Patents Examined by Stanley J. Friedman
  • Ethyl-3-(2-ethyl-2,2-dimethylhydrazinium)-propionate salts to treat arrhythmia
    Patent number: 5017611
    Abstract: The present invention relates to the art of organic chemistry. The novel compounds - ethyl-3-(2-ethyl-2,2-dimethylhydrazinium)-propionate salts have the general formula: ##STR1## wherein X is Cl, Br, I. The compounds of the present invention possess an antiarrhythmic effect.
    Type: Grant
    Filed: October 30, 1989
    Date of Patent: May 21, 1991
    Inventors: Gunar A. Bremanis, Felix Z. Meerson, Ivars Y. Kalvinsh, Nurlan Abdikaliev, Petr T. Trapentsier, Ma/Ya G. Pshennikova, Irene B. Antsena, Edmund Y. Lukevits, Boris Z. Simkhovich
  • Method for improving ventilation during sleep and treating sleep related ventilation abnormalities
    Patent number: 5017616
    Abstract: A method for improving ventilation during sleep and treating sleep-related ventilation abnormalities. To this end, the present invention provides a method of using branched-chain amino acids as an effective therapy for sleep apnea. The branched-chain amino acid composition can be administered either parenterally or enterally, and can be administered alone or in combination with other nutrients. The branched-chain amino acid composition of the present invention functions as a ventilatory stimulator during sleep and does not result in any adverse effects either to the patient or to the sleep patterns of the patient. Preferably, the branched-chain amino acids comprise 60 to 85% of an amino acid solution that is administered to the patient.
    Type: Grant
    Filed: November 30, 1989
    Date of Patent: May 21, 1991
    Inventor: Jeffrey Askanazi
  • Method to treat Parkinsons disease
    Patent number: 5017607
    Abstract: Pharmaceutical compositions for the treatment of Parkinson's disease and neurologic syndromes connected with it, containing as the active principle levodopa methyl ester optionally combined with other active principles selected from dopaminergic, anticholinergic, antidepressive drugs, carboxylase and monoaminoxidase inhibitors.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: May 21, 1991
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventor: Paolo Chiesi
  • Method of treating tissue damage with inositol triphosphate
    Patent number: 5015634
    Abstract: A method of preventing or alleviating tissue or bone damage in mammals is disclosed. The method comprises administering, to a mammal, a tissue damage or a bone damage preventing or alleviating effective amount of a pharmaceutical composition which includes at least one isomer of inositol trisphosphate.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: May 14, 1991
    Assignee: Perstorp AB
    Inventor: Matti Siren
  • Disinfectant for the treatment of water systems
    Patent number: 5015643
    Abstract: Disclosed is a solid composition that provides hypobromous for disinfecting water systems comprising from about 80-99% trichloro-s-triazinetrione and from 1-20% potassium bromide. Also disclosed is the incorporation of a chlorine stable dye in the composition.
    Type: Grant
    Filed: November 6, 1989
    Date of Patent: May 14, 1991
    Assignee: Bio-Lab, Inc.
    Inventors: Ronald L. Jones, Marion W. Wynn
  • Pharmaceutical compositions
    Patent number: 5015654
    Abstract: A pharmaceutical composition which comprises a mixture of an alpha-2 adrenoceptor antagonist, preferably idazoxan, or a pharmaceutically acceptable salt thereof, and either a catecholamine precursor or carbidopa.
    Type: Grant
    Filed: April 28, 1989
    Date of Patent: May 14, 1991
    Assignee: National Research Development Corporation
    Inventor: Saad Al-Damluji
  • 11.beta., 17.alpha.,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate]
    Patent number: 5015746
    Abstract: 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: May 14, 1991
    Assignee: Kuraray Co., Ltd.
