Patents Examined by Tamthom T. Ngo
  • Patent number: 6114341
    Abstract: The pyrimido[1,2-a]indoles according to the invention are prepared by reacting appropriately substituted phenylacetic acid derivatives with phenylglycinols. The pyrimido[1,2-a]indoles can be used as active compounds in medicaments, in particular in medicaments with antiatherosclerotic activity.
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: September 5, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Muller, Peter Eckenberg, Rudi Grutzmann, Hilmar Bischoff, Dirk Denzer, Stefan Wohlfeil, Stefan Lohmer, Ulrich Nielsch, Peter Kolkhof
  • Patent number: 6028072
    Abstract: A class of pyrazolyl compounds is described for use in treating inflammation and inflammation related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R.sup.1 is selected from hydrido, C.sub.1 -C.sub.20 -alkyl, C.sub.2 -C.sub.20 -alkenyl, C.sub.2 -C.sub.20 -alkynyl, C.sub.1 -C.sub.20 -haloalkyl, aryl-C.sub.1 -C.sub.20 -alkyl, heterocyclic-C.sub.1 -C.sub.20 -alkyl, heteroaryl-C.sub.1 -C.sub.20 -alkyl, C.sub.1 -C.sub.20 -hydroxyalkyl, C.sub.1 -C.sub.10 -alkoxyalkyl, C.sub.1 -C.sub.20 -cyanoalkyl, C.sub.1 -C.sub.20 -aminoalkyl, C.sub.1 -C.sub.20 -alkylamino-C.sub.1 -C.sub.20 -alkyl, carboxy-C.sub.1 -C.sub.20 -alkyl, C.sub.1 -C.sub.20 -alkoxycarbonyl-C.sub.1 -C.sub.20 -alkyl, C.sub.1 -C.sub.20 -alkylaminocarbonyl-C.sub.1 -C.sub.20 -alkyl, N-hydroxyaminocarbonyl-C.sub.1 -C.sub.20 -alkyl, N-hydroxy-N-C.sub.1 -C.sub.20 -alkyl-aminocarbonyl-C.sub.1 -C.sub.20 -alkyl, arylaminocarbonyl-C.sub.1 -C.sub.20 -alkyl and aminocarbonyl-C.sub.1 -C.sub.20 -alkyl;wherein R.sup.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: February 22, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Len F Lee, Thomas D Penning, Steven W Kramer, John J Talley
  • Patent number: 5968944
    Abstract: The compounds of the formula wherein A, R.sub.1, R.sub.3, X.sub.1, Y and Z are as defined herein, have corticotropin-releasing factor (CRF) antagonist activity. They are useful in the treatment of illnesses induced by CRF, such as stress and anxiety related disorders.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: October 19, 1999
    Assignee: Pfizer Inc.
    Inventors: Gene M Bright, Willard M Welch, Jr.
  • Patent number: 5969135
    Abstract: The present invention provides various novel oligonucleotide analogs having one or more properties that make the subject compounds superior to conventional oligonucleotides for use in procedures employing oligonucleotides. The compounds of the invention are oligonucleotide analogs in which the furanose ring of a naturally occurring nucleic acid is replaced with an amino acid or a modified amino alcohol residue. Some embodiments of the novel compounds of the invention are particularly useful for the antisense control of gene expression. The compounds of the invention may also be used as nucleic acid hybridization probes or as primers. Another aspect of the invention is to provide monomeric precursors of the oligonucleotide analogs of the invention. These monomeric precursors may be used to synthesize the subject polynucleotide analogs. Another aspect of the invention is to provide formulations of the subject polynucleotide analogs that are designed for the treatment or prevention of disease conditions.
    Type: Grant
    Filed: November 2, 1995
    Date of Patent: October 19, 1999
    Assignee: ICN Pharmaceuticals, Inc.
