Patents Examined by Stephen M. Kapner
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Patent number: 4673677Abstract: A method for the treatment of gastrointestinal disorders in a patient which comprises administering to the patient a gastric anti-secretory effective amount of a 2-amino-5-hydroxy-4-methylpyrimidine or a substituted amino derivative thereof, optionally in admixture with an additional gastric anti-secretory agent.Type: GrantFiled: August 9, 1985Date of Patent: June 16, 1987Assignee: Pfizer Inc.Inventor: John L. LaMattina
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Patent number: 4672126Abstract: A process for isolating levamisole or a therapeutically acceptable acid addition salt thereof from tetramisole or an acid addition salt thereof by precipitating levamisole. L-N-[(4-methoxyphenyl)sulfonyl]-glutamic acid (salt) and converting the diastereomeric salt into levamisole or a suitable acid addition salt thereof.Type: GrantFiled: October 1, 1984Date of Patent: June 9, 1987Assignee: Janssen Pharmaceutica, N.V.Inventors: Guido J. L. Van der Veken, Eric J. Guns, Albert L. A. Willemsens
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Patent number: 4666503Abstract: Novel substituted phenoxyalkanecarboxylic acid esters of the formula ##STR1## in which R.sup.1 and R.sup.2, independently of one another, are a hydrogen atom, a halogen atom, a lower alkyl group or a nitro group, orR.sup.1 and R.sup.2, together with the benzene ring to which they are bonded, are a naphthalene ring,R.sup.3 and R.sup.4, independently of one another, are a hydrogen atom or a methyl group,n is 1 or 2,m is 0 or 1,X is an oxygen atom, a sulfur atom, a sulfonyl group or a group of the formula ##STR2## in which R.sup.6 is a lower alkyl group,R.sup.5 is a hydrogen atom or a halogen atom, andY is an oxygen atom or a sulfur atom,and the use of the new compounds as herbicides.Type: GrantFiled: October 17, 1984Date of Patent: May 19, 1987Assignee: Nihon Tokushu Noyaku Seizo K.K.Inventors: Kozo Shiokawa, Koichi Moriya, Toshio Goto, Atsumi Kamochi, Seishi Ito, Mitsugu Horita
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Patent number: 4666499Abstract: Certain 2-methyl-4-phosphinylcinnolinium hydroxide inner salts, useful for controlling unwanted plants.Type: GrantFiled: August 29, 1985Date of Patent: May 19, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventors: John R. Ponte, James J. Steffens, Herbert Estreicher
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Patent number: 4665083Abstract: The invention relates to novel iminothiazolidine derivatives of the formula (I), ##STR1## wherein R.sup.1 and R.sup.3 represent, independently from each other, hydrogen or lower alkyl group,R.sup.3 is nitro or amino group,R stands for halo, lower alkyl, haloalkyl, nitro, amino, hydroxy, lower alkoxy, carboxy or lower alkoxycarbonyl group, andn is 0, 1 or 2,and pharmaceutically acceptable acid addition salts thereof.The iminothiazolidine derivatives of the formula (I) possess valuable antidepressant, antiparkinsonic, antiepileptic and spasmolytic activities.Type: GrantFiled: April 25, 1985Date of Patent: May 12, 1987Assignee: Egis GyogyszergyarInventors: Karoly Lempert, Gyula Hornyak, Ferenc Bartha, Gabor Doleschall, Jozsef Fetter, Jozsef Nyitrai, Gyula Simig, Karoly Zauer, Peter Huszthy, Antal Feller, Lujza Petocz, Eniko Szirt, Katalin Grasser, Edit Berenyi, Zsuzsanna Orr, Etelka Pjeczka
