Patents Examined by Suzanne Ziska
  • Catheter assembly with bactericidal effect
    Patent number: 8747882
    Abstract: A use in a medical device of at least one salt of organic acid(s), and preferably a benzoate or a sorbate, as an antimicrobial agent is disclosed, and in particular for the manufacturing of an antimicrobial coating for a medical device, e.g., hydrophyllic urinary catheters, for the prevention of bacterial infection. The pH of the hydrophilic coating may be controlled to be in the range 4.0-8.0, preferably in the range 5.0-6.0, and preferably to be below 7.0. The pH of the hydrophilic coating could be controlled by means of a pH buffer, and preferably a citrate or phosphate buffer. A salt of organic acid in combination with a pH buffer has proven surprisingly efficient for inhibition of bacterial growth, and for prevention of bacterial infections.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: June 10, 2014
    Assignee: Astra Tech AB
    Inventors: Jan Utas, Andrea Schmid, Agneta Nordholm, Martin Nyman
  • External patches containing etofenamate
    Patent number: 8747885
    Abstract: The present invention provides to patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation. In an external patch in which an adhesive layer containing an adhesive base and a drug are laminated with a backing, the external patch wherein the adhesive base contains 5-50% by weight of synthetic rubber polymer, 10-60% by weight of adhesive resin and 25-60% by weight of liquid paraffin, and the drug is etofenamate. According to the present invention, there is obtainable the patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: June 10, 2014
    Assignees: Teikoku Seiyaku Co., Ltd., Drossapharm AG
    Inventors: Tomohiro Ishima, Hiroyuki Yamasaki, Masahiro Yamaji
  • Graft materials containing ECM components, and methods for their manufacture
    Patent number: 8741352
    Abstract: Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: June 3, 2014
    Assignee: Cook Biotech Incorporated
    Inventors: Jason P. Hodde, David M. J. Ernst, Lal Ninan, Sherry Voytik-Harbin, Nathan Hammond
  • Hydrogel implants with varying degrees of crosslinking
    Patent number: 8734930
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: May 27, 2014
    Assignee: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla, Timothy Sargeant, Joshua Stopek, Saumya Banerjee, Arpan Desai
  • Aqueous fatty monoamine-containing systems for water-insoluble materials
    Patent number: 8728452
    Abstract: The present invention is drawn to an aqueous composition containing: (a) at least one fatty monoamine; (b) at least one nonionic surfactant; (c) at least one compound chosen from an alkyl ether carboxylic acid, an alkyl ether carboxylate, a fatty acid having from about 6 to about 40 carbon atoms, and mixtures thereof; and (d) at least one water-insoluble material, and wherein the composition is homogeneous and clear to substantially clear in appearance.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: May 20, 2014
    Assignee: L'Oreal
    Inventors: David W. Cannell, Hashimoto Sawa, Nghi Van Nguyen
  • Production of tissue engineered digits and limbs
    Patent number: 8728463
    Abstract: The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: May 20, 2014
    Assignee: Wake Forest University Health Science
    Inventors: Anthony Atala, James Yoo, Grace Lim, Sang Jin Lee
  • Foamable carriers
    Patent number: 8722021
    Abstract: The invention relates to an alcohol-free cosmetic or therapeutic foam carrier comprising water, a hydrophobic organic carrier, a foam adjuvant agent, a surface-active agent and a gelling agent. The cosmetic or therapeutic foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble therapeutic and cosmetic agents.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: May 13, 2014
    Assignee: Foamix Ltd.
    Inventors: Doron Friedman, Alex Besonov, Dov Tamarkin, Meir Eini
  • Cyclic acetal biomaterials
    Patent number: 8715708
    Abstract: A novel class of Cylic Acetal biomaterials (CABs) based on a cyclic acetal unit is disclosed and claimed by Applicants. Two novel biomaterials suitable for use in a variety of biological applications including in the orthopedic field for joint and cartilage replacement and/or repair, and bone cement. The biomaterials are comprised of either a network of monomers of 5-ethyl-5-(hydroxymethyl)-?,?-dimethyl-1,3-dioxane-2-ethanol diacrylate (EHD) and a hydrogel comprised of EHD and poly(ethylene glycol) diacrylate (PEG-EHD).
