Patents Examined by Sudhakar Katakam
  • Patent number: 11013760
    Abstract: Polyguanidines and methods of use thereof are described. In particular, polyguanidines of formula (I), formula (II), and formula (III) are described. The polyguanidines can be used to treat infection, such as bacterial, viral or fungal infection, and as an ex vivo microbial agent.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: May 25, 2021
    Inventors: Alexander Pretsch, Michael Nagl, Christoph Wiesner, Ralph Hollaus, Miroslav Genov
  • Patent number: 11013779
    Abstract: Antiviral protease inhibitors are disclosed, along with related antiviral dipeptidyl compounds, macrocyclic derivatives thereof and methods of using the same to treat or prevent viral infection and disease from coronaviruses, caliciviruses, and picornaviruses.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: May 25, 2021
    Assignees: Kansas State University Research Foundation, Wichita State University
    Inventors: Kyeong-Ok Chang, Yunjeong Kim, William C. Groutas
  • Patent number: 11007256
    Abstract: Single molecules useful in vaccine compositions, and methods of making and using the same, are described.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: May 18, 2021
    Assignee: The University of Toledo
    Inventors: Abhishek R. Vartak, Steven J. Sucheck, Katherine Ann Wall, Anthony Quinn, Marcia F. Mcinerney
  • Patent number: 11007273
    Abstract: The present disclosure provides prochelators as targeted prodrugs for cancer, such as prostate cancer, and methods of making and using the same.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: May 18, 2021
    Assignee: Duke University
    Inventors: Katherine J. Franz, Subha Bakthavatsalam, Tian Zhang, Daniel George, Mark Sleeper
  • Patent number: 11008279
    Abstract: Provided is a method for purifying 1,5-pentanediamine comprising: providing 1,5-pentanediamine to be purified and treating the 1,5-pentanediamine to be purified by a reduction reaction to obtain purified 1,5-pentanediamine. Meanwhile, further provided is 1,5-pentanediamine prepared by the method. The purification method has a concise process and a simple operation, and is suitable for industrial production, and can significantly improve the quality of 1,5-pentanediamine.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: May 18, 2021
    Inventors: Bingbing Qin, Charlie Liu, Shanshi Guo, Benliang Hou, Xiucai Liu
  • Patent number: 11006629
    Abstract: The present invention relates to antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same. The compositions may comprise one or more of a peracid, a hydroperoxide, a bis(hydroperoxide), or an epoxide.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: May 18, 2021
    Inventors: Ed Neas, Scott Noblitt
  • Patent number: 11001609
    Abstract: Aspects of the present disclosure include cell permeable cyclic peptide scaffolds that include a hexapeptide composed of naturally or non-naturally occurring amino acids. Pharmaceutical compositions having one or more of the cell permeable cyclic peptide scaffolds and pharmaceutically acceptable excipient are also provided. Methods for using the subject cell permeable cyclic peptide scaffolds are also described.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: May 11, 2021
    Assignee: The Regents of the University of California
    Inventor: Scott Lokey
  • Patent number: 11000050
    Abstract: The invention relates to bird feed comprising synthetic capsaicinoids for prohylactic use or treatment of salmonella infection.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: May 11, 2021
    Assignee: AXICHEM AB
    Inventor: Torsten Helsing
  • Patent number: 11001611
    Abstract: The present disclosure relates to relates methods and associated compositions that provide fast, efficient site-selective conjugation of a protein, such as the pore-forming protein ?-hemolysin, to a biomolecule, such as a DNA polymerase, and the use of such site-selective protein-biomolecule conjugates in nanopore devices and methods.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: May 11, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Dmitriy Gremyachinskiy, Christos Tzitzilonis
  • Patent number: 10995057
    Abstract: The present invention relates to a process for hydrogenating nitriles with hydrogen in the presence of a ZrO2-supported ruthenium catalyst.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: May 4, 2021
    Assignee: BASF SE
    Inventors: Christian Eidamshaus, Thomas Krug, Johann-Peter Melder, Joerg Pastre, Regine Helga Bebensee, Stephanie Jaegli
  • Patent number: 10993984
    Abstract: Methods are disclosed of treating or preventing hypotension (e.g., neurogenic orthostatic hypotension or postprandial hypotension) or portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) or ascites (e.g., ascites associated with liver cirrhosis), by oral administration to affected subjects of compositions comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: May 4, 2021
    Assignee: Chiasma, Inc.
