Patents Examined by Tamthom T. Ngo
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Patent number: 5856324Abstract: The present invention relates to the use of dioxomorpholines of the formula (I) ##STR1## in which the radicals R.sup.1 to R.sup.5 have the meanings given in the description, their use for combating endoparasites and new dioxomorpholines and processes for their preparation.Type: GrantFiled: May 2, 1997Date of Patent: January 5, 1999Assignee: Bayer AktiengesellschaftInventors: Andrew Plant, Jurgen Scherkenbeck, Peter Jeschke, Achim Harder, Norbert Mencke
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Patent number: 5854249Abstract: A method for the treatment or prophylaxis of one or more conditions or disorders selected from the group consisting of physiological pain, diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depressioysema, apnea, cognitive disorders and gastrointestinal disorders, comprising administration to a subject in need of such treatment or prophylaxis, of a diarylmethylpiperazine or piperidine opioid compound.Type: GrantFiled: May 28, 1997Date of Patent: December 29, 1998Assignee: Delta Pharmaceuticals, Inc.Inventors: Kwen-Jen Chang, Grady Evan Boswell, Dulce Garrido Bubacz, Mark Allan Collins, Ann Otstot Davis, Robert Walton McNutt, Jr.
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Patent number: 5852028Abstract: Compounds having utility as anti-inflammatory agents in general and, more specifically, for the prevention and/or treatment of immunoinflammatory and autoimmune diseases are disclosed. The compounds are pyrimidine-containing compounds and, in one embodiment, are esters of the same. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.Type: GrantFiled: December 18, 1995Date of Patent: December 22, 1998Assignee: Signal Pharmaceuticals, Inc.Inventors: Mark J. Suto, Leah M. Gayo, Moorthy S. S. Palanki, Lynn J. Ransone-Fong
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Patent number: 5849758Abstract: New herbicidal pyrimidine derivatives of general formula (I), ##STR1## wherein Z represents a nitrogen atom; A represents a substituted aryl group or an optionally substituted pyridyl or pyrazolyl group; n represents an integer from 0 to 2 and R.sup.1 or each R.sup.1 independently represents a hydrogen atom or an optionally substituted alkyl, alkoxy, alkylthio or dialkylamino group; m represents an integer from 0 to 5 and R.sup.2 or each R.sup.2 independently represents a hydrogen or a halogen atom or an optionally substituted alkyl, haloalkyl, haloalkoxy, alkoxy, alkylthio group or a nitro, cyano or a halosulphonyl group; and X represents an oxygen or sulphur atom.Type: GrantFiled: August 7, 1996Date of Patent: December 15, 1998Assignee: American Cyanamid CompanyInventors: Axel Kleemann, Helmut Siegfried Baltruschat, Thekla Hulsen, Thomas Maier, Stefan Scheiblich
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Patent number: 5847158Abstract: A process for preparing a compound of formula (I): ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl or benzyl, and wherein the phenyl moiety of said benzyl group is optionally substituted with one or two substituents each independently selected from halo, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, amino and trifluoromethyl, which comprises treating a solution of a compound of formula (II): ##STR2## wherein R is as defined for formula (I), and a halonitromethane in a first organic solvent, with a quaternary ammonium fluoride of formula (III):R.sup.1 R.sup.2 R.sup.3 F.sup.4 N.sup.+ F.sup.- (III)wherein R.sup.1,R.sup.2,R.sup.3 and R.sup.4 are each independently selected from C.sub.1 -C.sub.8 alkyl and benzyl, optionally in solution in a second organic solvent.Type: GrantFiled: June 19, 1997Date of Patent: December 8, 1998Assignee: Pfizer Inc.Inventor: Nicholas John Lawson
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Patent number: 5847211Abstract: The invention relates to new 1H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) ##STR1## in which A, B, X, Y and G have the meanings given in the description,to a plurality of processes for their preparation, and to their use as pesticides.Type: GrantFiled: December 3, 1996Date of Patent: December 8, 1998Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Thomas Bretschneider, Bernd-Wieland Kruger, Michael Ruther, Christoph Erdelen, Ulrike Wachendorff-Neumann, Hans-Joachim Santel, Markus Dollinger
