Patents Examined by Trevor Love
  • Dry powder formulations for inhalation
    Patent number: 9993488
    Abstract: A respirable dry powder including acetylsalicylic acid in particles having a mass median aerodynamic diameter (MMAD) within a range of about 0.5 ?m to about 10 ?m. The respirable dry powder may contain a pharmaceutically acceptable excipient, such as a phospholipid, in an amount ranging from about 0.1% (w/w) to about 10% (w/w) of the particles.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: June 12, 2018
    Assignee: OTITOPIC INC.
    Inventor: Kambiz Yadidi
  • Reduction of implant infection via tunable stimulation of localized adaptive immune response
    Patent number: 9987396
    Abstract: Compositions, implantation devices and methods for stimulating an immune response to infection are discussed. In some examples, the compositions, implantation devices or methods of regulating the amplification of an adaptive immune response to infection involves use of one or more particles locally at a surgical or implant site to control bacterial infections without detrimental systemic side-effects. In some examples, the particles can be coated or layered onto the surface of an implantable device or material. In other examples, the particles can be injected into the site of implantation.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: June 5, 2018
    Assignee: BIOSPHERES, INC.
    Inventors: William Wustenberg, Michael D Finch, Cyrus B. Munshi
  • Kits for local delivery of water soluble agents and methods of use
    Patent number: 9987400
    Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: June 5, 2018
    Assignee: TYRX, Inc.
    Inventors: Xiangji Chen, Satish Pulapura, Fatima Buevich
  • Materials with water-triggered drug-release properties for localized therapeutics
    Patent number: 9987363
    Abstract: Methods, devices, and/or systems for providing a three-dimensional printing of a structure encapsulating a drug comprising at least one Zn(II) complexed with acrylate groups capable of forming a 3D structure and capable of encapsulating a drug.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: June 5, 2018
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Juan Noveron, Shokooh Bahadorzadeh
  • Polymers which resist bacterial attachment
    Patent number: 9981068
    Abstract: The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C?CR?—C(?O)—O—]nR??(I) [H2C?CR?—C(?O)—NH—]nR??(II) wherein n is 1, 2 or 3, R? is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: May 29, 2018
    Assignees: The University of Nottingham, Massachusetts Institute of Technology
    Inventors: Paul Williams, Morgan Russell Alexander, Martyn Christopher Davies, Robert Langer, Daniel Griffith Anderson
  • Topical skin formulations
    Patent number: 9974729
    Abstract: The present invention relates generally to methods and compositions useful for application to skin and hair comprising saccharide isomerate, hydrolyzed algin, zinc sulfate, and a dermatologically acceptable vehicle, wherein the composition is capable of moisturizing and/or improving the appearance and/or condition of skin and/or hair.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: May 22, 2018
    Assignee: Mary Kay Inc.
    Inventors: Tiffany Carle, Edward Chadwick, Milagros Sanchez, Daniel Ramirez, Geetha Kalahasti
  • Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3- ]pyrazin-2(1)-one, a solid form there of and methods of their use
    Patent number: 9974786
    Abstract: Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologs and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: May 22, 2018
    Assignee: Signal Pharmaceuticals, LLC
    Inventors: Marie Georges Beauchamps, Antonio Christian Ferretti, Juan Antonio Gamboa, Kevin Klopfer, William Edward Konnecke, Matthew Michael Kreilein, Anil Menon, Amanda Nicole Miklos, John Fitzgerald Traverse
  • Development and manufacturing process of powdered additive for its use in coatings or substrates to repel, reduce and control insects
    Patent number: 9968095
    Abstract: The innovation herein refers to a formulation of powdered additive for its incorporation in coatings or substrates to repel, reduce and control insects, consisting of at least one active insecticide ingredient, or a combination of two or more active insecticide ingredients with high-performance double microencapsulation, and alternatively with least one reflective and/or photoluminescent, high-luminosity micro-encapsulated pigment, generating a dual insecticide effect, preventing insects from creating immunity to insecticides, which stops mutation, as completely different insecticides are delivered overtime. It is also very effective during night and day, over long period of time (years), with an efficient manufacturing process.
