Abstract: Disclosed is a method for efficiently synthesizing primary amines, which comprises using carbonyl compounds or alcohol compounds as reaction substrate, liquid ammonia or alcohol solutions of ammonia as nitrogen source, and hydrogen as hydrogen source, and reacting in reaction medium catalyzed by a cobalt-based catalyst to obtain the primary amines. Due to high catalytic activity, the method can realize the reductive amination of carbonyl compounds and the hydrogen-borrowing amination of alcohol compounds at low temperatures in a short time to obtain the primary amines with high yield, and is applicable to a wide range of substrates. The obtained primary amines can be used as raw materials with high extra value for producing polymers, medicines, dyes and surfactants. Further, the cobalt-based catalyst has a good industrial application prospect because it is magnetic which can facilitate separation and recycling of the catalyst.
Type:
Grant
Filed:
December 28, 2021
Date of Patent:
September 26, 2023
Assignee:
East China University of Science and Technology
Abstract: The present invention relates to compositions comprising daptomycin and at least one amino acid, methods of providing such compositions and the uses thereof.
Type:
Grant
Filed:
August 28, 2018
Date of Patent:
September 19, 2023
Assignee:
XELLIA PHARMACEUTICALS APS
Inventors:
Anita Bevetek Mocnik, Stipica Tomic, Barbara Fumic
Abstract: Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.
Type:
Grant
Filed:
October 9, 2018
Date of Patent:
September 12, 2023
Assignee:
Alpine Immune Sciences, Inc.
Inventors:
Lawrence Evans, Joseph L. Kuijper, Ryan Swanson
Abstract: The present invention relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics.
Type:
Grant
Filed:
October 8, 2020
Date of Patent:
September 12, 2023
Assignee:
Ra Pharmaceuticals, Inc.
Inventors:
Steven James DeMarco, Michelle Denise Hoarty, Grace Victoria Parker, Alonso Ricardo, Sylvia Tobe, Douglas A. Treco
Abstract: A process for continuous production of C2-C4-monoalkanolamines by reaction of a corresponding C2-C4-alkylene oxide with a molar excess of ammonia (NH3), wherein aqueous ammonia is employed, in the liquid phase and in the presence of an acidic cation exchanger as catalyst which contains a crosslinked copolymer comprising acidic functional groups as the carrier matrix, wherein the cation exchanger has a total exchange capacity of not less than 1.8 eq/L.
Type:
Grant
Filed:
January 28, 2019
Date of Patent:
September 12, 2023
Assignee:
BASF SE
Inventors:
Christian Gruenanger, Gabriele Iffland, Zeljko Kotanjac, Hermann Luyken, Thomas Krug, Jian Zhong Yi, Johann-Peter Melder
Abstract: The present invention relates to pharmaceutical compositions of the GLP-1 peptide semaglutide comprising no more than 0.01% (w/w) phenol, their preparation, kits comprising such compositions as well as uses thereof.
Type:
Grant
Filed:
December 8, 2020
Date of Patent:
September 12, 2023
Assignee:
Novo Nordisk A/S
Inventors:
Eva Horn Moeller, Michael Duelund Soerensen, Joakim Lundqvist
Abstract: The present disclosure provides peptides comprising a motif having four amino acids, wherein each of the amino acids at N-terminus and C-terminus of the sequence independently has a same or different positively charged side chain, and each of the amino acids between the N-terminal and C-terminal of the motif independently has a same or different uncharged side chain. The present disclosure surprisingly found that these peptides have advantageous effects in inhibiting or decreasing collagen breakdown, increasing production of collagen, elastin and/or hyaluronic acid, retarding aging, improving skin and inhibiting inflammation.
Abstract: IL-7R??c binding compounds and pharmaceutical compositions comprising the IL-7R??c binding compounds are disclosed. IL-7R??c bonding compounds can act as IL-7R agonists and are useful in treating cancer, viral diseases, autoimmune diseases, and inflammatory diseases.
Type:
Grant
Filed:
February 3, 2021
Date of Patent:
September 5, 2023
Assignee:
MEDIKINE, INC.
