Patents Examined by Stanley J. Friedman
  • Phosphinic acid substituted steroids as inhibitors of steroid 5.alpha.-reductase
    Patent number: 5026882
    Abstract: The invention relates to 3-phosphinic acid steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: June 25, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Microbicidal agrochemical compositions
    Patent number: 5026719
    Abstract: New microbicidal compositions having improved microbicidal activity comprise a compound of formula I: ##STR1## or an acid addition salt thereof; in which Z is --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, --CH(CH.sub.3)--CH(CH.sub.3)-- or --CH.sub.2 --CH(C.sub.1 -C.sub.10 alkyl)--; and Ar is a phenyl, thienyl, halothienyl or naphthyl group, or phenyl substituted with 1 to 3 halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, cyano or nitro substituents; and a compound having the formula II: ##STR2## in which R is C.sub.1 -C.sub.4 alkyl, R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl, m is 0, 1, 2, 3 or 4 and n is 0, 1, 2, 3 or 4; new salts of (restricted) formula II, a process for their preparation and a method for combatting microbicidal plant diseases using the above mentioned compositions.
    Type: Grant
    Filed: June 1, 1987
    Date of Patent: June 25, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Edward Nowak
  • Rapid method for interrupting or attenuating the nicotine/tobacco dependency syndrome
    Patent number: 5026697
    Abstract: The administration to a nicotine or tobacco addict of ibogaine, ibogamine or tabernanthine or non-toxic salts of those alkaloids, of the family apocynaceae, has been discovered to interrupt the physiological and psychological aspects of nicotine or tobacco dependency. A single treatment or series of treatments may be effective for one to eighteen months or longer. Treatment consists of the oral, rectal infusion or suppository administration of ibogaine, ibogamine, tabernanthine or their salts in dosage ranges of 1 mg/kg to 60 mg/kg.
    Type: Grant
    Filed: May 30, 1990
    Date of Patent: June 25, 1991
    Assignee: NDA International, Inc.
    Inventor: Howard S. Lotsof
  • Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
    Patent number: 5025032
    Abstract: Compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, which are active during ischemia in preventing ATP depletion of the cells which predisposes them to subsequent injury during reperfusion, and which are active during reperfusion as oxygen radical scavengers, in a suitable pharmaceutical carrier for systemic or local administration, especially to the CNS, spinal column and eyes. Based on animal studies, the dosage for treating damage due to stroke is in the range of 10 to 300 mg/kg. Similar dosages are useful in treating damage resulting from free radical generation during inflammation, either as a product of infection or exposure to inflammatory agents or abusive agents, including drugs and alcohol.
    Type: Grant
    Filed: October 17, 1989
    Date of Patent: June 18, 1991
    Assignees: Oklahoma Medical Research Foundation, University of Kentucky Research Foundation
    Inventors: John M. Carney, Robert A. Floyd
  • Use of tetrandrine and its derivatives to treat malaria
    Patent number: 5025020
    Abstract: The specification discloses the treatment of malaria through the use of tetrandrine and its derivatives.
    Type: Grant
    Filed: September 28, 1989
    Date of Patent: June 18, 1991
    Assignee: Cancer Biologics of America, Inc.
    Inventor: Knox Van Dyke
  • Method of treating depression
    Patent number: 5025035
    Abstract: The instant invention is a novel use of known cyclic amino acids. Such compounds, including gabapentin, are useful for treating major and minor forms of depression.
    Type: Grant
    Filed: October 12, 1990
    Date of Patent: June 18, 1991
    Assignee: Warner-Lambert Company
    Inventor: Jan D. Wallace
  • Method for augmenting fetal hemoglobin
    Patent number: 5025029
    Abstract: A method is provided for inhibiting the .gamma. to .beta.-globin switching in subjects afflicted with .beta.-globin disorders. The method is particularly adapted for ameliorating the clinical symptoms of sickle cell anemia by periodically introducing butyrate, or certain isomers, homologs, analogs or chemical variations thereof, into the bloodstream of the subject prior to natural completion of the switching process.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: June 18, 1991
    Assignee: Children's Hospital Medical Center of Northern California
    Inventor: Susan Perrine
  • Palatable ibuprofen solutions
    Patent number: 5024997
    Abstract: Palatable ibuprofen aqueous base solutions are described which contain dissolved therein ibuprofen and hydroxypropyl beta cyclodextrin, which form an inclusion complex, and sweeteners to mask the sour taste common to organic acids.
    Type: Grant
    Filed: June 22, 1990
    Date of Patent: June 18, 1991
    Assignee: American Home Products Corporation
    Inventors: Solomon Motola, Gary R. Agisim, Annabelle Mogavero
  • Central nervous system injury treatment with opiate-receptor antagonist
    Patent number: 5025018
    Abstract: The present invention involves methods of inducing opiate-receptor antagonistic activity in a patient suffering from ischemic or traumatic central nervous system injury by administering to said patient an effective amount of an opiate-receptor antagonist having enhanced activity at the kappa-opiate receptor suitable to permit the induction of opiate-receptor antogonistic activity.
    Type: Grant
    Filed: August 22, 1990
    Date of Patent: June 18, 1991
    Assignee: Medicis Corporation
    Inventor: Alan I. Faden
  • Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
    Patent number: 5025019
    Abstract: Pharmaceutical compositions and methods of using same comprising a non-steroidal anti-inflammatory drug in combination with at least one other active component selected from an antihistamine, decongestant, cough suppressant (antitussive) or expectorant are provided for the relief of cough, cold and cold-like symptoms.