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Patent number: 4664694Abstract: A compound is disclosed having the structural formula ##STR1## where R is hydrogen, chlorine, bromine, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --CH.sub.2 COOH, --CH.sub.2 COO (C.sub.1 -C.sub.4 alkyl), --CH.sub.2 CONHN (C.sub.1 -C.sub.2 alkyl).sub.2, --CH.sub.2 CONR.sup.4 R.sup.5, --SPS(C.sub.1 -C.sub.4 alkoxy).sub.2 or --SPO(C.sub.1 -C.sub.4 alkoxy).sub.2 (C.sub.1 -C.sub.4 alkylthio).sub.2 ;R.sup.1, R.sup.2 and R.sup.3 are the same or different and are hydrogen, hydroxy, fluorine, chlorine, bromine, iodine, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.6 fluoroalkyl, C.sub.1 -C.sub.6 chloroalkyl, C.sub.1 -C.sub.6 fluoroalkoxy, C.sub.1 -C.sub.6 chloroalkoxy, C.sub.1 -C.sub.6 fluoroalkylthio, C.sub.1 -C.sub.6 chloroalkylthio, C.sub.7 -C.sub.9 aralkyl, phenyl, phenoxy, phenylthio, C.sub.2 -C.sub.5 alkoxycarbonyl, carboxy, nitro or cyano; andR.sup.4 and R.sup.5 are the same or different and are hydrogen or C.sub.1 -C.sub.Type: GrantFiled: April 24, 1985Date of Patent: May 12, 1987Assignees: Uniroyal Chemical Company, Inc., Uniroyal Ltd.Inventors: Walter G. Brouwer, Allen R. Blem
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Patent number: 4665182Abstract: The compounds of formula (I) ##STR1## wherein R.sup.1 is hydrogen, lower alkyl of 1-4 carbons, lower alkenyl of 2-4 carbons, --B--X--R.sup.5).sub.n, or --B--Z--B--X--R.sup.5 --.sub.n ; n=0 when X is halogen or n=1 when X is --O--, --NR.sup.6 -- (where R.sup.6 is hydrogen or lower alkyl of 1-4 carbons) or --S(O)q-- (where q=0 to 2); B is lower alkanyl (straight or branched) of 1-5 carbons; R.sup.5 is hydrogen, aralkyl of 7 to 12 carbons or alkyl of 1-10 carbons; Z is --O--, NR.sup.6 --, or --S(O)q--; R.sup.2 is hydrogen or lower alkyl of 1-4 carbons or lower alkenyl of 2-4 carbons or either R.sup.1 and R.sup.2 together with the carbon atom in the pteridine ring structures to which they are attached, form a spirocycloalkyl ring system having 3 to 7 carbon atoms; R.sup.3 and R.sup.4 are hydrogen or methyl; R.sup.2 and R.sup.3, together with the carbon atoms in the pteridine ring structure to which they are attached, form a cycloalkyl ring system having 5 to 7 carbon atoms; provided that at least one of R.sup.Type: GrantFiled: November 19, 1985Date of Patent: May 12, 1987Assignee: Burroughs Wellcome Co.Inventors: Charles A. Nichol, John F. Reinhard, Jr., Gary K. Smith, Eric C. Bigham
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Patent number: 4661599Abstract: There are described compounds exerting an antidotal activity belonging to the classes of the 2-thiazolines-2-substituted and 2-oxazolines-2-substituted, useful in the defense of agrarian cultivations from the toxic action of non-selective herbicides. Utilization and preparation methods thereof are described as well.Type: GrantFiled: January 4, 1985Date of Patent: April 28, 1987Assignee: Montedison S.p.A.Inventors: Ottorino Palla, Giovanni Camaggi, Franco Gozzo, Augusto Menconi, Ernesto Signorini
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Patent number: 4661489Abstract: A compound of formula (I): ##STR1## in which R is optionally substituted phenyl; C.sub.3-8 cycloalkyl; C.sub.5-8 cycloalkenyl; C.sub.1-8 alkyl which may be straight or branched; C.sub.2-8 alkenyl which may be straight or branched; 5- or 6- membered heterocyclyl; or optionally substituted phenyl C.sub.1-4 alkyl, each of Y and Z, which may be the same or different, is oxygen or sulphur; and X is --CH.sub.2 -- or oxygen, a process for the preparation of such compounds and their use in human and veterinary medicine.Type: GrantFiled: July 13, 1984Date of Patent: April 28, 1987Assignee: Beecham Group p.l.c.Inventors: Roderick J. Dorgan, Richard L. Elliott
