Patents Examined by Theodore R West
  • Fungicidal compounds and methods of their use
    Patent number: 10477865
    Abstract: Antifungal compounds, an antifungal compound extracted from Epicoccum purpurascens, also known as Epicoccum nigrum, methods of producing the antifungal compounds, isolates and compositions comprising the antifungal compounds, and methods of using the antifungal compounds.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: November 19, 2019
    Assignee: Auckland UniServices Limited
    Inventor: Silas Granato Villas-Boas
  • Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
    Patent number: 10479803
    Abstract: This application relates to derivatives of Formula I: and pharmaceutically acceptable salts thereof, which are inhibitors of PI3K, and compositions and methods of treatment related thereto.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: November 19, 2019
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, Andrew P. Combs
  • Norepinephrine compositions and methods therefor
    Patent number: 10471026
    Abstract: The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: November 12, 2019
    Assignee: Nevakar Inc.
    Inventors: Tushar Hingorani, Prem Sagar Akasapu, Kumaresh Soppimath
  • Pharmaceutical compositions comprising meloxicam
    Patent number: 10471014
    Abstract: Disclosed herein are compositions comprising a drug such as a triptan (e.g. rizatriptan) and/or an NSAID (e.g. meloxicam) in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability, solubility, or pharmacokinetics of the drug for the treatment of conditions such as pain.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: November 12, 2019
    Assignee: AXSOME THERAPEUTICS, INC.
    Inventor: Herriot Tabuteau
  • Amino acid compositions and methods for the treatment of liver diseases
    Patent number: 10471034
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: November 12, 2019
    Assignee: AXCELLA HEALTH INC.
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
  • Pharmaceutical compositions comprising meloxicam
    Patent number: 10471068
    Abstract: Disclosed herein are compositions comprising a drug such as a triptan (e.g. rizatriptan) and/or an NSAID (e.g. meloxicam) in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the drug for the treatment of conditions such as pain.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: November 12, 2019
    Assignee: AXSOME THERAPEUTICS, INC.
    Inventor: Herriot Tabuteau
  • ACC inhibitors and uses thereof
    Patent number: 10472374
    Abstract: The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: November 12, 2019
    Assignee: Gilead Apollo, LLC
    Inventors: Sathesh Bhat, Jeremy Robert Greenwood, Geraldine C. Harriman, James Harwood, Craig E. Masse
  • Method for treating osteoporosis, osteopenia or low bone mineral density
    Patent number: 10463657
    Abstract: A method for treating osteoporosis and related methods are disclosed. The methods generally comprise administering to a patient in need of treatment an effective amount of tris(8-quinolinolato)gallium(III) or an analog thereof.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: November 5, 2019
    Assignee: Altum Pharmaceuticals Inc.
    Inventor: Hooshmand Sheshbaradaran
  • Indazole-3-carboxamides and their use as Wnt/?-catenin signaling pathway inhibitors
    Patent number: 10464924
    Abstract: Indazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole-3-carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: November 5, 2019
    Assignee: Samumed, LLC
    Inventors: John Hood, Sunil Kumar KC
  • Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
    Patent number: 10463595
    Abstract: The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: November 5, 2019
    Assignee: ALLERGAN HOLDINGS FRANCE S.A.S.
    Inventors: Geoffrey C. Gurtner, Kenneth N. Horne, Jayakumar Rajadas
  • Combinations comprising MABA compounds and corticosteroids
    Patent number: 10456390
    Abstract: A combination which comprises (a) corticosteroid and (b) a dual muscarinic antagonist-?2 adrenergic agonist compound, or any pharmaceutically acceptable salt or solvate thereof.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: October 29, 2019
    Assignee: Almirall, S.A.