    Type: Grant
    Filed: July 22, 2017
    Date of Patent: May 15, 2018
    Inventors: Jose Maria Ribot Barroso, Jose Luis Morales Martinez
  • Development and manufacturing process of powdered additive for its use in coatings or substrates to repel, reduce and control insects
    Patent number: 9968094
    Abstract: The innovation herein refers to a formulation of powdered additive for its incorporation in coatings or substrates to repel, reduce and control insects, consisting of at least one active insecticide ingredient, or a combination of two or more active insecticide ingredients with high-performance double microencapsulation, and alternatively with least one reflective and/or photoluminescent, high-luminosity micro-encapsulated pigment, generating a dual insecticide effect, preventing insects from creating immunity to insecticides, which stops mutation, as completely different insecticides are delivered overtime. It is also very effective during night and day, over long period of time (years), with an efficient manufacturing process.
    Type: Grant
    Filed: July 22, 2017
    Date of Patent: May 15, 2018
    Inventors: Jose Maria Ribot Barroso, Jose Luis Morales Martinez
  • Development and manufacturing process of powdered additive for its use in coatings or substrates to repel, reduce and control insects
    Patent number: 9968093
    Abstract: The innovation herein refers to a formulation of powdered additive for its incorporation in coatings or substrates to repel, reduce and control insects, consisting of at least one active insecticide ingredient, or a combination of two or more active insecticide ingredients with high-performance double microencapsulation, and alternatively with least one reflective and/or photoluminescent, high-luminosity micro-encapsulated pigment, generating a dual insecticide effect, preventing insects from creating immunity to insecticides, which stops mutation, as completely different insecticides are delivered overtime. It is also very effective during night and day, over long period of time (years), with an efficient manufacturing process.
    Type: Grant
    Filed: March 18, 2017
    Date of Patent: May 15, 2018
    Inventors: Jose Maria Ribot Barroso, Jose Luis Morales Martinez
  • Fish baits made from ultra strong hydrogels
    Patent number: 9961890
    Abstract: A hydrogel fishing bait has a fish attractive scent infused into a water swollen hydrogel. The hydrogel can be a copolymer of at least one water miscible monomer and a cross-linking monomer. The hydrogel can be a terpolymer of hydroxyethyl methacrylate (HEMA), acrylamide, and a crosslinking monomer. The hydrogel terpolymer can be prepared in the shape of a fish or other fish attracting shape. The scent can be an amino acid, protein, fatty acid, sugar, or any combination thereof, and can be from a natural or artificial source. The hydrogel can be filled with a fiber, mesh, or matrix material. The hydrogel can be an interpenetrating polymer network. The hydrogel can be biodegradable. The hydrogel baits when fully hydrated on their surface do not stick to each other.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: May 8, 2018
    Assignees: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., FISHING PHYSICS, LLC
    Inventors: William R. Niederhauser, Thomas E. Angelini, Wallace G. Sawyer, Wallace C. Sawyer, Mike Norton, Brent S. Sumerlin, Gregory John Toupalik
  • Compositions and methods for treating opioid receptor associated diseases
    Patent number: 9956187
    Abstract: The invention relates to dezocine compositions and uses thereof. Specifically, the invention relates to dezocine compositions, including nano-dezocine compositions and methods for preventing or treating opioid receptor associated diseases, including neuropathic pain; addiction, such as opioid or cocaine addiction; and depression.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: May 1, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Renyu Liu, Geoffrey Krug, Feixiang Wu, Julie Blendy
  • GABA analog prodrug sustained release oral dosage forms
    Patent number: 9949941
    Abstract: Sustained release oral dosage forms of a gabapentin prodrug, 1-{[(?-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid, are disclosed. The dosage forms are useful for treating or preventing diseases and disorders for which gabapentin is therapeutically effective.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: April 24, 2018
    Assignee: XENOPORT, INC.
    Inventors: Kenneth C. Cundy, Srikonda Sastry, Manshiu Leung, Balaji V. Kadri, Paul E. Stach
  • Compositions and methods for treating water
    Patent number: 9943541
    Abstract: A method of treating water to reduce or prevent bacterial infection in an aquatic organism may include administering a particulate kaolin clay to the water in a dosage sufficient to reduce the presence of at least one undesirable bacterial species present in the water, wherein the particulate kaolin clay has at least one property selected from: (a) a BET surface area of at least about 25 m2/g; (b) a particle size distribution such that at least about 80% by weight of the particles of kaolin clay have an equivalent spherical diameter of less than 2 microns as measured by Sedigraph; and (c) a particle size distribution such that at least about 25% by weight of the particles of kaolin clay have an equivalent spherical diameter of less than 0.25 microns as measured by Sedigraph. The method may further include contacting an aquatic organism with the treated water.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: April 17, 2018
    Assignee: Imerys USA, Inc.
