Patents Examined by Taylor Victor Oh
  • Hydrogenation processes
    Patent number: 7875742
    Abstract: The present invention is directed to a process for hydrogenating one or more organic compounds especially unsaturated organic compounds by bringing the compound into contact with a hydrogen-containing gas in the presence of a catalyst, which comprises one or more catalytically active metals applied to a porous catalyst support. The one or more catalytically active metals having been derived via a decomposed organic complex of the metal on the support, in particular amine complexes of the metal. The decomposed complex may be treated with hydrogen to activate the catalyst before use as a hydrogenation catalyst.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: January 25, 2011
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Stuart Leon Soled, Andrzej Malek, James Clarke Vartuli, Jennifer Schaefer Feeley, Sabato Miseo, Shifang Luo, Richard Henry Schlosberg, Joseph Ernest Baumgartner, Christine E. Kliewer, Steven T. Ragomo
  • Low pressure carbonylation of heterocycles
    Patent number: 7875734
    Abstract: Heterocycles, e.g., epoxides, are carbonylated at low pressure with high percentage conversion to cyclic, ring expanded products using the catalyst where L is tetrahydrofuran (THF).
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: January 25, 2011
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Geoffrey W. Coates, John W. Kramer, Joseph A. R. Schmidt
  • Inhibitors of ?mediated cell adhesion
    Patent number: 7872151
    Abstract: The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: January 18, 2011
    Assignee: Mitsubishi Tanabe Pharma Corporation
    Inventors: Takayuki Kawaguchi, Sumihiro Nomura, Mikiko Tsukimoto, Toshiyuki Kume, Ila Sircar
  • Synthesis of diester-based biolubricants from epoxides
    Patent number: 7867959
    Abstract: The present invention is generally directed to methods of making diester-based lubricant compositions, wherein formation of diester species proceeds via direct esterification of epoxide intermediates. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor and/or low value (e.g., Fischer-Tropsch (FT) olefins and/or alcohols) so as to produce high value diester-based lubricants. In some embodiments, such diester-based lubricants are derived from FT olefins and tatty acids. The fatty acids can be from a bio-based source (i.e., biomass, renewable source) or can be derived from FT alcohols via oxidation.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: January 11, 2011
    Assignee: Chevron U.S.A. Inc.
    Inventors: Stephen Joseph Miller, Zhen Zhou, Saleh A. Elomari
  • Carboxylic acid production process
    Patent number: 7863483
    Abstract: Disclosed are processes and apparatus for producing a carboxylic acid. The processes employ a concentration section disposed before and/or after a product isolation section, which allows for oxidation byproducts produced in the process to exit the product isolation section with the isolated carboxylic acid product and/or to be combined with the isolated carboxylic acid product downstream of the product isolation section at a rate of at least about 15 percent of the net make rate of the oxidation byproducts in the production process.
    Type: Grant
    Filed: February 12, 2007
    Date of Patent: January 4, 2011
    Assignee: Eastman Chemical Company
    Inventors: Philip Edward Gibson, Kenny Randolph Parker
  • Intermediate compounds useful to prepare dolasetron
    Patent number: 7858821
    Abstract: The present invention relates to intermediates useful in the synthesis of Dolasetron and synthetic precursors thereof, as well as to processes for obtaining them. In addition, it refers to the hydrochloric salt of Dolasetron and polymorphic forms of Dolasetron and precursors thereof.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: December 28, 2010
    Assignee: INKE, S.A.
    Inventors: Juan Antonio Pérez Andrés, Pere Dalmases Barjoan, Joan Huguet Clotet
  • S-(?, ??-disubstituted-??-acetic acid)—substituted dithiocarbonate derivatives for controlled radical polymerizations, process and polymers made therefrom
    Patent number: 7851582
    Abstract: Dithiocarbonate derivatives are disclosed, along with a process for preparing the same. The dithiocarbonate compounds can be utilized as initiators, chain transfer agents and/or terminators in controlled free radical polymerizations. The dithiocarbonates can be used to produce polymers having narrow molecular weight distribution. Advantageously, the compounds of the present invention can also introduce functional groups into the resulting polymers. The dithiocarbonate compounds have low odor and are substantially colorless.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: December 14, 2010
    Assignee: Lubrizol Advanced Materials, Inc.
