Patents Examined by Tekchand Saidha
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Patent number: 11987602Abstract: The methods and systems disclose enzymes that function to import malonic acid or malonates into a cell. The enzymes increase the output of precursor molecules by enriching certain pathways in the cell. The precursor molecules can be converted to cannabinoids. The enzymes are a family of proteins which have a majority of common alignments.Type: GrantFiled: June 16, 2021Date of Patent: May 21, 2024Assignee: CB Therapeutics, Inc.Inventors: Erin Marie Scott, Jacob Michael Vogan
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Patent number: 11987833Abstract: The present invention relates to a novel enzyme capable of producing multi-hydroxy derivatives from polyunsaturated fatty acids and a method for producing multi-hydroxy derivatives of polyunsaturated fatty acids using the same.Type: GrantFiled: October 16, 2020Date of Patent: May 21, 2024Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Jeong Woo Seo, Jong Jae Yi, Sun Yeon Heo, Young Bae Kim, Chul Ho Kim, Baek Rock Oh, Jung Hyun Ju, Hack Sun Choi
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Patent number: 11981941Abstract: The present invention relates to polypeptides, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides. The present invention also relates to detergent composition comprising polypeptides, a laundering method and the use of polypeptides.Type: GrantFiled: February 13, 2023Date of Patent: May 14, 2024Assignee: NOVOZYMES A/SInventors: Morten Gjermansen, Klaus Gori, Henrik Marcus Geertz-Hansen, Jesper Salomon, Thomas Holberg Blicher, Nikolaj Spodsberg
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Patent number: 11981947Abstract: The present invention relates to the use of one or more glycosidases in the process for the production and/or purification of a produced desired oligosaccharide. The process is preferably a microbial fermentation process using a host microorganism, which may also comprise nucleic acids expressing sugar catabolic pathway proteins suitable for the degradation of saccharides otherwise hindering the purification of the desired oligosaccharide.Type: GrantFiled: July 22, 2022Date of Patent: May 14, 2024Assignee: Chr. Hansen HMO GmbHInventor: Stefan Jennewein
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Patent number: 11981709Abstract: The present invent in discloses Hemipteran insect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.Type: GrantFiled: May 11, 2022Date of Patent: May 14, 2024Assignee: Monsanto Technology LLCInventors: James A. Baum, Artem G. Evdokimov, Farhad Moshiri, Timothy J. Rydel, Eric J. Sturman, Moritz von Rechenberg, Halong Vu, Andrew M. Wollacott, Meiying Zheng, Stanislaw Flasinski
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Patent number: 11970520Abstract: An expression vector is provided for production of human alpha-synuclein (?S) protein or a conservative variant thereof that exhibits a decreased tendency to self-aggregate in an ?S seed amplification assay (SAA). The expression vector comprises a nucleic acid sequence coding for human ?S protein or a conservative variant, the nucleic acid sequence comprising codons that have been optimized to produce human ?S protein or a conservative variant when expressed by a host cell such as E. coli. The codons have been optimized to avoid amino acid misincorporation in the expressed protein. Methods for purification of the expressed protein are also provided.Type: GrantFiled: January 19, 2022Date of Patent: April 30, 2024Assignee: Amprion, Inc.Inventors: Luis Concha, Carly Farris, Bret Holguin, Yihua Ma
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Patent number: 11969717Abstract: The present disclosure provides a method for preparing an organophosphorus degrading enzyme based multifunctional catalyst and an organophosphorus degrading enzyme based multifunctional catalyst and use thereof. In the present disclosure, the preparation method includes: directly adding a composite yolk-shell-structured nanomaterial into a crude enzyme solution of organophosphorus degrading enzyme with an affinity tag, and mixing, to obtain a mixture, and then subjecting the mixture to a separation, to obtain an organophosphorus degrading enzyme based multifunctional catalyst.Type: GrantFiled: May 11, 2021Date of Patent: April 30, 2024Assignee: Hebei University of TechnologyInventors: Yanjun Jiang, Liya Zhou, Saiguang Xue, Jing Gao
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Patent number: 11970722Abstract: The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.Type: GrantFiled: December 18, 2020Date of Patent: April 30, 2024Assignee: Codexis, Inc.Inventors: William Casey Hallows, Rachel Cathleen Botham, Yu Zhu, Chinping Chng, Nikki Dellas, Gjalt W. Huisman, Moulay Hicham Alaoui Ismaili, David William Homan, Adam P. Silverman, Jonathan Vroom, Jessica P. Lao
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Patent number: 11965203Abstract: Embodiments of the invention relate generally to methods to generate microorganisms and/or microorganism cultures that exhibit the ability to produce polyhydroxyalkanoates (PHA) from carbon sources at high efficiencies. In several embodiments, preferential expression of, or preferential growth of microorganisms utilizing certain metabolic pathways, enables the high efficiency PHA production from carbon-containing gases or materials. Several embodiments relate to the microorganism cultures, and/or microorganisms isolated therefrom.Type: GrantFiled: July 1, 2021Date of Patent: April 23, 2024Assignee: Newlight Technologies, Inc.Inventor: Markus D. Herrema