    Inventors: Kandasamy Ramasamy, Wilfried E. Seifert
  • Patent number: 5962453
    Abstract: The invention relates to a medicinal composition comprising a triazine derivative of the following general formula ?I! ##STR1## or a solvate thereof, or a salt thereof, as an active ingredient. In the above formula, R.sup.1 and R.sup.2 may be the same or different and each represents hydrogen, unsubstituted or substituted alkyl aralkyl, or alkenyl, or jointly represent cyclic amino (NR.sup.1 R.sup.2) in combination with the adjacent nitrogen atom. The cyclic amino may contain nitrogen, oxygen, or sulfur as a ring member in addition to the adjacent nitrogen and may be further substituted. Excluded is the case in which NR.sup.1 R.sup.2 is NH.sub.2. The compound of the invention is useful as a therapeutic drug for hepatitis.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: October 5, 1999
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Fusao Ueda, Takayuki Ozaki, Ken-ichi Nakamura
  • Patent number: 5952392
    Abstract: Therapeutic compositions including a nonionic surfactant combined with long chain fatty acids, alkanes, amides or mono-unsaturated alcohols, particularly stearyl alcohol, erucyl alcohol, brassidyl alcohol, arachidyl alcohol, n-docosane, n-docosanoic acid, erucamide and stearic acid, or mixtures thereof, as active ingredients are disclosed. Methods of preventing or treating viral infections, treating skin or membrane inflammation or inhibiting cell proliferation using such compositions are disclosed.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: September 14, 1999
    Assignee: Avanir Pharmaceuticals
    Inventors: David H. Katz, Laura E. Pope, Mohammed H. Khalil, John F. Marcelletti, Lee R. Katz
  • Patent number: 5932740
    Abstract: Disclosed is a novel near-infrared absorbing dye of formula: ##STR1## wherein X.sup.1, X.sup.2 independently represents --CR.sup.8 R.sup.9 --, --S--, --Se--, --NR.sup.10 --, --CH.dbd.CH-- or --O--;n is an integer of 2 or 3;R.sup.1 and R.sup.2 independently represent alkyl of 1 to 10 carbons or substituted alkyl of 1 to 10 carbons;R.sup.3 represents a ring chosen from a set consisting of aryl, substituted aryl, and a heterocyclic ring of a type present in photographic emulsions;R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently represent hydrogen, alkyl of 1-10 carbons, substituted alkyl of 1-10 carbons, R.sup.4 and R.sup.5 taken together or R.sup.6 and R.sup.7 taken together can represent atoms necessary to form a 5 or 6-membered aliphatic ring, an aromatic six-membered ring, an aromatic 10-membered ring, a substituted aromatic six-member ring or a substituted aromatic 10-member ring;R.sup.8, R.sup.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: August 3, 1999
    Assignee: Sterling Diagnostic Imaging, Inc.
    Inventors: Dietrich Max Fabricius, Gregory Charles Weed
  • Patent number: 5929072
    Abstract: A pharmaceutical compound having the formula: ##STR1## in which n is 1 or 2, m is 1 or 2, p is 1 to 6, q is 0 or 1 to 3,R.sup.1 and R.sup.2 are each hydrogen or C.sub.1-4 alkyl,R.sup.3, R.sup.4 and R.sup.5 are each hydrogen, C.sub.1-4 alkyl, optionally substituted phenyl or optionally substituted phenyl-C.sub.1-4 alkyl, or R.sup.3 and R.sup.4 together form an alkylene link of formula --(CH.sub.2).sub.3 -- or --(CH.sub.2).sub.4 --, or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached form a C.sub.3-6 cycloalkyl group,R.sup.6 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, carboxy, hydroxy, cyano, halo, trifluoromethyl, nitro or amino,the dotted line represents an optional double bond, andthe fluorine atom is attached at the 6 or 7-position;and salts and esters thereof.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: July 27, 1999
    Assignee: Eli Lilly and Company Limited
    Inventor: John Fairhurst
  • Patent number: 5929068
    Abstract: An optically active salt of 1,5-benzothiazepine compound of the formula (I) or (II): ##STR1## wherein each of Ring A and Ring B is a substituted or unsubstituted benzene ring, and R.sup.1 and R.sup.2 are the same or different and each is a lower alkyl group, can be prepared by resolving a racemic salt of 1,5-benzothiazepine compound of the formula (I) or (II) by means of preferential crystallization.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: July 27, 1999
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Ryuzo Yoshioka, Shin-ichi Yamada, Takeji Shibatani
  • Patent number: 5925649
    Abstract: The invention provides novel ascomycins bearing one or more physiologically hydrolyzable and acceptable oxycarbonyl moieties or carboxy moieties, such compounds being found useful as pharmaceuticals, especially in the treatment of asthma an dermatitis. Methods of producing the compounds and pharmaceutical compositions comprising the compounds are also provided.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: July 20, 1999
    Assignee: Novartis AG
    Inventors: Rene Hersperger, Reto Naef
  • Patent number: 5922738
    Abstract: The novel heteroaryloxypyridines of formula I: ##STR1## (A, B, R.sub.1 and R.sub.2 are defined in the specification) show excellent selective herbicidal activity.The new compounds can be prepared according to known methods and can be used as herbicides in agriculture and related fields.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: July 13, 1999
    Assignee: American Cyanamid Company
    Inventors: Thomas Maier, Stefan Scheiblich, Helmut Siegfried Baltruschat, Joseph Luke Pont
  • Patent number: 5922901
    Abstract: It is contemplated to provide an industrially adapted method for producing a dimerization product of acrylonitrile, which method is capable of producing a straight chain dimer of acrylonitrile efficiently at a high yield in a simple manner using a highly active catalyst exhibiting superior stability, without suffering from occurrence of difficulty removable by-products. In the method according to the present invention, acrylonitrile is subjected to dimerization in the presence of a ruthenium complex composed of a central atom of ruthenium and ligands including cyclopentadiene or its derivative coordinating thereto. The dimerization product, such as adiponitrile, 1,4-dicyanobutene or 1,4-dicyanobutadiene, is useful as an intermediate for producing hexamethylenediamine and adipic acid, both serving for the starting material of nylon 66, or as an intermediate for producing, for example, an antirusting agent and a vulcanization accelerator for rubbers.
