Patents Examined by Suzanne Ziska
  • Injectable, non-aqueous suspension with high concentration of therapeutic agent
    Patent number: 8802095
    Abstract: An injectable, nonaqueous suspension including at least one therapeutic agent suspended in a single component vehicle. The single component vehicle is a single amphiphilic material, such as a polyethoxylated castor oil or derivative thereof, a polyoxyethylene alkyl ether, a polyoxyethylene sorbitan fatty acid ester, a polyoxyethylene stearate, a block copolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide, a block copolymer of polypropylene oxide-polyethylene oxide-polypropylene oxide, a tetra-functional block copolymer of polyethylene oxide-polypropylene oxide, or a tetra-functional block copolymer of polypropylene oxide-polyethylene oxide. A dosage kit that includes the injectable, nonaqueous suspension and a method of administering the injectable, nonaqueous suspension are also disclosed.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: August 12, 2014
    Assignee: Durect Corporation
    Inventors: Paul R. Houston, Guohua Chen, Andrew Sheung-King Luk
  • Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease
    Patent number: 8784860
    Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: July 22, 2014
    Inventors: Robert Falotico, Jonathan Zhao
  • Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
    Patent number: 8778917
    Abstract: A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: July 15, 2014
    Assignee: Clarus Therapeutics, Inc.
    Inventors: Robert E. Dudley, Panayiotis P. Constantinides
  • Modified release amoxicillin products
    Patent number: 8778924
    Abstract: An amoxicillin product comprising: at least one modified release component(s), wherein the at least one modified release component(s) comprises at least amoxicillin and a pharmaceutically acceptable carrier; and wherein when administered to a patient or subject in the fed state said amoxicillin product exhibits a pharmacokinetic profile for amoxicillin in the plasma characterized as follows: (1) the ratio of the portion of the AUC as measured from 2 hours post-administration to 5 hours post-administration to the portion of the AUC as measured from administration to 2 hours post-administration is at least 2.0:1; and (2) the ratio of the portion of the AUC as measured from 5 hours post-administration to 12 hours post-administration to the portion of the AUC as measured from administration to 2 hours post-administration is at least 1.1:1.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: July 15, 2014
    Assignee: Shionogi Inc.
    Inventors: Henry H. Flanner, Sanna Tolle-Sander, Donald Treacy, Beth A. Burnside, Susan P. Clausen
  • Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
    Patent number: 8778916
    Abstract: A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: July 15, 2014
    Assignee: Clarus Therapeutics, Inc.
    Inventors: Robert E. Dudley, Panayiotis P. Constantinides
  • Method of making a cover material including a skin care composition
    Patent number: 8778817
    Abstract: A method of making a cover material for an absorbent article including the steps of providing a fibrous nonwoven substrate, the substrate having a tortuousity value in the range of about 0.8 to about 3.0, applying a particulate skin care material to the substrate, the particulate skin care comprising a particulate material having a particle size in the range of about 1 micron to about 75 microns, and applying a compressive force to the substrate to impregnate the substrate with the particulate skin care material.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: July 15, 2014
    Assignee: McNeil-PPC, Inc.
    Inventors: Krystyna M. Borysewicz, Ricky Ray Burrow, Jenny G. Du, Joseph Michael Luizzi, Maria Cristina Niciporciukas, Kenneth A. Pelley, John Poccia
  • Anti-no-reflow guide wire for vascular interventional procedures
    Patent number: 8771310
    Abstract: The present invention relates to compositions and methods for improving outcomes in vascular interventional procedures. In particular, the present invention relates to compositions and methods for improving outcomes in vascular interventional procedures using an anti-no-reflow guide wire that attenuates the “no-reflow” phenomenon that is associated with negative outcomes.
    Type: Grant
    Filed: May 28, 2008
    Date of Patent: July 8, 2014
    Assignee: Adenopaint, LLC
    Inventors: Mervyn B. Forman, Edwin K. Jackson, Jianying Zhang, Zaichuan Mi
  • Methods of blocking ultraviolet radiation and promoting skin growth using terpenes and terpenoids
    Patent number: 8771652
    Abstract: The present invention provides methods of treating humans and animals with terpenes and terpenoids in order to rejuvenate the skin and increase the protective layer against irradiation by ultraviolet radiation (UVR). More specifically it provides terpenes and terpenoids as ingredients that work as persistent UVR blockers. Terpenes and terpenoid compounds support the growth of skin, skin tissue and keratinocytes and additional UVR-blocking by reason of increased stratum corneum thickness and loricrin content. Both terpenes and terpenoids may be applied topically or orally at oral or topical concentrations from about 6 mg to about 600 mg per kilogram of body weight per day effective to stimulate growth of the skin layer and prevent damage from ultraviolet radiation (UVR).
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: July 8, 2014
    Assignees: New York University, Biokeys for Flavors, LLC
    Inventors: Ivica Labuda, Fredric Jay Burns
  • Modified release analgesic suspensions
    Patent number: 8771716
    Abstract: A pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: July 8, 2014
    Assignee: McNeil-PPC, Inc.
    Inventors: Der-Yang Lee, Jen-Chi Chen, Vincent Chen, Robert Shen
  • Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
    Patent number: 8765173
    Abstract: A drug delivery system (DDS) for administration of a water soluble, cationic, and amphiphilic pharmaceutically active substance (API) which DDS comprises poorly water soluble nanoparticles formed by the API together with a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester. A pharmaceutical composition comprising such a DDS. Methods for preparation of such a DDS and such a pharmaceutical composition. Use of such a DDS and pharmaceutical composition for treatment of cancer.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: July 1, 2014
    Assignee: Ardenia Investments, Ltd.
