Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.
Type:
Grant
Filed:
January 19, 2012
Date of Patent:
March 1, 2016
Assignee:
3M INNOVATIVE PROPERTIES COMPANY
Inventors:
Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, James I. Hembre, Robert T. Fitzsimons, Jr., George W. Griesgraber, Yi He
Abstract: Recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid and by reacting a portion of the crude ethanol product or one or more derivative streams containing ethyl acetate obtained therefrom in the presence of hydrogen, via hydrogenolyzis. The one or more derivative streams comprise ethyl acetate that are reacted via hydrogenolyzis to form additional ethanol that may be directly or indirectly fed to the separation zone or the hydrogenation reactor.
Type:
Grant
Filed:
July 8, 2011
Date of Patent:
March 1, 2016
Assignee:
Celanese International Corporation
Inventors:
R. Jay Warner, Trinity Horton, Radmila Jevtic, Victor J. Johnston, David Lee, Adam Orosco, Lincoln Sarager
Abstract: The invention is directed to improvements in the indirect hydration process for the production of alcohols that enable high alcohol yield by increasing ether recycle in an olefin hydration process, such as the hydration process to produce isopropyl alcohol (IPA) from propylene or the hydration process to produce sec-butyl alcohol (SBA) from butylene.
Type:
Grant
Filed:
June 17, 2010
Date of Patent:
February 23, 2016
Assignee:
ExxonMobil Chemical Patents Inc.
Inventors:
Charles Morris Yarbrough, Seth McConkie Washburn, Dennis Jay Davoren, Michael Alan Better
Abstract: The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Type:
Grant
Filed:
September 26, 2011
Date of Patent:
February 23, 2016
Assignee:
AbbVie Deutschland GmbH & Co. KG
Inventors:
Sean Colm Turner, Margaretha Henrica Maria Bakker, Marcel Van Gaalen, Falko Ernst Wolter, Wilfried Hornberger, Marjoleen Nijsen
Abstract: This invention relates to compounds of Formula (I) wherein Cy1, L1, Y, R1, L2, and Ar2 are defined herein, for the treatment of cancers, inflammatory disorders, and neurological conditions.
Type:
Grant
Filed:
September 3, 2009
Date of Patent:
February 23, 2016
Assignee:
BIOMARIN PHARMACEUTICAL INC.
Inventors:
James R. Rusche, Norton P. Peet, Allen T. Hopper
Abstract: Thermal interface materials are disclosed that include or are based on thermally reversible gels, such as thermally reversible gelled fluids, oil gels and solvent gel resins. In an exemplary embodiment, a thermal interface material includes at least one thermally conductive filler in a thermally reversible gel.
Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
Type:
Grant
Filed:
April 22, 2010
Date of Patent:
January 26, 2016
Assignee:
Boehringer Ingelheim International GmbH
Inventors:
Lars Van Der Veen, Darryl McConnell, Siegfried Schneider, Matthias Grauert, Andreas Schoop, Tobias Wunberg
Abstract: The present invention relates to novel heterocyclic compounds, to processes for preparation thereof and to the use thereof for controlling animal pests, which include arthropods and especially insects.
Type:
Grant
Filed:
July 15, 2011
Date of Patent:
January 12, 2016
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Friedrich August Mühlthau, Thomas Bretschneider, Reiner Fischer, Martin Füβlein, Markus Heil, Achim Hense, Joachim Kluth, Adeline Köhler, Eva-Maria Franken, Olga Malsam, Arnd Voerste, Peter Jeschke, Angela Becker, Peter Lösel, Yoshitaka Sato
Abstract: A method for making a support impregnated Ziegler-Natta-type catalyst precursor including at least two transition metals and a support material wherein the resulting catalyst precursor is free-flowing is provided. Also provided is a process for producing a Ziegler-Natta type procatalyst by halogenating the free flowing catalyst precursor. The Ziegler-Natta type procatalyst and the reaction product of at least one monomer in the presence of the Ziegler-Natta type procatalyst and cocatalyst are also provided.
Type:
Grant
Filed:
August 31, 2010
Date of Patent:
December 29, 2015
Assignee:
Union Carbide Chemicals & Plastics Technology LLC
Inventors:
Robert J. Jorgensen, Burkhard E. Wagner, Cynthia A. Hepburn
Abstract: Thiazolyl oxime ethers and hydrazones of the formula (I), in which the symbols A, L1, L2, Y, W, X, R1, R2, R3, R4, R5, R6 and R7 have the meanings given in the description, and also agrochemically active salts thereof, and their use for controlling phytopathogenic harmful fungi, and also methods for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I).
