Patents Examined by Shawquia Young
  • Near-infrared-ray absorbing material containing cyanine compound, and cyanine compound
    Patent number: 8460858
    Abstract: A near-infrared-ray absorbing material containing a cyanine compound per formula (I) exhibits a sharp light absorption in wavelength range 800-1000 nm, with excellent light resistance. R1 - R4, Y1, Y2 represents hydrogen atom, a group of formula (II) or (II?), etc., and Anq? represents a q-valent anion, provided that at least R1 is a group of formula (II) or (II?) or Anq? is an ion of formula (III); R11 - R13 each represents a hydrogen atom, hydroxyl group, etc.; Z1, Z2 represents a C1-10 alkyl group, etc. In formula (II?), the bond between G? and T? is a double bond or a conjugated double bond; G? represents a carbon atom; T? represents a carbon atom or a nitrogen atom; the ring including G? and T? represents a 6-membered ring, etc.; w? is 0-4; and R01? represents a hydrogen atom, hydroxy, etc. In formula (III), R5 and R6 represents a halogen-substituted C1-8 alkyl group.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: June 11, 2013
    Assignee: Adeka Corporation
    Inventors: Yosuke Maeda, Ryoya Otsuki, Koichi Shigeno
  • Processes for the manufacture of a pharmaceutically active agent
    Patent number: 8461353
    Abstract: Disclosed herein are processes for the preparation of a pharmaceutically active agent and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: June 11, 2013
    Assignee: H. Lundbeck A/S
    Inventors: Frans Therkelsen, Michael Harold Rock, Svend Treppendahl
  • Process for producing 3-(2-cyano-1-propenyl)-2,2- dimethylcyclopropanecarboxylic acid or salt thereof
    Patent number: 8461370
    Abstract: A process for producing comprising reacting a 3-formyl-2,2-dimethylcyclopropanecarboxylate and propionitrile in the presence of a base to obtain 3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid or its salt.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: June 11, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toru Uekawa, Jun Ohshita, Ichiro Komoto, Kouji Yoshikawa
  • Heteroaryl dihydroindolones as kinase inhibitors
    Patent number: 8455535
    Abstract: The present invention provides a compound represented by the formula: wherein ring systems A and B, and the variables R1, b, R6, Y, Z, X, R and a are defined in the specification. The compounds of the present invention may be used in a method for treating diseases related to unregulated tyrosine kinase signal transduction, such as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders, and metabolic diseases.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: June 4, 2013
    Assignee: Allergan, Inc.
    Inventors: Sougato Boral, Xialing Guo, Shimiao Wang, Julie A. Wurster, Thomas C. Malone
  • TRPV4 antagonists
    Patent number: 8450484
    Abstract: The present invention relates to diazabicyclo[2.2.1]hept-2-yl analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: May 28, 2013
    Assignee: GlaxoSmithKline, LLC
    Inventors: Michael Jonathan Bury, Mui Cheung, Hilary Schenck Eidam, Ryan Michael Fox, Krista Goodman, Eric Steven Manas
  • Indole derivative having, carbamoyl group, ureido group and substituted oxy group
    Patent number: 8445529
    Abstract: An indole compound having a carbamoyl group, a ureido group and a substituted oxy group having the following formula (1) or a salt thereof: In the formula (1), R1 represents a hydrogen atom, an alkyl group, a hydroxy group, or an alkoxy group; R2 represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R3 represents a halogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group, a heterocyclic group an alkoxy group, an alkenyloxy group, an alkynyloxy group, a cycloalkyloxy group, an aryloxy group or a heterocyclic oxy group; m represents 0, 1, 2, or 3.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: May 21, 2013
    Assignee: Santen Pharmaceutical Co., Ltd.
