Abstract: Outlet fittings are provided. Outlet fittings of interest include an elongate structure and an opening at a proximal end for receiving a flow stream from the distal end of a flow cell. In addition, the outlet fittings described herein are configured to reduce the formation of bubbles at the interface between the outlet fitting and the flow cell. In certain cases, outlet fittings do not include a planar surface in contact with the received flow stream. Flow cytometers and methods employing the subject outlet fittings are also provided.

Abstract: An apparatus and method of inspection are provided that inspects the end-face of two or more fiber optic connectors simultaneously without the need to move a probe from one end-face to another end-face and inspecting them one by one.

Abstract: An analysis system includes a reflective substrate; a hollow elongate structure with two ends; two polymer supports coupled to the ends and joined to the substrate; a piezoelectric device coupled to the substrate and designed to produce vibrations in the elongate structure; a laser for emitting a beam; a beam splitter; a photodetector; an amplification module; and a processor. The laser beam passes through the cavity and is absorbed by the photodetector, which generates a signal that is transmitted to the amplification module. The amplification module separates the signal into a modulated component and an unmodulated component. The signal is transmitted to the processor to obtain the resonance frequency and reflectance and to provide the piezoelectric device with an excitation signal at the resonance frequency.

Abstract: Aspects of the present disclosure describe distributed fiber optic sensing systems (DFOSa), methods, and structures for distributed temperature sensing (DTS) that 1) employs a GmAPD instead of a traditional LmAPD detector which advantageously produces a 10˜20 dB gain improvement of SNR for a far-end weak signal, thereby improving long range detectability; 2) employs an inventive gating scheme that advantageously and surprisingly overcomes the “dead time” problem for GmAPD working in SPC mode that plagues Geiger mode operation; and 3) third, employs an inventive post-processing technique that advantageously allows our methods to correct any dark noise caused signal distortion.

Abstract: A device for measuring a curvature radius includes a sample stage configured to support a sample to be measured, a diffracted light array generation module configured to generate and emit a diffracted light array to the sample, and a detection and analysis module configured to receive a reflected light array emitted from the sample and to obtain the curvature radius of the sample according to a dimension of the received reflected light array. Also disclosed is a method for measuring the curvature radius.

Abstract: In a plasmonic structure, a first conductor layer, a dielectric layer, and a second conductor layer are stacked in this order. The second conductor layer includes a plurality of conductor patterns that is two-dimensionally and periodically arranged, each of the plurality of conductor patterns having a circular shape or a regular polygonal shape. A diameter D of a circle circumscribed on each of the plurality of conductor patterns satisfies 200 nm?D?800 nm. A thickness g of the dielectric layer and the diameter D satisfy 0.3?g/D?0.6.

Abstract: Provided herein include various examples of an apparatus, flow cells that include these examples of the apparatus, and methods of making these examples of the apparatus. The apparatus can include a molding layer over a substrate and covering sides of a light detection device. The molding layer comprises a first region and a second region, which, with the active surface of the light detection device, form a contiguous surface. A waveguide integration layer is between the contiguous surface and a waveguide. The waveguide integration layer comprises optical coupling structures over the first and second regions, to optically couple light waves from a light source to the waveguide. The waveguide utilizes the light waves to excite light sensitive materials in nanowells. A nanostructure layer over the waveguide comprises the nanowells. Each nanowell shares a vertical axis with a location on the active surface of the light detection device.

Abstract: A Broadband Diffractive-Optical Element (BDOE) as a lens whose f-number and numerical aperture are decoupled. The BDOE can include a substrate and an array of optical cells formed on the substrate to have a non-linear arrangement of cell heights to diffract light into a focal spot. The geometry of the focal spot can be designed to decouple the f-number from the numerical aperture for an imaging device that employs the broadband diffractive optical element as a lens.

Abstract: The concentration measurement device 100 includes an electric unit 20 having a light source 22 and a photodetector 24, a fluid unit 10 having a measurement cell 1, a first light-transmission member 11 for transmitting light from the light source to the measurement cell, a second light transmission member 12 for transmitting light from the measurement cell to the photodetector, a lens 3A provided in the fluid unit, the lens 3A being arranged such that light from the first light transmission member is to be incident on the first position and light is to be emitted from the second position to the second light transmission member, a pressure sensor 5 for measuring pressure of fluid flowing through the measurement cell, and an arithmetic circuit 28 for detecting concentration of the fluid flowing through the measurement cell, the arithmetic circuit being configured to calculate the fluid concentration based on the output of the photodetector and a correction factor related to the pressure output by the pressure se

Abstract: A spectroscopy system that includes a light source that generates light having a plurality of wavelengths, a light transmitter that transmits the light to a target analyte, a light receiver that receives Raman-scattered light scattered from the target analyte, and a multi-wavelength spectroscopy assembly that acquires a spectrum by splitting the Raman-scattered light transmitted from the light receiver. The multi-wavelength spectroscopy assembly includes a single diffraction grating configured to diffract the Raman-scattered light and a single concave mirror configured to focus the Raman-scattered light.