    Inventor: John Ta-Yuan Lai
  • Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
    Patent number: 7850008
    Abstract: The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: December 14, 2010
    Assignee: Photocure ASA
    Inventors: Karl E. Gierskcky, Johan Moan, Qian Peng, Harald Steen, Trond Warloe, Alf Bjørseth
  • Carboxylic acid production process
    Patent number: 7847121
    Abstract: Disclosed are processes and apparatus for producing a carboxylic acid. The processes employ a concentration section disposed before and/or after a product isolation section, which allows for oxidation byproducts produced in the process to exit the product isolation section with the isolated carboxylic acid product and/or to be combined with the isolated carboxylic acid product downstream of the product isolation section at a rate of at least about 15 percent of the net make rate of the oxidation byproducts in the production process.
    Type: Grant
    Filed: February 12, 2007
    Date of Patent: December 7, 2010
    Assignee: Eastman Chemical Company
    Inventors: Philip Edward Gibson, Kenny Randolph Parker
  • Recovery and recycling of chiral tartaric acid resolving agents
    Patent number: 7838700
    Abstract: A process for the recovery of substituted tartaric acid resolving agents from resolution process liquors comprising organic solvents, wherein the substituted tartaric acid derivatives are neutralised by adding a base, extracted into an aqueous phase and crystallized from the aqueous phase by addition of a mineral acid in the presence of an organic solvent.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: November 23, 2010
    Assignee: Aesica Pharmaceuticals
    Inventors: Steve Martin, Daniele Piergentili
  • Control method for process of removing permanganate reducing compounds from methanol carbonylation process
    Patent number: 7838701
    Abstract: Disclosed is a method of controlling a separation process for removing permanganate reducing compounds from a process stream in the methanol carbonylation process for making acetic acid, where the method includes the steps of measuring the density of a stream containing acetaldehyde and methyl iodide, optionally calculating the relative concentrations of acetaldehyde and methyl iodide in the stream, and adjusting distillation or extraction process parameters based on the measured density or one or more relative concentrations calculated therefrom.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: November 23, 2010
    Assignee: Celanese International Corporation
    Inventors: David A. Trueba, Shrikant Kulkarni
  • Process for producing 1,4-dihydroxy-2-naphthoic acid
    Patent number: 7834061
    Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: November 16, 2010
    Assignee: Meiji Dairies Corporation
    Inventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
  • Calcilytic compounds
    Patent number: 7829594
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: November 9, 2010
    Assignee: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • Methylhydroxylaminopropanol derivative and its use as intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-OL
    Patent number: 7829731
    Abstract: The present invention provides a methylhydroxylaminopropanol derivative and the methylhydroxylaminopropanol derivative of the present invention is used as an intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (+)-(S)—N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing 3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: November 9, 2010
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Weichyun Wong
  • Process for continuous production of the salts of 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2,-dioxide
    Patent number: 7829701
    Abstract: The invention discloses a kind of sulfonation cyclization technique for synthesizing acesulfame potassium for continuous production without stirring and special equipment for this technique. An injection pump is adopted to directly inject the sulfonation raw material and sulfonating agent into autoclave for sulfonation cyclization reaction under high velocity. Moreover, the reciprocating pump is adopted to deliver part of materials in autoclave to condenser designed outside the autoclave for cooling, followed by delivering the cooled materials to another input end of injection pump which together with sulfonation raw material and sulfonating agent is injected into autoclave through high-velocity injection by injection pump. The apparatus is composed of autoclave, injection pump, reciprocating pump and condenser.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: November 9, 2010
    Assignee: Suzhou Hope Technology Co., Ltd
    Inventors: Jicai Liu, Lingwen Kong, Zhongxiang Bao, Xiaoping Chen
  • Process for the preparation of stilbene derivatives
    Patent number: 7820848
    Abstract: A novel process for the preparation of resveratrol and piceatannol and esters thereof involving a Heck type reaction is disclosed. Also disclosed are novel intermediates in that process.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: October 26, 2010
    Assignee: DSM IP Assets B.V.
