Patents Examined by Tracy Vivlemore
  • Patent number: 10364440
    Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: July 30, 2019
    Assignees: Brown University, Rhode Island Hospital, The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Thomas J. Webster, Qian Chen, Yupeng Chen, Hicham Fenniri, Usha Devi Hemraz
  • Patent number: 10357543
    Abstract: Disclosed are methods and compositions related to treatment and prevention of sarcopenia and/or nerve injury by increasing survival motor neuron (SMN) levels in an individual in need thereof.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: July 23, 2019
    Assignees: Ohio State Innovation Foundation, The Research Institute At Nationwide Children's Hospital
    Inventors: Arthur Burghes, William Arnold, Brian Kaspar, Vicki McGovern
  • Patent number: 10358641
    Abstract: Provided herein are monoliths with attached recognition compounds which selectively bind ligands, methods of preparing such monoliths, arrays thereof and uses thereof. For example, monoliths provide herein can be used in columns and arrays thereof.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: July 23, 2019
    Assignee: DiCE Molecules SV, LLC
    Inventors: Pehr Harbury, Madan Paidhungat, Robin Prince
  • Patent number: 10352927
    Abstract: It is intended to develop and provide a method for detecting a particular glycan-isoform rapidly and specifically by a small number of steps. The present invention provides a glycan-isoform detection method comprising quantifying an immune complex formed by the mixing of a test sample with a sugar chain non-reducing terminal residue-binding lectin and an antibody specifically binding to the protein moiety of the glycan-isoform, etc., comparing the obtained amount of the immune complex with the amount of a control immune complex obtained when a control sample is not mixed with the sugar chain non-reducing terminal residue-binding lectin or is mixed with a control protein, and determining the presence or absence of the glycan-isoform of interest in the test sample on the basis of the difference between these amounts.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: July 16, 2019
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hisashi Narimatsu, Atsushi Kuno, Yuzuru Ikehara, Yasuhiro Hashimoto, Keiro Shirotani, Kiyomitsu Nara, Yoshinobu Kariya, Hiromi Ito, Kyoka Hoshi
  • Patent number: 10351846
    Abstract: An apparatus and method for applying a chemistry to samples of interest are provided. The apparatus and method include a flexible tape mounted on an arrangement of guide rollers. Samples of interest (e.g., clusters of DNA templates) are bound to at least one surface of the flexible tape. The method and apparatus further comprise one or more read heads in relation to the flexible tape and a plurality of reservoirs along a path of the flexible tape. The reservoirs comprise liquids comprising chemical reagents for performing the chemistry on the samples of interest bound to the at least one surface of the flexible tape. The method and apparatus further comprise a drive system for driving at least one of the guide rollers to advance the flexible tape into and out of the reservoirs.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: July 16, 2019
    Assignee: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Jonathan Mark Boutell, Gary Mark Skinner, Gareth Jenkins
  • Patent number: 10345308
    Abstract: Anti-carbohydrate antibodies are detected by (a) contacting an array of oligomannose-serum albumin conjugates immobilized on a substrate with an antibody-containing serum sample under conditions wherein TM10 antibodies bind the oligomannose of the conjugates at at least micromolar affinity; and (b) detecting resultant binding of specific antibodies of the sample to the oligomannose of the conjugates, as indicative of the anti-carbohydrate antibodies.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: July 9, 2019
    Assignee: SRI INTERNATIONAL
    Inventor: Denong Wang
  • Patent number: 10344300
    Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: July 9, 2019
    Assignees: Brown University, Rhode Island Hospital, The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Yunpeng Chen, Qian Chen, Thomas J. Webster, Hicham Fenniri, Usha Devi Hemraz
  • Patent number: 10338080
    Abstract: The invention provides methods for sensitive and specific detection of complement fixing antibodies in a biological sample using complement factor C1q, including autologous complement factor C1q present in the biological sample and a detectably labeled antibody that binds the autologous complement factor C1q, exogenous human complement factor C1q and a detectably labeled antibody that binds the exogenous human complement factor C1q, detectably labeled exogenous human complement factor C1q, or a combination of autologous complement factor C1q and exogenous human complement factor C1q. The invention also features kits, systems, and devices for use in the methods of the invention.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Dolly B. Tyan, Ge Chen
  • Patent number: 10338069
    Abstract: Glycan arrays that can detect and distinguish between various sub-types and strains of influenza virus are provided. Methods for using the glycan arrays with assays using nanoparticle amplification technique are disclosed. Sandwich assays using gold nanoparticles conjugated to phage particles comprising influenza virus-specific antibodies for detecting multiple serotypes using a single reaction are provided. Plurality of glycans directed to specific target HA of influenza virus comprises the array. Detector molecules comprising noble metals conjugated to (a) phage display particles expressing antibodies against hemagglutinin and (b) neuraminidase binding agents are disclosed.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: July 2, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu, Chi-Hui Liang, An-Suei Yang
  • Patent number: 10335428
    Abstract: Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: July 2, 2019
    Assignee: BIO-PATH HOLDINGS, INC.
