Abstract: An automated DNA sequencing apparatus having a reactor for providing at least two series of DNA products formed from a single primer and a DNA strand, each DNA product of a series differing in molecular weight and having a chain terminating agent at one end; separating means for separating the DNA products to form a series bands, the intensity of substantially all nearby bands in a different series being different, band reading means for determining the position anThis invention was made with government support including a grant from the U.S. Public Health Service, contract number AI-06045. The U.S. government has certain rights in the invention.

Abstract: A method of sterilizing a material web is disclosed and involves directing a material web toward the inlet of a chamber having constriction zones located therein whose flow area is less than the flow area of other portions of the chamber. The material web is moved through the inlet and through the constriction zone while a gaseous sterilizing agent is introduced into the chamber on one side of the constriction zone and while a vacuum is being drawn in the chamber from an opposite side of the constriction zone. The constriction zone causes the gaseous sterilizing agent to accelerate and flow in close contact with the material web at very high speed to ensure that the gaseous sterilizing agent contacts and is uniformly distributed over the whole width of the material web so that effective sterilization of the entire material web takes place.

Abstract: An apparatus for removing the dispersion medium in a metal or ceramic molded body which comprises a dispersion medium-removing vessel includes a condensing zone located in a upper part and a boiling zone located in a lower part, a separator to separater a solvent in the dispersion medium solution discharged from the vessel by heating the solution at a temperature higher than the boiling point of the solvent to evaporate it, the boiling zone being connected with the separator through a pipe to transport the dispersion medium solution and a pipe to transport the vaporized solvent to form a circuit, and a pump provided in the circuit. In the apparatus since the dispersion medium is removed in the boiling solvent, keeping a constant temperature is easy. The dispersion medium is promptly removed by contacting it with a solution of which the concentration of the dispersion medium is always low due to continuous removal of the dispersion medium in the separator. Since the boiling point of the solvent is about 20.

Abstract: The device serves to sterilize the filler neck and stopper associated with non-rigid bags of the type utilized for packaging tomato juice and similar foodstuffs. The neck is inserted into a heated and temperature-regulated cylindrical housing provided internally with an array of nozzles from which sterilizer (H.sub.2 O.sub.2) is sprayed into the encompassed enclosure; sterilization is achieved as the atomized fluid condenses uniformly on contact with the colder surfaces of the mouth and stopper.

Abstract: There are disclosed a spring and its combination with an evaporation cover for a test element, and a station of an incubator. The spring comprises two portions bent to form the letter "J". The longer portion includes means for retaining the spring in the incubator station, and the shorter portion includes means for retaining a cover under the spring.

Abstract: A dilution and mixing cartridge is provided that allows single (or multiple) dilutions of a sample with a diluent in a disposable cartridge in which a measurement, such as optical density, is made. Addition of sample to the device automatically measures the sample, and addition of diluent automatically causes a fixed ratio of sample and diluent to enter a receiving chamber, in which mixing and measurement can take place. A number of preferred embodiments are provided in which the diluent application site is located at a vertical height below the sample application site, flow directing chambers are provided to control flow of desired volumes of sample or diluted sample at the appropriate locations in the device and to direct excess sample and diluent to waste locations, or control mechanism are provided at flow directing chambers and other internal locations to verify correct operation of the device.

Abstract: An apparatus comprising a supporting structure having a surface, an optical sensor for sensing a compositional blood parameter and a deformable optical coupling element carried by the supporting structure. The optical sensor is carried by the supporting structure and is responsive to an optical input signal to provide an optical output signal related to the compositional blood parameter. The optical coupling element is in a position to receive at least one of the optical signals and the optical coupling element is transmissive to such received signal.

Abstract: An evaporation reduction apparatus for open mouth liquid containers and a method for substantially reducing liquid to air evaporation surface exposure wherein an elongated tube having an upper end portion of such outside dimension in relationship to the inside container mouth dimension to form a press fit upon insertion of the tube into the container. The tube having a bottom end and bottom end portion with at least one elongated slot open at the tube bottom end extending upwardly from the tube bottom, the tube having at least one bore passage in an upper end portion wall for fill venting purposes. The tube or evaporation chimney providing a method for reducing liquid evaporation from the open mouth container by reducing the actual liquid surface area exposed to ambient air.

Abstract: A particle control chamber enables experiments to be carried out on biological cells and the like using a laser system to trap and manipulate the particles. A manipulation chamber provides a plurality of inlet and outlet ports for the particles and for fluids used to control or to contact the particles. A central manipulation area is optically accessible by the laser and includes first enlarged volumes for containing a selected number of particles for experimentation. A number of first enlarged volumes are connected by flow channels through second enlarged volumes. The second enlarged volumes act as bubble valves for controlling the interconnections between the first enlarged volumes. Electrode surfaces may be applied above the first enlarged volumes to enable experimentation using the application of electric fields within the first enlarged volumes.

