Abstract: An injectable substance delivery device comprising a pen device body, a cartridge, a plunger, a drive mechanism, and at least one of a lock-out mechanism and a rate-limiting mechanism. The lock-out mechanism is provided through a ratchet engagement between the body and the plunger to restrict plunger movement and to ensure that the required needle puncture depth is realized prior to injection by locking out the injection mechanism from advancing until a specified force is applied to the skin. A rate-limiting mechanism is also provided through a user compressed plunger drive spring to ensure that a specific rate of injection is realized during the injection of a medicament.

Abstract: The disclosures made herein relate to an infusion device specifically adapted for syringe injections. In one embodiment of the disclosures made herein, an infusion device comprises a body including an accessible surface having a single inlet port therein, an engagement surface having a single outlet port therein, a medication delivery channel extending between the single inlet port and the single outlet port, and an identification feature on the accessible surface of the body adjacent to the single inlet port. The single inlet port of the medication delivery channel is tapered thereby forming a funnel-shaped entry into the medication delivery channel. A cannula is coupled to the body at the single outlet port and is adapted for receiving medication from the single outlet port and transmitting the medication therethrough.

Abstract: A delivery device for delivery of a medicament to a user including a container defining a reservoir storing the medicament, a body in which the container is received, a spray nozzle arranged on one of the body and the container for receiving medicament expelled from the container, and a pusher actuatable for pushing the medicament from the container reservoir through the nozzle, said pusher being movable from a rest position to a fully activated position relative to said body in response to an actuating force. The assembly is particularly applicable to nasal syringes where it is desirable to deliver the medicament in the form of a spray.

Abstract: An infusion set has a disposable inserter that can insert a needle at a controlled rate of speed to a depth to deliver insulin or other medicament to the upper 3 mm of skin surface, and a skin securing, adhesive layer to secure the skin surface at the insertion site such that the inserter that can insert a needle without a risk of tenting of the skin surface. Position of the inserted needle can be maintained by providing a separated inner and outer hub of the infusion set that can isolate the inserted needle from external forces such that the needle can be maintained at a depth to deliver insulin or other medicament to the upper 3 mm of skin surface during normal use.

Abstract: A sealing arrangement for a medical introducer having a distal end for introduction into a patient's blood vessel. The introducer includes a flexible sealing member having an aperture for introduction of a guide wire or other medical device therethrough. A constraining structure, such as a washer, tightly contacts and surrounds the sealing member just proximal to an enlarged diameter flange at the distal end of the sealing member. The inner diameter of the constraining member is less than the outer diameter of the flange providing a constraint on the sealing member and lessening the distortion of the sealing member normally occasioned when a device is pulled outwardly or proximally through the introducer away from the patient. When the constraining structure is a washer, the washer is easily assembled to the introducer by simply being fitted into an annular notch formed just proximal to the distal end of the sealing member.

Abstract: The present invention relates to a holder for an injection syringe (18), with a housing (12) designed to receive the syringe, with a stand (14) for placing on a supporting surface, and with retaining means (38, 52, 54, 62, 64) for axially and/or radially fixing the syringe (18) on or in the holder, wherein the retaining means (38, 52, 54, 62, 64) are designed in such a way that an outlet (26) of a syringe (18) arranged vertically in the holder comes to lie facing the free end of the stand (14) and at a distance therefrom.

Abstract: A respiratory treatment device comprising a self-sensing respiratory treatment device comprising: power supply means; a liquid dispensing element comprising an actuator and a dispensing aperture; electronic control means operable to control said actuator; liquid supply means; valving means; wherein said actuator is operable to execute in itself at least a dispensing function and a detecting function, the detecting function detecting at least characteristics external to the self-sensing respiratory treatment device and causing said actuator to generate a command signal, and wherein said electronic control means is operable to control said valving means and said actuator based on the reception of said command signal, wherein said actuator is a piezoelectric actuator, and the respiratory treatment degvice further comprising: a mouthpiece, and a fluidic interface, wherein said electronic control means and said piezoelectric actuator being arranged to detect a breathing pattern of a user through said mouthpiece.

Abstract: Among the various embodiments, objects and features of the present invention may generally be noted an inflation/deflation syringe that enables one-handed operation to inflate a medical device to a given pressure or volume and one-handed operation to deflate said medical device.

Abstract: Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.

