Patents Examined by Tekchand Saidha
  • Patent number: 10851353
    Abstract: The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: December 1, 2020
    Assignees: Roche Sequencing Solutions, Inc., Roche Molecular Systems, Inc.
    Inventors: Evan Amato, Cleoma Arnold, Aruna Ayer, Mara Boenitz-Dulat, Barbara Eckert, Ilya Lederman, Colin McGaw, Preethi Sarvabhowman, Charles Wayan Schwab, Shawn Suko, Eileen Thai, Bigna Woersdoerfer, David Wunderlich
  • Patent number: 10844327
    Abstract: An automatic dishwashing detergent composition comprising: a. at least 0.1 mg of active protease per gram of composition, wherein the protease is a variant of a protease that has at least 70% identity with the amino acid sequence of SEQ ID NO:1. wherein said variant comprise variations in one or more of the following positions: 32, 33, 48-54, 58-62, 94-107, 116, 123-133, 150, 152-156, 158-161, 164, 169, 175-186, 197, 198, 203-216 as compared with the protease in SEQ ID NO:1; and b. at least 0.05 mg of an active low temperature amylase per gram of composition.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: November 24, 2020
    Assignee: The Procter & Gamble Company
    Inventor: Philip Frank Souter
  • Patent number: 10844348
    Abstract: The present disclosure relates to a microorganism of the genus Corynebacterium producing 5?-xanthosine monophosphate and a method for producing 5?-xanthosine monophosphate using the same.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: November 24, 2020
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Min Ji Baek, Ji Hye Lee, Boram Lim, Byoung Hoon Yoon, Jeong Eun Lee, Su-bin Lim, Jaeho Jeong
  • Patent number: 10837032
    Abstract: The present invention relates to a method for producing dioic acids from a substrate containing hydrocarbons or fatty acids using a Candida infanticola strain, and to a Candida infanticola microorganism used therefor. The present invention reduces the cost increase resulting from the fluctuation in the international oil price and the burden of environmental pollution, which are caused by the use of fossil fuels, and thus can be utilized in various industrial fields using DDDA as a raw material.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: November 17, 2020
    Assignee: Lotte Chemical Corporation
    Inventors: Dong Myung Shin, Jong Pill Kim, Heejoon Park, Seung Hoon Lee, Hye Ran Jang, Hongweon Lee, Jung Oh Ahn, Woo Young Jeon, Gyu Yeon Park, Hee Suk Lee
  • Patent number: 10814724
    Abstract: The present invention provides for a genetically modified host cell capable of producing isopentenol and/or 3-methyl-3-butenol, comprising (a) an increased expression of phosphomevalonate decarboxylase (PMD) (b) an increased expression of a phosphatase capable of converting isopentenol into 3-methyl-3-butenol, (c) optionally the genetically modified host cell does not express, or has a decreased expression of one or more of NudB, phosphomevalonate kinase (PMK), and/or PMD, and (d) optionally one or more further enzymes capable of converting isopentenol and/or 3-methyl-3-butenol into a third compound, such as isoprene.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: October 27, 2020
    Assignee: The Regents of the University of California
    Inventors: Taek Soon Lee, Aram Kang
  • Patent number: 10808268
    Abstract: The present invention relates to methods of releasing galactose from legumes using polypeptides having alpha-galactosidase activity. The invention also relates to polypeptides having alpha-galactosidase activity, polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of 5 producing the polypeptides. The invention also relates to compositions comprising the polypeptides of the invention and the use of the polypeptides in animal feed.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: October 20, 2020
    Assignee: Novozymes A/S
    Inventors: Lone Carstensen, Nikolaj Spodsberg, Morten Gjermansen, Jesper Salomon, Kristian B. R. M. Krogh, Eduardo Antonio Della Pia
  • Patent number: 10808255
    Abstract: The present invention relates to a promoter system inducing expression of 3-hydroxypropionic acid (3-HP) and a method of biologically producing 3-HP using the same. To improve production of 3-HP in a biological manner, continuous synthesis of new enzymes having enzyme activity is necessary. As a result of screening 3-HP reactive transcription regulators and 3-HP reactive promoters from several microorganisms including Pseudomonas denitrificans, it was confirmed that the transcriptions regulations and promoters are composed of LysR proteins and particular gene nucleotide sequences binding to the LysR proteins. Therefore, the 3-HP inducible system is expected to be effectively used to regulate 3-HP metabolic pathways.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: October 20, 2020
    Assignees: NOROO IC CO., LTD., NOROO R&C CO., LTD.
    Inventors: Sung-Hoon Park, Shengfang Zhou, Somasundar Ashok, Eun Hee Seol, Satish Kumar Ainala
  • Patent number: 10808265
    Abstract: Genetically engineered cells and methods are presented that enhance the consumption of xylose in a medium comprising a mix of five- and six-carbon sugars. Method of using these microbes to enhance xylose utilization and methods of making value products using these microbes are also disclosed herein.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: October 20, 2020
    Assignee: NANTBIO, INC.