Type:
Grant
Filed:
February 28, 2014
Date of Patent:
December 22, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Pierre Cristau, Nicola Rahn, Tomoki Tsuchiya, Ulrike Wachendorff-Neumann, Arnd Voerste, Jürgen Benting
Abstract: Process for the preparation of catalytic support and supported bimetallic catalysts for production of homopolymers and copolymers of ethylene with ?-olefins, of high and ultra high molecular weight and with broad molecular weight distribution in slurry, bulk and gas phase processes and products thereof. The present invention relates to a process for the preparation of catalytic support and the supported bimetallic catalysts, used in the production of ethylene homopolymers and ethylene copolymers with ?-olefins, of high and ultra high molecular weight with broad molecular weight distribution, in gas or liquid phase polymerization processes, the latter being in slurry, bulk or suspension, and the products obtained from these processes.
Type:
Grant
Filed:
July 3, 2008
Date of Patent:
December 15, 2015
Assignee:
Braskem America, Inc.
Inventors:
Marcia Silva Lacerda Miranda, Fernanda Oliveira Vieira da Cunha
Abstract: The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2, 4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5- disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).
Type:
Grant
Filed:
February 16, 2009
Date of Patent:
November 24, 2015
Assignee:
BRACCO IMAGING S.P.A.
Inventors:
Giovanni Battista Giovenzana, Camilla Cavallotti, Luciano Lattuada, Fulvio Uggeri
Abstract: The invention relates to a process for producing polyester polyols with secondary hydroxyl end groups, including the step of the reaction of a polyester including carboxyl end groups with an epoxide of the general formula (1): wherein R1 stands for an alkyl residue or an aryl residue and the reaction is carried out in the presence of a catalyst that includes at least one nitrogen atom per molecule. The process is distinguished in that the polyester including carboxyl end groups exhibits an acid value from ?25 mg KOH/g to ?400 mg KOH/g and a hydroxyl value from ?5 mg KOH/g and in that the polyester including carboxyl end groups is produced by ?1.03 mol to ?1.90 mol carboxyl groups or carboxyl-group equivalents of an acid component being employed per mol hydroxyl groups of an alcohol. The polyester polyols obtained, including secondary hydroxyl end groups, can be used for the purpose of producing polyurethane polymers.
Abstract: This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles.
Type:
Grant
Filed:
February 24, 2013
Date of Patent:
October 20, 2015
Assignee:
Biochemtex S.p.A.
Inventors:
Steven Ryba, Aaron Murray, Guliz Arf Elliott, Dan Gastaldo
Abstract: The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.
Type:
Grant
Filed:
July 6, 2010
Date of Patent:
October 13, 2015
Assignee:
Bracco Imaging S.P.A.
Inventors:
Pier Lucio Anelli, Carlo Felice Viscardi, Pietro Delogu, Fabrizio Goffredi, Alfonso Nardelli, Giovanni Battista Giovenzana
Abstract: The present invention provides a novel sulfonic acid group-containing diamine compound represented by formula (1) below, and a method for producing the same. This compound has a fluorene skeleton with sulfonic acid groups or derivatives thereof. In this compound, a substituent having an amino group is bonded to each of carbon atoms at the 2-position and the 7-position in the skeleton, and no substituent is bonded to a carbon atom at the 9-position in the skeleton. A in formula (1) denotes an optionally-substituted divalent aliphatic group (having a carbon number of 10 or less) or an optionally-substituted divalent aromatic group (having the number of rings of 4 or less), for example.
Abstract: Methods of preparing sulfate salts of heteroatomic compounds using dialkyl sulfates as a primary reactant are disclosed. Also disclosed are methods of making ionic liquids from the sulfate salts of the heteroatomic compound, and electrochemical cells comprising the ionic liquids.
Type:
Grant
Filed:
June 18, 2012
Date of Patent:
September 29, 2015
Assignee:
FLUIDIC, INC.
Inventors:
Cody A. Friesen, Derek Wolfe, Paul Bryan Johnson
Abstract: The present invention relates to novel heterocyclic alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.
Type:
Grant
Filed:
September 14, 2012
Date of Patent:
September 29, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Carl Friedrich Nising, Pierre Cristau, Hendrik Helmke, Gorka Peris, Tomoki Tsuchiya, Pierre Wasnaire
Abstract: This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles.
Type:
Grant
Filed:
February 24, 2013
Date of Patent:
September 22, 2015
Assignee:
Biochemtex, S.p.A.
Inventors:
Dan Gastaldo, Steven Ryba, Aaron Murray, Guliz Arf Elliott