Patents Examined by Taina D Matos Negron
  • Substituted benzimidazoles and benzopyrazoles as CCR(4) antagonists
    Patent number: 9790204
    Abstract: Benzimidazole, benzopyrazole and benzotriazole compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: October 17, 2017
    Assignee: CHEMOCENTRYX, INC.
    Inventors: Manmohan Reddy Leleti, Yandong Li, Venkat Reddy Mali, Jay Powers, Ju Yang
  • Glucagon antagonists
    Patent number: 9783494
    Abstract: Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. Moreover, provided herein are methods of making or manufacturing compounds disclosed herein, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or Co-crystals and prodrugs thereof.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: October 10, 2017
    Assignee: METABASIS THERAPEUTICS, INC.
    Inventors: Jorge E. Gomez-Galeno, Scott J. Hecker, Qun Dang, Mali Venkat Reddy, Zhili Sun, Matthew P. Grote, Thanh Huu Nguyen, Robert Huerta Lemus, Haiqing Li
  • Method of managing chemotherapy induced alopecia or cachexia or both
    Patent number: 9775825
    Abstract: The present disclosure is related to management of chemotherapy induced side effects namely cachexia and alopecia by administering a pharmaceutical composition comprising pentameric type A procyanidin flavonoid, trimeric procyanidin flavonoid and tetrameric procyanidin flavonoid, optionally along with pharmaceutical excipients.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: October 3, 2017
    Assignee: Indus Biotech Private Limited
    Inventors: Sunil Bhaskaran, Mohan Vishwaraman
  • Synergistic fungicidal compositions
    Patent number: 9750248
    Abstract: A synergistic fungicidal mixture contains a fungicidally effective amount of a compound of Formula I, (3S,6S,7R,8R)-8-benzyl-3-(3-((isobutyryloxy)methoxy)-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl isobutyrate, and at least one triazole fungicide wherein Formula I is
    Type: Grant
    Filed: December 28, 2013
    Date of Patent: September 5, 2017
    Assignee: Dow Agrosciences LLC
    Inventors: David Ouimette, John Todd Mathieson, Chenglin Yao, Olavo Correa da Silva, Greg Kemmit
  • Methods of colchicine administration
    Patent number: 9675613
    Abstract: The invention provides improved methods for coadministration of colchicine with drugs metabolized by CYP3A4 (anciently referred to as cytochrome P450 isozyme 3A4) or the P-glycoprotein transporter, but not both. The method enables non-toxic coadministration of colchicine and the second drug at their ordinary levels safely and effectively without reducing the dose or frequency for either drug.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: June 13, 2017
    Assignee: Hikma Pharmaceuticals LLC
    Inventor: Murray Ducharme
  • Pharmaceutical compositions comprising POH derivatives
    Patent number: 9663428
    Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene for sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: May 30, 2017
    Assignee: NeOnc Technologies Inc.
    Inventors: Thomas Chen, Daniel Levin, Satish Pupalli
  • Proliposomal testosterone formulations
    Patent number: 9623033
    Abstract: Novel testosterone formulations are disclosed where testosterone is incorporated into a phospholipid/cholesterol system to produce a proliposomal powder dispersion. The proliposomal powder dispersions of the invention may be formulated with pharmaceutically acceptable excipients to form pharmaceutical compositions. Enterically coated oral dosage forms are disclosed as are methods of treatment for testosterone replacement therapy.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: April 18, 2017
    Assignees: WESTERN UNIVERSITY OF HEALTH SCIENCES, TESORX PHARMA, LLC
    Inventors: Guru V. Betageri, Ramachandran Thirucote, Veeran Gowda Kadajji
  • Method for on-demand contraception
    Patent number: 9616073
    Abstract: The invention relates to a method for on-demand contraception, which method comprises administering a progestogen agent or progesterone receptor modulator, such as 17a-acetoxy-11b-[4-N,N-dimethylamino-phenyl)-19-norpregna-4,9-diene-3,20-dione (ulipristal acetate) in a woman, within 72 hours before an intercourse or within 120 hours after the intercourse.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: April 11, 2017
    Assignees: Laboratoire HRA-Pharma, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Andre Ulmann, Erin Gainer, Henri Camille Mathe, Lynnette Nieman, Diana Blithe
  • Methods and compositions for the treatment of diverticulosis
    Patent number: 9616041
    Abstract: The present invention is directed to methods and compositions for the treatment of diverticulosis. It is more specifically directed to compositions including L-glutamine, its salts, or its derivatives, and uses of such compositions in the treatment of diverticulosis. In a method aspect, the present invention provides a method of treating diverticulosis. The method includes ingestion of 0.05 g/kg body weight to 10.0 g/kg body weight of L-glutamine, an L-glutamine salt or an L-glutamine derivative per day by a person who has diverticulosis.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: April 11, 2017
    Assignee: Emmaus Medical, Inc.
    Inventor: Yutaka Niihara
  • Thermally stable oil-in-water emulsions containing an oil that contains polyunsaturated fatty acids
    Patent number: 9585837
    Abstract: The present invention relates to thermally, stable oil-in-water emulsions comprising an oil comprising a polyunsaturated fatty acid, water, an emulsifier, and a water-soluble stabilizer, and processes for preparing the thermally stable oil-in-water emulsions. The thermally stable oil-in-water emulsions remain flowable at a temperature of ?40° C., and are free from a variation in particle size after 9 months in storage at a temperature of ?40° C. to ?15° C.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: March 7, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jimbin Mai, Micah Hazzy Needham, Gang Su, Wei Wang-Nolan, Chia-Ping Charles Hsu
  • Pharmaceutical compositions comprising POH derivatives
    Patent number: 9580372
    Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: February 28, 2017
    Assignee: NeOnc Technologies Inc.
    Inventors: Thomas Chen, Daniel Levin, Satish Pupalli
  • Purine derivatives for the treatment of viral infections
    Patent number: 9556176
    Abstract: The present invention relates to purine derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: January 31, 2017
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Jean-François Bonfanti, Frédéric Marc Maurice Doublet, Werner Embrechts, Jérôme Michel Claude Fortin, David Craig McGowan, Philippe Muller, Pierre Jean-Marie Bernard Raboisson
  • Methods of colchicine administration
    Patent number: 9555029
    Abstract: The invention provides improved methods for coadministration of colchicine with drugs metabolized by CYP3A4 (anciently referred to as cytochrome P450 isozyme 3A4) or the P-glycoprotein transporter, but not both. The method enables non-toxic coadministration of colchicine and the second drug at their ordinary levels safely and effectively without reducing the dose or frequency for either drug.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: January 31, 2017
    Assignee: HIKMA PHARMACEUTICALS LLC
    Inventor: Murray Ducharme
  • Composition containing serine as an active ingredient for the prevention and treatment of fatty liver diseases, and the use thereof
    Patent number: 9539226
    Abstract: The present invention is related to a composition comprising a serine as an active ingredient for treating or preventing fatty liver diseases. The inventive compound significantly inhibits the SREBP-1 transcription activity involved in lipid synthesis and reduced the fatty liver formation through various in vitro test and in vivo test therefore it can be useful in the prevention and treatment of the fatty liver diseases as a medicament or health functional food.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: January 10, 2017
    Assignee: SNU R&DB FOUNDATION
    Inventors: Byung-Hoon Lee, Hu-Quan Yin
  • Compositions containing berberine or analogs thereof for treating rosacea or red face related skin disorders
    Patent number: 9486402
    Abstract: The invention pertains to topical pharmaceutical formulations of berberine and its biologically equivalent analogs, such as palmatine and coptisine, for the treatment of rosacea and other red face-related skin disorders. The topical pharmaceutical formulations of this invention contain purified berberine as the primary active drug ingredient at concentrations higher than 0.1%. The invention also pertains to methods of treating rosacea and other red face related skin disorders, such as steroid-induced rosacea-like dermatitis, comprising the administration of topical pharmaceutical formulations that contain berberine or its biologically equivalent analogs, such as palmatine.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: November 8, 2016
    Assignee: Derman Biomedicine Co. Ltd
    Inventors: Shuen-Iu Hung, Wen-Hung Chung, Tse-Wen Chang
  • Aqueous compositions
    Patent number: 9468644
    Abstract: Suggested is a non-therapeutic aqueous composition for topical application, comprising (a) at least one solid active agent having at 20° C. a solubility in water (20° dH) of less than 5 g/L; (b) at least one 1,2-alkandiol having 4 to 12 carbon atoms; and (c) at least one aliphatic alcohol having 2 to 4 carbon atoms.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: October 18, 2016
    Assignee: Symrise AG
    Inventor: Cecile Kalem
  • Agent for stabilizing acetaminophen
    Patent number: 9452216
    Abstract: Provided is an agent for stabilizing acetaminophen in an aqueous composition, the agent comprising glycine. The agent further comprising at least one kind of sulfurous acid salt selected from the group consisting of sodium sulfite, potassium sulfite and potassium pyrosulfite is more effective. The stabilizing includes preventing precipitation.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: September 27, 2016
    Assignee: MARUISHI PHARMACEUTICAL CO., LTD.
    Inventors: Yutaka Itsuji, Yuko Itsuji, Mai Nomura, Hironori Nagahara
  • Proliposomal testosterone formulations
    Patent number: 9445995
    Abstract: Novel testosterone formulations are disclosed where testosterone is incorporated into a phospholipid/cholesterol system to produce a proliposomal powder dispersion. The proliposomal powder dispersions of the invention may be formulated with phamarceutically acceptable excipients to form pharmaceutical compositions. Enterically coated oral dosage forms are disclosed as are methods of treatment for testosterone replacement therapy.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: September 20, 2016
    Assignees: WESTERN UNIVERSITY OF HEALTH SCIENCES, TESORX PHARMA, LLC
    Inventors: Guru V. Betageri, Ramachandran Thirucote, Veeran Gowda Kadajji
  • Methods of colchicine administration
    Patent number: 9399036
    Abstract: The invention provides improved methods for coadministration of colchicine with drugs metabolized by CYP3A4 (anciently referred to as cytochrome P450 isozyme 3A4) or the P-glycoprotein transporter, but not both. The method enables non-toxic coadministration of colchicine and the second drug at their ordinary levels safely and effectively without reducing the dose or frequency for either drug.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: July 26, 2016
    Assignee: Hikma Pharmaceuticals LLC
    Inventor: Murray Ducharme
  • Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same
    Patent number: 9351966
    Abstract: The present disclosure relates to pharmaceutical compositions comprising omeprazole, lansoprazole and sodium bicarbonate. Methods of using such compositions are also provided.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: May 31, 2016
    Assignee: The Curators of the University of Missouri
    Inventor: Jeffrey O. Phillips