Abstract: The disclosure relates to a drug delivery device for expelling a pre-determined or pre-settable amount of a liquid medicament formulation which improves the stalling behavior and indicates the stalling state to the user. The device comprises: a medicament reservoir attached to a housing and an expelling mechanism configured for acting against the medicament reservoir in order to expel a portion of the liquid medicament formulation therefrom, the expelling mechanism comprising an arrangement of a threaded nut in a fixed axial relation to the housing and a lead screw in threaded engagement with the threaded nut, the threaded nut and the lead screw being rotatable relative to each other by a rotational input interface, a mechanical energy reservoir (for storing energy, the stored energy being releasable from the energy reservoir by a rotational interface, a drive train having upstream and downstream interfaces; and a trigger movable relative to the housing.

Abstract: Aspects of the present invention relate to a delivery device for locating an expandable implant for treating BPH within the prostatic urethra of a patient. The delivery device comprises an inner tube and an outer sleeve movable relative to the inner tube between a stored position and a deployed position. The outer sleeve surrounds the inner tube to define an annulus therebetween and the expandable implant is retained within the annulus when the outer sleeve is in the stored position.

Abstract: A clutch assembly with a blocking system for a medical injection device, in which a first ratchet sleeve (3) is mounted on the clutch sleeve (2), the first ratchet sleeve (3) being rotatable in two directions and cooperating with a second ratchet sleeve (4) which is mounted on the first ratchet sleeve (3), the second ratchet sleeve (4) being rotatable only in one direction, the housing (1) has an internal toothed ring (1.1), the first ratchet sleeve (3) has at least one ratchet (3.1), and the second ratchet sleeve (4) has an internal toothed ring (4.1) and at least one ratchet (4.2). The second ratchet sleeve (4) and the housing (1) have blocking means (4.3, 1.2) for preventing the arming of the device when an insufficient volume of the medicament remains in the container, by blocking the rotation of the second ratchet sleeve (4) in relation to the housing (1).

Abstract: An add-on device adapted to be releasably mounted on a drug delivery device, the add-on device comprising an outer assembly with an add-on dose setting member adapted to be coupled to the outer housing of a pen housing, as well as an inner assembly engaging the pen dose setting member and being in rotational engagement with the add-on dose setting member during dose setting. The invention addresses the issue of preventing transfer of movement from the add-on dose setting member to the inner assembly during dose expelling, which in accordance with the invention is realized by rotationally de-coupling the inner and outer assembly during dose expelling.

Abstract: A needle-equipped outer cylinder includes: a needle tube; a joining member comprising: a needle tube accommodation hole that accommodates a proximal end side portion of the needle tube and penetrates the joining member from a distal end of the joining member to a proximal end of the joining member, and a joining outer peripheral portion provided on an outer peripheral portion of the needle tube accommodation hole; and an outer cylinder member comprising: a distal end joint that comprises an inner cavity that receives the joining outer peripheral portion of the joining member from a distal end side, and a projection located at a proximal end portion of the inner cavity and projecting into the inner cavity. The joining member comprises, at a proximal end portion of the joining member, an abutment portion that abuts the projection of the outer cylinder member.

Abstract: Provided is an indwelling catheter which is stiff when being inserted into a vessel such as a blood vessel, softens after indwelling in the vessel, and conforms to a shape in a direction in which the vessel runs. In the indwelling catheter, the maximum value of a catheter repulsive force in a dry state at 25° C. is 0.10 N or more; the maximum value of the catheter repulsive force when immersed in warm water at 37° C. is 0.01 to 0.25 N; a ratio of the maximum value of the catheter repulsive force in a dry state at 25° C. to the maximum value of the catheter repulsive force when immersed in warm water at 37° C. is in a range of 3.5:1 or more; and the maximum value of the catheter repulsive force when immersed in warm water at 37° C. is 0.027 N or less after 5 minutes from indwelling.