    Inventors: Yutaka Mizushima, Keiko Hoshi, Rie Igarashi, Hirofusa Ajioka, Noriyuki Yamamoto, Masahito Komuro, Koichi Kanehira, Masayuki Inoue, Takashi Nishida, Manzo Shiono, Michio Terasawa, Kenzo Arizono
  • Antiglaucoma agents
    Patent number: 5015641
    Abstract: Pharmaceutical compositions and a method for reducing intraocular pressure by topically applying a carboxyalkyl dipeptide are disclosed.
    Type: Grant
    Filed: May 9, 1989
    Date of Patent: May 14, 1991
    Inventors: David R. Andrews, Federico C. A. Gaeta, Robert W. Watkins
  • Treatment of conditions requiring enhanced oxygen availability of mammalian tissues
    Patent number: 5015663
    Abstract: Disclosed are pharmaceutical compositions containing naphthoic acid derivatives and method of use for enhancing oxygen availability to mammailian tissue.
    Type: Grant
    Filed: March 5, 1990
    Date of Patent: May 14, 1991
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: John T. Suh, Robert G. Pendleton, Charles E. Pendley, II, Kin T. Yu, Paul R. Menard, Alain B. Schreiber
  • Water-soluble antiseptic or antifungal composition
    Patent number: 5013747
    Abstract: A water-soluble antiseptic or antifungal composition containing 2-(thiocyanomethylthio)benzothiazole as the active ingredient, a polyoxyalkylene styrylphenyl ether phosphoric acid ester, or alkali metal salt thereof as a surfactant and an organic solvent. The composition forms a clear solution which is stable for long periods of time and which can be diluted with water.
    Type: Grant
    Filed: November 7, 1989
    Date of Patent: May 7, 1991
    Assignee: Katayama Chemical, Inc.
    Inventors: Sakae Katayama, Yosuke Ito, Yasuhiro Nomura
  • Germicidal composition
    Patent number: 5013755
    Abstract: A germicidal composition is disclosed which includes:a first ingredient which is tribromoacetoxypropane of the formula: ##STR1## a second ingredient selected from the group consisting of (a) an alcohol of the general formula: ##STR2## wherein R.sup.1 and R.sup.2 stand independently from each other for hydrogen, a halogen, an alkyl or a substituted alkyl and X stands for a halogen and (b) dibromocyanoacetamide of the formula: ##STR3## .
    Type: Grant
    Filed: October 25, 1989
    Date of Patent: May 7, 1991
    Assignee: Somar Corporation
    Inventors: Susumu Mitsui, Ryoji Funatsu, Shigeru Kurose
  • Method for treating emotional numbness and coma
    Patent number: 5013740
    Abstract: An opiate antagonist or a pharmaceutically acceptable salt thereof is used to treat emotional numbness associated with Post Traumatic Stress Disorder and other psychopathologic conditions. Opiate antagonist or a pharmaceutically acceptable salt thereof is also used to treat coma.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: May 7, 1991
    Inventor: Hillel Glover
  • Serotonin antagonists
    Patent number: 5013761
    Abstract: This invention provides a method of selectively antagonizing the 5-HT.sub.1A receptor in mammals by administering aryloxypropanolamines. Novel aryloxypropanolamines are also claimed.
    Type: Grant
    Filed: November 8, 1989
    Date of Patent: May 7, 1991
    Assignee: Eli Lilly and Company
    Inventors: Edward E. Beedle, David W. Robertson, David T. Wong
  • Method of treating therapy-resistant schizophrenia with amperozide (N-ethyl-4-(4',4'-bis(p-fluorophenyl)butyl)-1-piperazine-carboxamide
    Patent number: 5013735
    Abstract: The present invention relates to a method for treating a patient suffering from therapy-resistant schizophrenia by administering to the patient a therapeutically effective amount of amperozide.
