Patents Examined by Trevor Love
  • Co-encapsulation of live cells with oxygen-generating particles
    Patent number: 9775866
    Abstract: Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the duration of viability of said animal cells in said microcapsules. Compositions comprising such microcapsules and uses thereof, such as in treating diabetes, are also described.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: October 3, 2017
    Assignee: Wake Forest University Health Sciences
    Inventors: Emmanuel C. Opara, Benjamin S. Harrison
  • Compositions and methods for the reduction or prevention of hepatic steatosis
    Patent number: 9724319
    Abstract: Methods useful for reducing or preventing hepatic steatosis are provided herein. Such methods may comprise administering to a subject in need thereof a sirtuin pathway activator and/or PDE5 inhibitor alone or in combination with an amount of a branched amino acid in free amino acid form, or a metabolite thereof. Also provided herein are compositions and kits for practicing any of the methods described herein.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: August 8, 2017
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, Antje Bruckbauer
  • Remineralizing and desensitizing compositions, treatments and methods of manufacture
    Patent number: 9724542
    Abstract: Improved remineralizing and desensitizing compositions containing remineralizing ingredients in aqueous-free emulsions that, in the presence of saliva, form mucoadhesive gels substantive to tooth surfaces; wherein the gels are dissolved by saliva gradually releasing remineralizing ingredients onto tooth surfaces, treatments with these compositions and methods of manufacture.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: August 8, 2017
    Assignee: Premier Dental Products Company
    Inventors: William A. McHale, Dale G. Brown
  • Antiperspirant active compositions and manufacture thereof
    Patent number: 9717663
    Abstract: An antiperspirant active composition comprising an aluminum salt, the aluminum salt (i) having an aluminum to chloride molar ratio of 0.3:1 to 3:1; and (ii) having a species of polyhydroxyoxoaluminum cation detectable at 76 ppm by 27Al NMR that is present in a relative abundance on a 27Al NMR spectrograph that is greater than any other polyhydroxyoxoaluminum cation detectable by 27Al NMR. Also, disclosed are methods of making the antiperspirant active.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: August 1, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: John Vaughn, Iraklis Pappas, Long Pan
  • Compositions, methods, and kits for regulating energy metabolism
    Patent number: 9713609
    Abstract: The present invention provides for compositions, methods and kits for regulating energy metabolism. In one aspect, the invention provides for compositions that comprise a combination of (a) branched chain amino acids, such as leucine, and (b) vitamin B6, or any precursors or metabolites of (a) or (b). These combinations may be synergistic and/or effective for reducing weight or adipose volume. In another aspect, the invention provides for methods of regulating energy metabolism by the administration of one or more compositions comprising branched chain amino acids and vitamin B6. The invention also provides for kits comprising compositions of branched chain amino acids and vitamin B6 packaged in an oral dose form with usage instructions.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: July 25, 2017
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, E. Douglas Grindstaff, II
  • Sustained-release composition and method for producing the same
    Patent number: 9713595
    Abstract: Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt % to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drug sustained-release over a long period of time, and method for producing the same.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: July 25, 2017
    Assignee: Takeda Pharmaceuticals Company Limited
    Inventors: Tomomichi Futo, Kazuhiro Saito, Tetsuo Hoshino, Masuhisa Hori
  • Device for applying a cosmetic composition
    Patent number: 9713580
    Abstract: A cosmetic applicator for providing a natural looking cosmetic benefit. The cosmetic applicator includes a substrate and a solid, transferrable cosmetic composition disposed on the substrate. The cosmetic composition is configured as a multitude of dots arranged in a discontinuous stochastic pattern. The cosmetic composition comprises a colorant and an adhesive and in some instances has an L* value of from about 30 to 80, a c* value of from about 15 to 50, and an h* value of from about 30 to 80.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: July 25, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Jorge Max Sunkel, Karen Kay Kalla, Larry Wayne Marshall, Jr.
  • Compositions, methods and kits for reducing lipid levels
    Patent number: 9707213
    Abstract: Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites in combination with leucine and/or a leucine metabolite, with or without resveratrol.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: July 18, 2017
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, Antje Bruckbauer
  • Compositions and methods for reducing overdose
    Patent number: 9700516
    Abstract: Drug delivery formulations, uses thereof and methods of making same are provided in order to reduce the potential for abuse, misuse or improper administration of an addictive substance or any active substance and to prevent, reduce, inhibit, or delay purposeful or accidental overdose of an active substance by ingesting too many dosage forms at once, for example.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: July 11, 2017
    Inventor: Isa Odidi
  • Compositions and methods for reducing overdose
    Patent number: 9700515
    Abstract: Drug delivery formulations, uses thereof and methods of making same are provided in order to reduce the potential for abuse, misuse or improper administration of an addictive substance or any active substance and to prevent, reduce, inhibit, or delay purposeful or accidental overdose of an active substance by ingesting too many dosage forms at once, for example.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: July 11, 2017
    Inventor: Isa Odidi
  • Method of solubilizing a composition of a cleaned photochromic dye suitable for use on human skin
    Patent number: 9693945
    Abstract: A method of solubilizing a composition, such as an organic manufactured photochromic dye that is free of carcinogens, non-mutagenic, non-toxic to human skin in any concentration, and suitable for application to, and absorbable by, human skin. The photochromic dye is suitable to be applied directly to human skin, and which dye is configured to indicate exposure to UV rays. The composition is configured to change color upon exposure to UVA, UVB and/or UVC rays. The composition can be used with other compositions, such as sunscreen, and be applied to human skin prior to application of the sunscreen, or, formulated with the sunscreen such that when the active ingredients of the sunscreen diminish, the photochromic dye will change color to generate a visual indicator of this condition.
