Patents Examined by Vasu S. Jagannathan
  • Human signal transduction MAPK kinase
    Patent number: 5663314
    Abstract: An isolated nucleic acid molecule which hybridizes under stringent conditions with the nucleic acid shown in SEQ ID NO:32 or its complement or the nucleic acid shown in SEQ ID NO:34 or its complement, and which encodes mitogen activated protein kinase kinase protein.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: September 2, 1997
    Assignee: The Board of Regents of the University of Washington
    Inventors: Rony Seger, Dalia Seger, Natalie G. Ahn, Edwin G. Krebs
  • Method of administering human pluripotent hematopoietic colony stimulating factor
    Patent number: 5662895
    Abstract: Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparant homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5.times.10.sup.8 U/mg protein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 2, 1997
    Assignee: Sloan-Kettering Institute
    Inventors: Karl Welte, Erich Platzer, Janice L. Gabrilove, Roland Mertelsmann, Malcolm A. S. Moore
  • Blood substitutes
    Patent number: 5661124
    Abstract: The present invention provides blood substitutes comprised of recombinantly produced mutant hemoglobin having an osmolarity greater than 303 milliosmoles per liter and less than 800 milliosmoles per liter. Such hyperosmolar blood substitute additionally comprises a physiologically acceptable molecule less diffusible than dextrose.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: August 26, 1997
    Assignee: Somatogen, Inc.
    Inventors: Stephen J. Hoffman, Kiyoshi Nagai
  • High molecular weight desulphatohirudin
    Patent number: 5661001
    Abstract: The invention pertains to the field of thrombin inhibitors and describes the production of modified desulphatohirudins, particularly desulphatohirudins, with the aid of genetic engineering. The present invention is also directed to a method for the denaturation and renaturation of a modified desulphatohirudin to a biologically active thrombin inhibitor and the combination of two or more of desulphatohirudins to form higher molecular weight thrombin inhibitors.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: August 26, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Hugo Grossenbacher, Jui Yoa Chang, Walter Marki
  • Methods of inducting formation of tendon and/or ligament tissue comprising administering BMP-12, BMP-13, and/or MP-52
    Patent number: 5658882
    Abstract: The present invention relates to methods for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair, using a composition comprising BMP-12, BMP-13 or MP-52, or combinations of the above.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: August 19, 1997
    Assignees: Genetics Institute, Inc., President and Fellows of Harvard College
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • Cloned leptospira outer membrane protein
    Patent number: 5658757
    Abstract: An antigenic preparation is provided which contains a 31 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: August 19, 1997
    Assignee: The Regents of the University of California
    Inventors: David A. Haake, David R. Blanco, Cheryl I. Champion, Michael A. Lovett, James N. Miller
  • Method of using interleukin-4
    Patent number: 5656266
    Abstract: Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the invention include native human and murine IL-4s, muteins thereof, and nucleic acids which are effectively homologous to disclosed cDNAs, and/or which are capable of coding for mammalian IL-4s and their muteins.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 12, 1997
    Assignee: Schering Corporation
    Inventors: Frank Lee, Takashi Yokota, Ken-ichi Arai, Timothy Mosmann, Donna Rennick
  • Promotion of cell proliferation by use of transforming growth factor beta (TGF-.beta.)
    Patent number: 5656587
    Abstract: A composition for the promotion of cell proliferation and tissue repair in animals having as active ingredients a TGF-.beta. which is activated by either a TGF-.alpha. or an EGF or both; and methods for administration. As another embodiment these active ingredients can be admixed with other (secondary) growth factors.
    Type: Grant
    Filed: April 16, 1993
    Date of Patent: August 12, 1997
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Michael B. Sporn, Anita B. Roberts
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5654173
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: August 5, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • DNA comprising lamb secretion signal sequence and mature IGF-1 sequence
    Patent number: 5652139
    Abstract: A method for bacterially producing IGF-I is disclosed in which Gram-negative bacteria are caused to express a gene consisting of a lamB or ompF signal sequence operatively joined to a DNA sequence encoding IGF-I and producing IGF-I which is secreted into the periplasmic space of the bacteria.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: July 29, 1997
    Assignee: Monsanto Company
    Inventors: Edith Wong, Michael L. Bittner
  • Hirudin HV2 having a SN7LYS substitution, method of making, and method of use
    Patent number: 5650301
    Abstract: The present invention relates to variants of hirudin containing an amino acid different from the amino acid in the natural form at position 47 or 63.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 22, 1997
    Assignee: Transgene S.A.
    Inventors: Michael Courtney, Eric DeGryse, Gerard Loison, Yves LeMoine
  • IGF-I purification process
    Patent number: 5650496
    Abstract: Disclosed is an improved process for obtaining purified, monomeric, intact, correctly-folded insulin-like growth factor-I (also known as somatomedin-C). The improvements, consisting primarily of the addition of an IGF-I unfolding/refolding step and the substitution of a reverse phase chromatography step for a gel filtration chromatography step result in a three-fold increase in final yield. The process includes the following steps, in order: first cation exchange, unfolding/refolding, hydrophobic interaction chromatography, second cation exchange, and reverse phase chromatography.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: July 22, 1997
    Assignee: Cephalon, Inc.