    Inventors: Wendy M. Higashide, Xiaoqian Li, Lars Erik Ulf Rohlin
  • Patent number: 10801044
    Abstract: A method of producing a long-chain fatty alcohol, containing culturing a microorganism wherein expression of a gene encoding a 3-ketoacyl-ACP synthase and expression of a gene encoding a fatty acyl-CoA reductase are enhanced; a method of providing ability to produce a long-chain fatty alcohol for a microorganism wherein expression of a gene encoding a 3-ketoacyl-ACP synthase and expression of a gene encoding a fatty acyl-CoA reductase are enhanced in a microorganism cell; and a transformant of a microorganism in which expression of a gene encoding a ?-ketoacyl-ACP synthase and expression of a gene encoding a fatty acyl-CoA reductase are enhanced.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: October 13, 2020
    Assignee: Kao Corporation
    Inventors: Mika Terai, Akihito Kawahara, Tatsuro Ozaki
  • Patent number: 10801047
    Abstract: The present disclosure relates to a putrescine-producing microorganism of the genus Corynebacterium, and a method of producing putrescine using the same.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: October 13, 2020
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Kyoung Min Lee, Sung Gun Lee, Seon Hye Kim, Kyungsu Na, Hong Xian Li, Hyun-jung Bae, Young Lyeol Yang, Hye Won Um, Hyo Hyoung Lee
  • Patent number: 10787648
    Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: September 29, 2020
    Assignee: GENOMATICA, INC.
    Inventors: Andreas Schirmer, Baolong Zhu, Emanuela Popova
  • Patent number: 10787671
    Abstract: Provided herein are methods of production of recombinant Erwinia asparaginase. Methods herein produce asparaginase having high expression levels in the periplasm or the cytoplasm of the host cell having activity comparable to commercially available asparaginase preparations.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: September 29, 2020
    Assignee: Pfenex Inc.
    Inventors: Russell J. Coleman, Torben Bruck
  • Patent number: 10774320
    Abstract: The present invention relates to methods and recombinant microorganisms useful for the production of glycolic acid and/or glyoxylic acid. The methods of the invention involve either only one step of fermentation of the modified microorganisms of the invention or one step of fermentation of the modified microorganisms of the invention and one step of either biological or chemical conversion of the glycolic acid or of the glyoxylic acid, the microorganism of the invention over expressing a phosphoketolase gene.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: September 15, 2020
    Assignee: METABOLIC EXPLORER
    Inventors: Wanda Dischert, Gwenaƫlle Corre, Philippe Soucaille
  • Patent number: 10774346
    Abstract: The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: September 15, 2020
    Assignee: MANUS BIO INC.
    Inventors: Ajikumar Parayil Kumaran, Ryan Lim, Jason Donald, Hsien-Chung Tseng, Christine Nicole S. Santos, Ryan Philippe
  • Patent number: 10760037
    Abstract: The present invention relates to a composition comprising: (a) a source of sulfite; and (b) a lipase variant of a parent lipase, wherein said variant has improved stability towards sulfite as compared to the parent lipase.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: September 1, 2020
    Assignee: NOVOZYMES A/S
    Inventors: Marco Malten, Thomas Agersten Poulsen, Lise Munch Mikkelsen, Dorte Marie Koefoed Klitgaard, Vibeke Skovgaard Nielsen, Katarina Larson
  • Patent number: 10760104
    Abstract: The invention relates to a method of producing D-xylonate from D-xylose, which includes converting D-xylose to D-xylonate from a coryneform bacterium in which the activity of the iolR gene is reduced or completely switched off compared with the wild type or a mutation of the wild type, or the iolR gene is completed or partially deleted, as well as to a bacterium for carrying out the method.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: September 1, 2020
    Assignee: FORSCHUNGSZENTRUM JUELICH GMBH
    Inventors: Stephan Noack, Andreas Radek, Jan Marienhagen, Karin Krumbach
  • Patent number: 10752887
    Abstract: The present invention relates to variants of Terminal deoxynucleotidyl Transferase (TdT), each of which (i) has an amino acid sequence similarity to SEQ ID NO: 2. 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33 or 35 with corresponding amino acid substitutions, (ii) is capable of synthesizing a nucleic acid fragment without a template and (iii) is capable of incorporating a modified nucleotide into the nucleic acid fragment.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: August 25, 2020
    Assignees: DNA Script, Institut Pasteur
    Inventors: Elise Champion, Mikhael Soskine, Thomas Ybert, Marc Delarue
  • Patent number: 10752888
    Abstract: The present disclosure relates to a method for preparing myo-inositol using myo-inositol monophosphate synthase consisting of an amino acid sequence of SEQ ID NO: 1 and/or myo-inositol monophosphate phosphatase consisting of an amino acid sequence of SEQ ID NO: 3.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: August 25, 2020
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Sungjae Yang, Hyun Kug Cho, Young Mi Lee, Seong Bo Kim, Seong Jun Cho
  • Patent number: 10741863
    Abstract: The present disclosure provides engineered photosynthetic cells and organisms, methods for engineering photosynthetic cells and organisms with increased extracellular electron transport, photo-bioelectrochemical cells (PBECs), anodes for a PBECs and/or photosynthetic microbial fuel cells (PMFCs), methods of generating an electrical current with PBECs, and methods and systems for generating H2 fuel.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: August 11, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Ramaraja P. Ramasamy, Narendran Sekar
  • Patent number: 10738292
    Abstract: The present invention relates to a novel endoglucanase gene (GH5 family) from the soil metagenome. More specifically, this invention provides a recombinant plasmid and the recombinant hosts for the expression of novel gene sequence having cellulase activity. The cellulase in the invention has high specific activity towards ?-1,4 linkages in substrates such as carboxy-methyl cellulose and barley-?-glucan etc. This novel cellulase can have many industrial applications eg. food and feed industry, detergent, textile and biofuel industry etc.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: August 11, 2020
    Assignee: Council of Scientific & Industrial Research
    Inventors: Roma Garg, Vijaya Brahma, Lata Verma, Girish Sahni