Inventors:
William J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
Abstract: Disclosed herein are small molecule GIP/GLP-1 dual receptor agonist compositions, pharmaceutical compositions, the use and preparation thereof.
Type:
Grant
Filed:
November 18, 2022
Date of Patent:
September 5, 2023
Assignee:
Viking Therapeutics, Inc.
Inventors:
Brian Lian, Geoffrey E. Barker, Maureen Barnes, Kader Yagiz, Erland Stevens
Abstract: Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more modified HMG-box 1 domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system.
Type:
Grant
Filed:
March 14, 2018
Date of Patent:
September 5, 2023
Assignee:
Research Institute at Nationwide Children's Hospital
Inventors:
Steven David Goodman, Lauren O. Bakaletz
Abstract: A method of reducing color in an alkanolamine is described. The method includes contacting the alkanolamine with a color-reducing amount of a borane complex effective to provide a color-reduced alkanolamine composition having a Platinum-Cobalt Color Value, according to Test Method ASTM D1209, of less than 50.
Abstract: The present invention relates to a method for purification of liquid compositions containing at least one sphingolipid and the use of a specific clay mineral for the purification of such liquid compositions.
Type:
Grant
Filed:
September 9, 2020
Date of Patent:
August 29, 2023
Assignee:
Clariant Produkte (Deutschland) GmbH
Inventors:
Carina Bitterwolf, Joern Kretzschmar, Lina Tubes, Benjamin Fuerst
Abstract: The present invention relates to a method for synthesizing artepillin C and a synthetic method for synthesizing an intermediate compound for use in preparing artepillin C. The structural formula of artepillin C is shown in the following formula (IV), and the intermediate compound is shown in the following formula (II). The synthesis method includes the following steps: a first reaction step: in the presence of a base initiator, a compound A shown in formula I and 3,3-dimethylallyl bromide are mixed, the reaction continues for a first reaction time and is stopped to generate an intermediate of artepillin C shown in formula II; and a second reaction step: the intermediate of artepillin C is dissolved in an aqueous alcohol solution and then mixed with an alkali metal salt, and the reaction continues for a second reaction time to generate artepillin C.
Type:
Grant
Filed:
February 23, 2021
Date of Patent:
August 29, 2023
Assignee:
GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.
Abstract: The instant invention describes hydrazide-containing compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.
Type:
Grant
Filed:
August 21, 2020
Date of Patent:
August 22, 2023
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Daiqing Liao, William R. Roush, Ryan L. Stowe
Abstract: Provided herein are synthetic peptides developed from slug and insect neuropeptides. Peptides described can be used to repel, control or deter slugs, including the gray garden slug (Deroceras reticulatum), from feeding on agricultural and horticultural plants. The peptides can be combined with bait materials, or applied directly to plants or areas, or produced by genetically modified plants.
Type:
Grant
Filed:
August 25, 2020
Date of Patent:
August 15, 2023
Assignees:
The United States of America, as represented by The Secretary Agriculture, Oregon State University
Inventors:
Man Y. Choi, Ruth C. Martin, Seungjoon Ahn, Rory McDonnell, Sujaya Rao
Abstract: A cationic surfactant and a method of making the cationic surfactant are described. The method comprises reacting a lipophilic bio-based material having at least one epoxy functional group and a hydrophilic organic compound having at least one cationic functional group and at least one hydroxyl functional group to form a reaction product containing a stable ether linkage connecting the lipophilic bio-based material to the organic compound. At least a portion of the cationic functional groups is neutralized or ion exchanged with an organic acid. Incorporation of the simple organic acid reduces the surfactant's aquatic toxicity and acts as a substrate to encourage co-digestion of the surfactant molecule, making the compound more biodegradable.
Type:
Grant
Filed:
May 30, 2019
Date of Patent:
August 15, 2023
Assignee:
Battelle Memorial Institute
Inventors:
Ramanathan S. Lalgudi, Robert J. Cain, Manoj Kumar Valluri
Abstract: Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.