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Patent number: 5843984Abstract: Sulfated benzothiophenes of the formula I ##STR1## wherein R.sup.1 is hydrogen, hydroxy, C.sub.1 -C.sub.4 alkoxy, --OCOO(C.sub.1 -C.sub.6 alkyl), --OCO(C.sub.1 -C.sub.6 alkyl), --OCOAr wherein Ar is phenyl or optionally substituted phenyl, --OSO.sub.2 (C.sub.4 -C.sub.6 straight chain alkyl), or --OSO.sub.3 H;R.sup.2 is R.sup.1, Cl or F; with the proviso that at least one of R.sup.1 or R.sup.2 is --OSO.sub.3 H;R.sup.3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; andn is 2 or 3;or a pharmaceutically acceptable salt or solvate thereof.Type: GrantFiled: April 14, 1997Date of Patent: December 1, 1998Assignee: Eli Lilly and CompanyInventors: Michael Paul Clay, Charles Alan Frolik, Charles David Jones, Terry Donald Lindstrom
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Patent number: 5837719Abstract: The present invention addresses 2, 5-substituted aryl pyrroles of the formula: ##STR1## or a pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods of treatment. The compounds are useful for treating Cytokine mediated diseases, which refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved in immunoregulation and other physiological conditions, such as inflammation. The compounds also have glucagon antagonist activity.Type: GrantFiled: August 8, 1996Date of Patent: November 17, 1998Assignee: Merck & Co., Inc.Inventors: Stephen E. de Laszlo, Nigel J. Liverton, Gerald S. Ponticello, Harold G. Selnick, Nathan B. Mantlo
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Patent number: 5834411Abstract: An aqueous metal cleaning composition is provided which comprises an alkalinity providing agent such as alkali metal carbonate and/or bicarbonate salts and a low foaming surfactant. The aqueous cleaning solution has specific foam height and foam collapse characteristics, and provides for substantially complete phase separation of a contaminant phase from the aqueous cleaning composition such that there is substantially no aqueous phase drag out into the contaminant phase; and the contaminant phase can be removed easily, and the aqueous cleaning solution can be recovered and reused.Type: GrantFiled: September 5, 1996Date of Patent: November 10, 1998Assignee: Church & Dwight Co., IncInventors: Steven A. Bolkan, Gale A. Byrnes, Steven Dunn, Alfredo Vinci, Antony E. Winston, Patricia L. Phillips
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Patent number: 5827877Abstract: The present invention is directed to novel ketomethylene group-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.Type: GrantFiled: May 7, 1996Date of Patent: October 27, 1998Assignee: Cephalon, Inc.Inventor: Sankar Chatterjee
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Patent number: 5824822Abstract: A phosphine-phosphinite compound represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represent a substituted or unsubstituted phenyl group or a substituted or unsubstituted naphthyl group, and a process for preparing a 4-?(R)-1'-formylethyl!azetidin-2-one derivative using the compound (I). The compound (I), either in combination, or as a complex, with a transition metal compound, is useful as a catalyst for asymmetric hydroformylation and makes it possible to easily synthesize an important intermediate for carbapenem antibiotics or a precursor thereof at high regioselectivity and diastereo-selectivity.Type: GrantFiled: July 9, 1996Date of Patent: October 20, 1998Assignee: Takasago International CorporationInventors: Takao Saito, Akifumi Yoshida, Kazuhiko Matsumura, Takashi Miura, Hidenori Kumobayashi
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Patent number: 5824813Abstract: A number of layered vanadium oxide crystalline compositions are prepared by simple hydrothermal reactions. Generally, the compositions comprise parallel layers of mixed valence vanadium oxides with guest cations intercalated between the layers. The guest cations may comprise metal coordination complexes with bidentate ligands, monomeric ammonium or diammonium cations, or mixtures of alkali metal cations with monomeric ammonium cation or diammonium cations.Type: GrantFiled: October 31, 1997Date of Patent: October 20, 1998Assignees: NEC Research Institute, Inc., Texas A&M University, Syracuse UniversityInventors: Jeffrey Robert Douglas DeBord, Robert C. Haushalter, Yiping Zhang