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Patent number: 4661641Abstract: Compounds of the formula ##STR1## wherein n is either 0 or 1; R.sup.1 and R.sup.2 is hydrogen and the other is hydrogen, hydroxy, oxo group, a protected hydroxy or protected oxo group; R.sup.3 is hydroxy oxo group, .dbd.CH--CH.sub.2 --OH, .dbd.CH--CHO or one of the foregoing groups where the hydroxy or oxo functions are protected; R.sup.4 is --CO--OR.sup.6, --CO--R.sup.6, --CO--NR.sup.6 R.sup.7, --CO--Cl or --SO.sub.2 --R.sup.6 ; R.sup.6 is saturated or aromatic hydrocarbon; and R.sup.7 is saturated or aromatic hydrocarbon or hydrogen,are converted by cleavage of R.sup.4 OH into corresponding cycloalkenes and protecting groups, if present, are hydrolyzed.The compounds obtained are valuable intermediates in carotenoid syntheses.Type: GrantFiled: May 29, 1984Date of Patent: April 28, 1987Assignee: Hoffmann-La Roche Inc.Inventors: Teodor Lukac, Milan Soukup, Erich Widmer
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Patent number: 4659362Abstract: The invention concerns novel compounds of the formula I ##STR1## wherein: X are selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, alkanoyloxy, benzyloxy, substituted benzyloxy, amino, substituted amino, and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof;R.sup.1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl;R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl;R.sup.4 is selected from hydrogen, halogen, alkyl, cyano and alkoxycarbonyl; andn is the integer 3.Type: GrantFiled: August 22, 1983Date of Patent: April 21, 1987Assignee: ICI Australia LimitedInventors: Keith G. Watson, Graeme J. Farquharson
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Patent number: 4657920Abstract: 1,2,4-Triazol-1-yl-methyl-carbinols of the formula ##STR1## in which Ar is optionally substituted aryl, andHet is optionally substituted heteroaryl with at least 2 different hetero-atoms,or addition products thereof with plant-tolerated acids or metal salts, which possess fungicidal activity.Type: GrantFiled: March 22, 1985Date of Patent: April 14, 1987Assignee: Bayer AktiengesellschaftInventors: Jan Gajowski, Erik Regel, Karl H. Buchel, Wilhelm Brandes, Paul Reinecke
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Patent number: 4658074Abstract: Oxidative dehydrogenation of organic compounds in vapor phase with catalysts comprising crystalline compositions of iron, oxygen and at least one other metallic element. Preferred catalysts are ferrites.Type: GrantFiled: May 28, 1965Date of Patent: April 14, 1987Assignee: Petro-Tex Chemical CorporationInventors: Laimonis Bajars, Louis J. Croce
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Patent number: 4656171Abstract: Compounds of the formula ##STR1## wherein A, B, C and D are each independently --N.dbd. or --CH.dbd., provided, however, that at least two of them must be --N.dbd., and when A and C are both --N.dbd., at least one or both of B and D must be --N.dbd.; andR.sub.1, R.sub.2 and R.sub.3 are substituents of diverse types;tautomers thereof; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds are useful as cardiotonics.Type: GrantFiled: November 27, 1984Date of Patent: April 7, 1987Assignee: Dr. Karl Thomae GmbHInventors: Volkhard Austel, Norbert Hauel, Joachim Heider, Manfred Reiffen, Jacobus C. A. Van Meel, Willi Diederen
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Patent number: 4656184Abstract: This invention relates to therapeutic compositions comprising, as active ingredient, N-substituted hydrazones having the formula: ##STR1## in which Z is a 2-thienyl or phenyl radical. Said compositions have an anti-inflammatory activity, particularly in the ocular field.Type: GrantFiled: February 7, 1984Date of Patent: April 7, 1987Inventors: Claude Coquelet, Chantal Bertez, Claude Bonne, Daniel Sincholles
