Patents Examined by Stephen M. Chong
  • Patent number: 10246727
    Abstract: The invention provides processes for the conversion of pyruvate obtained from sugars or other carbon sources, to valuable C5 materials such as levulinic acid, levulinate esters, valerolactone, and derivatives thereof.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: April 2, 2019
    Assignee: ARZEDA CORP.
    Inventor: Alexandre Luc Zanghellini
  • Patent number: 10246644
    Abstract: The present invention provides a method for preparing biodiesel, comprising: adding oil and fat, short-chain alcohol, water, and liquid lipase into a single-stage or multi-stage enzyme reactor; then separating the reaction fluid into an enzyme-containing heavy phase and a light phase; recovering and reusing the enzyme in the heavy phase; using the light phase for subsequent conversion by immobilized lipase; flowing the light phase and the short-chain alcohol into single-stage or multi-stage enzyme reactor containing an immobilized lipase; performing online dehydration during the whole reaction process or part of the reaction process.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: April 2, 2019
    Assignee: Tsinghua University
    Inventors: Wei Du, Dehua Liu, Luole Zhu
  • Patent number: 10232004
    Abstract: A pharmaceutical composition based on centella asiatica (Hydrocotyle asiatica L.) for the treatment of lower limb ulcers, including as active ingredients, centella asiatica and sodium acexamate in amounts producing a reciprocal synergistic effect when mixed with at least one adjuvant selected from a healing agent, an antibiotic agent and/or combinations thereof is described.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: March 19, 2019
    Inventor: Flor Lucía Montañez-Soto
  • Patent number: 10227623
    Abstract: A process for mechanical destructuring of cellulosic biomass was developed that makes use of a short application of high compression, impact, and shearing forces. The biomass may be destructured using a specific energy input that is less than 40% of the total combustible energy of the biomass. The destructured biomass, with or without saccharification and/or in-feed glycosyl hydrolase enzymes, may be used in feed applications.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: March 12, 2019
    Inventors: Wathudura Indika Namal De Silva, Paul Joseph Fagan, F Glenn Gallagher, Zheng-Zheng Huang, Guangliang Gary Liu, Aaron Perelman, Luis Fernando Romero Millan, Anton Shpilsky, Daniel A Slanac, Maria Walsh
  • Patent number: 10174279
    Abstract: An embodiment of the present invention provides an apparatus and method for expanding skin capable of expanding autologous skin to the maximum extent and performing a tissue culture of skin at the outside of the body. While an apparatus for expanding autologous skin of body's outside in general takes a form of expanding skin by applying a certain amount of constant force for a period of time regardless of the skin properties, the apparatus and method for expanding skin according to the embodiment of the present invention expands the skin to the maximum extent without rupturing the skin based on measurements of elasticity of the skin to find the maximum expanded area reachable just before rupturing of the skin.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: January 8, 2019
    Inventors: Yun Jeong Song, Hwi Gang Kim, Jung Wook Suh, Eun Chang Choi, Chang Hyuk Hong, Dae Sik Kim, Hyung Soo Lee
  • Patent number: 10159724
    Abstract: The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: December 25, 2018
    Assignees: Icahn School of Medicine at Mount Sinai, Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Edward H. Schuchman, Erich Gulbins, Anthony Futerman, Yael Pewzner-Jung
  • Patent number: 10143709
    Abstract: Disclosed herein is that the systemic administration of ASC conditioned media diminished LPS-induced lung injury by inhibiting epithelial permeability, neutrophil inflammatory response, and secretion of pro-inflammatory TNF?. It is also shown that ARDS lung is able to retain IV-delivered ASC for a substantial amount of time, with no evidence of the significant cell distribution to other organs at this time point. These findings provide optimization of cell-based and cell-free therapy for the treatment of ARDS, including occurrences of ARDS caused by upper respiratory tract infections such as SARS and MERS.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: December 4, 2018
    Assignees: Indiana University Research and Technology Corporation, The United States of America Department of Veteran Affairs As Represented By The Technology Transfer Program
    Inventors: Keith March, Natalia Bogatcheva
  • Patent number: 10132730
    Abstract: The present invention relates to an apparatus for preparing cell-derived artificial microvesicles, and more specifically, to an apparatus for preparing artificial microvesicles by allowing cells, which are concentrated using centrifugal force, to pass through a porous filter. Artificial microvesicles prepared according to the present invention maintains the structure of the cell membrane as it is, and contains cytoplasm by minimizing the loss of cytoplasm by using a buffer solution during preparation. Therefore, the artificial microvesicles prepared using the apparatus of the present invention is expected to be useful for applied research such as the diagnosis of diseases, drug delivery techniques and basic research.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: November 20, 2018
    Inventors: Jae-Sung Park, Wonju Jo, Jun Ho Kim, Siwoo Cho, Hwapyeong Jeong
  • Patent number: 10105419
    Abstract: Provided are dietary supplements, formulations, kits and methods for administration to an individual with type II diabetes or at risk of developing type II diabetes. Provided herein are formulations, kits and methods useful for treating, preventing, supporting, controlling, restoring, and/or maintaining blood sugar levels in individuals with type II diabetes or at risk of developing the same. Also provided are formulations, kits and methods useful for reducing and/or eliminating requirement of ex-vivo insulin administration in an individual diagnosed with type II diabetes.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: October 23, 2018
    Assignee: Eastern Vision Limited
    Inventors: Michael Holstein, Eric Huntington
  • Patent number: 10047379
    Abstract: The invention relates to a method for the simultaneous production of a fermented, solid product and ethanol comprising the following steps: 1) providing a mixture of milled or flaked or otherwise disintegrated biomass, comprising oligosaccharides and/or polysaccharides and live yeast in a dry matter ratio of from 2:1 to 100:1, and water; 2) fermenting the mixture resulting from step (1) under conditions where the water content in the initial mixture does not exceed 65% by weight, for 1-36 hours at a temperature of about 25-60° C. under anaerobic conditions; 3) incubating the fermented mixture resulting from step (2) for 0.5-240 minutes at a temperature of about 70-150° C.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: August 14, 2018
    Assignee: HAMLET PROTEIN A/S
    Inventors: Ole Kaae Hansen, Katrine Hvid Ellegård, Karl Kristian Thomsen
  • Patent number: 10022407
    Abstract: Provided are the use of Lactobacillus rhamnosus strain CNCM I-3690 for reducing diet-induced weight gain and/or diet-induced insulin resistance, and treating disorders resulting therefrom, such as overweight, obesity and obesity-related disorders in a subject.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: July 17, 2018
    Assignees: Compagnie Gervais Danone, Tufts University
    Inventors: Jian Shen, Jingjing Wang, Liping Zhao, Martin Saul Obin, Muriel Derrien, Emilie Rocher, Johan Van Hylckama Vlieg
  • Patent number: 10006923
    Abstract: The present invention provides a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample, and then measuring a substance produced or consumed by the oxidation; and a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample using an enzyme, and then measuring a substance produced or consumed by the oxidation. A method for measuring glycated hemoglobin of the present invention is useful for diagnosing lifestyle-related disease such as diabetes mellitus.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: June 26, 2018
    Inventors: Noriyuki Ogawa, Fumi Umehara, Takehide Kimura, Kousaku Murata, Wataru Hashimoto
  • Patent number: 9988597
    Abstract: In a method for cultivating cells, there is provided a container (4) comprising an at least partly flexible container wall structure (41). The container is at least resting on a support structure (2). Into the container's interior space (42) there is introduced a gas, a liquid medium (5) and a cell culture. At least part of said support structure together with the container thus resting thereon are being moved, thereby inducing motion to the liquid medium in the container. An upwardly facing outer surface structure of said support structure comprises an elongate downwardly recessed portion (24, 25, 26) which causes a gutter (7) in the container's bottom wall structure (43).
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: June 5, 2018
    Assignee: Strix Beheer B.V.