    Type: Grant
    Filed: March 4, 2017
    Date of Patent: July 4, 2017
    Inventors: Clifton Sanders, Courtland Imel
  • Compositions and methods for modulating metabolic pathways
    Patent number: 9682053
    Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: June 20, 2017
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
  • Coloured disinfectant preparation based on bispyridiniumalkane
    Patent number: 9675701
    Abstract: The non-solid disinfectant preparation includes a) bispyridiniumalkane (in particular octenidine) and b) dye selected from xanthene dyes, azo dyes and polyterpene compounds. The preparation is free from fluorescein and salts thereof. The novel preparations exhibit an excellent remanence effect.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: June 13, 2017
    Assignee: L'AIR LIQUIDE, SOCIETE ANONYME POUR L'ETUDE ET L'EXPLOITATION DES PRECEDES GEORGES CLAUDE
    Inventors: Sabine Behrends, Andreas Dettmann, Mona Hahn, Nadine Radischat, Carsten Vollmann
  • (2S,4R)-5-(5?-chloro-2?-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxmethyl-2-methylpentanoic acid
    Patent number: 9670143
    Abstract: In one aspect, the invention relates to a compound of the structure: or a pharmaceutically acceptable salt thereof, and a crystalline form of this compound, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this compound; methods of using this compound; and processes for preparing this compound.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: June 6, 2017
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Adam D. Hughes, Erik Fenster, Melissa Fleury, Anne-Marie Beausoleil, Venkat R. Thalladi, Jerry Nzerem, Miroslav Rapta
  • SCFA colonic composition
    Patent number: 9668991
    Abstract: The present invention is directed to a colonic composition including a core having at least one short chain fatty acid selected from the group consisting of butyrate, acetate and propionate, and combinations thereof, or a pharmaceutically acceptable salt or ester thereof; wherein at least one of acetate or propionate is present in the core; and at least one digestion-resistant layer covering the core, the digestion-resistant layer disintegrating in the colon. The present invention is also directed to methods of treatment using the above composition.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 6, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: Amos Cahan
  • Device for transdermal administration of drugs including acrylic based polymers
    Patent number: 9668981
    Abstract: A transdermal delivery system is provided where the drug delivery rates, onset and profiles of at least one active agent are controlled by selectively manipulating the monomeric make up of an acrylic-based polymer in the transdermal drug delivery system. The drug carrier composition may be comprised of (a) one or more acrylic-based polymers having one or more different monomers selected from the group consisting of hard and soft monomers; (b) one or more silicone-based polymers; and (c) one or more active agents where the device provides a desired solubility for the active agent and controls drug delivery rates, onset and profiles of at least one active agent.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: June 6, 2017
    Assignee: NOVEN PHARMACEUTICALS, INC.
    Inventor: David Kanios
  • SCFA colonic composition
    Patent number: 9668992
    Abstract: The present invention is directed to a colonic composition including a core having at least one short chain fatty acid selected from the group consisting of butyrate, acetate and propionate, and combinations thereof, or a pharmaceutically acceptable salt or ester thereof; wherein at least one of acetate or propionate is present in the core; and at least one digestion-resistant layer covering the core, the digestion-resistant layer disintegrating in the colon. The present invention is also directed to methods of treatment using the above composition.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: June 6, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: Amos Cahan
  • Extemporaneous care product based on a lyophilizate of microorganisms and surfactant(s) with an HLB greater than or equal to 12
    Patent number: 9636297
    Abstract: The present invention relates to a method for the cosmetic treatment of a keratin material comprising at least the steps of: (a) having available a lyophilizate containing at least one live or inactivated, physiologically acceptable microorganism, one of its metabolites or one of its fractions and at least one surfactant with an HLB greater than or equal to 12, (b) having available a physiologically acceptable medium, separate from the said lyophilizate, (c) bringing the said lyophilizate extemporaneously into contact with the said medium under conditions favorable for the solubilization and/or dispersion of the said lyophilizate in the said medium, and (d) bringing the mixture obtained in the preceding step into contact with the said keratin material. It further relates to a lyophilizate as defined above.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: May 2, 2017
    Assignee: L'OREAL
    Inventors: Jean-Thierry Simonnet, Karine Lucet-Levannier
  • Microsphere compositions, preparation method and applications thereof
    Patent number: 9629811
    Abstract: A cell carrying microsphere composition, wherein the microsphere composition comprises a microspheric core comprising a triblock copolymer matrix A-B-A wherein A is selected from poly(lactide-co-glycolide) (PLGA) or polylactide (PLA) and B is poloxamer or poloxamine, wherein the microspheric core is coated with a cell adhesion coating and further comprises whole cells or cell fragments bonded to the cell adhesion coating, a process for the preparation of a cell carrying microsphere composition, and applications thereof.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: April 25, 2017
    Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Marie Morille, Van-Thanh Tran, Xavier Garric, Jean Coudane, Marie-Claire Venier-Julienne, Claudia Montero-Menei
  • Enamel protectant and repair toothpaste
    Patent number: 9616004
    Abstract: Substantially aqueous-free, enamel protectant and enamel repair toothpastes containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein: (a) substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and (b) said toothpastes indicate substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: April 11, 2017
    Assignee: Premier Dental Products Company
    Inventors: William A. Mchale, Dale G. Brown