Abstract: A CO.sub.2 /O.sub.2 or pH/O.sub.2 gas sensor comprising a single optical fiber and a method for making the same. The optical fiber carries light signals at different wavelengths for monitoring either CO.sub.2 concentration or pH level, in combination with O.sub.2 concentration. Attached to the distal end of the fiber-optic probe is a cylindrical pellet that has one surface covered by a light reflective material (gold foil) and the other surface attached adjacent to the distal end of the optical fiber. Depending on whether the sensor is to monitor either CO.sub.2 or pH, the pellet comprises either a CO.sub.2 analyte indicator molecule or a pH analyte indicator molecule covalently bonded to a polymer matrix material. Also adjacent to the distal end of the optical fiber is disposed a second polymer matrix material which is codissolved with an O.sub.2 analyte reactive indicator molecule.

Abstract: An apparatus for transferring a test liquid between chambers of a chemical reaction pack. The apparatus includes a series of actuation modules arranged in adjacent relationship to each other to define chemical reaction pack receiving stations therebetween. Each actuation module includes pressure applicators for applying external pressure to the chambers of the reaction pack and temperature control elements for heating and cooling the test liquid within the chemical reaction pack.

Abstract: In a device for analyzing samples for mercury and/or hydride-forming elements by means of atomic absorption spectroscopy, a first arrangement for determining the mercury according to the amalgam method comprising passage throttling means in the form of a washing bottle and a tube connected downstream to a reaction vessel, the other end of which tube is connected to the measuring cell. The tube contains a gold net adapted to be heated and recooled according to the amalgam method. The second arrangement by which hydrides of the sample are directly connected to the measuring cell employs a conduit which leads directly to the measuring cell, bypassing the gold net by branching off from between the reaction vessel and washing bottle. The tube is connectable to a carrier gas source between the washing bottle and position of the gold net in the tube through a first shut-off valve. A second shut-off valve is arranged in the conduit directly leading to the measuring cell.

Abstract: An apparatus comprising a housing, a curved wall surface on the housing and a tube compressor carried by the housing. A compressible tube, which defines at least a portion of the passage, is positioned between the curved wall surface and the tube compressor. The tube compressor is mounted on the housing for free radial movement relative to the curved wall surface and for rotational movement. The tube compressor can be releasably drivingly coupled to an external rotary input so that the tube compressor can be rolled along the tube to pump fluid in the tube.

Abstract: An appliance for sterilizing contact lenses or the like includes a reaction vessel for containing the lenses in sterilizing contact with hydrogen peroxide solution and two catalytic elements for decomposing the hydrogen peroxide during the lens sterilization. The first catalytic element decomposes a portion of the initial concentration of hydrogen peroxide in the solution during the lens sterilization, and the second catalytic element accelerates combined decomposition of the reduced concentration of hydrogen peroxide in the solution resulting from decomposition by the first catalytic element, in order to achieve sufficiently reduced terminal hydrogen peroxide concentration at completion of the lens sterilization for safe contact by the eyes of a wearer with residues of hydrogen peroxide at the terminal concentration which may adhere to the sterilized lenses.

Abstract: The invention is directed to an arrangement for measuring the concentration of gaseous or vaporous components of a gas mixture by using optically distinguishable reaction zones from gas test tubes which contain a substance reacting with the component to be detected. The change of the reaction zone is determined by means of direct observation and/or by means of an opto-electronic scanning device. This arrangement is improved in accordance with the invention in that the reacting substance is accommodated at least in one channel formed in a carrier. The channel has a cross section in the reaction zone which is less than 1 mm.sup.2.

Abstract: A chemical analyzer includes a transport mechanism having a rotatable turntable adapted to hold a plurality of reagent test slides, a sample metering device, an incubator or temperature controller, a reflectometer and associated electronics and software. The rotatable turntable preferably holds up to twelve slides about its circumference, which slides are loaded onto the turntable by an inserter mechanism. The turntable positions the reagent test slides under the metering device, which device deposits a predetermined amount of sample onto each slide. The turntable also carries the slides above a reflectometer. After testing has been completed, an ejector mechanism automatically removes the reagent slides from the turntable.

Abstract: There is disclosed an apparatus useful in an analyzer, comprising a first mechanism for moving a stack of elements around at least one generally circular, horizontal track, a second mechanism for temporarily holding a stack on the track, and a third mechanism for altering the second mechanism between two states, one which holds the stack on the track and the other which releases the stack from the track.

Abstract: An ozone deodorizing device for use in refrigerators, in which ozone is intermittently generated under action of a timer by use of a creepage discharger to avoid consumption of the battery, the discharge quantity is equalized by use of a pulse generator varying its pulse width to compensate for the reduction of battery power.

Abstract: An automatic analyzing apparatus in which a plurality of analyzing modules, a plurality of analyzing routes and at least one bypass route bypassing at least one analyzing module are arranged. Each analyzing module is capable of analyzing samples with respect to one or more items, and samples successively supplied from the introduction sides of the modules are selectively delivered into each module in accordance with the possible analyzing items of each module and the analyzing items of the samples to be analyzed. The sample cup can pass the module via a bypass or can be returned to the introduction side of the module via a bypass, in accordance with the items to be analyzed, the effective distribution of the sample cups can be performed.

Abstract: A luminometer for assaying bioluminescence and chemiluminescence reactions characterized by sample wells having transparent bottom walls, a light detector positioned beneath the sample wells and a reagent injector above the wells.