Abstract: The present invention relates to a medicament delivery device comprising a housing (10, 20, 24, 30), a biased medicament delivery member guard (64) arranged movable in relation to the housing from a proximally extended position to a retracted position, a power pack (87) comprising a plunger rod (88) and a force element (118) arranged to act on said plunger rod (88), which power pack (87) is actuated by a release clip (96) movable in relation to the housing and arranged to said plunger rod (88) for releasibly holding said plunger rod (88) with the force element (118) in a tensioned state; a rotator (82) rotatably arranged inside said housing, which rotator (82) is arranged with a guide element (80) and a medicament delivery member guard lock element (84, 86) on its outer surface, wherein said medicament delivery member guard (64) is arranged with release clip activation elements (112) operably arranged to act on said release clip (96) for releasing said plunger rod, and wherein said medicament delivery member

Abstract: A needle-equipped syringe reduces an inclination of a needle by reducing an inclination of a core pin when insert molding is performed. The needle-equipped syringe includes a barrel formed using a resin and having a cylindrical body, a nozzle part provided at a distal end of the body, and an opening part provided at a proximal end of the body; and an injection needle held by the nozzle part. The injection needle and the barrel are integrally molded so that an axis of the injection needle is substantially parallel to an axis of the body. The body has a thick part and a thin part located at a proximal end of the body at opposing positions across the axis of the body. At the proximal end of the body, an axis of an inner surface of the body is offset from an axis of an outer surface of the body.

Abstract: This disclosure relates to preventing over-delivery of a drug and related systems and methods. In certain aspects, a method is performed by a data processing apparatus. The method includes receiving, from a drug delivery device, information pertaining to a desired amount of fluid to be delivered by the drug delivery device and receiving information pertaining to a delivered amount of a fluid that has been delivered by the drug delivery device. The method also includes determining that the delivered amount satisfies a predetermined threshold amount and in response to the determination, detecting whether an initial amount of fluid provided to the drug delivery device corresponds to the desired amount of fluid to be delivered.

Abstract: A micropump according to the invention uses axially oriented pistons to define a pump volume. Translating the pistons axially with respect to each other within a pump housing draws a metered amount of fluid into the pump volume from a reservoir port for delivery to a cannula port when the space is collapsed. Radially situated seals on the pistons cooperate with the axial movement to close off and open the cannula port and the reservoir port respectively at different positions of the piston stroke.

Abstract: A long nose manipulatable catheter is described herein. The catheter generally comprises a flexible joint region defining a main lumen and an adjacent wire lumen. The wire lumen has an opening near or at a distal end of the flexible joint region and a push/pull wire can be pushed or pulled through the wire lumen. The catheter assembly may also comprise at least one radio-opaque marker band for securing the push/pull wire. The joint region has a predetermined length sized to affect a flexure of the joint and is generally located at the distal end of the catheter. The joint region itself may be varied to extend distally from where the braid terminates, or it may extend to encompass a portion of the braid. By varying a length of the joint region, the amount of curvature and flexure of the joint region can be controlled.

Abstract: In one embodiment, the present invention includes a method for repairing a cartilage defect including: preparing a cartilage defect by removing unwanted or damaged tissue; creating at least one perforation into or through subchondral bone, below and/or adjacent to the cartilage defect to induce the flow of bone fluid; allowing the bone fluid to bleed through the at least one perforation up into the cartilage defect to fill at least a portion of the cartilage defect; and applying a biomaterial into the defect to produce a clot for cartilage regeneration.

Abstract: A cannula seal is presented. The cannula seal includes a cross-slit seal that can include a side wall that includes folded sidewalls; slits that are formed by the folded sidewalls when the cross-slit seal is in a closed position; and a concave end surface at the slits. The cross-slit seal can include energizing ribs formed to close the seal. The instrument guide includes a pyramidal shaped seal that seals against doors when no instrument is inserted and seals against an instrument when the instrument is inserted.

Abstract: This invention relates to a transnasal tube assembly comprising a transnasal tube and an integrated tether for anchoring the transnasal tube, wherein the integrated tether is permanently fixed to the transnasal tube at a first fixation point, and wherein the integrated tether is reversibly fixable to the transnasal tube at a second fixation point.

Abstract: A catheter has excellent torque transmissivity and excellent flexibility, thus enabling easy insertion of the catheter into a blocked portion of a blood vessel. Additionally, the catheter easily restores to its original form even when the catheter is curved and deformed a large amount. Thus, a break at a border area between a catheter main body part and a distal end tip is prevented when the catheter is bent and deformed. This improves the operability of the catheter with a combination device such as a guide wire. The catheter includes a hollow coil body formed of at least one helically wound stranded wire. The at least stranded wire includes a plurality of wires wound into a helical structure.