    Inventors: Ralph Haerter, Ulrike Lemke, Alexander Radspieler
  • Siglec inhibitors
    Patent number: 7820714
    Abstract: The invention relates to Siglec inhibitors that have an increased affinity for the receptor molecule. The Siglec inhibitors provided by the invention are preferably selective of a given Siglec molecule. The invention further relates to a method for producing Siglec inhibitors and to a method for increasing the binding selectivity for a given Siglec molecule. The invention also relates to pharmaceutical compositions that contain the Siglec inhibitors and to medical indications for the Siglec inhibitors.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: October 26, 2010
    Inventors: Sorge Kelm, Reinhard Brossmer
  • Method of producing unsaturated acid from olefin
    Patent number: 7816559
    Abstract: Disclosed is a shell-and-tube heat exchanger type reactor that can be used for a process of producing unsaturated acids from olefins via fixed-bed catalytic partial oxidation, which comprises at least one reaction tube, each including at least one first-step catalyst layer, in which olefins are oxidized by a first-step catalyst to mainly produce unsaturated aldehydes, and at least two second-step catalyst layers, in which the unsaturated aldehydes are oxidized by a second-step catalyst to produce unsaturated acids, wherein a first catalyst layer of the second-step catalyst layers, disposed right adjacent to the first-step catalyst layer, has an activity corresponding to 5˜30% of the activity of the catalyst layer having a highest activity among the second-step catalyst layers. A method of producing unsaturated acids from olefins by using the reactor is also disclosed.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: October 19, 2010
    Assignee: LG Chem, Ltd.
    Inventors: Boo Gon Woo, Jun Seok Ko, Kyoung Su Ha, Seong Pil Kang, Seok Hwan Choi, Young Bae Kim
  • Derivatization and solubilization of fullerenes for use in therapeutic and diagnostic applications
    Patent number: 7812190
    Abstract: The invention provides improved therapeutic and diagnostic fullerenes and endohedral fullerenes. The fullerenes and endohedral fullerenes of the invention are derivatized with at least two charged functional groups (and preferably more than two charged functional groups) to provide for water-solubility and improved in vivo biodistribution. Improved derivatized fullerenes and endohedral fullerenes carry a plurality of functional groups at least two of which are charged. Preferably at least about ? of the possible derivations sites on the fullerene caged carry derivatives and preferably at least about ½ of the functional groups on the fullerene cage are charged groups. The invention also provides water-soluble endohedral metallofullerene with improved biodistribution which are useful as in vivo imaging agents, including MRI contrast agents.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: October 12, 2010
    Assignee: TDA Research, Inc.
    Inventors: Robert D. Bolskar, J. Michael Alford
  • Mixed metal oxide catalysts and processes for their preparation and use
    Patent number: 7807601
    Abstract: A catalyst for the oxidation of an alkane, alkene or mixtures thereof. The catalyst includes a mixed-metal oxide having the formula MoaVbNbcTedSbeOf wherein, when a=1, b=0.01 to 1.0, c=0.01 to 1.0, d=0.01 to 1.0, e=0.01 to 1.0, and f is dependent upon the oxidation state of the other elements, the catalyst further characterized by having at least two crystal phases, the first crystal phase being an orthorhombic M1 phase and the second crystal phase being a pseudo-hexagonal M2 phase, the orthorhombic M1 phase present in an amount between greater than 60 weight percent to less than 90 weight percent. The catalysts disclosed herein exhibit a chemisorption of NH3 of less than about 0.2 mmole per gram of metal oxide.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: October 5, 2010
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Kun Wang, James C. Vartuli, Wilfried J. Mortier, Jihad M. Dakka, Robert C. Lemon