    Type: Grant
    Filed: February 26, 1997
    Date of Patent: July 13, 1999
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Yasuhiko Suzuki, Yoshihisa Kiso
  • Patent number: 5922720
    Abstract: Compounds of formula I are piperazinothiopyridines which are useful for controlling Helicobacter bacteria. They are useful as active compounds for treating diseases based on such bacteria, and are thus useful for making appropriate medicament compositions for administering to humans afflicted with diseases based on or caused by such bacteria.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: July 13, 1999
    Assignee: Byk Gulden Lomberg Chemische Fabrik GmbH
    Inventors: Bernhard Kohl, Gerhard Grundler, Jorg Senn-Bilfinger
  • Patent number: 5919791
    Abstract: The compounds of formula: ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and A are as defined in the description, their optical isomers and N-oxides and addition salts thereof with a pharmaceutically acceptable acid or base, and their use as anti-tumour agents.
    Type: Grant
    Filed: December 29, 1997
    Date of Patent: July 6, 1999
    Assignee: Adir et Compagnie
    Inventors: Claude Guillonneau, Emile Bisagni, Yves Charton, Ghanem Atassi, Alain Pierre, Stephane Leonce
  • Patent number: 5916863
    Abstract: The present invention generally relates to a textile softening composition which comprises, as the softening agent, a quaternary ammonium salt which comprises a mixture of mono-, di- and tri-ester components, wherein the amount of diester quaternary is greater than about 55% by weight, and the amount of triester quaternary is less than about 25% by weight based on the total amount of quaternary ammonium salt. The invention also relates to a process for preparing said softening agent.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: June 29, 1999
    Assignee: Akzo Nobel NV
    Inventors: Paul Albert Iacobucci, Ralph Franklin, Phuong-Nga Trinh
  • Patent number: 5914329
    Abstract: The dimesylate salt of cis-1-(3-ethoxyphenyl)-1-(4-phenylpiperazin-1-yl)4-methyl-cyclohexane has superior properties and is useful to treat physiological disorders associated with an excess of neuropeptide Y.
    Type: Grant
    Filed: November 18, 1997
    Date of Patent: June 22, 1999
    Assignee: Pfizer Inc.
    Inventors: Douglas J. M. Allen, Lyle R. Brostrom, Alireza S. Kord, Laurie A. Whipple
  • Patent number: 5912375
    Abstract: Reaction products of an iridium (III) salt or a hydrate thereof, a diphosphine having secondary phosphine groups and a metal or ammonium chloride, bromide or iodide are excellent hydrogenation catalysts for ketimine. Using chiral diphosphines and prochiral ketimines, diastereoisomeric secondary amines are obtained in high optical yields.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: June 15, 1999
    Assignee: Novartis Corporation
    Inventors: Felix Spindler, Ulrich Pittelkow
  • Patent number: 5912243
    Abstract: A compound having the formula R--S(O).sub.n CH.sub.2 CH.sub.2 CH.dbd.CF.sub.
    Type: Grant
    Filed: August 28, 1996
    Date of Patent: June 15, 1999
    Assignee: Zeneca Limited
    Inventors: Alan John Dowling, Alison Mary Craig, Christopher Richard Ayles Godfrey, Harjinder Singh Bansal, Matthew Brian Hotson, Michael Drysdale Turnbull, Nan Catherine Sillars, Roger Salmon, Steven Fitzjohn
  • Patent number: 5910506
    Abstract: An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R.sup.1 represents hydrogen, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.7 alkenyl, C.sub.4 -C.sub.12 cycloalkylalkyl, etc.; R.sup.2 represents C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 acyl, hydroxyiminomethyl, hydrazonomethyl or --(CH.sub.2)n--R.sup.4 (R.sup.4 being halogeno, alkoxy, hydroxy, etc.; and n being an integer of 1 to 3); R.sup.3 represents substituted or unsubstituted C.sub.1 -C.sub.6 alkyl; X and Y represent each independently hydrogen, C.sub.1 -C.sub.3 alkyl, halogeno, or nitro; and Z represents S, SO, SO.sub.2 or CH.sub.2.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: June 8, 1999
    Assignee: Shionogi & Co., Ltd.
    Inventors: Hirohiko Sugimoto, Tamio Fujiwara
  • Patent number: 5910495
    Abstract: A method of controlling gastric emptying in patients having an early non-insulin-dependent diabetic condition and exhibiting rapid gastric emptying comprising the administration of an effective gastric emptying controlling amount of a compound of Formula (I) ##STR1## or a physiologically acceptable salt or solvate thereof.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: June 8, 1999
    Assignee: Glaxo Wellcome Inc.
    Inventor: Rochelle Marie Hanley