    Inventors: Kenji Kawashima, Hiroshi Enomoto, Minoru Yamamoto, Masaaki Murai
  • Synthetic methods for spiro-oxindole compounds
    Patent number: 8445696
    Abstract: This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: May 21, 2013
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Jean-Jacques Cadieux, Mikhail Chafeev, Sultan Chowdhury, Jianmin Fu, Qi Jia, Stefanie Abel, Emad El-Sayed, Elke Huthmann, Thomas Isarno
  • 1,3-oxazolidin -2-one derivatives useful as CETP inhibitors
    Patent number: 8440702
    Abstract: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. The compounds have 3 cyclic groups connected by single bonds, as for example triphenyl, which are attached directly to the ring of formula I or attached at the position B.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: May 14, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Amjad Ali, Zhijian Lu, Peter J. Sinclair, Yi-Heng Chen, Cameron J. Smith, Hong Li
  • 2-aryl-2-fluoropropanoic acids and derivatives and pharmaceutical compositions containing them
    Patent number: 8440711
    Abstract: The present invention relates to (R,S) 2-aryl-2-fluoropropanoic acids, their single enantiomers (R) and (S), their derivatives amides and acylsulfonamides and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PMN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the treatment of damages caused by ischemia and reperfusion.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: May 14, 2013
    Assignee: Dompe Pha.r.ma S.p.A.
    Inventors: Marcello Allegretti, Andrea Aramini, Maria Candida Cesta
  • Stable isotope-labeled aromatic amino acids, method for incorporating the same in target protein and method for NMR-structural analysis of proteins
    Patent number: 8440169
    Abstract: The present invention herein provides, for instance, a stable isotope-labeled phenylalanine wherein a carbon atom of the phenyl group linked to an amino acid residue is 13C, 2 to 4 carbon atoms of the remaining 5 carbon atoms constituting the phenyl group are 12C atoms to which deuterium atoms are bonded, and the remaining carbon atoms are 13C atoms to which hydrogen atoms are linked, and a stable isotope-labeled tyrosine wherein a carbon atom of the phenyl group linked to an amino acid residue is 13C, the carbon atom bonded to the hydroxyl group (OH group) of the phenyl group is 12C or 13C, 2 to 4 carbon atoms of the remaining 4 carbon atoms constituting the phenyl group are 12C atoms to which deuterium atoms are bonded, and the remaining carbon atoms are 13C atoms to which hydrogen atoms are linked.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: May 14, 2013
    Assignee: Japan Science and Technology Agency
    Inventors: Masatsune Kainosho, Tsutomu Terauchi
  • Environmentally sensitive fluorophores
    Patent number: 8440835
    Abstract: The present invention generally relates to environment-sensitive fluorophores, including environment-sensitive fluorophores for reporting protein/protein and peptide/protein interactions. In one aspect, the present invention is directed to compounds and salts thereof, compositions and methods useful in determining biological interactions. In some cases, the compounds of the present invention are environment-sensitive fluorophores that have spectroscopic behavior that may depend on factors such as the physicochemical properties of the surrounding environment. The compounds of the present invention can be used, in certain embodiments, to monitor ions, small molecules, and biological processes such as protein folding, protein-protein interactions and phosphorylation events.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: May 14, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Barbara Imperiali, Galen S. Loving
  • Halogen alkoxy spirocyclic tetramic and tetronic acid derivatives
    Patent number: 8435549
    Abstract: The invention relates to novel haloalkoxyspirocyclic tetramic and tetronic acid derivatives of the formula (I) in which W, X, Y, Z, A, D, Q1, Q2, m and G have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides. Moreover, the invention provides selective herbicidal compositions comprising, firstly, haloalkoxyspirocyclic tetramic and tetronic acid derivatives and, secondly, a crop plant compatibility-improving compound. The invention furthermore relates to increasing the action of crop protection compositions comprising compounds of the formula (I) through the addition of ammonium salts or phosphonium salts and optionally penetrants.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: May 7, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Reiner Fischer, Thomas Bretschneider, Stefan Lehr, Christian Arnold, Jan Dittgen, Dieter Feucht, Heinz Kehne, Olga Malsam, Christopher Hugh Rosinger, Eva-Maria Franken, Ulrich Görgens
  • Compositions and methods for controlling nematodes
    Patent number: 8435999
    Abstract: Compositions and processes for controlling nematodes are described herein, e.g., nematodes that infest plants or animals. The compounds include oxazoles, oxadiazoles and thiadiazoles.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: May 7, 2013
    Assignee: Monsanto Technology LLC
    Inventors: Deryck J. Williams, Matt W. Dimmic, William P. Haakenson, Jr., Al Wideman, Barry J. Shortt, Tim Cheeseright, Michael J. Crawford
  • Azeotrope-like composition of hexafluoropropane, hexafluoropropene and hydrogen fluoride
    Patent number: 8436218
    Abstract: The present invention relates to an azeotropic or azeotrope-like mixture consisting essentially of 1,1,1,2,3,3-hexafluoropropane, hexafluoropropene and hydrogen fluoride.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: May 7, 2013
    Assignee: Honeywell International Inc.