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Patent number: 5824679Abstract: The invention concerns novel phosphanoxides of formula 1 in which R.sup.1 means aryl or heteroaryl group. The invention further concern the optically active forms, racemates and diastereomers mixtures of these compounds, a method of preparing them and pharmaceutical compositions containing these compounds, and methods of use to produce a thrombin-inhibiting effect.Type: GrantFiled: February 28, 1997Date of Patent: October 20, 1998Assignee: Boehringer Mannheim GmbHInventors: Wolfgang Von Der Saal, Herbert Leinert, Karlheinz Stegmeier
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Patent number: 5821251Abstract: This invention concerns a compounds of generic formula: ##STR1## or a pharmaceutically acceptable salt thereof, where the dotted lines represent optional bonds with the nitrogen ring optional bonds being between one adjacent pair on ring atoms,R.sup.3 is an optionally substituted C.sub.6 -C.sub.10 aryl or heteroaryl group; said aryl or heteroaryl radicals being optionally substituted by one or more substituents the same or different,R.sup.4 represents hydrogen, or a group of formula --CR.sup.a R.sup.b R.sup.c where R.sup.a, R.sup.b and R.sup.c are independently selected from hydrogen, C.sub.1 -C.sub.6 alkyl, optionally substituted C.sub.6 -C.sub.10 aryl, optionally substituted heteroaryl, C.sub.1 -C.sub.6 alkyl substituted by optionally substituted C.sub.6 -C.sub.10 aryl or heteroaryl,R' represents one or more optional substituents the same or different, selected from one or more of the following: halogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.7 alkoxycarbonyl, C.sub.1 -C.sub.Type: GrantFiled: April 10, 1996Date of Patent: October 13, 1998Assignee: John Wyeth & Brother LimitedInventors: Roger Crossley, Albert Opalko, Peter Jonathan Meade, Barry John Langham
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Patent number: 5817659Abstract: This invention relates to stable crystalline salts of (6R,S)-, (6S)- and (6R)-tetrahydrofolic acid, to methods of preparing these salts and to their use as an ingredient for the production of drugs and pharmaceutical preparations.Type: GrantFiled: November 7, 1996Date of Patent: October 6, 1998Assignee: Eprova AGInventors: Hans R. Muller, Martin Ulmann, Rudolf Moser, Thomas Ammann
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Patent number: 5817683Abstract: Naphthoic derivatives of the Formula (I) ##STR1## wherein the variables are defined herein; and pharmaceutical compositions containing these compounds, and their use as endothelin receptor antagonists are disclosed.Type: GrantFiled: April 8, 1996Date of Patent: October 6, 1998Assignee: SmithKline Beecham CorporationInventors: John Duncan Elliott, Jia-Ning Xiang
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Patent number: 5817656Abstract: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-?2,3-b!?1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of mental disorders.Type: GrantFiled: November 13, 1996Date of Patent: October 6, 1998Assignees: Eli Lilly and Company, Eli Lilly and Company LimitedInventors: Charles M. Beasley, Jr., Jiban Kumar Chakrabarti, Terrence Michael Hotten, David Edward Tupper
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Patent number: 5817657Abstract: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-?2,3-b!?1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders relating to the use of psychoactive substances.Type: GrantFiled: November 13, 1996Date of Patent: October 6, 1998Assignees: Eli Lilly and Company, Eli Lilly and Company LimitedInventors: Charles M. Beasley, Jr., Jiban Kumar Chakrabarti, Terrence Michael Hotten, David Edward Tupper
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Patent number: 5817655Abstract: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno -?2,3-b!?1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system.Type: GrantFiled: November 13, 1996Date of Patent: October 6, 1998Assignees: Eli Lilly and Company, Eli Lilly and Company LimitedInventors: Jiban Kumar Chakrabarti, Terrence Micharl Hotten, David Edward Tupper
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Patent number: 5807851Abstract: Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions.Type: GrantFiled: April 4, 1997Date of Patent: September 15, 1998Assignee: Egis Gyogyszergyar Rt.Inventors: Istvan Ling, Gizella Abraham, Pal Berzsenyi, Istvan Tarnawa, Sandor Solyom, Ferenc Andrasi, Tamas Hamori, Emese Csuzdi, Katalin Horvath, Melinda Gal, Imre Moravcsik, Marta Szollosy