Abstract: The present invention includes a cosmetic film. The film includes butylphthalimide isopropylphthalimide, one or more primary film forming polymers and one or more secondary film forming resins.
Type:
Grant
Filed:
November 6, 2002
Date of Patent:
March 14, 2006
Assignee:
Coty, Inc.
Inventors:
Steven W. Amato, Wayne M. Hoyte, Alexander Naranjo, Shirish Patel, Salvatore Barone
Abstract: Porous materials are disclosed having densities of at least about 6 pounds per cubic foot (96.1 kg/m3). The materials comprise silica and/or alumina. The porous materials are useful as supports for binding various chemical and biological molecules. The materials are useful as supports for analytical processes such as ELISA, blotting, and hybridization assays. The materials can be used as reinforcement agents for organic, inorganic, or metallic materials.
Abstract: An orally administered antihyperlipidemia composition according to the present invention includes from about 250 to about 3000 parts by weight of nicotinic acid, and from about 5 to about 50 parts by weight of hydroxypropyl methylcellulose. Also, a method of treating hyperlipidemia in a hyperlipidemic having a substantially periodic physiological loss of consciousness, includes the steps of forming a composition having an effective antihyperlipidemic amount of nicotinic acid and a time release sustaining amount of a swelling agent. The method also includes the step of orally administering the composition to the hyperlipidemic once per day “nocturnally,” that is in the evening or at night.
Abstract: A method for the protection of a human being against any health impairment as a result of the ingestion of the whole or parts of a transdermal therapeutic system containing at least one pharmacologically active ingredient, which is toxic or induces nausea or addiction at oral, but not at transdermal administration is disclosed. The method comprises adding to said transdermal therapeutic system a substance being able to keep off a human being from said ingestion.
Abstract: Disclosed are oxidized collagen compositions wherein the thiomethyl group of one or more of the methionine residues of the collagen have been replaced with methylsulfoxy and/or methylsulfonyl groups.
Abstract: The present invention presents a pharmaceutical composition for oral use with improved absorption, which comprises drug, aminoalkyl methacrylate copolymer E, and acidic substance and is obtained by bringing said 3 components together and uniformly mixing at least this polymer and this acidic substance, and a method of improving oral absorption by using this pharmaceutical composition. Moreover, the present invention presents an agent for improving oral absorption that increases drug permeability of the digestive tract mucous membrane and/or mucous layer present on the surface of this membrane, whose active ingredient is aminoalkyl methacrylate copolymer E. In addition, the present invention presents an oral agent for improving absorption by increasing drug permeability of the digestive tract mucous membrane and/or the mucous layer distributed over this mucous membrane, whose effective component is aminoalkyl methacrylate copolymer E.
Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
Type:
Grant
Filed:
October 10, 2002
Date of Patent:
March 7, 2006
Assignee:
SurModics, Inc.
Inventors:
Stephen J. Chudzik, Aron B. Anderson, Ralph A. Chappa, Timothy M. Kloke
Abstract: Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.
Type:
Grant
Filed:
March 20, 2002
Date of Patent:
March 7, 2006
Assignee:
Advanced Inhalation Research, Inc.
Inventors:
Richard P. Batycky, Blair C. Jackson, Lloyd P. Johnston, Jeffrey D. Mintzes, Ernest E. Penachio
Abstract: The invention concerns Gelatin compositions for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard gelatin capsules wherein the gelatin used is of non-bovine and non-pig origin and preferably derived from fish, poultry or plant sources. Especially preferred are film compositions for hard gelatine capsules prepared from fish gelatin.
Type:
Grant
Filed:
June 10, 2004
Date of Patent:
March 7, 2006
Assignee:
Warner-Lambert Company LLC
Inventors:
Robert Scott, Dominque Cadé, Xiongwei He
Abstract: The present invention provides an osmotic device containing controlled release venlafaxine in the core in combination with an anti-psychotic agent in a rapid release external coat. A wide range of anti-psychotic agents can be used in this device. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. One embodiment of the osmotic device includes an external coat that has been spray-coated rather compression-coated onto the device. The device with spray-coated external core is smaller and easier to swallow than the similar device having a compression-coated external coat. The device is useful for the treatment of depression, anxiety or psychosis related disorders.
Abstract: A method for simultaneously treating ocular rosacea and acne rosacea in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat ocular rosacea and acne rosacea but has substantially no antibiotic activity.
Abstract: Methods regarding local regional treatment in situ for an individual, such as of a tumor, are provided herein. A hydrogel composition is generated in situ in the tumor by administering a polymer, such as a polysaccharide or a polyamino acid, with a therapeutic agent, such as a radionuclide or a drug, and administering a cross-linking agent. The hydrogel/therapeutic agent composition is retained in the tumor for safe and efficient tumor therapy. Alternatively, a hydrogel composition is generated in situ in an artery which nourishes a tumor to occlude the artery.