    Inventors: Julian Aleksov, Igor Lokot
  • Preparation of an enteric release system
    Patent number: 8765030
    Abstract: Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: July 1, 2014
    Assignee: Intercontinental Great Brands LLC
    Inventors: Ahmad Akashe, Anilkumar Ganapati Gaonkar, Les Lawrence, Amado R. Lopez, Ronald L. Meibach, Dana Sebesta, Yan Wang, James D. White
  • Water-soluble films comprising low-viscosity alginates
    Patent number: 8759282
    Abstract: A film comprising as a film-forming agent an alginate salt of monovalent cation or a mixture of alginate salts containing at least one alginate salt of monovalent cation, the film-forming agent being such that a 10% aqueous solution thereof at a temperature of 20° C. has a viscosity of 100-1000 mPas, as measured at a shear rate of 20 rpm by use of a Brookfield viscometer with a spindle No. 2. A method of preparing the film. The film is useful for delivery of active ingredients to a mammal.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: June 24, 2014
    Assignee: Uppsalagruppen Medical AB
    Inventors: Kjell G Stenberg, Fredrik Hubinette
  • Polymer coatings containing drug powder of controlled morphology
    Patent number: 8758429
    Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: June 24, 2014
    Assignee: Micell Technologies, Inc.
    Inventors: Doug Taylor, Jim McClain, Clint Smoke, Mike Cole, James DeYoung
  • Elastomeric flexible article with absorbant polymer and manufacturing method
    Patent number: 8752215
    Abstract: An elastomeric flexible article and method for manufacture has moisture absorbing characteristics. An example of such an article is a disposable protective glove that includes a first layer; and a second layer with an effective amount of super absorbent polymer dispersed therein, the second layer to be closer to a hand than the first layer, when the glove is worn on the hand. The second layer is configured to absorb excess moisture, when the glove is worn for a period of time, to facilitate wet donning and provide for breathability of the skin, and thereby to provide for a comfortable environment for the skin.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: June 17, 2014
    Assignee: Shen Wei (USA) Inc.
    Inventors: Belle L. Chou, Ping Zhang
  • Activating extraction of demineralized bone matrix
    Patent number: 8753660
    Abstract: Demineralized bone matric (DBM) and native bone morphogenetic protein (nBMP) are complex mixtures of non-collagenous bone proteins. These mixtures contain many of the BMPs that are available as recombinant molecules. Information regarding the presence in these materials of molecules that may affect the availability and activity of the BMPs is very limited. A chemical extraction of DBM, such as using alkali-urea produces a water soluble extractate which inhibits the osteogenic activity of DBM. Noggin, an extracellular BMP ligand antagonist is found in the water soluble extractate from DBM. Differential chemical extraction is a useful means of removing non-osteogenic, or osteogenic inhibitory molecules from DBM and nBMP.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: June 17, 2014
    Assignees: The Regents of The University of California, The United States of America as Represented by The Department of Veterans Affairs
    Inventors: Keyvan Behnam, Elsa J. Brochmann-Murray, Samuel S. Murray
  • Methods and compositions for synaphically-targeted treatment for cancer
    Patent number: 8753604
    Abstract: Disclosed are compositions and methods useful for targeting therapeutics to cancerous cells and tumors. The disclosed targeting is useful for delivering therapeutic and detectable agents to cancerous cells and tumors.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: June 17, 2014
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Erkki Ruoslahti, Venkata Ramana Kotamraju, Priya Karmali
  • Functionalized non-phenolic amino acids and absorbable polymers therefrom
    Patent number: 8754135
    Abstract: The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: June 17, 2014
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Methods and compositions for the disruption of biofilms
    Patent number: 8753662
    Abstract: The invention relates to methods of inhibiting biofilm formation or reducing biofilms in a subject or on a device or surface by administering a charged compound such as a polyamino acid to a subject, device or surface. The invention also relates to compositions for inhibiting biofilm formation or reducing biofilms.
    Type: Grant
    Filed: February 14, 2008
    Date of Patent: June 17, 2014
    Assignee: National Jewish Health
    Inventors: Jerry A. Nick, Quinn M. Parks
  • Methods of forming coatings with a crystalline or partially crystalline drug for implantable medical devices
    Patent number: 8753709
    Abstract: Methods for making coatings on an implantable device, such as a drug-eluting stent. The coatings comprise a polymer and a drug in a crystalline or partially crystalline form. In addition, implantable devices produced by the methods and methods of using the coated implantable devices are described.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: June 17, 2014
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed Faiyaz Ahmed Hossainy, Yiwen Tang, Homayon Askaryar, Qing Lin, Thierry Glauser
  • Anti-hypertensive functional food products
    Patent number: 8753698
    Abstract: The present invention provides novel protein hydrolysates with anti-hypertensive properties, as well as food products and food supplements comprising these.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: June 17, 2014
    Assignee: Globus Egg Sciences B.V.
    Inventors: Aart Van Amerongen, Maria Josepha Catharina Beelen-Thomissen, Arie Van der Bent, Jan Hendrik Buikema, Wiekert Hendrikus Van Gilst, Maria Henrieette Johanna Loonen, Karin Beatrice Merck, Jos Nelissen, Wilhelmus Johannes Gertrudes Thielen, Klaas Arnoud Togtema