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Patent number: 4654343Abstract: Novel organic compounds which are N-substituted-N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides , carbamates and ureas which are useful as anxiolytic or antiepileptic agents, methods of using the compounds, compositions of matter containing them as the active ingredient and processes for their production.Type: GrantFiled: October 31, 1985Date of Patent: March 31, 1987Assignee: American Cyanamid CompanyInventors: Jay D. Albright, Dennis W. Powell, John P. Dusza
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2-(ethylene-thio methyl furanyl)amino thiazole derivatives having acid secretion inhibiting activity
Patent number: 4652575Abstract: Compound of formula (I) ##STR1## wherein R is an alkyl or an aromatic group, having pharmaceutical utility as an agent for treating a condition mediated through gastric acid secretion for reducing the volume and the acidity of gastric juice.Type: GrantFiled: September 12, 1985Date of Patent: March 24, 1987Assignee: Medosan Industrie Biochimiche Riunite S.p.A.Inventor: Alessandro Baglioni -
Patent number: 4652652Abstract: A useful intermediate for synthesizing penicillins or cephalosporins {i.e., 1-(2-protected amino-4-thiazolyl)propene-1,3-dicarboxylic acid half ester (VI)} is prepared by a process comprising (1) treating haloacetylmalonic acid ester (I) with thiourea to give 2-(2-amino-4-thiazolyl)malonic acid ester (II), (2) protecting the amino group of the latter to give 2-(2-protected amino-4-thiazolyl)malonic acid ester (III), (3) treating the product with haloalkenoic acid ester to give 1-(2-protected amino-4-thiazolyl)-2-propene-(1,1,3-tri or 1,1,3,3-tetra)carboxylic acid ester (IV), (4) hydrolyzing and decarboxylating the latter to give 1-(2-protected amino-4-thiazolyl)propene-1,3-dicarboxylic acid (V), and (5) treating the product with alcohol and a hemi-esterifying reagent to give the objective 1-(2-protected amino-4-thiazolyl)propene-1,3-dicarboxylic acid half ester (VI).Type: GrantFiled: June 19, 1985Date of Patent: March 24, 1987Assignee: Shionogi & Co., Ltd.Inventors: Hiromu Matsumura, Toshisada Yano
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Patent number: 4652651Abstract: The manufacture of 1-sulpho-2-oxazetidine derivatives of the formula ##STR1## in which Het is an optionally amino-substituted, 5- or 6-membered, aromatic heterocycle containing 1 or 2 nitrogen atoms and optionally also an oxygen or sulphur atom, R.sup.1 is hydrogen, lower alkyl, phenyl-lower alkyl, lower alkanoyl, lower alkoxycarbonyl, lower alkenyl-lower alkyl, lower alkoxycarbonyl-lower alkyl, phenyl-lower-alkoxycarbonyl-lower alkyl, nitrophenyl-lower-alkoxycarbonyl-lower alkyl or carboxy-lower alkyl and R.sup.2 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxycarbonyl, lower alkanoyloxy-lower alkyl, lower alkoxycarbonyl-lower alkenyl, hydroxyiminomethyl, lower alkoxyiminomethyl, carbamoyl, carbamoyl-lower alkenyl or carbamoyloxy-lower alkyl, the group .dbd.NOR.sup.Type: GrantFiled: April 14, 1986Date of Patent: March 24, 1987Assignee: Hoffmann-La Roche Inc.Inventors: Andre Furlenmeier, Werner Hofheinz, Christian N. Hubschwerlen, Hans P. Isenring
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Patent number: 4652667Abstract: A process is provided for the transesterification of carbonate esters and carboxylic acid esters at elevated temperatures and in the presence of an effective amount of an amidine compound.Type: GrantFiled: January 18, 1985Date of Patent: March 24, 1987Assignee: BP Chemicals LimitedInventor: Michael J. Green