Type:
Grant
Filed:
December 18, 2001
Date of Patent:
March 7, 2006
Assignee:
Board of Regents, The University of Texas System
Inventors:
David J. Yang, Dong-Fang Yu, Ali Azhdarinia, Tommy L. Lee, E. Edmund Kim
Abstract: The present invention is drawn to set of formulations of at least one compound selected from tolterodine, salts thereof, prodrugs thereof and/or metabolites thereof, wherein in the set of formulations contains at least one device for transdermal administration and at least one formulation for oral, sublingual, buccal, nasal, pulmonary, rectal and/or other transmucosal administration, in order to achieve an effect against overactive bladder and/or symptoms associated with this condition. The present invention is further drawn to methods of treating an overactive bladder with the formulations.
Type:
Grant
Filed:
November 22, 2002
Date of Patent:
March 7, 2006
Assignee:
Pfizer Health AB
Inventors:
Lene Orup Jacobsen, Bo Kreilgard, Ulla Hoeck, Helle Kristensen
Abstract: Methods and compositions are disclosed for the intravaginal or rectal delivery of selected serotonin reuptake inhibitors (SSRIs) to the systemic circulation. Such methods and compositions are useful in the treatment of depression, migraine headaches, chronic pain, psychoactive substance abuse disorders, pre-menstrual dysphoric disorder (PMDD) and obsessive compulsive disorders. The compositions may be formulated for the immediate release or controlled release of SSRIs over an extended period of time. A preferred SSRI is fluoxetine.
Type:
Grant
Filed:
March 12, 2002
Date of Patent:
February 28, 2006
Assignee:
Duramed Pharmaceuticals, Inc.
Inventors:
Anu Mahashabde, Martha Francine Kay, Brian Glazer, Junxiong Zhang
Abstract: Personal care products, particularly hair care products, are made herein by mixing (A) a polymer having defined repeat units of a monomer (e.g. ?-olefin) maleic anhydride alkyl half-ester or full acid, maleamic acid and maleimide, which is derivatized with an amine, and (B) a compound or polymer having a carboxylic acid functionality. These products exhibit excellent high humidity curl retention properties, as well as an advantageous blend of toughness and cohesiveness, and a strong affinity to natural fibers, when applied to keratin-based fibers, e.g. hair, skin, or textiles, e.g. cotton, wool; and also they are water-soluble and water-resistant.
Type:
Grant
Filed:
January 29, 2003
Date of Patent:
February 28, 2006
Assignee:
ISP Investments Inc.
Inventors:
Herbert Ulmer, Timothy Gillece, John Katirgis
Abstract: The invention relates to a packaging of products which are additionally packed in a pouch (2) in order to protect the same, whereby the packaging is comprised of at least two pouches. The products placed in these pouches can be identical or different. These products are to be preferably removed and used in a predetermined order.
Type:
Grant
Filed:
March 9, 2000
Date of Patent:
February 28, 2006
Assignee:
LTS Lohmann Therapie-Systeme AG
Inventors:
Detlef Palm, Ronald Hackbarth, Michael Heberle, Detlev Neuland
Abstract: The present invention provides prodrug and multiprodrug complexes comprising drugs specifically bound to synthetic receptors in such a manner that active drug becomes available only in the presence of a targeted pathophysiologic receptor. Methods for preparation end use of these prodrug complexes in drug delivery systems are also provided.
Abstract: The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form drug containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
Type:
Grant
Filed:
August 20, 2002
Date of Patent:
February 28, 2006
Assignee:
Emisphere Technologies Inc.
Inventors:
Sam J. Milstein, Evgueni N. Barantsevitch, Donald J. Sarubbi, Andrea Leone-Bay, Duncan R. Paton
Abstract: The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a fatty acid analog. The invention also provides methods for using the novel imaging agents, and kits containing one or more of the novel imaging agents of the invention.
Abstract: The invention relates to biocidal polymers based on guanidine salts characterized in that they are representatives of a number of polyoxyalkylene guanidines and their salts and are a product of a polycondensation of guanidine salts with diamines which include two amino groups and polyoxyalkylene chains therebetween. In addition to a high bactericidity, these new polymer products are provided with a relatively low toxicity, an increased hydrophily, a quick and complete dilution in water, increased values of relative molar mass, and distinct characteristics of polymer surface active substances.
Type:
Grant
Filed:
May 8, 2001
Date of Patent:
February 21, 2006
Assignee:
P.O.C. Oil Industry Technology Beratungsges m.b.H.
Inventors:
Oskar J. Schmidt, Andreas Schmidt, Dimitri Toptchiev