Patents Examined by Shawquia Young
  • Substituted arylsulfonylaminomethylphosphonic acid derivatives, their preparation and their use in the treatment of type I and II diabetes mellitus
    Patent number: 8357689
    Abstract: The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: January 22, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Holger Wagner, Elke Langkopf, Matthias Eckhardt, Ruediger Streicher, Corinna Schoelch, Annette Schuler-Metz, Alexander Pautsch
  • Selective opioid compounds
    Patent number: 8354534
    Abstract: The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which relates to morphinan compounds useful as ?, ?, and/or ? receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug overdose, mental illness, bladder dysfunctions, neurogenic bladder, interstitial cystitis, urinary incontinence, premature ejaculation, inflammatory pain, peripherally mediated and neuropathic pain, cough, lung edema, diarrhea, cardiac disorders, cardioprotection, depression, and cognitive, respiratory, diarrhea, irritable bowel syndrome and gastro-intestinal disorders, immunomodulation, and anti-tumor agents.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: January 15, 2013
    Assignee: Alkermes, Inc.
    Inventors: Derrick Arnelle, Daniel Deaver, Reginald L. Dean, III, Mark Todtenkopf
  • Low triphenylphosphate, high phosphorous content isopropyl phenyl phosphates with high ortho alkylation
    Patent number: 8350074
    Abstract: The present invention relates to low triphenyl phosphate, high phosphorous content aryl phosphates with high ortho alkylation that are suitable for use as flame retardant compositions, processes for their preparation, and their use as flame retardants.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: January 8, 2013
    Assignee: Albemarle Corporation
    Inventors: William J. Layman, Arthur G. Mack, Techen Tsao, Jeffrey Todd Aplin, Hoover Chew, Douglas W. Luther
  • Bis-(1(2)H-tetrazol-5-yl) amine and production method therefor
    Patent number: 8350050
    Abstract: High-quality bis-(1(2)H-tetrazol-5-yl)amine and a method for easily, safely, and inexpensively producing the compound are provided. The method for producing bis-(1(2)H-tetrazol-5-yl)amine includes the steps of heating to 50 to 120° C. a solution mixture in which a necessary amount of an azide salt and a dicyanamide salt in an amount corresponding to 1 to 80 wt % of a necessary amount are added to a solvent, adding an acid in an amount of 1.54 to 2.22 chemical equivalents of the dicyanamide salt in the solution mixture to carry out a reaction at 50 to 120° C., and then adding an acid and a dicyanamide salt solution in which the remaining dicyanamide salt is dissolved in a solvent to promote the reaction. Bis-(1(2)H-tetrazol-5-yl)amine is obtained according to the production method.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: January 8, 2013
    Assignee: Toyo Boseki Kabushiki Kaisha
    Inventors: Toshiyuki Toda, Toru Kofukuda
  • Immobilized 1,2-benzisothiazolin-3-one
    Patent number: 8350049
    Abstract: The present invention provides novel antimicrobial immobilized 1,2-benzisothiazolin-3-one/zinc oxide (BIT/ZnO) complexes useful as antimicrobial agents because of their resistance to being leached from the substrate to which they are attached. The present invention is also directed to methods for preparing the BIT/ZnO complexes, to BIT/ZnO complexes prepared by the novel methods, to methods for using the BIT/ZnO complexes to inhibit microbial growth or reduce the level of bacteria on the surface of a substrate, and to substrates protected to from microbial attack by being treated with the BIT/ZnO complexes. The present invention is further directed to compositions comprising 1,2-benzisothiazolin-3-one which has been immobilized with zinc oxide.
    Type: Grant
    Filed: January 12, 2011
    Date of Patent: January 8, 2013
    Assignee: Troy Corporation
    Inventor: Wolfgang Lindner
  • (2,5-dioxoimidazolidin-i-yl)-n-hydroxy-acetamides as metalloproteinase inhibitors
    Patent number: 8338471
    Abstract: The invention provides compounds of the formula (I) wherein the variables are as defined in the specification. The compounds of the invention are inhibitors of metalloproteinase MMP-12 and are among other things useful for the treatment of obstructive airway diseases, such as chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: December 25, 2012
    Assignee: Medivir AB
    Inventors: Hans Wallberg, Ming-Hua Xu, Guo-Qiang Lin, Xin-Sheng Lei, Piaoyang Sun, Kevin Parkes, Tony Johnson, Bertil Samuelsson
  • Amines as small molecule inhibitors
    Patent number: 8338437
    Abstract: The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof as defined herein. The compound are useful as inhibitors of PRMTs and/or CARM-I. The invention further relates to compositions comprising such compounds and methods for their use.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: December 25, 2012
    Assignee: MethylGene Inc.