    Inventors: Ryan Hulse, Hang T. Pham, Rajiv Ratna Singh, Hsueh Sung Tung, Daniel C. Merkel, Konstantin A. Pokrovski
  • Indolesulfonyl protecting groups for protection of guanidino and amino groups
    Patent number: 8431720
    Abstract: The invention relates to indolesulfonyl halogenides which are useful for the protection of organic compounds comprising at least one guanidino moiety and/or at least one amino group. The invention further relates to a process for their preparation and their use as protecting reagents. The invention also relates to the process for the protecting reaction and to the protected compounds thereof.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: April 30, 2013
    Assignee: Lonza Ltd.
    Inventors: Matthieu Giraud, Fernando Albericio, Albert Isidro Liobet, Mercedes Alvarez Domingo
  • Process for preparation of high molecular weight molybdenum succinimide complexes
    Patent number: 8426608
    Abstract: Disclosed is a process for preparing a molybdated succinimide complex, the process comprising: (a) reacting an alkyl or alkenyl mono- or bis-succinimide of a polyamine of formula I or formula II or mixtures thereof: wherein R is an alkyl or alkenyl group having a number average molecular weight of about 500 to about 5,000, R? is a straight or branched-chain alkylene group having 2 to 3 carbon atoms, x is 2 to 11, and y is 1 to 10, with an ?,?-unsaturated mono-carboxylic acid or carboxylic acid ester, in a charge mole ratio of the ?,?-unsaturated mono-carboxylic acid or carboxylic acid ester to the succinimide of formula I or formula II or mixtures thereof of greater than 1.05:1 to about 6:1, and wherein the reaction temperature is in the range of from greater than 80° C. to no greater than about 150° C.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: April 23, 2013
    Assignee: Chevron Oronite Company LLC
    Inventors: Kenneth D. Nelson, James J. Harrison, Paula Rogers, Mitra Hosseini
  • Anti-tumor compounds derived from 1,4,5,8-tetrachloroanthraquinone
    Patent number: 8420861
    Abstract: Compounds for utilization as anti-tumor agents against cancer and certain inflammatory and arthritic conditions designed with multiple active sites to cause inhibition and cell death synthesized from the starting compound 1,4,5,8-tetrachloroanthraquinone. Included are anti-tumor compounds of the class 1,4,5,8-tetrakis-alkylaminoalkyl, 1,4,5,8-tetrakis-hydroxyalkylaminoalkyl, 1,4,5,8-tetrakis-chloroethylamino, 1,2-bischloroethylamino-1,4,5,8-tetrakis-aminoethylamino derivatives of Anthraquinone. Also includes mixtures of groupings such as 1-aminoalkylamino-4,5,8-tris-(1,2-dimethyl)aminoalkylamino anthraquinone, 1,2-dichloroethyl 1-aminoalkyl amino-4,5,8-tris-aminoethylamino anthraquinone, bis-1,4aminoalkylamino bis-5,8-alkylaminoanthraquinone, 1,4-bis-chloroalkylamino-5,8-bisaminoalkylamino anthraquinone and others.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: April 16, 2013
    Inventor: D. Richard Ishmael
  • Processes for the preparation of 2-(1-phenylethyl)isoindolin-1-one compounds
    Patent number: 8415485
    Abstract: Methods for preparation of isoindolin-1-one compounds are described.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: April 9, 2013
    Assignee: Celgene Corporation
    Inventors: Anthony J. Frank, Hon-Wah Man, Chuansheng Ge, Manohar Saindane
  • Modulators of ATP-binding cassette transporters
    Patent number: 8415387
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: April 9, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Peter D. J. Grootenhuis, Mark T Miller, Jason McCartney, Fredrick van Goor, Mehdi Michel Djamel Numa, Jinglan Zhou, Brian Bear
  • Acid secretion inhibitor
    Patent number: 8415368
    Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: April 9, 2013
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Masahiro Kajino, Atsushi Hasuoka, Haruyuki Nishida