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Patent number: 11952558Abstract: The present invention relates to novel protease variants exhibiting improved stability and or improved wash performance in liquid detergent. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.Type: GrantFiled: April 6, 2021Date of Patent: April 9, 2024Assignee: NOVOZYMES A/SInventors: Miguel Duarte Guilherme Pereira Toscano, Esben Peter Friis, Rolf Thomas Lenhard, Signe Eskildsen Larsen, Astrid Munch, Bena-Marie Lue, Mikael Bauer
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Patent number: 11950618Abstract: Provided are dry-milling methods for producing an aqueous fermentation feedstock ingredient. The methods include providing a corn-processing filtration feed; filtering at least a fraction of said filtration feed on a microfiltration membrane, whereby an aqueous filtration permeate and a filtration retentate are formed; separating said filtration permeate from said filtration retentate, to form separated permeate and separated retentate; forming a fermentation feedstock comprising said separated permeate, and saccharifying and/or washing said separated retentate.Type: GrantFiled: December 16, 2021Date of Patent: April 9, 2024Assignees: SUPERBREWED FOOD INC., AdvanceBio, LLCInventors: Bryan P. Tracy, Dale A. Monceaux
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Patent number: 11952607Abstract: The disclosure provides genetically engineered microorganisms and methods for improved biological production of ethylene glycol and precursors of ethylene glycol. The microorganism of the disclosure produces ethylene glycol or a precursor of ethylene glycol through one or more of 5,10-methylenetetrahydrofolate, oxaloacetate, citrate, malate, and glycine. The disclosure further provides compositions comprising ethylene glycol or polymers of ethylene glycol such as polyethylene terephthalate.Type: GrantFiled: August 5, 2022Date of Patent: April 9, 2024Assignee: LanzaTech, Inc.Inventors: Zachary Robert Cowden, Ching Leang, Michael Koepke, Rasmus Overgaard Jensen, Alexander Paul Mueller
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Patent number: 11946078Abstract: Disclosed herein are cellulase variants, or active fragments thereof, and polynucleotides encoding same, where the cellulase variants, or active fragments thereof, have endoglucanase activity. Also disclosed herein are compositions comprising the cellulase variants, or active fragments thereof; vectors and/or host cells comprising the polynucleotides encoding the cellulase variants, or active fragments thereof; and methods for making and/or using the cellulase variants, or active fragments thereof and/or compositions containing same; where the cellulase variants, or active fragments thereof, have endoglucanase activity.Type: GrantFiled: April 22, 2021Date of Patent: April 2, 2024Assignee: Danisco US Inc.Inventors: Neeraj Pandey, Sina Pricelius, Annapurna Sachan, Stepan Shipovskov, Richard Bott, Ajit Kumar Satapathy
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Patent number: 11939618Abstract: The present invention provides for a fusion protein comprising: (a) a terpene synthase (TS), or a homolog thereof, (b) a peptide linker, and (c) a P450 enzyme, or a homolog thereof.Type: GrantFiled: March 19, 2021Date of Patent: March 26, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Taek Soon Lee, Xi Wang
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Patent number: 11939557Abstract: The present disclosure concerns recombinant yeast host cells expressing heterologous enzymes for hydrolyzing flavor compounds glycosidically bound to a sugar molecule. The recombinant yeast host cells can be used in a subsequent production process to make alcoholic beverage products such as wines and beers.Type: GrantFiled: March 18, 2021Date of Patent: March 26, 2024Assignee: Danstar Ferment AGInventors: Charles F. Rice, Aaron Argyros
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Patent number: 11925193Abstract: A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto.Type: GrantFiled: October 27, 2021Date of Patent: March 12, 2024Assignee: DSM IP Assets B.V.Inventors: Viktor Marius Boer, Priscilla Zwartjens, Eric Van Den Berg
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Patent number: 11926858Abstract: The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.Type: GrantFiled: April 4, 2022Date of Patent: March 12, 2024Assignee: GLYCOM A/SInventors: Margit Pedersen, Manos Papadakis, Peter Becker, Eric Samain, Pauline Peltier-Pain, Katrine Bych, Ted Johanson, Elise Champion, Gyula Dekany
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Patent number: 11920290Abstract: The present invention relates to a process wherein one or more dye precursors, e.g., indole, are provided to a textile and converted by one or more enzymes, e.g., an oxidizing enzyme, to provide the textile with a dye, e.g. indigo. At least the oxidizing enzyme is a hybrid enzyme including a binding domain that is suitable to bind the enzyme to the textile and/or increase the affinity of the enzyme for the textile, in particular, a cellulose binding domain (CBD).Type: GrantFiled: January 14, 2021Date of Patent: March 5, 2024Assignee: Sanko Tekstil Isletmeleri San. Ve Tic A.S.Inventors: Jitka Eryilmaz, Fatih Konukoglu, Halil Ibrahim Akbas, Esref Tuncer, Mahmut Ozdemir
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Patent number: 11918633Abstract: Phenylalanine ammonia-lyase (PAL) variants with a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL for therapeutic uses, including the treatment of adolescent subjects having PKU.Type: GrantFiled: May 18, 2022Date of Patent: March 5, 2024Assignee: BIOMARIN PHARMACEUTICAL INC.Inventor: Debra Lounsbury
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Patent number: 11920170Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.Type: GrantFiled: December 9, 2016Date of Patent: March 5, 2024Assignee: DANISCO US INC.Inventors: William Cuevas, Vivek Sharma, David E. Wildes, Sang-Kyu Lee, Dina Finan