Abstract: A method of diagnosing cat scratch disease and a method of diagnosing bacillary angiomatosis in a subject by detecting the presence of Rochalimaea henselae or an immunogenically specific determinant thereof in the subject is provided. Also provided is a vaccine comprising an immunogenic amount of a nonpathogenic Rochalimaea henselae or an immunogenically specific determinant thereof and a pharmaceutically acceptable carrier. A method of diagnosing Rochalimaea quintana infection in a subject by detecting the presence of a nucleic acid specific to Rochalimaea quintana in a sample from the subject is provided. A purified heat shock protein of Rochalimaea is provided.
Type:
Grant
Filed:
May 18, 1994
Date of Patent:
July 1, 1997
Assignee:
The United States of America as represented by the Department of Health and Human Services
Abstract: The present invention relates to a method of identifying DNA encoding an osteoclast-specific or -related gene product. The method comprises hybridizing DNA with a stromal cell+, osteoclast+probe, or with cDNA or mRNA from an osteoclastoma, and with a stromal cell+, osteoclast-probe, or with cDNA or mRNA from stromal cells; and identifying DNA which hybridizes to the stromal cell+, osteoclast+probe, or to cDNA or mRNA from osteoclastoma, but not to the stromal cell+, osteoclast-probe, or to cDNA or mRNA from stromal cells.
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
April 29, 1997
Assignee:
Forsyth Dental Infirmary for Children
Inventors:
Philip Stashenko, Yi-Ping Li, Anne L. Wucherpfennig
Abstract: A process for producing useful quantities of a cyclic hydroxide, such as pyrocatechol from a compound having a benzene ring, such as phenol using a Bacillus is described. The process uses tetracycline to inhibit the modification of the cyclic hydroxide by the Bacillus. Pyrocatechol and other related compounds are commercially useful chemicals.
Type:
Grant
Filed:
January 17, 1989
Date of Patent:
January 16, 1990
Assignee:
Board of Trustees operating Michigan State University
Inventors:
Patrick J. Oriel, Gopalakrishnan Gurujeyalakshmi