Abstract: The present invention provides an aqueous extract of Andrographis paniculata leaves containing as main components andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide. The Invention also provides a method of production of said extract, comprising the steps of drying the leaves of Andrographis paniculata, and extracting them with water at a temperature of at least 50° C. The aqueous extract of Andrographis paniculata Leaves Is suitable for use as cognition enhancing agent having antineuroinflammatory and antioxidative effects.
Type:
Grant
Filed:
July 18, 2017
Date of Patent:
September 22, 2020
Inventors:
Johnson Stanslas, Dahiru Sani, Hamidon Basri, Md. Shariful Hasan Sumon, Chee Woei Lim, Charng Choon Wong, Mohd Al-Saufreen Akhiruddin, Audrey Chee Hui Yong, Brian Patrick Kirby
Abstract: An object of the present invention is to provide a protective method for liver comprising the administration of an extract from inflamed tissues inoculated with vaccinia virus to a patient who needs the treatment and to provide a liver protective agent, etc. where such an extract is an active ingredient. In the present invention, it has been recognized that, in hepatocytes, activation of NF-B, expression of NF-B target genes, activation of JNK, apoptosis and fat accumulation can be inhibited or suppressed. The agent containing the extract as an active ingredient is a drug exhibiting less adverse action and high safety. Accordingly, the present invention provides very useful protective method for liver and liver protecting agent.
Type:
Grant
Filed:
August 7, 2015
Date of Patent:
September 22, 2020
Assignees:
NIPPON ZOKI PHARMACEUTICALS CO., LTD., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: Provided is a composition for treating diabetes, including a hypoglycemic agent and a Yukmijihwang-tang extract. More particularly, the hypoglycemic agent is administered into an individual, and the Yukmijihwang-tang extract is administered into the individual, thereby considerably increasing a hypoglycemic effect of the hypoglycemic agent, and preventing and reducing various diabetic complications such as diabetes and diabetic liver damage, renal damage, hyperlipidemia immunosuppression and ocular damage.
Type:
Grant
Filed:
May 3, 2018
Date of Patent:
September 8, 2020
Assignee:
COMPREHENSIVE AND INTEGRATIVE MEDICINE INSTITUTE
Inventors:
Seok Bong Kang, Ho Sang Sohn, Joon Seok Byun, Ki Cheul Sohn, Sae Kwang Ku
Abstract: The present invention provides a topical formulation comprising an active agent, which comprises salvigenin and optionally asiaticoside. The present invention also relates to the use of the topical formulation for the promotion of wound healing.
Abstract: Disclosed is a composition comprising an beautyberry total glycosides extract, and a method of preparation thereof, and the use of the composition thereof in preparing drugs for treating neurodegenerative diseases or skin diseases. The extract thereof is prepared from the leaves of Callicarpa cathayana H.T. Chang or Callicarpa formosana Rolfe, and contains 18% to 45% verbascoside and 15% to 40% Arenarioside.
Abstract: A formulation for a dietary supplement includes standardized extracts of Astragalus root, phlorizin, root bark of white mulberry, olive leaf, and bitter melon. The formulation may further include chromium, 2-deoxy-D-glucose, biotin, vitamin D and vitamin C. A method of controlling postprandial blood glucose includes administering the formulation for the dietary supplement to a patient.
Abstract: The present invention relates to a novel use of an Anemarrhena asphodeloides Bunge extract, and the like, and a Rhizoma Coptidis extract, and the like, and specifically, provides a composition for preventing, relieving, or treating colitis, including, as active ingredients: one or more selected from the Anemarrhena asphodeloides Bunge extract, a C3 to C8-alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract, mangiferin, a pharmaceutically acceptable salt of mangiferin, neomangiferin, or a pharmaceutically acceptable salt of neomangiferin; and one or more selected from a Rhizoma Coptidis extract and a C3 to C8-alcohol-soluble fraction of the Rhizoma Coptidis extract.
Type:
Grant
Filed:
December 11, 2018
Date of Patent:
August 25, 2020
Assignee:
UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
Abstract: Pharmaceutically effective compositions and methods for topically treating pain due to swelling or inflammation of fascia, tendons, or ligaments in a patient in need of treatment, thereof. The pharmaceutically effective composition consists essentially of: 68.6-29.4 parts by weight of a pharmaceutically acceptable excipient; 40.0-50.0 parts by weight DMSO; 1.0-5.0 parts by weight of an anesthetic, wherein the anesthetic is advantageously characterized as containing only lidocaine; and 1.2-3.2 parts by weight of an anti-inflammatory in 100 parts by weight of the pharmaceutically effective composition. In one embodiment, the anesthetic is advantageously 4.0 parts by weight Lidocaine. In one embodiment, the pharmaceutically acceptable excipient is 48.0 parts by weight, DMSO is 45 parts by weight, anesthetic is advantageously 4.0 parts by weight Lidocaine, Echinaceas is 1.0 part by weight and Arnica is 1.0 part by weight, and the condition causing pain of the foot is Plantar Fasciitis.
Abstract: The invention relates to an anti-inflammatory factor isolated from milk, methods of purifying the anti-inflammatory factor through ultrafiltration and diafiltration to produce Milk Protein Concentrate resulting in substantially or highly purified preparations and to methods for using this factor to remove adhered neutrophils from endothelial cells, to prevent the emigration of cells from the vasculature and to suppress the response of lymphocytes to foreign antigens.
Abstract: The present invention discloses a biodegradable and biocompatible pharmaceutical composition comprising silk Sericin, sophorolipid, a gelling or thickening agent and one or more pharmaceutically acceptable carriers or excipients for faster wound healing and limit scarring.
Type:
Grant
Filed:
September 20, 2016
Date of Patent:
July 14, 2020
Assignee:
Council of Scientific & Industrial Research
Abstract: A medicament includes a parsley extract for use in the treatment and/or prevention of endometriosis. The medicament may also include an oleander extract.
Abstract: The present invention relates to compositions and methods of inducing angiogenesis and methods of treating a pathology that would benefit from angiogenesis by use of a composition comprising partially purified intact mitochondria and/or ruptured mitochondria derived therefrom.
Abstract: New extracts of microalgae, halophytes and psammophilous plants are suggested, obtainable by treating said microalgae and plants with a solvent selected from the group consisting of C1-C4 aliphatic alcohols, ethyl acetate, water or their mixtures, removing the dissolved extracts from the residues and recovering the pure extracts from the solvent. The extracts show excellent activity as regulators of the metabolism of human sebaceous glands.
Type:
Grant
Filed:
August 3, 2015
Date of Patent:
June 30, 2020
Assignee:
Symrise AG
Inventors:
Lorenzo Zanella, Paolo Pertile, Michele Massironi
Abstract: Disclosed is a topical skin composition, and methods for its use, that includes Arctium lappa root extract, Epilobium angustifolium extract, and Cystoseira amentacea/Caespitosa Brachycarpa extract.
Abstract: A Chinese medicine extract and preparation method and application thereof. Raw materials of the extract are Artemisia carvifolia and propolis. The extract has an excellent effect of inhibiting CaN-NF-AT pathway and a lower relative toxicity for cells.
Abstract: A composition for the enhancement of free testosterone is provided, the composition comprising: vitamin B6; vitamin B12; zinc; L-citrulline; fenugreek seed extract; an adenosine triphosphate (ATP) stimulating component, comprising: ancient peat extract, and apple fruit extract; eurycoma root extract; and boron. A method of increasing free testosterone is provided, the method comprising administering to an individual an effective dose of a composition comprising: vitamin B6; vitamin B12; zinc; L-citrulline; fenugreek seed extract; an adenosine triphosphate (ATP) stimulating component, comprising: ancient peat extract, and apple fruit extract; eurycoma extract; and boron.
Abstract: Capsicum compositions are described that include biologically active constituents non-capsaicinoids and capsaicinoids in a specific ratio are useful for the treatment and management of cardiometabolic syndrome and associated risk factors, in a subject in need thereof. The capsicum compositions include a capsicum extract which is prepared by extracting capsicum pods by using suitable polar and non-polar solvents. Capsicum compositions include non-capsaicinoid components like saponins and polyphenols such as flavonoids, which along with capsaicinoids effectively reduce risk factors of cardiometabolic syndrome and also reduce oxidative stress on vital body organs by reducing inflammatory and/or oxidative markers. The capsicum compositions inhibit pancreatic lipase enzyme and enhance lipolysis, when administered in an effective amount to a subject in need thereof. Capsicum compositions as described herein are prepared by human intervention and are safe for consumption.
Abstract: A method of treating a fine line or wrinkle on a person's skin or increasing collagen production in skin is disclosed. The method can include topically applying to the skin a composition comprising an effective amount of an aqueous, alcoholic, or aqueous-alcoholic extract of Diospyros mespiliformis leaf to treat the fine line or wrinkle or to increase collagen production in the skin.
Abstract: A topical composition comprising ginger, curcumin, one or more of glutathione, MSM, Vitamin C, hyaluronic acid, sodium lauryl sulfate, Vitamin D and Vitamin E, and a carrier, wherein each of the glutathione, MSM, Vitamin C, hyaluronic acid, sodium lauryl sulfate, Vitamin D, and Vitamin E. When applied to human skin or animal skin, the composition can improve the appearance of skin and speed up wound healing.
Abstract: The invention relates to cosmetic and topical compositions containing an effective amount of a photosynthetic cell extract comprising a functional thylakoid system. The cosmetic compositions have anti-wrinkle and anti-aging effects on a user's skin. In addition, the photosynthetic cell extract protects skin against ultraviolet A (UVA) and ultraviolet (UVB) damage.