    Inventors: Amal Wahhab, Eric Therrien, Martin Allan, Sukhdev Manku
  • Selective glycosidase inhibitors and uses thereof
    Patent number: 8334310
    Abstract: The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: December 18, 2012
    Assignee: Simon Fraser University
    Inventors: David Vocadlo, Ernest McEachern, Keith Stubbs, Tong-Shuang Li, Garrett Whitworth, Julia Heinonen, Matthew Macauley
  • Process for the preparation of alkylene glycol
    Patent number: 8329959
    Abstract: The invention provides a process and a reactor for the preparation of an alkylene glycol from an alkylene oxide. Alkylene oxide, water, a homogeneous carboxylation catalyst and a homogenous hydrolysis catalyst are supplied to a reactor comprising a carboxylation zone and a hydrolysis zone. One or more ejectors are used to mix carbon dioxide and the liquid reagents in the carboxylation zone so that alkylene oxide reacts with carbon dioxide in the presence of water in the carboxylation zone to form a reaction solution comprising alkylene carbonate, water, the homogeneous carboxylation catalyst and the homogeneous hydrolysis catalyst. The reaction solution is supplied from the carboxylation zone to a hydrolysis zone, wherein alkylene carbonate and water react to form a product solution comprising alkylene glycol, the homogeneous carboxylation catalyst and the homogeneous hydrolysis catalyst.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: December 11, 2012
    Assignee: Shell Oil Company
    Inventors: Hendrik Johannes Van Milligen, Peter Veenstra
  • Polymorphs of sunitinib malate
    Patent number: 8329740
    Abstract: The present invention provides a novel crystalline form of sunitinib malate, process for its preparation and to pharmaceutical composition containing it. The present invention also provides a process for preparation of sunitinib malate crystal form I. Thus, for example, sunitinib malate was added to water, the mixture was heated to 80 deg C. to obtain a clear solution and stirred for 30 minutes at 80 deg C., slowly cooled to room temperature and the solution was subjected to freeze drying at about ?90 deg C. for 8 hours to give sunitinib malate crystalline form III.
    Type: Grant
    Filed: January 2, 2009
    Date of Patent: December 11, 2012
    Assignee: Hetero Research Foundation
    Inventors: Bandi Parthasaradhi Reddy, Kura Rathnakar Reddy, Rapolu Raji Reddy, Dasari Muralidhara Reddy, Thungathurthy Srinivasa Rao
  • Process for the preparation of O-desmethylvenlafaxine succinate polymorphic forms
    Patent number: 8329952
    Abstract: The present invention relates to process for the preparation of novel crystalline Desmethylvenlafaxine succinate polymorphic Forms-A, B. The present invention also relates to novel processes for the preparation of 0-Desmethylvenlafaxine succinate polymorphic Forms-(I), (II), (III) and amorphous.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: December 11, 2012
    Assignee: Matrix Laboratories Limited
    Inventors: Ramakoteswara Rao Jetti, Purandhar Koilkonda, Jagan Mohana Chary Tummanapally, Mohana Vamsi Krishna Vadlamudi, Prasanth Kumar Barik, Om Dutt Tyagi
  • Macrocyclic compounds useful as pharmaceuticals
    Patent number: 8329742
    Abstract: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: December 11, 2012
    Assignee: EISAI Co., Ltd.
    Inventors: Roch Boivin, Kenichi Chiba, Jesse Chow, Hong Du, Yoshihito Eguchi, Masanori Fujita, Masaki Goto, Fabian Gusovsky, Jean-Christophe Harmange, Atsushi Inoue, Yimin Jiang, Megumi Kawada, Takatoshi Kawai, Yoshiyuki Kawakami, Akifumi Kimura, Makoto Kotake, Yoshikazu Kuboi, Charles-André Lemelin, Xiang-Yi Li, Tomohiro Matsushima, Yoshiharu Mizui, Kenzo Muramoto, Hideki Sakurai, Yong-Chun Shen, Hiroshi Shirota, Mark Spyvee, Isao Tanaka, John (Yuan) Wang, Satoshi Yamamoto, Naoki Yoneda
  • Substituted indoles and a method for the production and use thereof
    Patent number: 8329689
    Abstract: The invention relates to novel substituted indoles, to the use thereof in the form of pharmacological composition substances and to use of said composition for producing medicinal preparations used for preventing and treating viral diseases, in particular caused by viruses of infectious hepatitis (HCV, HBV), human immune deficiency (HIV), atypical pneumonia (SARS) and bird flu.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: December 11, 2012
    Inventors: Andrey Alexandrovich Ivashchenko, Sergey Yevgenievich Tkachenko, Alexander Viktorovich Khvat, Oleg Dmitrievich Mitkin, Ilya Matusovich Okun, Alexandr Sergeevich Kyselvev, Volodymyr Mikhailovich Kysil, Nikolay Filippovich Savchuk, Alexander Vasilievich Ivachtchenko
  • Pyrazolylaminopyridine derivatives useful as kinase inhibitors
    Patent number: 8324252
    Abstract: This invention relates to novel compounds having the Formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: December 4, 2012
    Assignee: Astrazeneca AB
    Inventors: Audrey Davies, Michelle Lamb, Paul Lyne, Tao Wang, Dingwei Yu, Peter Mohr, Bin Wang
  • Heterocyclic spiro-compounds
    Patent number: 8324235