    Inventor: Gary Patou
  • Patent number: 10995058
    Abstract: A process for preparing hydroxyethyl ethylene amines and/or ethylene urea derivatives thereof includes reacting monoethylene glycol with an amine-functional compound having at least two —NH— units, of which at least one is selected from the group of primary amine groups and cyclic secondary amine groups, in the presence of a carbon oxide-delivering agent. The amine-functional compound includes at least one —NH—CH2-CH2-NH— unit, wherein one or more —NH—CH2-CH2-NH— units in the amine-functional compound may be present in the form of piperazine moieties or ethylene urea moieties. The molar ratio of amine-functional compound to monoethylene glycol is in the range of 0.2:1 to 1.5:1 and the molar ratio of carbon oxide-delivering agent to —NH—CH2-CH2-NH— units in the amine-functional compound is at least 0.5:1. The process allows the conversion of monoethylene glycol into ethanol amines in the absence of metals-containing catalysts and without using ammonia.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: May 4, 2021
    Inventors: Eike Nicolas Kantzer, Karl Fredrik Lake, Antoon Jacob Berend Ten Kate, Michiel Jozef Thomas Raaijmakers, Rens Veneman, Ina Ehlers, Michael Bertil Einar Sarning, Hendrik Van Dam, Rolf Krister Edvinsson
  • Patent number: 10995081
    Abstract: A compound represented by Formula (1): The compound can be used as insecticides.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: May 4, 2021
    Inventors: Kei Yoshida, Takeo Wakita, Hiroyuki Katsuta, Akiyoshi Kai, Yutaka Chiba, Kiyoshi Takahashi, Hiroko Kato, Nobuyuki Kawahara, Michikazu Nomura, Hidenori Daido, Junji Maki, Shinichi Banba
  • Patent number: 10988437
    Abstract: The invention relates to bis(aniline) compounds containing multiple arylethynyl, alkylethynyl, ethynyl groups or their combinations, processes of making such compounds and materials comprising such compounds. Such, bis(aniline) compounds preferably comprise multiple phenylethynyl (PE) groups, i.e. 2-4 PE moieties. Such compounds are useful monomers for the preparation of polyimides, polyamides and poly(amide-imides) whose post-fabrication crosslinking chemistry (i.e. reaction temperature) can be controlled by the number of PE per repeat unit as well as finding utility in thermosetting matrix resins, 3D printable resins, and as high-carbon-content precursors to carbon-carbon composites.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: April 27, 2021
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Loon-Seng Tan, Zhenning Yu
  • Patent number: 10988507
    Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: April 27, 2021
    Assignee: bristol-myers squibb company
    Inventors: Kevin W. Gillman, Jason Goodrich, David R. Langley, Paul Michael Scola
  • Patent number: 10983134
    Abstract: The present invention relates to the identification of proteins of the WNT signaling pathway as therapeutic targets of pigmentation disorder and as biomarkers of pigmentation status. The invention in particular relates to products and methods for treating a hypopigmentation disorder. The invention also relates to products and methods for detecting, diagnosing, staging or monitoring the course of hypopigmentation disorder and is particularly suited for human subjects.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: April 20, 2021
    Inventors: Thierry Passeron, Florence Joly
  • Patent number: 10975121
    Abstract: The subject invention provides compositions and methods for alleviating pain. Specifically, the subject invention provides pharmaceutical formulations of peptides, and/or their salts, having advantageous ?-opioid receptor binding activity.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: April 13, 2021
    Inventors: Theodore E. Maione, Constantine Basil Maglaris
  • Patent number: 10967061
    Abstract: The present system is directed in several embodiments to a method of administration of a therapeutic composition for protection of the brain of a subject at risk of injury leading to traumatic brain injury (TBI) and/or treatment of injury to the brain resulting from TBI. The method includes administering one or more therapeutic compositions comprising an effective amount of insulin directly to the subject patient's CNS, with no to minimal systemic exposure. Preferably, this method comprises administration of an effective amount of insulin to the upper third of a patient's nasal cavity, thereby bypassing the patient's blood-brain barrier and delivering the therapeutic composition directly to the patient's central nervous system.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: April 6, 2021
    Assignees: HealthPartners Research & Education, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: William H. Frey, II, Leah Ranae Bresin Hanson, Kimberly Byrnes, Fiona Brabazon
  • Patent number: 10961401
    Abstract: The invention relates to benzophenone-terminated quaternary ammonium compounds, processes for preparing benzophenone-terminated quaternary ammonium compounds, environmentally friendly antimicrobial formulations of said quaternary ammonium compounds and their use as durable antimicrobial surface coatings for surfaces.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 30, 2021
    Assignee: Nano Safe Coatings Incorporated
    Inventors: Lukasz Porosa, Amanda Mocella, Gideon Wolfaardt, Daniel Foucher
  • Patent number: 10961274
    Abstract: Self-assembling peptides comprising non-ionic polar amino acids for anti-adhesion are provided herein. Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided to prevent adhesion or to provide anti-adhesion properties. Particular peptides include those consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods and kits are also provided.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 30, 2021
    Assignee: 3-D Matrix, Ltd.
    Inventors: Eun Seok Gil, Marc Rioult, Keiji Nagano, Karl Patrick Gilbert, Toshiro Kiyofuji, Yuya Hasegawa