiming to detect counterfeit drugs, pharmaceuticals, or medicines based on comparison of the isotopic composition of the tested drugs, pharmaceuticals, or medicines with the isotopic composition of the authentic products.

Abstract: Presented herein are systems and methods directed to a multispectral absorption-based imaging approach that provides for rapid and accurate detection, localization, and quantification of gas leaks. The imaging technology described herein utilizes a scanning optical sensor in combination with structured and scannable illumination to detect and image spectral signatures produced by absorption of light by leaking gas in a quantitative manner over wide areas, at distance, and in the presence of background such as ambient gas and vapor. Moreover, the specifically structured and scannable illumination source of the systems and methods described herein provides a consistent source of illumination for the scanning optical sensor, allowing imaging to be performed even in the absence of sufficient natural light, such as sunlight. The imaging approaches described herein can, accordingly, be used for a variety of gas leak detection, emissions monitoring, and safety applications.

Abstract: Provided are a fluorescent testing system, a molecular testing method, and a fluorescent testing method that can avoid enlargement and complication. A fluorescent testing system (1) includes: an excitation light source (23) that radiates excitation light (L1) to protein to which a fluorescent probe is added; a silicon integrated circuit (10) including a photon detection unit (13) that detects light by a photodiode (12); a holding layer (30) including a microwell (31) that is provided above the photodiode (12) and holds the protein to which the fluorescent probe is added; and a control unit (24) that causes the excitation light source (23) to radiate the excitation light (L1) to the protein which. is held and to which the fluorescent probe is added and causes the photon detection unit (13), after extinguishment of the excitation light (L1), to detect fluorescence emitted from the protein to which the fluorescent probe is added.

Abstract: Provided is an optical scanning device. The optical scanning device includes a swingable reflection unit; a blocking unit that is provided in the reflection unit to move in linkage with the reflection unit; and a sensor unit that includes an output unit configured to output a detection target and a detection unit configured to detect the detection target, wherein, when the reflection unit is in a predetermined swing angle range, the blocking unit blocks a path of the detection target between the output unit and the detection unit.