Abstract: A method is for producing propylene oxide, the method including the steps of: reacting hydrogen peroxide with propylene either in an acetonitrile solvent or in a mixture of solvents which include acetonitrile and water, in presence of a titanosilicate catalyst, whereby a reaction mixture containing propylene oxide is obtained; separating the reaction mixture obtained in the reacting into a gas and a reaction liquid; and distilling the reaction liquid obtained in the separating, whereby the reaction liquid is separated into a column top liquid containing propylene oxide, and a column bottom liquid including acetonitrile or a combination of acetonitrile and water, in combination with other steps. This enables industrially efficient production of propylene oxide with use of acetonitrile.
Abstract: A process for producing epoxide, the process including contacting an organic phase including at least one halohydrin(s) with at least one aqueous phase including a base in a plug-flow mixer/reactor system to disperse the organic phase in the aqueous phase via a mixing device imparting a power-to-mass ratio of at least 0.2 W/kg to convert at least a portion of the at least one halohydrin to an epoxide.
Type:
Grant
Filed:
July 30, 2009
Date of Patent:
December 25, 2012
Assignee:
Dow Global Technologies LLC
Inventors:
William W. Fan, Christian D. Kneupper, Sascha Noormann, Ranate Patrascu, Bruce D. Hook, Charles W. Lipp, Michael D. Cloeter, Heinz Groenewald
Abstract: A process for heterogeneously catalyzed partial direct oxidation of propane and/or isobutane, in which target product is removed in a workup stage from the product gas mixture obtained in the reaction stage, the remaining residual product gas mixture is divided into two portions of the same composition, one portion is recycled into the reaction stage and the other portion is discharged, and both the reaction stage and the workup stage are operated at elevated pressure.
Type:
Grant
Filed:
April 2, 2004
Date of Patent:
December 25, 2012
Assignee:
BASF Aktiengesellschaft
Inventors:
Otto Machhammer, Sven Crone, Frieder Borgmeier, Klaus Joachim Mueller-Engel, Christoph Adami, Armin Diefenbacher
Abstract: Method for the manufacture of 5-alkoxymethylfurfural derivatives by reacting a fructose and/or glucose-containing starting material with an alcohol in the presence of a catalytic or sub-stoechiometric amount of heterogeneous acid catalyst. The catalysts may be employed in a continuous flow fixed bed or catalytic distillation reactor. The ethers can be applied as a fuel or fuel additive.
Type:
Grant
Filed:
December 8, 2011
Date of Patent:
December 25, 2012
Assignee:
Furanix Technologies B.V.
Inventors:
Gerardus Johannes Maria Gruter, Frits Dautzenberg
Abstract: A solid phase reaction system for oxidation of an organic compound, having high industrial value in which an organic solvent exerting a reverse influence on earth environments is not necessary, reuse of a catalyst is possible, and high yield can be attained, comprising a mixture of a powdery dispersion medium and a powder of a solid catalyst for the above-described oxidation reaction, and the above-described organic compound and aqueous hydrogen peroxide, wherein the above-described organic compound, the above-described solid catalyst and the above-described aqueous hydrogen peroxide are dispersed in the above-described mixture so that they get into contact mutually.
Abstract: A process and apparatus for recovering dichlorohydrins from a mixture comprising dichlorohydrins, water, one or more compounds selected from esters of dichlorohydrins, monochlorohydrins and/or esters thereof, and multihydroxylated-aliphatic hydrocarbon compounds and/or esters thereof, and optionally one or more substances comprising chlorinating agents, catalysts and/or esters of catalysts while minimizing formation of heavies is disclosed.
Type:
Grant
Filed:
April 11, 2008
Date of Patent:
December 18, 2012
Assignee:
Dow Global Technologies LLC
Inventors:
Anil J. Mehta, Danil Tirtowidjojo, Jose Javier Longoria
Abstract: The invention relates to a process for preparing 2,4-dihydroxyphenyl 4-methoxybenzyl ketones of the formula (I) by Friedel-Crafts acylation in hydrogen fluoride (HF). 2,4-Dihydroxyphenyl 4-methoxybenzyl ketones of the formula (I) in which R1 and R2 are each hydrogen, chlorine, fluorine, bromine, iodine, CF3, methyl, optionally substituted alkoxy, —OCF3, —C(CH3)3, —CH2(CH3)2, —CH(CH3)2, R3 is hydrogen, Cl, F, Br, optionally substituted alkyl, optionally substituted alkoxy, —C(CH3)3, and X is hydroxyl, F, Cl, Br, optionally substituted alkoxy, are obtained in high yield and high purity by reacting phenylacetic acid derivatives of the formula (II) with phenols of the formula (III) in liquid hydrogen fluoride (HF).
Abstract: The invention offers an improvement in a process for start-up in the occasion of producing acrylic acid by catalytically oxidizing acrolein at vapor phase under high load conditions, the start-up meaning the step of increasing the acrolein supply rate (loading) from the non-reacting condition to the prescribed reaction conditions. This process is characterized in that the acrolein supply rate is increased in the start-up stage of the reaction until the prescribed composition of starting reactant gas and the flow rate of the starting reactant gas are obtained, while adjusting at least one of the reaction temperature, the composition of the starting reactant gas and the flow rate of the starting reactant gas, so as to maintain the acrolein conversion at not lower than 90 mol %, the maximum peak temperature of the catalyst layer in each reaction zone at no higher than 400° C.
Abstract: A process for preparing a coated catalyst in which a finely divided mixture of a multielement oxide comprising the elements Mo and V and a molybdenum oxide or a molybdenum oxide former is applied to the surface of a support body as an active composition.