    Type: Grant
    Filed: March 1, 1990
    Date of Patent: May 7, 1991
    Assignee: Pharmacia AB
    Inventor: Anders K. Bjork
  • Selective antibacterial agent against campytobacter
    Patent number: 5013743
    Abstract: The compound represented by the formula; ##STR1## [wherein R.sup.1 stands for hydrogen, methoxy or trifluoromethyl; R.sup.2 and R.sup.3, being the same or different from each other, stand for hydrogen or methyl; R.sup.4 stands for optionally substituted hydrocarbon residue; and n denotes 0 or 1] or a salt thereof show excellent antibacterial activities, against the genus Campylobacter, especially against Campylobacter pylori, and they are used for preventing or treating infectious diseases caused by the said bacteria.
    Type: Grant
    Filed: February 12, 1990
    Date of Patent: May 7, 1991
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tomoyuki Iwahi, Hiroshi Satoh
  • Treatment of glaucoma using phosphodiesterase inhibitors
    Patent number: 5011843
    Abstract: Lowering of intraocular pressure, e.g. in the treatment of glaucoma is carried out by administering a phosphodiesterase inhibitor to a patient. Particular ophthalmic pharmaceutical compositions are disclosed for topical application to the eye.
    Type: Grant
    Filed: June 1, 1990
    Date of Patent: April 30, 1991
    Assignee: Iolab Corporation
    Inventor: John W. Shell
  • Method of inhibiting interleukin-1 release
    Patent number: 5011857
    Abstract: Methods useful for inhibiting the release of interleukin-1 and for alleviating interleukin-1 mediated conditions, such as IL-1-mediated inflammation, comprising administration of an effective amount of a pharmaceutically acceptable antioxidant compound such as disulfiram, tetrakis [3-(2,6-di-tert-butyl-4-hydroxyphenyl)propionyloxy methyl]methane or 2,4-disobutyl-6-(N,N-dimethylaminomethyl)-phenol.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: April 30, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: George Ku, Niall Doherty
  • Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs
    Patent number: 5011852
    Abstract: A one phase, liquid composition for oral administration comprises a NSAID such as an indoleacetic acid derivative or a pyrroleacetic acid derivative plus a di- or triglyceride of a medium chain fatty acid edible oil which has the characteristics of a pharmaceutical solvent carrier as known to those skilled in the art. Other pharmaceutical additives may be optionally added. An additional stipulation is that ethanol or other monohydric alcohol solvents should not be present.
    Type: Grant
    Filed: March 6, 1990
    Date of Patent: April 30, 1991
    Assignee: Applied Analytical Industries, Inc.
    Inventors: Moo K. Park, Henry C. Caldwell
  • PCP receptor ligands and the use thereof
    Patent number: 5011834
    Abstract: The invention relates to methods for the treatment or prevention of neuronal loss in ischemia, hypoxia, hypoglycemia, brain and spinal cord trauma as well as for treatment of Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Down's Syndrome by administering a pharmaceutical composition comprising an effective amount of 10,5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (IDDC) or derivatives thereof to an animal.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: April 30, 1991
    Assignee: State of Oregon, acting by and through the Oregon State Board of Higher Education, acting for and on behalf of the Oregon Health Sciences University and the University of Oregon
    Inventors: Eckard Weber, John F. W. Keana, Peter Barmettler
  • Aggregation pheromones of the driedfruit beetle, Carpophilus hemipterus
    Patent number: 5011683
    Abstract: A male-produced aggregation pheromone was demonstrated in Carpophilus hemipterus (L.) (Coleoptera: Nitidulidae) using a wind-tunnel bioassay. The attractiveness of the pheromone is greatly enhanced by volatiles from a host plant, and combinations of pheromone and food volatiles typically attract 3-10 times more beetles than either source by itself. The pheromone consists of a series of 13-, 14-, and 15-carbon unsaturated hydrocarbons, the most abundant of which is 3,5,7-trimethyl-(E,E,E,E)-2,4,6,8-decatetraene.
    Type: Grant
    Filed: November 25, 1988
    Date of Patent: April 30, 1991
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Robert J. Bartelt, Patrick F. Dowd