Abstract: A temporary low profile intraluminal catheter for infusing agents into, or extracting fluids from, a bodily lumen featuring securement structure, wherein the securement structure allows the catheter to be placed with minimal intrusion into the bodily lumen is disclosed. With such design affording a more efficient, verifiable placement of the catheter with less complication due to infection and biofilm related issues, among other types of complications.

Abstract: A tampon and delivery system for a pharmaceutical, holistic or medicinal component, includes: (1) a nonabsorbent vaginal implant having a generally cylindrical shape including a leading end and a cylindrical outer surface; (2) an outer delivery sheath applied to at least a portion of the cylindrical outer surface of the tampon, distal from the leading end (and preferably leaving the leading end exposed), where the outer delivery sheath comprises a formulation including (a) a water soluble polymer film carrier and (b) a pharmaceutical, holistic or medicinal component; and (3) an applicator containing the tampon and applied delivery sheath. Methods for preparation of the delivery system and methods of use are also disclosed.

Abstract: A catheter insertion device for inserting a catheter into a body of a patient is disclosed. The catheter insertion device includes a retractable needle for establishing access to a subcutaneous vessel of the patient and a manually extensible guidewire for guiding the initially attached catheter into the vessel. In one embodiment, the catheter insertion device comprises a housing, a hollow needle retractably extending from the housing, a catheter initially disposed on a portion of the needle, a guidewire including a portion initially disposed within the needle, a guidewire advancement feature configured to selectively advance a distal end of the guidewire distally past a distal end of the needle, and a needle retention component configured to selectively enable retraction of the needle into the housing. The needle retention component is configured to be actuated by the guidewire advancement feature. In one embodiment, one-handed operation of the device is possible.

Abstract: An auto-injector is provided which includes a housing with a syringe slidably received therein. The syringe has a barrel with a piston movable therein and a needle extending therefrom. The piston is releasably secured to one end of a plunger which is slidably secured within a body in the housing and is operable through a bias provided by a motive source. In use, the plunger moves under the bias from a loaded condition to a discharged condition to move the syringe so that the needle extends from a tip at an injection end of the housing and to slide the piston within the barrel to expel the contents of the syringe. The plunger is held in the loaded condition against the bias by a detent extending from the body and which can be selectively released by operation of an actuator when pressure is applied to the tip.

Abstract: The invention relates to an autoinjector 59 for administering a fluid medicament to a subject comprising: a housing 1 for receiving a cartridge holder; a driver assembly 8; the driver assembly on actuation may move the cartridge 3 forward in the cartridge holder 2; a needle cover 4 may be coupled to the housing wherein the needle cover 4 travels in a linear or translational movement; said needle cover 4 is adapted to protect a needle when the needle cover may be in first locking position 17 and second locking position 18; the linear or translational movement may be achieved by a cam profile 13 and a cam follower 14; the cam profile 13 may be provided on outside surface of housing and the cam follower 14 located between the needle cover 4 and the housing 1; a first biasing member 15; and a second biasing member 16 configured to bias the cartridge 3 and the needle cover 4 respectively; and a safety cap 11 to control the actuation of the autoinjector.

Abstract: A guidewire support accessory includes one or more hollow tubular sections, each of the hollow tubular sections including a first end and an opposing second end for individually supporting a plurality of medical guidewires. A connector is disposed at the first end. Each of the one or more hollow tubular sections is sized and configured to receive a medical guidewire maintained in a coiled arrangement. The accessory includes at least one clamp configured to releasably retain a guidewire in the coiled arrangement, as well as at least one wiping or cleaning feature.

Abstract: A syringe adapter includes a housing having a first end and a second end and defining an interior space, a seal arrangement received within the interior space of the housing, a connector body positioned adjacent the first end of the housing and configured to be connected with a syringe barrel with the connector body secured to the housing and rotatable relative to the housing in first and second directions, and a cannula secured to the connector body. The connector body is axially fixed relative to the housing. The seal arrangement is configured to cooperate with the cannula to provide a sealed transfer of fluids through the cannula to a mating connector.