Abstract: A detector system for Fourier spectroscopy such as a spectral domain optical coherence tomography instrument includes a diffractive optic for diffracting the interfering light into angularly dispersed wavenumbers, a prism for reduces a nonlinear angular dispersion among the wavenumbers, and a focusing optic for converting the angularly dispersed wavenumbers from the prism into spatially distributed wavenumbers along a detector having an array of pixels. A field lens between the focusing optic and the detector has a freeform surface for more evenly distributing the wavenumbers along the array of pixels.

Abstract: An apparatus comprising: a double path interferometer comprising a sample path for an object and a reference path; a source of linearly polarized light for the double path interferometer, a phase plate positioned in the sample path; means for superposing the sample path and reference path to create a beam of light for detection; means for spatially modulating the beam of light to produce a modulated beam of light; means for dispersing the modulated beam of light to produce a spatially modulated and dispersed beam of light; a first detector; a second detector, and means for splitting the spatially modulated and dispersed beam of light, wherein light of a first linear polarization is directed to the first detector and light of a second linear polarization, orthogonal to the first linear polarization, is directed to the second detector.

Abstract: The disclosure belongs to the technical field of precision test and measurement, and provides a two-dimensional photoelectric autocollimation method and device based on wavefront measurement and correction. According to the disclosure, a link of wavefront measurement and correction of a reference light path is added to a traditional autocollimator measuring method. By using wavefront distortion information of the reference light path in the instrument and driving a deformable mirror to compensate for phase distortion of a beam, the link realizes measurement and control on aberration of the optical system of the autocollimator and improves the imaging quality and spot positioning accuracy of the optical system, thereby improving the angle measurement accuracy of the autocollimator.

Abstract: A shape sensing system for an anthropomorphic test device is disclosed that includes a plurality of body parts and at least one optical fiber that has a plurality of cores in a spaced and parallel relationship with one another that extend between ends of the optical fiber for sensing positions of the body parts. Each of the cores have a plurality of grating sensors disposed along a length thereof capable of determining a position and orientation of the body parts.

Abstract: A background correction method for a fluorescence microscopy system includes receiving a raw image stack, determining a number of temporal minimum intensity values for each pixel location from the raw image stack, and calculating an expected background value for each pixel location based on the number of temporal minimum intensity values for the pixel location. Also, an emitter localization method includes receiving a raw image stack, determining a rough position of each of a plurality of emitters within the raw image stack by employing a linear deconvolution process, and determining a precise position of each of the plurality of emitters by employing the rough position of the emitter and gradient fitting.

Abstract: A method for detecting abnormal growth of graphene includes: measuring, through spectroscopic ellipsometry, a reflection spectrum of a measurement object having a graphene film formed through CVD on a substrate; creating a film structure model, calculating polarization parameters, and matching calculated values of the polarization parameters to measured values through fitting; and detecting abnormal growth of the graphene based on a value of goodness of fit obtained when fitting the polarization parameters.

Abstract: Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties.

Abstract: Systems and methods for image-based guidance using automated instrument tracking. An en face image frame, generated from en face image data captured by a first imaging system (e.g., an SER imaging system), is analyzed to determine a location of an instrument in the first imaging plane. A control signal is then generated for the movement stage to control the scanning movement of a depth-based imaging system (e.g., an OCT imaging system) based on the determined location of the instrument. In some implementations, a trained neural-network is used to determine the location of the instrument based on the en face image frame and, in some implementations, the control signal adjusts the speed of the scanning movement to capture image data at a higher density7 at areas corresponding to the determined location of the instrument.

Abstract: A surface profile inspection method and a surface profile inspection system are provided. The surface profile inspection method includes capturing a plurality of interferograms of a surface profile depicting interference between a specimen beam reflected from a surface having the surface profile and a modulated reference beam, wherein each of the plurality of interferograms corresponds to a phase of modulation of the modulated reference beam; extracting pixel values of the plurality of interferograms; calculating phase information of each of the plurality of interferograms based on the extracted pixel values, the phase information of each of the plurality of interferograms related to the phase of modulation of the modulated reference beam at a time the interferogram was captured; and reconstructing the surface profile based on the calculated phase information.

Abstract: Examples of the disclosure relate to an apparatus (101), a wearable electronic device and an optical arrangement for optical coherence tomography. The apparatus comprises an optical coherence tomography system (103) and an optical arrangement (105). The optical arrangement comprises at least one means for beam shaping (109) configured to shape a beam of light from the optical coherence tomography system. The optical arrangement also comprises at least one minor (111) positioned so that light from the means for beam shaping is incident on the at least one minor. The at least one mirror is configured to move in at least one direction relative to the optical coherence tomography system.