Abstract: This disclosure describes techniques and devices for improvement of surgical outcomes for tissue removal surgeries. A surgical instrument with adjustable and selective resection is described. The disclosed devices and methods allow selective tissue removal.

Abstract: This disclosure describes techniques and devices for improvement of surgical outcomes for tissue removal surgeries. A surgical instrument with adjustable and selective resection is described. The disclosed devices and methods allow selective tissue removal.

Abstract: A medical connector including a first rigid body capable of being connected to a medical infusion line and having an elongated tubular element in which there is a conduit opening out at opposite extremities, a first extremity of the tubular element being capable of being directly connected to the medical infusion line, the elongated tubular element being capable of being closed off at one of its first open extremities by a second body associated with the first body. The second body is of yielding material and at least partly covers the elongated element and extends beyond the second extremity of that element in such a way as to close off the opening thereof, such second body being overmoulded onto the first body and forming a single piece therewith.

Abstract: A surgical hand piece is described that maintains a vacuum pressure within the hand piece at a selected level. A check valve is provided substantially near an inlet of an integrated aspirating pump. The check valve opens to introduce fluid into the hand piece to maintain the vacuum pressure within the hand piece at or above the selected level so as to prevent or substantially reduce post-occlusion flow.

Abstract: The subject matter disclosed herein relates to systems, methods and/or devices for calibrating sensor data to be used in estimating a blood glucose concentration. A relationship between sensor measurements and reference readings may be used to estimate a relationship between sensor measurements and blood glucose concentration. Such sensor measurements may be weighted according to a decreasing function of uncertainty associated with sensor values.

Abstract: The present invention relates to a fluid injection needle unit having a function of preventing needlestick injury and infection wherein a cover, a needle body and a body are improved in shape, and after the needle body is inserted into a blood vessel of a patient, the cover is coupled to the bottom end periphery of the body and the needle body is detached from the body by means of detachable mounting members, so that a needle and the needle body are inserted unitarily into the cover to prevent the occurrence of the needlestick injury and infection.

Abstract: A PIVC includes a catheter adapter having a catheter that extends distally from the catheter adapter, and an introducer needle that inserts through the catheter. The introducer needle has a grip component at a proximal end of the introducer needle. The grip component extends outwardly and distally to form a winged grip adjacent the catheter adapter when the introducer needle is inserted within the catheter. The grip component can be rotatable within the catheter adapter to allow repositioning of the winged grip with respect to the catheter adapter.

Abstract: The invention relates to a breast pump kit comprising a breast pump collection system which is to be replaceable and detachable connected to an electrical driving unit during use. The breast pump collection system comprises a breast shield for placing on a breast of a user, a pump unit, and tubing connecting the breast shield to the pump unit. The pump unit comprises a compartment of a variable volume in fluid connection to the exterior only via the tubing. The pump unit is configured to be detachable combined to the driving unit such that a driving motion of the driving unit acts to alternatingly expand and contract the compartment of the pump unit. In this way the pump unit creates alternating suction and pressure in the breast shield and at the breast of the user when in use. The invention further relates to a breast pump collection system for use in such breast pump kit.

Abstract: MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.

Abstract: A fluid delivery device comprising a fluid reservoir; a transcutaneous access tool fluidly coupled to the fluid reservoir; and a drive mechanism for driving fluid from the reservoir, the drive mechanism comprising a plunger received in the reservoir; a leadscrew extending from the plunger; a nut threadably engaged with the leadscrew; a drive wheel; and a clutch mechanism coupled to the drive wheel, wherein the clutch mechanism is configured to allow the nut to pass through when disengaged and is configured to grip the nut when engaged such that the drive wheel rotates the nut to advance the drive rod and the plunger into the reservoir.

Abstract: A needleless syringe comprises an enclosing unit for an injection objective substance, a pressurizing unit for the injection objective substance, a discharge unit having a flow passage for allowing the injection objective substance to flow therethrough so that the injection objective substance is discharged from an open end of the flow passage to an injection target area, the open end being formed so that an area thereof is smaller than a flow passage area of the enclosing unit, and a minute pore unit including a minute pore having a flow passage area smaller than the area of the open end of the discharge unit and which is arranged on an outer side of the open end so that the injection objective substance discharged from the open end passes through the minute pore and arrives at a side of the injection target area.