Abstract: The invention is related to a manifold comprising at least two valve receptacles, further comprising a fluid groove arrangement comprising at least two fluid grooves, wherein a first fluid groove of the at least two fluid grooves has a starting point near a first valve receptacle of the at least two valve receptacles and an end point near a second valve receptacle of the at least two valve receptacles and wherein a second fluid groove of the at least two fluid grooves has a starting point near a second valve receptacle of the at least two valve receptacles. The invention is further related to an apparatus comprising a manifold of the aforementioned kind and further comprising an inner body of a dispense interface.

Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Abstract: A connector includes a housing having a flow path through which liquid passes, and a male connector connecting portion having a substantially circular tube hole communicating with the flow path; and a valve formed of an elastic material and adapted to block the male connector connecting portion of the housing. The valve includes a top surface exposed from the male connector connecting portion, a bottom surface opposite to the top surface, and a slit opened at least on the top surface or the bottom surface. The housing includes a stopping portion configured to be engaged with a tip end of a male connector to define an insertion length of the male connector.

Abstract: A medical device comprises a flexible member that can be adhesively attached to a housing of the medical device, allowing implantation of the medical device into a body through an incision of reduced size. The flexible member can be attached to the housing either before or after implantation into the body. The flexible member comprises suture locations, including a permeable membrane or a suture hole, for suturing the medical device to tissue of the body. The suture holes can be filled with a substance penetrable by a suture needle, to minimize tissue ingrowth before or after suturing.

Abstract: The invention relates to a transdermal therapeutic system (TTS), which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system includes a back layer and an active substance-containing layer that contains at least one peptide and a carrier substance, preferably as a textile web material.

Abstract: Apparatus and methods for an endovascular catheter that can be inserted within tortuous body anatomies and then selectively stiffened and fixed in place. In a particular embodiment, this stiffness is reversible. The stiffness or a comparable mechanical characteristic of the catheter assembly may be adjusted to a relatively low value during insertion (so that it easily navigates a guide wire or the like), and then subsequently adjusted to a relatively high value in situ to keep the catheter assembly substantially fixed in place (i.e., during delivery of an interventional device).

Abstract: A centrifugal fan includes an impeller and a motor which rotates the impeller. The impeller includes an upper shroud, a lower shroud, and blades arranged therebetween. A rotor of the motor is attached to an attachment part of the lower shroud. In a section passing a rotary shaft of the impeller, the rotor and the attachment part are provided at a more outer side than a circle having a center on a line passing an upper end portion of an inlet opening at an inner side and parallel to the rotary shaft of the impeller, having a radius of 80% of a distance from the upper end portion of the inlet opening to a surface of the lower shroud below the upper end portion, and being tangent to the surface of the lower shroud or passing an end edge portion of the lower shroud.

Abstract: A medication delivery system for delivering medicament to a body of a user. The medication delivery system may include a housing having a plurality of medicament reservoirs therein, a first sensor configured to continuously monitor a parameter of the body, and a pump mechanism configured to pump medicament from each of the plurality of medicament reservoirs to a delivery mechanism having a portion disposed within the body of the user.

Abstract: An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.

Abstract: An infusion set has a partially integrated ballistic inserter that can insert a needle at a controlled rate of speed to a depth to deliver content to the upper 3 mm of skin surface, and a skin-securing adhesive layer to secure the skin surface at the insertion site such that the inserter that can insert a needle with a reduced risk of tenting of the skin surface. A removable turnkey or pushable handle can be provided to release a driving spring of the ballistic inserter to insert a needle at a controlled rate of speed, of 3.3 ft/sec. (1.0 m/sec.) up to and including those greater than 10 ft/sec. (3.0 m/sec.), then release from the set for disposal. The infusion set can further include an extendable interface ring that retracts when the inserter is removed from the infusion set.

Abstract: An infusion site retainer configured to maintain tubing coupled to an infusion port includes a base configured to be secured to a patient and comprises a patient surface opposite a first surface. At least one trench is formed in the base to couple the tubing to the base.