    Type: Grant
    Filed: November 20, 1989
    Date of Patent: June 18, 1991
    Assignee: Analgesic Associates
    Inventors: Abraham Sunshine, Eugene M. Laska, Carole E. Siegel
  • Combined interferon/antiestrogen therapy for treatment of breast cancer
    Patent number: 5024833
    Abstract: Proliferation of breast cancer is treated by a combined type I interferon/antiestrogen therapy. Preferably artiestrogen treatment is sequential to treatment with interferon.
    Type: Grant
    Filed: May 30, 1989
    Date of Patent: June 18, 1991
    Assignee: Industrial Farmaceutica Serono SpA
    Inventors: Sergio Del Bianco, Gigliola Sica
  • Method of treating diabetes with inositol triphosphate
    Patent number: 5023248
    Abstract: A method of treating diabetes or complications of diabetes is disclosed. In this method a pharmaceutically effective amount of at least one isomer of inositol triphosphate is administered to a human or an animal in need thereof.
    Type: Grant
    Filed: September 30, 1988
    Date of Patent: June 11, 1991
    Assignee: Perstorp AB
    Inventor: Matti Siren
  • Method of treatment of psychotic disorders
    Patent number: 5023266
    Abstract: Ifenprodil and its analogues are useful for the treatment of psychoses such as schizophrenia.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: June 11, 1991
    Assignee: Synthelabo
    Inventors: Salomon Z. Langer, Jonathan R. Frost, Johannes Schoemaker, Bernard Gaudilliere, Jean Bertin, Jean Rousseau, Regis Dupont, Alexander E. Wick
  • Insecticidal coating composition and processes for making and using it
    Patent number: 5023247
    Abstract: A coating composition comprising a first phase containing a cross-linkable resin; a second phase containing water; and a third phase containing an insecticide dissolved in a solvent wherein the solvent is immiscible with the first phase and with water.These coating compositions kill insects even after exposure to weather for extended periods of time. They have kill rates higher than prior art compositions containing the same amount of the same insecticide.
    Type: Grant
    Filed: May 30, 1989
    Date of Patent: June 11, 1991
    Assignee: Insecta Paint, Inc.
    Inventors: Jean-Paul Boulanger, Jacques Lupuyo, Francois Klug
  • Antidepressant method of use
    Patent number: 5023270
    Abstract: This invention concerns a pharmaceutical composition useful for treating depression in humans, comprising an effective amount of 5-methoxypsoralen, and optionally, a suitable carrier or diluent, e.g., carboxymethylcellulose, and optionally, a dispersing agent, e.g., polysorbate 80. Also disclosed is a method for treating depression, e.g., endogenous or clinical depression, comprising administering to humans in need of such treatment an effective amount of 5-methoxypsoralen, optionally, a pharmaceutically suitable carrier or diluent, and optionally, a dispersing agent.
    Type: Grant
    Filed: April 13, 1989
    Date of Patent: June 11, 1991
    Inventor: Jean-Jacques Goupil
  • Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist
    Patent number: 5021448
    Abstract: A method of reducing serum uric acid and/or increasing renal clearance of uric acid in a mammal in need thereof comprising administering to such mammal a uricosuric effective amount of a thromboxane synthetase inhibitor, a thromboxane receptor antagonist, or both in a combined uricosuric effective amount is disclosed. Compositions having one or more of the foregoing in combination with one or more known uricosurics are also set forth.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: June 4, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Anthony J. Piraino, Steven D. Saris
  • Method for aiding cessation of smoking
    Patent number: 5021457
    Abstract: Individuals are aided in smoking cessation by administering internally phenylpropanolamine.
    Type: Grant
    Filed: August 9, 1989
    Date of Patent: June 4, 1991
    Assignee: Plough Inc.
    Inventors: Frank J. Akin, Robert Klesges, Lisa Klesges
  • Method of treating diabetes mellitus with bisphenol derivatives
    Patent number: 5021461
    Abstract: The present invention relates to a method of lowering blood glucose in a patient afflicted with diabetes mellitus comprising administering to said patient a therapeutically effective glucose lowering amount of a 4,4'-bis(2,6-di-alkylphenol). The present invention also relates to a process for making 4,4'-bis(2,6-di-alkyl-phenol).
    Type: Grant
    Filed: August 21, 1990
    Date of Patent: June 4, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Keith M. Robinson, Simon J. T. Mao, Roger A. Parker, Richard L. Jackson
  • Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
    Patent number: 5021416
    Abstract: Certain (2-imidazolin-2-ylamino) quinoxalines are disclosed. Such quinoxalines reduce or maintain intraocular pressure when administered directly to the eye of a mammal.
    Type: Grant
    Filed: October 31, 1989
    Date of Patent: June 4, 1991
    Assignee: Allergan, Inc.
    Inventor: Charles Gluchowski
  • Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
    Patent number: 5021410
    Abstract: Methods and pharmaceutical formulations of alpha.sub.2 agonists and alpha.sub.3 antagonists which are useful in lowering intraocular pressure (IOP) and treatment of intraocular hypertension. Co-administration of a therapeutic amount of alpha.sub.2 agonist with a potentiating amount of alpha.sub.3 agonist is effective in lowering IOP and treatment of intraocular hypertension.
    Type: Grant
    Filed: May 22, 1989
    Date of Patent: June 4, 1991
    Assignee: Allergan, Inc.
    Inventor: James A. Burke