Abstract: An injection device (10) comprises an injection solution receptacle (30) and a plunger (70) at least a portion of which is slidably received in the injection solution receptacle (30), wherein the plunger (70) is displaceable relative to the injection solution receptacle (30) in a distal direction in order to expel an injection solution contained in the injection solution receptacle (30) from the injection solution receptacle (30). A first plunger stop mechanism (140) is adapted to stop a displacement of the plunger (70) relative to the injection solution receptacle (30) in the distal direction at a first dosing position (P1).

Abstract: A guide extension catheter includes a push member and a distal shaft coupled to and extending distally from the push member. The distal shaft includes a shaft wall and a passageway. The shaft wall includes a helically-shaped proximal end and a distal end. The helically-shaped proximal end coils helically about a first central longitudinal axis of the passageway of the distal shaft. The helically-shaped proximal end of the shaft wall defines a helically-shaped entry port of the distal shaft. The distal shaft may include a helically-shaped collar coupled to the helically-shaped proximal end of the distal shaft, the collar defining the helically-shaped entry port of the distal shaft.

Abstract: A syringe cartridge including a reservoir part and an extension extending from the reservoir part. The extension defining a fluid path and including a molding and a first needle extending from the molding. The extension turning to a finite angle with respect to an axis of the reservoir part and at least part of the first needle is likewise at the finite angle. At least some of the part of the first needle at the finite angle being enclosed within the molding of the fluid path. A drug delivery device may be used with the cartridge and includes a skin-contacting surface. In use the longitudinal axis of the interior of the cartridge may be disposed substantially parallel to the skin-contacting surface.

Abstract: An injection-device and an injection-measuring method are described. The injection-device includes a pen-type sleeve for accommodating a cartridge holder, a mechanical injection system provided in the pen-type sleeve, which has a dosing sleeve by which a dosage quantity to be injected is predefinable and which is configured to execute a rotatory motion during the injection process; a selector device, connected to the dosing sleeve, for adjusting the dosage quantity to be injected; an injection button, connected to the selector device, for applying an injection force; and an optical sensor device for detecting the rotatory motion of the dosage sleeve during injection of the dosage quantity, which has a signal-processing device for ascertaining and storing the injected dosage quantity based on the detected rotatory motion of the dosage sleeve. The injection button has a switch device by which the optical sensor device is activatable when applying the injection force.

Abstract: Implementations of the present disclosure are directed to a module for attachment to an injection device that includes a flexible carrier foil configured to be attached to a surface of the injection device independent of a geometry of the surface, at least one light emitting diode attached to the flexible carrier foil in a first position and configured to emit a light signal in a direction based on the first position through a transparent wall of the injection device, at least one photodiode attached to the flexible carrier foil in a second position relative to the first position, the at least one photodiode being configured to detect at least a portion of the light signal from a direction based on the second position and being configured to emit an electrical signal based on the light signal to a microprocessor, and wherein the microprocessor is configured to receive the electrical signal emitted by the photodiode and to determine the position of a stopper and the amount of the fluid within the injection dev

Abstract: A medicament delivery device includes a housing configured to receive a container of medicament and a piston rod moveable within the housing and configured to engage a container of medicament when received within the housing. The medicament delivery device further includes a position-sensing mechanism configured to detect the position of the piston rod within the housing. The position-sensing mechanism includes a first light source configured to emit light, a first sensor disposed proximate the first light source and configured to receive light emitted by the first light source, and a blocking member moveable between the first light source and the first sensor. The first sensor is configured to detect the light pattern received to determine the position of the piston rod within the housing.

Abstract: A drug delivery device comprises a medication container containing medication for delivery and a detachable unit having an electronic circuit with a microprocessor. The electronic circuit is open and non-operational when the detachable component is assembled on the drug delivery device; and the electronic circuit is closed and operational when the detachable component is detached from the drug delivery device. The detachment of the detachable unit is an essential step to operate the drug delivery device. The detachable unit can be an activation protection cap or a needle shield remover for an autoinjector device. Alternatively, the detachable unit can be a needle shield remover for a pre-filled syringe.