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: May 6, 2014
    Assignee: University of Maryland
    Inventors: John Patrick Fisher, Sachiko Kaihara, Jennifer Lynn Moreau, Parth Modi
  • Inorganic resorbable bone substitute material
    Patent number: 8715744
    Abstract: The invention relates in particular to a hydroxyl apatite/silica granular material of defined morphology, a highly porous bone substitute material based on this granular material and a glass ceramic material based in turn thereon as bone substitute material which is characterized by a variable mechanical strength, and shaped bodies of this material, materials of different mechanical strength being preferably used in the shaped body. The bone substitute materials according to the invention are characterized by a high resorbability in vivo.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: May 6, 2014
    Assignee: Artoss GmbH
    Inventor: Thomas Gerber
  • Implant and method for production of the same
    Patent number: 8709073
    Abstract: One example embodiment of the present invention relates to an implant, particularly an intraluminal endoprosthesis, having a body that contains metallic material, preferably iron. The implant body has a first layer with at least one ionic compound that contains ions of at least one halogen, particularly chloride ions and/or bromide ions, on at least part of its surface. Furthermore, a method for the production of such an implant is described.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: April 29, 2014
    Assignee: BIOTRONIK VI Patent AG
    Inventors: Bjoern Klocke, Ullrich Bayer
  • Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery
    Patent number: 8709379
    Abstract: Formulations of neutral retinoids, in particular fenretinide (HPR) in the form of lipid nanoparticles, solid dispersions and emulsions are disclosed. These compositions are used to treat diseases that are amenable to treatment by HPR, such as neoplastic diseases by achieving higher and more prolonged concentrations of HPR in the subject. The key steps for preparing lipid nanovesicles of HPR include mixing and sonication, sterile filtration, without or without lyophilization for long-term stable storage, and employ processes and materials that are scalable from the laboratory to the manufacturing level. The formulation are suitable for injection into human or animal patients without causing allergic or hypersensitivity responses by avoiding chemical surfactants and animal sources of phospholipids in their manufacture.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: April 29, 2014
    Assignee: Scitech Development, LLC
    Inventors: Ralph E. Parchment, Bhaskara R. Jasti, Ramesh R. Boinpally, Stephen E. Rose, Earle T. Holsapple
  • Sublingual coated tablet of fentanyl
    Patent number: 8709479
    Abstract: The present invention relates to a fentanyl coated tablet and to the method for the preparation thereof.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: April 29, 2014
    Assignee: Ethypharm
    Inventors: Pascal Oury, Guillaume Benoist, Catherine Herry, Joseph Duvochel
  • Compositions for enternal application of microorganisms
    Patent number: 8697126
    Abstract: The present invention describes a process for the manufacture of a solid composition comprising a microorganism, which process comprises a first step of blending and/or compacting the microorganism with a salt of a medium or long-chain fatty acid to prepare a powderous mixture or compacted granulate, and a second step of providing said powderous mixture or compacted granulate with a coating. The microorganisms are preferably probiotics. The invention also relates to the solid composition obtained by said process and to its use in food.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: April 15, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Chyi-Cheng Chen, Bruno H. Leuenberger, Loni Schweikert, Ernst Zedi
  • Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
    Patent number: 8691279
    Abstract: Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent. The present hyaluronic acid-based compositions have enhanced flow characteristics, hardness, and persistence compared to known hyaluronic acid-based compositions. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: April 8, 2014
    Assignee: Allergan, Inc.
    Inventors: Karina H. Guillen, Ahmet Tezel
  • Controlled degradation of expandable polymers in gastric volume reduction treatment
    Patent number: 8691269
    Abstract: Orally administrable polymer-carrying units for expanding in a stomach of a mammal to fill a space in the stomach, the polymer-carrying units including: a carrier; a plurality of polymer molecules expandable in aqueous solutions, releasably coupled to the carrier; and means for selectively decoupling the polymer molecules from the carrier so that the polymer molecules and carrier are released in the stomach, are provided.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: April 8, 2014
    Inventors: Martin Pavlov Mintchev, Orly Yadid-Pecht
  • Gallium-containing sealant for medical use
    Patent number: 8691288
    Abstract: Chronic rhinosinusitis and other bacterial sinus conditions may be treated by applying a solvating system containing a surfactant to a bacterial biofilm in a nasal or sinus cavity, disrupting the biofilm, and applying a protective layer of a polymeric film-forming medical sealant.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: April 8, 2014
    Assignee: Medtronic, Inc.
    Inventor: Matthew F. Myntti
  • Template-fixed peptidomimetics with antimicrobial activity
    Patent number: 8685922
    Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining Symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These ?-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and Solution phase synthetic strategy.
    Type: Grant
    Filed: January 15, 2007
    Date of Patent: April 1, 2014
    Assignees: POLYPHOR Ltd., Universitaet Zuerich
    Inventors: Steven J. Demarco, Wim Vrijbloed, Ricardo Dias, John Anthony Robinson, Nityakalyani Srinivas, Frank Gombert, Daniel Obrecht
  • Absorbable coating for implantable device
    Patent number: 8685433
    Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: April 1, 2014
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar W. Kleiner, Syed F. A. Hossainy, Mikael Trollsas, Stephen D. Pacetti
  • Sustained-release formulations of topiramate
    Patent number: 8663683
    Abstract: Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: March 4, 2014
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Likan Liang, Hua Wang, Padmanabh P. Bhatt, Michael L. Vieira
  • Cosmetic composition containing a block copolymer, a tackifier, a silsesquioxane wax and/or resin
    Patent number: 8658141
    Abstract: The present invention is directed to a method of making up keratinous substrates involving applying onto the keratinous substrate a composition containing a) a block copolymer, b) a tackifier, c) an alkyl silsesquioxane wax, d) a liquid fatty phase, and e) optionally, a colorant.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: February 25, 2014
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Ann Marie Rohmeyer, Padraig McDermott