    Inventor: Peter Nielsen
  • Patent number: 10337011
    Abstract: The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Fibroblast growth factor 21 (FGF21), in particular, by targeting natural antisense polynucleotides of Fibroblast growth factor 21 (FGF21). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of FGF21.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: July 2, 2019
    Assignee: CuRNA, Inc.
    Inventors: Joseph Collard, Olga Khorkova Sherman
  • Patent number: 10336816
    Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: July 2, 2019
    Assignee: Academia Sinica
    Inventors: An-Suei Yang, Hong-Sen Chen, Ing-Chien Chen, Chao-Ping Tung, Shin-Chen Hou, Chung-Ming Yu, Chi-Kai Yang, Yi-Kai Chiu
  • Patent number: 10329564
    Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: June 25, 2019
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Nitin Puri, Irudaya Charles, Susan Maylin Magdaleno, Alexander Vlassov, Christopher Burnett
  • Patent number: 10330677
    Abstract: This invention provides:—an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix;—a method of manufacturing said aptamer-based electrochemical sensor;—the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and—a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: June 25, 2019
    Assignee: Universiteit Antwerpen
    Inventors: Ronny J. P. Blust, Freddy Dardenne, Karolien De Wael, Lucien Nagels, Guido F. E. Van Camp
  • Patent number: 10316321
    Abstract: The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: June 11, 2019
    Assignee: SomaLogic Inc.
    Inventors: Dominic Zichi, Sheri K. Wilcox, Chris Bock, Daniel J. Schneider, Bruce Eaton, Larry Gold
  • Patent number: 10302651
    Abstract: The present invention relates to a method of capturing, enriching, purifying, detecting or measuring a cell in a sample at a sub-nanogram level comprising providing a nanocomposition, contacting the sample with the nanocomposition to form a mixture solution and allowing the binding of the cell with the nanocomposition, applying a magnetic field to the mixture, and evaluating the presence of or absence of the cell. The nanocomposition is capable of capturing or enriching an analyte at a sub-nanogram level, and comprise a nanostructure operably linked to an analyte-capturing member.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: May 28, 2019
    Inventors: Aihua Fu, Zheng Meng
  • Patent number: 10294511
    Abstract: Embodiments provided herein relate to methods and compositions for preparing nucleic acid libraries. Some embodiments include preparing libraries from nucleic acids obtained from degraded samples, such as ancient samples and fixed samples.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: May 21, 2019
    Assignee: ILLUMINA, INC.
    Inventors: Raquel Maria Sanches-Kuiper, Vincent Peter Smith, Sean Humphray
  • Patent number: 10287586
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 59.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: May 14, 2019
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilson, Sue Fletcher, Abbie Adams, Penny Meloni
  • Patent number: 10287628
    Abstract: The present invention provides, inter alia, methods and kits for identifying where a polypeptide of interest binds in a genome. The methods include a) carrying out a chromatin immunoprecipitation coupled to exonuclease digestion (ChIP-exo) process with an antibody against the polypeptide of interest; (b) extracting a polynucleotide fragment to which the polypeptide of interest binds; (c) carrying out a library preparation protocol adapted from an individual nucleotide resolution UV cross-linking and immunoprecipitation (iCLIP) process on the ChIP-exo processed polynucleotide fragment; and (d) sequencing the resulting polynucleotides. The kits include: (a) reagents sufficient to carry out ChIP-exo; (b) reagents sufficient to carry out the library preparation protocol adapted from the iCLIP process; and (c) instructions for use.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: May 14, 2019
    Assignee: Stowers Institute for Medical Research
    Inventors: Julia Zeitlinger, Qiye He, Jeffrey Johnston
  • Patent number: 10287622
    Abstract: The present invention relates to transposase adapters and uses thereof, including uses in preparing DNA molecules, in vitro amplification, sequencing of nucleic acids, and screening of DNA libraries for sequences of interest as well as nucleic acid delivery.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: May 14, 2019
    Assignee: Agilent Technologies, Inc.
    Inventor: Alexander S. Belyaev