Type:
Grant
Filed:
February 28, 2008
Date of Patent:
November 27, 2012
Assignee:
BASF SE
Inventors:
Ulrich Cremer, Andreas Raichle, Frank Rosowski, Ulrich Hammon, Klaus Joachim Mueller-Engel
Abstract: Problem To provide an environmentally-friendly method for producing industrially an ester compound. Solution The present invention is a method for producing an ester compound which comprises subjecting a carboxylic acid and an alcohol to dehydration-condensation reaction using an involatile acid catalyst and then removing the residual acid catalyst by bringing a weak basic substance into contact with the residual acid catalyst.
Abstract: Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The compounds of the present invention exhibit enhanced activity or reduced side effects or both.
Type:
Grant
Filed:
July 18, 2007
Date of Patent:
November 20, 2012
Assignee:
Antibe Therapeutics Inc.
Inventors:
John Wallace, Giuseppe Cirino, Vincenzo Santagada, Giuseppe Caliendo
Abstract: Accordingly, the current invention provides a method for the manufacture of an ether or ester of 5-hydroxymethyl-furfural by reacting a hexose-containing starting material or HMF with an alcohol or an organic acid dissolved into an ionic liquid, using a metal chloride as catalyst.
Type:
Grant
Filed:
September 5, 2008
Date of Patent:
November 20, 2012
Assignee:
Furanix Technologies B.V.
Inventors:
Gerardus Johannes Maria Gruter, Leo Ernest Manzer, Ana Sofia Vagueiro De Sousa Dias, Frits Dautzenberg, Jindra Purmova
Abstract: The invention broadly relates to the use of ?,?-unsaturated fatty acids to inhibit the filamentous growth of fungi and yeasts and to a method for producing same. In particular the invention relates to the use of optionally substituted C8 to C15 ?,?-unsaturated fatty acids or salts, esters or amides thereof for inhibiting or retarding the yeast-to-mycelium transition of organisms having a dimorphic life cycle.
Type:
Grant
Filed:
April 12, 2010
Date of Patent:
November 20, 2012
Assignee:
Agency for Science, Technology and Research
Abstract: The present invention is directed to a regio-and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
Type:
Grant
Filed:
April 20, 2010
Date of Patent:
November 6, 2012
Assignee:
Pfizer Inc.
Inventors:
Michael P. Burns, Justin K. Weaver, John Wing Wong
Abstract: An oral dosage form comprising a pharmaceutical tablet of one or more layers, one of which carries a biologically active substance; the formulation of said tablet includes different percentages of hydrophilic and lipophilic polymeric materials, and adjuvant substances. The tablets of the present invention show a release rate which is independent from the amounts of active substance present in the tablet.
Type:
Grant
Filed:
June 5, 2009
Date of Patent:
November 6, 2012
Assignee:
Jagotec AG
Inventors:
Guy Vergnault, Pascal Grenier, Lauretta Maggi, Ubaldo Conte
Abstract: The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of hydrogen chloride at superatmospheric, atmospheric and subatmospheric pressure conditions for a sufficient time and at a sufficient temperature, preferably wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; said process carried out without a step undertaken to specifically remove volatile chlorinated hydrocarbon by-products or chloroacetone, wherein the combined concentration of volatile chlorinated hydrocarbon by-products and chloroacetone is less than 2000 ppm throughout any stage of the said process.
Type:
Grant
Filed:
January 31, 2011
Date of Patent:
November 6, 2012
Assignee:
Dow Global Technologies LLC
Inventors:
William J. Kruper, Tina Arrowood, Bruce M. Bell, John Briggs, Robert M. Campbell, Bruce D. Hook, Anh Nguyen, Curt Theriault, Ralf Fitschen
Abstract: The invention relates to a process for removing poly(propylene oxide) from propylene oxide by membrane separation, wherein a membrane having an average pore size of from 0 to 5 nm is used. In said process, a liquid feed comprising propylene oxide and poly(propylene oxide) may be separated by the membrane into a permeate comprising propylene oxide and either no poly(propylene oxide) or poly(propylene oxide) at a concentration which is lower than the poly(propylene oxide) concentration in the feed, and a retentate comprising propylene oxide and poly(propylene oxide) at a concentration which is higher than the poly(propylene oxide) concentration in the feed.
Type:
Grant
Filed:
December 18, 2007
Date of Patent:
November 6, 2012
Assignee:
Shell Oil Company
Inventors:
Johannes Gerhardus Joseph Beckers, Johannes Leendert Willem Cornelis Den Boestert, Nigel Wagstaff
Abstract: A process for recovering hexafluoropropylene and hexafluoropropylene oxide from a liquid mixture of these components is provided. The process includes, in a stripping stage, contacting the mixture with a gaseous stripping agent, thereby to strip hexafluoropropylene from the mixture. A gaseous product comprising hexafluoropropylene and gaseous stripping agent is withdrawn from the stripping stage, as is a liquid product comprising hexafluoropropylene oxide.
Type:
Grant
Filed:
October 27, 2009
Date of Patent:
October 30, 2012
Assignee:
University of Kwazulu-Natal
Inventors:
Deresh Ramjugernath, Paramespri Naidoo, Clinton Shalendra Subramoney, Michael Wayne Nelson
Abstract: A process for making optically pure (R) and (S) salbutamol comprises obtaining the (R) or (S) isomer of either salbutamol or a salbutamol precursor in substantially optically pure form by resolving a racemic or optically impure mixture of enantiomers of salbutamol or of said precursor with either (L) or (D) tartaric acid, and where necessary converting said isomer of said precursor into either (R or (S) salbutamol respectively; then optionally converting said optically pure (R) and/or (S) salbutamol into a pharmaceutically acceptable salt.
Type:
Grant
Filed:
December 10, 2001
Date of Patent:
December 4, 2012
Assignee:
Cipla Limited
Inventors:
Yusuf Khwaja Hamied, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao