Patents Examined by Stephen M. Chong
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Patent number: 10953133Abstract: A process providing a method to create 3D scaffolds using nano-scale fibers, comprising: deposition and alignment of a plurality of electrospun fiber layers on a substrate; application of a photosensitive biomedical polymer liquid to each fiber layer deposited on said substrate; deposition and cross-alignment of a plurality of electrospun fiber layers on said substrate; retaining said polymer liquid in place using said cross-aligned fiber layers; curing said polymer liquid on top of each fiber layer using UV light.Type: GrantFiled: February 22, 2017Date of Patent: March 23, 2021Assignee: University of Central OklahomaInventors: Morshed Khandaker, Shahram Riahinezhad
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Patent number: 10849858Abstract: The present invention relates to a process for preparing erythrocytes loaded with one or more substance of pharmaceutical interest. The present invention is also directed to loaded erythrocytes thus obtained and pharmaceutical compositions comprising said population of loaded erythrocytes as well as therapeutic application thereof, in particular in the treatment of Ataxia telangiectasia.Type: GrantFiled: May 9, 2014Date of Patent: December 1, 2020Assignee: ERYDEL S.P.A.Inventors: Giovanni Mambrini, Luca Benatti, Giovanni Capogrossi, Marco Mandolini
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Patent number: 10851396Abstract: The present invention provides isolated acidophilic Fusarium oxysporum strains, such as MK7, and their progeny, compositions comprising such strains and their progeny, methods of producing such strains and their progeny, and methods of using such strains and their progeny.Type: GrantFiled: June 14, 2019Date of Patent: December 1, 2020Assignee: THE FYNDER GROUP, INC.Inventors: Mark A. Kozubal, Richard E. Macur, William P. Inskeep
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Patent number: 10828165Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to TMJ implantation materials and implants (e.g., temporomandi bular joint (TMJ) methods of making TMJ implantation materials and implants, methods of forming a TMJ implantation material or an implant, and the like.Type: GrantFiled: December 7, 2012Date of Patent: November 10, 2020Assignee: University of Florida Research Foundation, IncorporatedInventor: Peter S. McFetridge
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Patent number: 10711215Abstract: A method to generate dioxolanes from renewable feedstocks, and more specifically, these oxygenated hydrocarbons can be used as gasoline-range fuels and diesel additives.Type: GrantFiled: August 24, 2015Date of Patent: July 14, 2020Assignee: The Government of the United States of America as represented by the Secretary of the NavyInventors: Benjamin G. Harvey, Heather A. Meylemans
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Patent number: 10513717Abstract: The present invention relates to enzymes which possess desaturase, conjugase, epoxidase and/or hydroxylase activity that can be used in methods of synthesizing fatty acids.Type: GrantFiled: August 25, 2014Date of Patent: December 24, 2019Assignees: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION, GRAINS RESEARCH AND DEVELOPMENT CORPORATIONInventors: Katherine Damcevski, Karen Glover, Allan Green, Victoria S. Haritos, Irene Horne, Surinder Pal Singh, Craig C. Wood, Xue-Rong Zhou
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Patent number: 10494599Abstract: The invention is comprised within automated devices for cell culture. The invention relates to a cell culture method and system which allows modifying in a controlled manner the density and the number of cells in a culture. Specifically, the present invention relates to an iterative method the number of iteration steps of which is modified depending on the demand for the density and the number of cells necessary for the culture duration.Type: GrantFiled: January 30, 2017Date of Patent: December 3, 2019Assignee: ALGARIS CELL S.L.Inventors: David Horna Tomas, Miguel Costa Ferrando
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Patent number: 10246644Abstract: The present invention provides a method for preparing biodiesel, comprising: adding oil and fat, short-chain alcohol, water, and liquid lipase into a single-stage or multi-stage enzyme reactor; then separating the reaction fluid into an enzyme-containing heavy phase and a light phase; recovering and reusing the enzyme in the heavy phase; using the light phase for subsequent conversion by immobilized lipase; flowing the light phase and the short-chain alcohol into single-stage or multi-stage enzyme reactor containing an immobilized lipase; performing online dehydration during the whole reaction process or part of the reaction process.Type: GrantFiled: November 29, 2011Date of Patent: April 2, 2019Assignee: Tsinghua UniversityInventors: Wei Du, Dehua Liu, Luole Zhu
