Abstract: A sterile environment system can include an enclosure and a support system. The enclosure can include a barrier separating a sterile environment inside of the enclosure from a non-sterile environment outside of the enclosure. The barrier can include an expandable portion configured to expand from an unexpanded state to an expanded state for working within the sterile environment, and a patient-interfacing portion including a fenestration configured for placement directly over an area of interest of a patient, the fenestration having a sealed state and an unsealed state for access to the area of interest from within the sterile environment. The support system can be coupled to the patient-interfacing portion of the barrier such that it is positioned on at least opposite sides of the fenestration.

Abstract: Provided are systems, methods, and devices for implementation of custom sleep age profiles. Methods include generating at least one sleep model based, at least in part, on reference data, the at least one sleep model being configured to identify an estimated sleep age based on an input. Methods further include receiving measurement data comprising data values representing measurements of neural activity of at least one user, and generating an estimated sleep age of the at least one user based, at least in part, on the at least one sleep model and the received measurement data. Methods also include generating a plurality of stimulation parameters based, at least in part, on the estimated sleep age, the plurality of stimulation parameters being configured to modify the estimated sleep age of the at least one user.

Abstract: Examples disclosed herein are relevant to a wearable device configured to selectively receive a primary magnet set selected from among multiple primary magnet sets of varying magnetic strengths. A supplemental magnet set is used with the wearable device to supplement the selected primary magnet set to increase a strength of a magnetic connection. The wearable device can selectively couple with a selected cover. The cover can be an accommodating cover configured to accommodate the at least one supplemental magnet set or a non-accommodating cover for use as the selected cover when a supplemental magnet set is not being used.

Abstract: An interstitial source including a base suitable for implanting in a tumor and radioactive atoms of one or more isotopes, which are attached to the base. The radioactive atoms have a radon release rate of at least 0.5 micro-Curie (?Ci) per centimeter length, and emit beta radiation achieving at 2 millimeters from the base an asymptotic dose of at least 10 Gy. Additionally, the ratio between the beta radiation asymptotic dose at a distance of 2 millimeters from the device, to the radon release rate, is greater than 15 Gy/(microcurie/cm).

Abstract: An intraoral positioning device (IPD) is disclosed for positioning in a patient's mouth for radiation therapy planning and treatment, the device comprising an engagement member configured to engage structure within a patient's mouth during radiation planning or treatment, wherein the engagement member includes an upper wall, a lower wall and first and second side walls extending from and between the upper and lower walls, whereby the upper, lower and first and second side walls form top, bottom, front and rear walls of a bite block, and a handle extending from the engagement member to enable a user to grasp the IPD for introducing and removing it from the patient's mouth.

Abstract: An apparatus and method configured to control a brain stimulation device. The apparatus and method include a brain stimulation apparatus including, an input unit configured to receive at least one biological metric measurement value of a user, a neural network unit configured to determine a treatment pulse frequency equal to a weighted sum of the at least one biological metric measurement value of the user, wherein the weighted sum includes a plurality of weighting factors corresponding to each of the at least one biological metric measurement values, and wherein the plurality of weighting factors are determined based on optimized outcome results from previous administered treatments using treatment pulse frequencies determined by previous weighting factors, and a control unit configured to control a motor to operate at the treatment pulse frequency determined.

Abstract: An apparatus includes a first multileaf collimator comprising a plurality of pairs of beam-blocking leaves each comprising an end portion. The end portions of the beam-blocking leaves of one pair are contoured to allow forming a first aperture when the beam-blocking leaves of the pair are closed. The first aperture has a closed shape such as a circle in a beam's eye view.

Abstract: A method of artificial-intelligence-based robotic vitrification includes placing at least one oocyte in a buffer or CPA solution. The method includes processing an image object produced by an imaging system, using an AI/ML system, to determine a location of a retrievable target oocyte. The method includes positioning a robotic pipettor at a target physical orientation relative to the retrievable target oocyte. The method includes confirming the robotic pipettor's location at the target physical orientation, using the AI/ML system. The method includes instructing the robotic pipettor to initiate contact with the retrievable target oocyte and apply negative pressure to secure the oocyte to the robotic pipettor. The method includes using a robotic microtool holder to lower a vitrification assembly or cryo-device of any other make into a buffer or CPA solution dish to a position in proximity to the target physical orientation.

Abstract: An illustrative system includes a coil configured to be positioned over a wound on a body and held in place on the body by a magnet implanted within the body; and a controller communicatively coupled to the coil, the controller configured to apply therapeutic electromagnetic pulses by way of the coil to the wound. Other systems and methods for providing therapeutic electromagnetic pulses to a recipient are also disclosed.