    Inventors: Monica Aparici Virgili, Marta Calbet Murtro, Montserrat Miralpeix Guell, Amadeu Gavalda Monedero, Carlos Puig Duran
  • Sphingosine kinase type 1 inhibitors and uses thereof
    Patent number: 10456370
    Abstract: Provided are inhibitors of sphingosine kinase Type I and their use in the treatment of asthma, among other indications and diseases.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: October 29, 2019
    Assignees: Enzo Therapeutics, Inc., Virginia Commonwealth University
    Inventors: Sarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
  • Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
    Patent number: 10456381
    Abstract: Disclosed herein are methods of treating conditions, which may be associated with elevated levels of plasma cells and/or B-cells, with a therapeutically effective amount of dexpramipexole or pharmaceutical acceptable salt thereof.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: October 29, 2019
    Assignee: Knopp Biosciences LLC
    Inventors: Michael E. Bozik, Steven Dworetzky
  • Phenylethynyl-substituted benzenes and heterocycles for the treatment of cancer
    Patent number: 10449186
    Abstract: Halogenated phenylethynyl-substituted heterocycles that possess either an N-alkylamino or N,N-dialkylamino group attached to the heterocycle or halogenated phenylethynyl-substituted benzenes that a nitrogen-containing heterocycle attached to the benzene inhibit the proliferation cancer cells and are useful antineoplastic agents.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: October 22, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: David S. Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang, Markos Leggas
  • Applications for etonogestrel in preparing anti-prostate cancer products
    Patent number: 10441591
    Abstract: This invention discloses uses for etonogestrel in preparing anti-prostate cancer products. This invention provides uses for etonogestrel in preparing anti-prostate cancer products. From carrying out cancer drug repositioning for the FDA- and CFDA-approved drug etonogestrel, experiments for this invention show, based on screening of non-anti-cancer drugs for various cancer cell lines (tissue types) and mutation sites, that etonogestrel has a new use as an anti-prostate cancer medication, thus achieving a new purpose for an old drug.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: October 15, 2019
    Assignee: SHANGHAI JIAO TONG UNIVERSITY
    Inventors: Yongyong Shi, Zhijian Song
  • Anti-fungal compositions for treating nails and methods for fabricating and using thereof
    Patent number: 10426744
    Abstract: Pharmaceutical compositions for treating, mitigating or preventing fungal nail diseases, disorders or pathologies are described, the compositions comprising at least one functionalized allylamine compound, at least one functionalized triazole compound, and at least one functionalized imidazole compound. Methods for fabricating the compositions and using them are also described.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: October 1, 2019
    Assignee: Harrow Health, Inc.
    Inventor: Dennis Elias Saadeh
  • Methods for inhibiting cancer cells
    Patent number: 10426755
    Abstract: The present invention provides methods for treating cancer, by administering a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods for reducing cancer cell metastasis, by administering a therapeutically effective amount of a compound of formula (I) described herein or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 1, 2019
    Assignees: CHANG GUNG MEMORIAL HOSPITAL, CHIAYI, CHANG GUNG UNIVERSITY
    Inventors: Ching-Yuan Wu, Kuan-Der Lee, Hong-Yo Kang, Yu-Shih Lin
  • Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids
    Patent number: 10426786
    Abstract: Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose, and administration of such compositions for mitigation of an epileptic seizure. Further provided are compositions comprising a benzodiazepine, a neurosteroid, and an NMDA blocker, and administration of such compositions for mitigation of an epileptic seizure.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: October 1, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael A. Rogawski, Isaac N. Pessah, Zhengyu Cao, Pamela J. Lein
  • Norepinephrine compositions and methods therefor
    Patent number: 10420735
    Abstract: The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: September 24, 2019
    Assignee: NEVAKAR INC.
    Inventors: Tushar Hingorani, Prem Sagar Akasapu, Kumaresh Soppimath
  • Compositions and methods for treating dementia
    Patent number: 10420770
    Abstract: The present invention provides methods and compositions for improving episodic memory and treating dementia.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: September 24, 2019
    Assignee: EIP Pharma, LLC
    Inventor: John Jahangir Alam