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Patent number: 10246727Abstract: The invention provides processes for the conversion of pyruvate obtained from sugars or other carbon sources, to valuable C5 materials such as levulinic acid, levulinate esters, valerolactone, and derivatives thereof.Type: GrantFiled: November 9, 2016Date of Patent: April 2, 2019Assignee: ARZEDA CORP.Inventor: Alexandre Luc Zanghellini
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Patent number: 10232004Abstract: A pharmaceutical composition based on centella asiatica (Hydrocotyle asiatica L.) for the treatment of lower limb ulcers, including as active ingredients, centella asiatica and sodium acexamate in amounts producing a reciprocal synergistic effect when mixed with at least one adjuvant selected from a healing agent, an antibiotic agent and/or combinations thereof is described.Type: GrantFiled: April 9, 2014Date of Patent: March 19, 2019Inventor: Flor Lucía Montañez-Soto
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Patent number: 10227623Abstract: A process for mechanical destructuring of cellulosic biomass was developed that makes use of a short application of high compression, impact, and shearing forces. The biomass may be destructured using a specific energy input that is less than 40% of the total combustible energy of the biomass. The destructured biomass, with or without saccharification and/or in-feed glycosyl hydrolase enzymes, may be used in feed applications.Type: GrantFiled: November 18, 2014Date of Patent: March 12, 2019Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: Wathudura Indika Namal De Silva, Paul Joseph Fagan, F Glenn Gallagher, Zheng-Zheng Huang, Guangliang Gary Liu, Aaron Perelman, Luis Fernando Romero Millan, Anton Shpilsky, Daniel A Slanac, Maria Walsh
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Patent number: 10174279Abstract: An embodiment of the present invention provides an apparatus and method for expanding skin capable of expanding autologous skin to the maximum extent and performing a tissue culture of skin at the outside of the body. While an apparatus for expanding autologous skin of body's outside in general takes a form of expanding skin by applying a certain amount of constant force for a period of time regardless of the skin properties, the apparatus and method for expanding skin according to the embodiment of the present invention expands the skin to the maximum extent without rupturing the skin based on measurements of elasticity of the skin to find the maximum expanded area reachable just before rupturing of the skin.Type: GrantFiled: July 20, 2016Date of Patent: January 8, 2019Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Yun Jeong Song, Hwi Gang Kim, Jung Wook Suh, Eun Chang Choi, Chang Hyuk Hong, Dae Sik Kim, Hyung Soo Lee
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Patent number: 10159724Abstract: The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.Type: GrantFiled: October 5, 2016Date of Patent: December 25, 2018Assignees: Icahn School of Medicine at Mount Sinai, Yeda Research and Development Co. Ltd. at the Weizmann Institute of ScienceInventors: Edward H. Schuchman, Erich Gulbins, Anthony Futerman, Yael Pewzner-Jung
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Patent number: 10143709Abstract: Disclosed herein is that the systemic administration of ASC conditioned media diminished LPS-induced lung injury by inhibiting epithelial permeability, neutrophil inflammatory response, and secretion of pro-inflammatory TNF?. It is also shown that ARDS lung is able to retain IV-delivered ASC for a substantial amount of time, with no evidence of the significant cell distribution to other organs at this time point. These findings provide optimization of cell-based and cell-free therapy for the treatment of ARDS, including occurrences of ARDS caused by upper respiratory tract infections such as SARS and MERS.Type: GrantFiled: May 6, 2015Date of Patent: December 4, 2018Assignees: Indiana University Research and Technology Corporation, The United States of America Department of Veteran Affairs As Represented By The Technology Transfer ProgramInventors: Keith March, Natalia Bogatcheva