    Inventors: Peter Biza, Philip J. Jones
  • Method of removing polymerized coatings for human nails, polymerized coating for human nails having improved removability, and two package system
    Patent number: 9931284
    Abstract: A method for removing a radiation-polymerized cosmetic coating from nails comprising applying a solvent system comprising a hydroxyl-containing solvent and a non-hydroxyl-containing solvent to a polymerized nail coating. A two package system comprising a first package comprising polymerizable nail coating composition comprising a (meth)acrylic oligomer, (meth)acrylic monomer, or a mixture of a (meth)acrylic oligomer and a (meth)acrylic monomer, and a photoinitiator, wherein the oligomer or monomer has an acidic or basic ionizable group and a second package comprising a solvent system for removing the polymerizable nail coating composition after it has been applied to a nail and radiation cured, the solvent system comprising a hydroxyl-containing solvent and a non-hydroxyl-containing solvent. A radiation-curable coating composition for human nails is also disclosed.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 3, 2018
    Assignee: MYCONE DENTAL SUPPLY COMPANY, INC.
    Inventors: Joseph Kozacheck, George Lein, Larry Steffier
  • Hemostatic injection needle coated with crosslinked chitosan having catechol group and oxidized catechol group
    Patent number: 9931443
    Abstract: The present invention relates to a hemostatic injection needle coated with a chitosan in which a catechol group and an oxidized catechol group are introduced and cross-linked. The hemostatic injection needle according to the present invention can suppress bleeding during and after injection, and thus can be effectively used for injection not only into coagulopathy patients, including diabetic patients, patients under anticancer treatment, and haemophilia patients, who have a low hemostatic ability, but also into patients showing blood rejection responses, and children.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: April 3, 2018
    Assignee: INNOTHERAPY INC.
    Inventors: Haeshin Lee, Mikyung Shin, Moon Sue Lee, Suk Song Oh
  • Process for annealing amorphous atorvastatin
    Patent number: 9932307
    Abstract: Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: April 3, 2018
    Assignee: Pfizer Inc.
    Inventors: Renuka Devi Reddy, Evgenyi Shalaev, Ravi Mysore Shanker, Carl Bernard Ziegler
  • Non-mutagenic photo chromic dye
    Patent number: 9925131
    Abstract: A method of solubilizing a composition, such as an organic manufactured photochromic dye that is free of carcinogens, non-mutagenic, non-toxic to human skin in any concentration, and suitable for application to, and absorbable by, human skin. The photochromic dye is suitable to be applied directly to human skin, and which dye is configured to indicate exposure to UV rays. The composition is configured to change color upon exposure to UVA, UVB and/or UVC rays. The composition can be used with other compositions, such as sunscreen, and be applied to human skin prior to application of the sunscreen, or, formulated with the sunscreen such that when the active ingredients of the sunscreen diminish, the photochromic dye will change color to generate a visual indicator of this condition.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: March 27, 2018
    Inventors: Clifton Sanders, Courtland Imel
  • Kits for local delivery of water soluble agents and methods of use
    Patent number: 9919080
    Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: March 20, 2018
    Assignee: TYRX, INC.
    Inventors: Xiangji Chen, Satish Pulapura, Fatima Buevich
  • Composition containing polycationic triblock copolymer, polyanionic polymer and physiologically active peptide
    Patent number: 9918935
    Abstract: [Problem] To provide a physiologically active peptide-loaded stable composition for injection into living bodies. [Solution] A composition containing a triblock copolymer represented by formula (I), a polyanionic polymer and a physiologically active peptide: CNR-PEG-CNR??(I) in the formula, CNR moieties are each independently a polymer segment containing a repeating unit that contains, as a part of a pendant group, a cyclic nitroxide radical bonded to a main polymer chain via a linking group that contains at least one amino group, and PEG is a segment that contains poly(ethylene glycol).
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: March 20, 2018
    Assignee: UNIVERSITY OF TSUKUBA, A JAPANESE NATIONAL UNIVERSITY
    Inventors: Yukio Nagasaki, Junya Kaneko, Toru Yoshitomi, Shiro Ishii