Abstract: The device can be used in a method to protect tissue in the gastrointestinal tract of a patient during radiation therapy, the method comprising positioning a biodegradable device to cover a perforation at a perforation site on a tissue of a patient prior to applying radiation therapy, closing the perforation through surgery, and securing the biodegradable device to cover the perforation site, so that the biodegradable device protects the tissue adjacent to the perforation site during radiation therapy. Wherein the biodegradable device is a biodegradable tubular straw or surgical patch. The surgical patch is a medical device made of tissue engineered materials designed to cover, repair, or augment damaged or weakened tissue or organs during surgery.

Abstract: A system and method for adaptive speech and biofeedback control of sexual stimulation devices. In an embodiment, the system and method involve receiving audio from a microphone, processing the audio through an automated speech detection engine to detect speech within the audio, matching the speech to a control command for a sexual stimulation device, generating a control signal for the sexual stimulation device based on the control command, receiving biometric data from a biometric sensor, and adjusting the control signals based on the biometric data before outputting the adjusted control signal for use in operating the sexual stimulation device. In some embodiments, the adjustment to the control signal is made automatically by a machine learning algorithm using the command and biometric data as inputs.

Abstract: A system and method for providing sensory relief from distractibility, inattention, anxiety, fatigue, and/or sensory issues to a user in need. The user can be autistic/neurodiverse, or neurotypical. The system can be configured to obtain user sensory sensitivity data indicating a user's visual, sonic, or interoceptive, sensitivities; determine, using at least the user sensory sensitivity data, sensory thresholds specific to the user and mediation data corresponding to mediations specific to the user; store the sensory thresholds and mediation data; record, using one or more sensors, a sensory input stimulus to the user; compare the sensory input stimulus with the sensory thresholds; in response to comparing the sensory input stimulus with the sensory thresholds, determine, based at least on the mediation data, a mediation to be provided to the user, the mediation configured to provide the user relief from distractibility, inattention, anxiety, fatigue, or sensory issues.

Abstract: One aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; placing the resected anatomical vessel in a chamber; and allowing the tissue passivation agent to cross-link while the resected anatomical vessel is in the chamber.

Abstract: An apparatus is provided which includes a biocompatible housing configured to be implanted within a recipient. The housing includes a unitary wall including a first wall portion and a second wall portion surrounding a perimeter of the first wall portion. The first wall portion is sufficiently flexible to transmit vibrations between an outer region outside the housing and an inner region within the housing.

Abstract: A method of relieving fear in an individual, the method can include experiencing at least one fearing event by the individual; obtaining an audio listening device; accessing at least one fear-relieving file corresponding to the at least one fearing event; placing the audio listening device on the individual's ears; playing the at least one fear-relieving file; and listening to the at least one fear-relieving file to relieve the fear in the individual.

Abstract: A reciprocating stimulation device includes a handle portion including a rotating motor disposed therein. A stimulation body is disposed over the handle portion and includes a stimulation component. A stretchable tube connects an exterior of the handle portion with an exterior of the stimulation body. A screw is coupled to the handle portion and is configured to be driven in rotation by the rotating motor. A nut is coupled to the stimulation body, the screw is threaded through an opening of the nut. The nut is configured to drive a reciprocating motion of the stimulation body relative to the handle portion as the screw rotates therein.

Abstract: A treatment method for a user with attention deficit hyperactivity disorder, that includes the use of a mask to create a tunnel vision restriction for the user. Different sets of visual tasks are assigned to the user as he or she progress to reduce the number of distraction episodes. Depending on the progress the user experiences, the mask is removed, and the user is assigned initially the same tasks he or she undertook with the mask on. The steps are repeated to reduce the number of distracting episodes experienced by the user and increasing the complexity and completion time of the tasks.

Abstract: Disclosed are a method and an apparatus for classifying patients with brain disorders based on EEG analysis. The method for classifying patients with brain disorders based on EEG analysis includes: (a) receiving an EEG data set with a clinical diagnosis label, wherein the EEG data set includes a plurality of EEG signals and age information; (b) augmenting the EEG data set through a deep learning-based screening model, and augmenting the EEG signals and the age information in different schemes; (c) training the deep learning-based screening model to classify EEG data of patients into a target clinical diagnosis label by using the augmented EEG signals and age information; and (d) predicting a brain diagnosis label of brain disorders by applying EEG data of patients to the trained deep learning-based screening model.

Abstract: An implantable device for treating a patient suffering from female urinary stress incontinence includes an elongate sling for supporting the urethra, the sling having first and second ends. First and second tabs extend from the first and second ends of the sling, respectively for engaging supportive tissue superior to the portion of the urethra being supported. Each tab has a ratcheted section of alternating relatively projecting and relatively recessed portions for engaging the supportive tissue.

Abstract: The present invention provides compositions, systems and methods for treating diabetes in a subject. The composition of the present invention includes a decellularized vascular graft, a biocompatible hydrogel encasement with tunable rigidity, and a plurality of cells such as pancreatic islet cells.