Abstract: This invention provides novel sulfonium compounds, processes for the preparation of the sulfonium compounds, and pharmacological composition containing the sulfonium compound. The compounds of this invention are useful for treating allergy.

Abstract: Isochromans, isothiochromans, 2-benzoxepins, and 2-benzothiepins are described. The compounds possess hypotensive and anti-psychotic properties; methods and compositions using them are described.

Abstract: Pyrazolo[3,4,5-kl]acridines are described as antibacterial agents and antitumor agents as well as pharmaceutical compositions and methods for their preparation.

Abstract: Novel 2-amino-5-hydroxy-4-methylpyrimidines and substituted amino derivatives thereof useful as inhibitors of leukotriene synthesis for the treatment of pulmonary, inflammatory and cardiovascular diseases, cancer and psoriasis. In addition these compounds are cytoprotective and therefore useful in the treatment of peptic ulcers. A process for the preparation of such active compounds by ring rearrangement of 2-amino-5-acetyloxazole, pharmaceutical compositions containing the novel active compounds and compositions containing these compounds in combination with other anti-inflammatory agents or gastric anti-secretory agents.

Abstract: An improved process for the preparation of aromatic carbonates selected from aliphatic aromatic carbonates, diaromatic carbonates, and mixtures thereof comprising reacting a phenolic compound with a dialiphatic carbonate or an aliphatic aromatic carbonate in the presence of a catalytic amount of at least one catalyst selected from polymeric tin compounds containing recurring structural units represented by the general formula ##STR1## wherein: R is selected from monovalent hydrocarbon radicals; andR.sup.1 is selected from monovalent hydrocarbon radicals.

Abstract: An improved process for the preparation of aromatic carbonates selected from aliphatic aromatic carbonates, diaromatic carbonates, and mixtures thereof comprising reacting at least one phenolic compound with at least one dialiphatic carbonate or at least one aliphatic aromatic carbonate in the presence of a catalytic amount of at least one transesterification catalyst represented by the general formula ##STR1## wherein: X is selected from Sn and Ti; andR is selected from monovalent hydrocarbon radicalsand monovalent hydrocarbonoxy radicals.

Abstract: A purified isolate of an actinomycete identified as ATCC 39364 is capable of producing the antimicrobial/antitumor compound 2-amino-1,9-dihydro-6H-purine-6-one-7-oxide, commonly known as guanine-N.sup.7 -oxide.Guanine-N.sup.7 -oxide is produced by cultivating isolate ATCC 39364 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of the compound is produced and thereafter isolating the compound.The antibiotic/antitumor compound guanine-N.sup.7 -oxide and pharmaceutical compositions comprising this compound or one of its pharmaceutically acceptable salts together with a pharmaceutically acceptable carrier are also disclosed as is a method of treating microbial infections in a mammal or of treating tumors in a mammal.

Abstract: Disclosed herein are a novel compound, 5-methylthiopyrimidine derivative, notably that represented by the following general formula: ##STR1## wherein X means an oxygen or sulfur atom and R.sup.2 denotes a methyl, allyl or propargyl group, its preparation process and an agricultural and horticultural fungicide containing same as an active ingredient. The above compound exhibits outstanding control effects against plant diseases, especially, late blight of potatoes and the like and downly mildew. It permits preparation of an ideal agricultural and horticultural fungicide owing to its very low toxicity against mammal and fish and its no phytotoxicity.

Abstract: Novel compounds of the formula: ##STR1## wherein R.sup.1 is lower alkyl; R.sup.2 is hydrogen or lower alkyl, which are produced by reacting a compound of the formula: ##STR2## wherein R.sup.3 is hydrocarbon residue, with a compound of the formula: ##STR3## The novel compounds have antiviral and antibacterial activity, and are useful to prolong the life span of tumor-bearing warm-blooded animals.