    Inventors: Russell A. Brierley, Joan N. Abrams, John M. Hanson, Francis C. Maslanka
  • Cycloolefin block copolymers and a process for their preparation
    Patent number: 5646220
    Abstract: Cycloolefin block copolymers, which in particular are suitable as phase promoters, are preferably obtained by copolymerization of polycyclic olefins, such as norbornene, with acyclic olefins, such as ethylene, by, at a molecular weight distribution M.sub.w /M.sub.n of the polymer block forming of less than 2, changing the reaction conditions one or more times in such a way that the monomer/comonomer ratio changes by at least 10% or a further polymerizable monomer is metered into the monomer or the monomers.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: July 8, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael-Joachim Brekner, Frank Osan, Jurgen Rohrmann
  • Method of measuring immunokinetics
    Patent number: 5639623
    Abstract: A method of measuring and assessing T and B cell immunokinetics in human, particularly cancer immunokinetics by applying the multiple regression analysis, one of multivariate data analyses, to the counts in blood samples of CD3, CD4, CD8 and OKIa1 positive lymphocytes, helper, suppression inducer, cytotoxic and suppressor T lymphocytes, activated suppression inducer/helper and activated suppressor/cytotoxic T lymphocytes and natural killer cell, monocyte, basophil, eosinophil and neutrophil.
    Type: Grant
    Filed: January 13, 1994
    Date of Patent: June 17, 1997
    Inventor: Tamio Yamauchi
  • Method of increasing the yield and heme saturation of cystathione .beta.-synthase
    Patent number: 5635375
    Abstract: A method of increasing the yield and heme saturation of hemoproteins in microorganisms. In this method, an effective amount of a heme precursor is added to a culture of hemoprotein producing microorganisms.
    Type: Grant
    Filed: January 9, 1995
    Date of Patent: June 3, 1997
    Assignee: Regents of the University of Colorado
    Inventors: Jan P. Kraus, Vladimir Kery
  • Adhesive beads
    Patent number: 5625006
    Abstract: Adhesive beads comprise a core comprising a pressure sensitive adhesive material and an essentially discontinuous organic polymer disposed about the core. The beads are free-flowing at room temperature. Upon application of heat and/or pressure the core is activated and blends with the coating to provide a pressure sensitive adhesive.
    Type: Grant
    Filed: January 24, 1996
    Date of Patent: April 29, 1997
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Joseph P. Callahan, Jr., Rudyard M. Enanoza, Mark D. Weigel
  • Process for preparing a polymeric gloss modifier
    Patent number: 5612420
    Abstract: Polymeric glass modifier having a partially crosslinked structure capable of effectively reducing the surface gloss of a thermoplastic resin, is prepared by (a) emulsion polymerizing an acrylic monomer, an ethylenically unsaturated cyanide compound end, optionally, an aromatic vinyl monomer to obtain a copolymer latex of a linear structure; (b) conducting a crosslinking emulsion polymerization of the resultant linear copolymer latex obtained in step (a) with an addition of the same monomers used in step (a), an acrylamide inter-particle crosslinking agent and an ethylenically unsaturated crosslinking agent to produce a partially crosslinked latex; and (c) coagulating and interparticle crosslinking the partially crosslinked latex obtained in step (b) with an addition of an acid to obtain the polymeric gloss modifier.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: March 18, 1997
    Assignee: Lucky Limited
    Inventors: Jin N. Yoo, Dong O. Kim, Yeong R. Chang, Jong K. Yeo
  • Flexible polar thermoplastic polyolefin compositions
    Patent number: 5610234
    Abstract: Polar thermoplastic polyolefin blends are provided which are flexible and are particularly useful in replacing polyvinyl-chloride sheeting used as liners, folders, etc. The blends comprise, in general, a non-polar thermoplastic polyolefin, a polar ethylene copolymer, and an acid grafted olefin polymer as a compatibilizing agent, all of which are chlorine-free.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: March 11, 1997
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Heinz H. Spelthann
  • Method to produce bowls of a plastic material and bowls thus produced
    Patent number: 5601772
    Abstract: Method to produce bowls of a plastic material, whereby polypropylene is mixed with an additive and/or dye after suitable dosing and is introduced into a moulding press, wherein it is heated to 180.degree.-210.degree. C., and is then injected into a mould, where it is kept under a further pressure for 20-60 seconds, the product then being extracted and cooled in water before removal of flash so as to produce the bowl. Bowl consisting of polypropylene and produced according to the above method.
    Type: Grant
    Filed: September 13, 1995
    Date of Patent: February 11, 1997
    Assignee: Plastic Legno Giocattoli di Contessi & C.Snc
    Inventor: Claudia Contessi
  • Polyolefin molding composition for the production of molding of high rigidity and transparency by injection molding
    Patent number: 5597881
    Abstract: A polyolefin molding composition essentially comprising a polyolefin derived from an olefin having at least 3 carbon atoms, of the formula R.sup.a --CH.dbd.CH--R.sup.b, in which R.sup.a and R.sup.b are identical or different and are hydrogen or C.sub.1 -C.sub.15 -alkyl, straight-chain or branched, or R.sup.a and R.sup.b, together with the atoms connecting them, form a ring, where the polyolefin molding composition may contain up to 10% by weight of ethylene or a second olefin as defined above as comonomer, having a molecular weight M.sub.w of >80,000 g/mol, a polydispersity M.sub.w /M.sub.n of from 1.8 to 3.5, a viscosity of >70 cm.sup.3 /g, a melting point of from 130.degree. to 160.degree. C., an aligned transparency of >30% and an ether-extractable content of less than 2% by weight.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: January 28, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Andreas Winter, Horst Bormuth, Bernd Bachmann