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Patent number: 10132730Abstract: The present invention relates to an apparatus for preparing cell-derived artificial microvesicles, and more specifically, to an apparatus for preparing artificial microvesicles by allowing cells, which are concentrated using centrifugal force, to pass through a porous filter. Artificial microvesicles prepared according to the present invention maintains the structure of the cell membrane as it is, and contains cytoplasm by minimizing the loss of cytoplasm by using a buffer solution during preparation. Therefore, the artificial microvesicles prepared using the apparatus of the present invention is expected to be useful for applied research such as the diagnosis of diseases, drug delivery techniques and basic research.Type: GrantFiled: March 28, 2014Date of Patent: November 20, 2018Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Jae-Sung Park, Wonju Jo, Jun Ho Kim, Siwoo Cho, Hwapyeong Jeong
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Patent number: 10105419Abstract: Provided are dietary supplements, formulations, kits and methods for administration to an individual with type II diabetes or at risk of developing type II diabetes. Provided herein are formulations, kits and methods useful for treating, preventing, supporting, controlling, restoring, and/or maintaining blood sugar levels in individuals with type II diabetes or at risk of developing the same. Also provided are formulations, kits and methods useful for reducing and/or eliminating requirement of ex-vivo insulin administration in an individual diagnosed with type II diabetes.Type: GrantFiled: August 18, 2016Date of Patent: October 23, 2018Assignee: Eastern Vision LimitedInventors: Michael Holstein, Eric Huntington
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Patent number: 10047379Abstract: The invention relates to a method for the simultaneous production of a fermented, solid product and ethanol comprising the following steps: 1) providing a mixture of milled or flaked or otherwise disintegrated biomass, comprising oligosaccharides and/or polysaccharides and live yeast in a dry matter ratio of from 2:1 to 100:1, and water; 2) fermenting the mixture resulting from step (1) under conditions where the water content in the initial mixture does not exceed 65% by weight, for 1-36 hours at a temperature of about 25-60° C. under anaerobic conditions; 3) incubating the fermented mixture resulting from step (2) for 0.5-240 minutes at a temperature of about 70-150° C.Type: GrantFiled: November 8, 2016Date of Patent: August 14, 2018Assignee: HAMLET PROTEIN A/SInventors: Ole Kaae Hansen, Katrine Hvid Ellegård, Karl Kristian Thomsen
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Patent number: 10022407Abstract: Provided are the use of Lactobacillus rhamnosus strain CNCM I-3690 for reducing diet-induced weight gain and/or diet-induced insulin resistance, and treating disorders resulting therefrom, such as overweight, obesity and obesity-related disorders in a subject.Type: GrantFiled: November 12, 2012Date of Patent: July 17, 2018Assignees: Compagnie Gervais Danone, Tufts UniversityInventors: Jian Shen, Jingjing Wang, Liping Zhao, Martin Saul Obin, Muriel Derrien, Emilie Rocher, Johan Van Hylckama Vlieg
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Patent number: 10006923Abstract: The present invention provides a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample, and then measuring a substance produced or consumed by the oxidation; and a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample using an enzyme, and then measuring a substance produced or consumed by the oxidation. A method for measuring glycated hemoglobin of the present invention is useful for diagnosing lifestyle-related disease such as diabetes mellitus.Type: GrantFiled: July 7, 2014Date of Patent: June 26, 2018Assignees: KYOWA MEDEX CO., LTD., KYOTO UNIVERSITYInventors: Noriyuki Ogawa, Fumi Umehara, Takehide Kimura, Kousaku Murata, Wataru Hashimoto
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Patent number: 9986751Abstract: This invention relates to the use of the Aspergillus niger aspergilloglutamic peptidase in a feed composition containing cereals, pulses, oilseeds, and/or tubers to improve animal performance, reduce nitrogen excretion and/or reduce intestinal inflammation. Furthermore, the present invention relates to a feed composition or a feed additive comprising the Aspergillus niger aspergilloglutamic peptidase. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of efficiently hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat, barley and related cereal species, as well as hydrolyzing trypsin inhibitors that are present in pulses, oilseeds, and tubers.Type: GrantFiled: December 11, 2014Date of Patent: June 5, 2018Assignees: DSM IP ASSETS B.V., NOVOZYMES A/SInventors: Maaike Johanna Bruins, Luppo Edens, Helena Maria Nan