Abstract: A method and apparatus are disclosed for delivery of a drug to a recipient. In some embodiments, the delivery apparatus may unseal a drug containing reservoir. In some embodiments, the delivery rate may be controlled and/or adjustable. Optionally the apparatus may be disposable. Optionally, the apparatus may have a low profile and/or be wearable and/or attachable to the recipient. Optionally, discharge of the drug and/or unsealing of the reservoir may be driven by a plunger moving parallel to the base of the apparatus. Optionally, the apparatus may release a hypodermic needle into the recipient. Optionally, release of the hypodermic needle may be in a direction non-parallel and/or orthogonal to the direction of movement of the plunger. Optionally, prior to release, the hypodermic needle may be preserved in an aseptic state by a needle opening septum sealing a needle opening. Optionally, upon release, the hypodermic needle may pierce the needle opening septum.

Abstract: A method and system for detecting information related to a drug reservoir. The method includes transmitting energy at a coded material disposed on a drug reservoir, where the energy has at least one predefined characteristic. The coded material identifies information related to the drug reservoir. The coded material modifies the energy and emits the modified energy to a receiver. The method further includes receiving at the receiver the modified energy. The method further includes determining information related to the drug reservoir based on the modified energy as the drug reservoir is loaded into a drug delivery device.

Abstract: A control valve is configured such that a suction pressure, which is used to displace a sub-valve element in a valve opening direction after a main valve has been closed, is varied according to a value of current supplied to a solenoid. A crankcase communication port, which communicates with a crankcase of a compressor, and a suction chamber communication port, which communicates with a suction chamber of the compressor, are provided in a body. A sub-valve chamber whose diameter is larger than that of the main valve hole is formed between the crankcase communication port and a main valve hole, and a sub-valve is placed in the sub-valve chamber.

Abstract: A multistage ejector has a nozzle arrangement, which has at least three nozzles which are arranged in series in the direction of a longitudinal axis, wherein the nozzles are designed for passage of a throughflow of a fluid, wherein a fluid gap is provided between adjacent nozzles in each case, wherein at least two of the at least three nozzles are interconnected monolithically to form a nozzle string, and wherein the nozzle string is arranged at least partially in a sleeve and the nozzle string and the sleeve are detachably fastened to each other. The nozzle string and the sleeve are axially fastened to each other by fastening mechanism which acts in a positively locking manner.

Abstract: A valve is provided for controlling flow along a fluid line that includes an outer shell and an inner housing slidably disposed therein that includes connector threads surrounding a boss on one end and a passage through the boss. A backing member is coupled to the outer shell and has a sealing pin extending into the passage. The inner housing is movable helically relative to the outer shell from a closed position wherein a sealing pin engages an outlet opening at the distal end of the boss to seal the opening and an open position in which the inner housing is directed away from the sealing pin to open a fluid path through the valve. A torque limiter mechanism between the outer shell and inner housing resists movement from the valve closed position to the valve open position until a selected torque level is reached.

Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Abstract: Aerosolizing delivery apparatuses can include cartridges configured to be detachably connected to a delivery device. The cartridges can include: a housing defining a reservoir and a cartridge outlet, the cartridge outlet configured to permit fluid communication between the reservoir and an exterior of the cartridge. A surface of the housing can be configured to define a bypass port between the housing and a surface of the delivery device when the cartridge is assembled with the delivery device.

Abstract: A diaphragm pump may comprise a housing defining a first pumping chamber, a second pumping chamber, and a hydraulic fluid chamber, a first flexible diaphragm separating the first pumping chamber from the hydraulic fluid chamber, a second flexible diaphragm separating the second pumping chamber from the hydraulic fluid chamber, a rod mechanically linking the first flexible diaphragm and the second flexible diaphragm such that an expansion of one of the first and second flexible diaphragms exerts a contraction force on the other of the first and second flexible diaphragms, and a piston disposed within the hydraulic fluid chamber and configured to reciprocate to cause a hydraulic fluid contained within the hydraulic fluid chamber to alternately exert an expansion force on the first and second flexible diaphragms.

Abstract: An infusion set has a retraction dial that can be removably assembled with the infusion set and access a threaded needle hub contained therein such that the dial can be used to advance or retract a needle hub and an inserted needle to a more precisely controlled insertion depth to deliver insulin or other medicament intradermally (i.e. to the upper 3 mm of skin surface). Position of the inserted needle can be maintained by providing a separated and isolated needle hub, main base and main hub of the infusion set that can isolate the inserted needle from external forces such that the needle can be maintained at a depth to deliver content to the upper 3 mm of skin surface during normal use.