Abstract: A method and apparatus are disclosed for delivery of a drug to a recipient. In some embodiments, the delivery apparatus may unseal a drug containing reservoir. In some embodiments, the delivery rate may be controlled and/or adjustable. Optionally the apparatus may be disposable. Optionally, the apparatus may have a low profile and/or be wearable and/or attachable to the recipient. Optionally, discharge of the drug and/or unsealing of the reservoir may be driven by a plunger moving parallel to the base of the apparatus. Optionally, the apparatus may release a hypodermic needle into the recipient. Optionally, release of the hypodermic needle may be in a direction non-parallel and/or orthogonal to the direction of movement of the plunger. Optionally, prior to release, the hypodermic needle may be preserved in an aseptic state by a needle opening septum sealing a needle opening. Optionally, upon release, the hypodermic needle may pierce the needle opening septum.

Abstract: The present invention relates to a medical device for administering a medicinal product to a patient comprising at least one component (2, 8, 10, 12, 14, 15, 16, 17, 18, 20, 22, 24, 26, 28) comprising a material having an additive embedded therein, wherein the additive is adapted to provide a visually perceptible signal when exposed to electromagnetic radiation. The invention is particularly intended for drug delivery devices, such as e.g. of pen-type injectors. With the visually perceptible signal embedded in the at least one component, visually controlled assembly of such devices can be improved. Additionally the invention provides an effective means antagonize counterfeiting of drugs and of medical devices.

Abstract: An arrangement for coupling a plunger to either a syringe or a stopper arranged in the syringe. The arrangement includes a syringe holder which is slidably arranged in a housing. The syringe holder is provided with at least one resilient syringe holder arm arranged distally, the syringe holder arm having an inclined surface for bearing against a shoulder, which is arranged at the plunger. The syringe holder arm is supportable by an inner surface of the housing in order to prevent it from being flexed outward in a first position. A widened portion is provided in the housing for allowing the syringe holder arm to flex outwards and disconnect from the plunger when in a more proximal position so as to switch load of the plunger from the syringe to the stopper.

Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

Abstract: Several needle assemblies and intracellular delivery devices that are used for the delivery of prophylactic and/or therapeutic material (i.e., delivered agents) into a tissue of a subject are disclosed. Preferably, the needle assemblies and/or the intracellular delivery devices comprise needles and/or needle electrodes, which are disposed in an array (e.g., a Y-type array having three outer needles and a center needle), wherein each needle in the array has a closed end and a plurality of apertures along each needle barrel, and the apertures on the needle barrels of the outer needles of the array are positioned to deliver the delivered agent toward the apertures of the center needle and/or an adjacent needle, but not outside of the active zone defined by the area within the needle array and the apertures on the needle barrel of the center needle are positioned to deliver the delivered agent toward the outer needles.

Abstract: Systems, devices and methods are presented in the subject disclosure for recommending an insulin dose adapted for use with an insulin delivery device. In some embodiments, the method may include receiving blood glucose (BG) data, determining one or more insulin sensitivity (IS) values associated with the BG data, and determining an insulin dose based on the determined one or more IS values. A system for carrying out such a method is also presented.

Abstract: An intravenous pump system includes an intravenous pump having an air bubble detector, a separate air trap module and a patient line. The air trap module is connectable to a set interface upon which the pump can operate. The air trap module includes an air chamber capable of receiving fluids and air, a plurality of valves controlling the flow of the fluids and air, and an air vent. The patient line is connectable to the air trap module and to a patient. The air trap module includes an actuator to control the state of the valves to enable, at least during a venting mode, the pump to push air out of the air chamber via the vent without disconnecting the patient from the patient line.

Abstract: A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.

Abstract: A method and apparatus for determining stability of a patient's intrinsic rhythm in a cardiac pacing device. Cardiac pacing pulses are delivering to a chamber of a patient's heart by the pacing device at a first pulse amplitude. The device measures a first series of intervals between successive sensed and paced events. The device then determines whether the first measured series of intervals meets a stability criterion. Responsive to the first measured series of intervals failing to meet the stability criterion, the device determines whether the first measured series of intervals includes an interval between a delivered pacing pulse and a sensed event that is less than a defined duration.

Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module is initially in a locked state until attached to a drug delivery where a locking plate is moved to a triggering state. The medicated module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a biasing member automatically activates the reservoir when the needle guard is retracted when the module is in the triggering state. The needle guard prevents accidental needle sticks before and after an injection, and locks after dose delivery.

Abstract: Some embodiments of an infusion pump system can be configured to provide improved safety monitoring features so that a user receives proper dosage amounts.