    Inventors: Nicolaas Marius Gerard Oosterhuis, Anthonie Tromper
  • Patent number: 9986751
    Abstract: This invention relates to the use of the Aspergillus niger aspergilloglutamic peptidase in a feed composition containing cereals, pulses, oilseeds, and/or tubers to improve animal performance, reduce nitrogen excretion and/or reduce intestinal inflammation. Furthermore, the present invention relates to a feed composition or a feed additive comprising the Aspergillus niger aspergilloglutamic peptidase. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of efficiently hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat, barley and related cereal species, as well as hydrolyzing trypsin inhibitors that are present in pulses, oilseeds, and tubers.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: June 5, 2018
    Inventors: Maaike Johanna Bruins, Luppo Edens, Helena Maria Nan
  • Patent number: 9980942
    Abstract: The present invention relates generally to methods and pharmaceutical compositions for rejuvenating hematopoietic stem cells and progenitor cells from blood, intestinal tissue and dermal tissue by administration of at least one inhibitor of a GT-Pase, such as Cdc42 GTPase.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: May 29, 2018
    Inventors: Hartmut Geiger, Maria Carolina Florian, Yi Zheng
  • Patent number: 9980989
    Abstract: A bacterial composition for the treatment of colibacillosis on farms, in particular poultry farms, contains at least 105 cfu/ml of at least one of the following four strains of Bacillus subtilis or of Bacillus licheniformis: NOL01, NOL02, NOL03 and NOL04, and at least 105 cfu/ml of at least one lactic acid bacterium chosen from the following lactic acid bacteria: Lactococcus lactis spp lactis 1 strain NOL11 and Pediococcus pentosaceus 2 strain NOL12.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: May 29, 2018
    Assignee: NOLIVADE
    Inventors: Marc De Brueker, Stéphane Thebault
  • Patent number: 9982283
    Abstract: Provided is a biomass hydrothermal decomposition system which includes: a biomass supply unit that supplies a biomass raw material; hydrothermally decomposing the biomass raw material using pressurized hot water; a hydrothermal decomposition unit that dissolves lignin components and hemicellulose components in the pressurized hot water; a biomass solid fraction discharge unit that discharges a biomass solid fraction from the hydrothermal decomposition unit; an enzymatic liquefaction tank that is in connection with the biomass solid fraction discharge unit, and in which the discharged biomass solid fraction is introduced, and an enzyme is supplied to the biomass solid fraction to liquefy the biomass solid fraction; and a discharge unit that discharges the liquefied biomass solid fraction.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: May 29, 2018
    Inventors: Minoru Genta, Seiichi Terakura, Ryosuke Uehara, Seiji Kobayashi
  • Patent number: 9969134
    Abstract: A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film on the substrate, where the solidified biopolymer film is formed with a surface having a nanopattern thereon. In another embodiment, the method also includes annealing the solidified biopolymer film. A nanopatterned biopolymer optical device includes a solidified biopolymer film with a surface having a nanopattern is also provided.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: May 15, 2018
    Assignee: Trustees of Tufts College
    Inventors: David Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Patent number: 9963676
    Abstract: The current invention concerns a method for obtaining a cellular composition comprising epithelial stem cells (EpSCs) from mammalian skin, whereby said composition comprises at least 90% of viable EpSCs, comprising the steps of: —obtaining a mammalian skin sample; —obtaining a cell suspension from said skin sample by performing at least one enzymatic dissociation step; and —culturing said cell suspension under low-attachment conditions. Preferably cellular composition comprises epithelial stem cells derived from the epidermal layer. In a second aspect, the current invention provides for a cellular composition obtained by the method according to the invention.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: May 8, 2018
    Assignee: Pell Cell Medicals NV
    Inventors: Sarah Y. Broeckx, Jan H. Spaas
  • Patent number: 9944956
    Abstract: The present technology pertains to methods and microbial co-cultures for converting lignocellulosic biomass to biofuels and/or other carbon-based chemicals. Aspects of the present disclosure relate to novel consolidated bioprocessing (CBP) methods by which the efficiency of the production of biofuels and/or other carbon-based chemicals from cellulosic biomass-containing materials can be increased. In particular, the present disclosure provides numerous microbiological co-cultures for increasing the efficiency of ethanol and/or lactic acid production from biomass.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: April 17, 2018
    Assignee: DIREVO Industrial Biotechnology GmbH
    Inventors: Simon Curvers, Vitaly Svetlitchnyi