    Abstract: The patent application relates to new heterocyclic compounds of the general formula (I), in which R, R1, R2, Q, T, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: December 4, 2012
    Assignee: Novartis AG
    Inventors: Peter Herold, Robert Mah, Stefan Stutz, Vincenzo Tschinke, Aleksandar Stojanovic, Nathalie Jotterand, Bibia Bennacer
  • N-acyl amino acid derivatives, a method for the preparation thereof, a pharmaceutical composition and use thereof as anti-allergic, anti-inflammatory and hypolipidemic agents
    Patent number: 8318950
    Abstract: The present invention relates to N-acyl derivatives of amino acids and pharmaceutically acceptable salts thereof wherein n is 2 or 3; and R1 represents or pharmaceutically acceptable salts thereof, to novel processes for preparing the same, to use thereof as anti-allergic, anti-anaphylactic, anti-inflammatory and hypolipidemic agents as well as to a pharmaceutical composition comprising the indicated compounds in an efficient amount and to a method for treating allergic and inflammatory diseases and lipid metabolism disorders: bronchial asthma, allergic rhinitis, pollinoses, seasonal and year-round rhinitis, allergic pneumonitis, atopic dermatitis, psoriasis, urticaria, allergic (including anaphylactic) reactions to insect stings and medicaments, cold allergy, allergic conjunctivitis, atherosclerosis, obesity, ischemic heart and cerebral disease, myocardial infarction and stroke.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: November 27, 2012
    Assignee: Otkrytoe Aktsionernoe Obschestvo-Otechestvennye Lekarstva
    Inventors: Vladimir Evgenievich Nebolsin, Tatyana Alexandrovna Kromova, Galina Alexandrovna Alexandrovna Zheltukhina, Violetta Leonidovna Kovaleva
  • Triazole fused heteroaryl compounds and methods of use thereof
    Patent number: 8314131
    Abstract: The present invention comprises a new class of compounds useful for modulating the activity of p38 MAP kinase. The compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R1 and R5 are defined herein. The invention further provides pharmaceutical compositions including one or more compounds of Formula I, use of such compounds and compositions for treatment of p38 MAP kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: November 20, 2012
    Assignee: Amgen Inc.
    Inventors: Liping H. Pettus, Kelvin K. C. Sham, Andrew Tasker, Shimin Xu
  • Toluene sulfonic acid salt of a therapeutic compound and pharmaceutical compositions thereof
    Patent number: 8314139
    Abstract: The present invention is directed to the tosylate salt of trans-N-ethyl-3- fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)-phenyl]-cyclobutanecarboxamide (1): to solvates (e.g., hydrates) thereof, to polymorphs thereof, to pharmaceutical compositions thereof and to a method of treating depression, mood disorders, schizophrenia, anxiety disorders, cognitive disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper- and hypo-motility and acidic secretion of the gastro-intestinal tract comprising administering a therapeutically effective amount thereof.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: November 20, 2012
    Assignee: Pfizer Inc.
    Inventors: Todd W Butler, Travis T Wager
  • Recycling methane-rich purge gas to gasifier
    Patent number: 8309617
    Abstract: A process for improving the overall carbon conversion efficiency of a gasification process, as well as improving the suitability of a syngas containing 0.5-10% methane for use as a feedstock for chemical production. A gasification reactor converts carbonaceous feedstock to syngas that is, in turn, utilized for a chemical production process in a chemical production reactor. An off-gas from this chemical production reactor is directed to a selective membrane that separates the off-gas into methane-rich and hydrogen-rich fractions. The hydrogen-rich fraction, is re-utilized as feedstock for the chemical production process, while the methane-enriched fraction is returned to the gasification reactor to form additional syngas.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: November 13, 2012
    Assignee: Phillips 66 Company
    Inventor: Shuncheng Ji
  • Granular water dispersible agent and production process
    Patent number: RE43816
    Abstract: A water dispersible granule formulation prepared by pulverized a part of active ingredients into fine particles under wet milling and pulverized another part of the active ingredients into coarse particles under dry milling, then kneading the both active ingredients for the granulation, and a process for producing the water dispersible granule formulation are disclosed. The water dispersible granule formulation according to the present invention is applicable for production of a water dispersible granule formulation comprising an active ingredient which is easily decomposed owing to environmental conditions and allows to provide the water dispersible granule formulation provided with enhanced initial and residual biological activities.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: November 20, 2012
    Assignee: Nippon Soda Co., Ltd.
    Inventor: Masahiro Suzuki