Abstract: Described herein are methods and compositions for the treatment of prostate cancer in a subject in need thereof. The prostate cancer may be a castration resistant and an androgen receptor antagonist-resistant prostate cancer. The methods may comprise administering to the subject a CYP17-lyase inhibitor of Formula II.
Type:
Grant
Filed:
August 12, 2014
Date of Patent:
November 7, 2017
Assignees:
Tokai Pharmaceuticals, Inc., University of Washington, University of Maryland, Baltimore
Inventors:
Vincent C. O. Njar, Amina Zoubeidi, Karen Ferrante, Eva Corey, Douglas Jacoby
Abstract: A method of photooxygenating furfural in a photooxygenating system, whereby a liquid mixture comprising furfural, a photosensitizer, and a reaction solvent is passed through a reaction section of the photooxygenating system, wherein the liquid mixture is exposed to solar radiation, while a portion of the furfural is oxidized in presence of the photosensitizer and a furanone compound is produced. Various embodiments of the photocatalytic water splitting reactor, and the water splitting system are also provided.
Type:
Grant
Filed:
July 18, 2017
Date of Patent:
October 31, 2017
Assignee:
King Fahd University of Petroleum and Minerals
Abstract: This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds. More particularly, it relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds comprising phenylacetophenone derivatives using oxabenzonorbornadienes with terminal alkynes.
Type:
Grant
Filed:
June 18, 2015
Date of Patent:
October 10, 2017
Assignees:
HONG KONG BAPTIST UNIVERSITY, YUNNAN MINZU UNIVERSITY
Abstract: It is already known that 1-(benzofuran-2-yl)-2-propylaminopentane or a pharmacologically acceptable acid addition salt thereof exhibits an excellent effect as an antidepressant, a psychotropic drug, an antiparkinsonian drug, and an anti-Alzheimer's disease drug. However, it has not been known at all that the compound is effective for the prevention or therapy of attention-deficit/hyperactivity disorder (ADHD). The present invention has newly found that 1-(benzofuran-2-yl)-2-propylaminopentane or a pharmacologically acceptable acid addition salt thereof is effective for the prevention or therapy of ADHD, and has been accomplished.
Abstract: A method for producing an epoxy compound by reacting a compound having a carbon-carbon double bond with hydrogen peroxide in the coexistence of the compound having a carbon-carbon double bond, aqueous hydrogen peroxide, a powder of a solid catalyst support and a powder of a solid catalyst, wherein the solid catalyst comprises an isopolyacid, and the isopolyacid is produced from a catalyst raw material comprising (a) tungstic acid or a salt thereof and (b) at least one selected from the group consisting of a salt of an alkaline earth metal and a cationic polymer.
Type:
Grant
Filed:
November 17, 2014
Date of Patent:
October 10, 2017
Assignees:
JX NIPPON OIL & ENERGY CORPORATION, OSAKA UNIVERSITY
Abstract: Provided are a pyranochromenyl phenol derivative, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical composition for preventing or treating metabolic syndrome or inflammatory disease comprising same. The present invention is efficacious in preventing or treating metabolic syndrome or inflammatory disease and is chemically stable.
Type:
Grant
Filed:
December 23, 2014
Date of Patent:
October 10, 2017
Assignee:
Glaceum Inc.
Inventors:
Sang Ku Yoo, Jin Wook Chung, In Geun Jo, Jeong Ho Im, Ku Suk Kang, Jin Young Kim
Abstract: Provided herein are trioxacarcin-antibody drug conjugates of Formula (A): and pharmaceutically acceptable salts thereof, comprising at least one instance of the group -L1-(A-L2)a-B attached thereto, wherein a is an integer between 1 and 10, inclusive, L1 is absent or is a linking group, A is a moiety formed from the reaction of two complimentary groups (X and Y), L2 is absent or is another linking group, and B is an antibody or antibody fragment. Also provided are methods of preparing these antibody-drug conjugates, pharmaceutically acceptable compositions thereof, and methods of their use and treatment. Further provided are precursors to the trioxacarcin-antibody drug conjugates, novel trioxacarcins without an antibody conjugated thereto, pharmaceutical compositions thereof, and methods of their use and treatment.
Type:
Grant
Filed:
November 26, 2013
Date of Patent:
October 3, 2017
Assignee:
President and Fellows of Harvard College
Inventors:
Andrew G. Myers, Daniel J. Smaltz, Andreas Schumacher
Abstract: Methods are disclosed for converting a biomass-derived product containing levulinic acid and/or gamma-valerolactone to a transportation fuel precursor product containing diesel like hydrocarbons. These methods are expected to produce fuel products at a reduced cost relative to conventional approaches.
Type:
Grant
Filed:
November 7, 2016
Date of Patent:
October 3, 2017
Assignee:
BATTELLE MEMORIAL INSTITUTE
Inventors:
Michael A. Lilga, Asanga B. Padmaperuma
Abstract: Illuminating devices are disclosed having plastic light-transmitting article(s) formed from a thermoplastic composition including a polycarbonate having repeating structural carbonate units according to the formula: in which at least 60 percent of the total number of R1 groups contain aromatic moieties and the balance thereof are aliphatic, alicyclic, or aromatic. The composition also includes an epoxy additive having at least two epoxy groups per molecule and a phenolic diphosphite derived from pentaerythritol. The thermoplastic composition exhibits a dE (2000 hrs.) value of less than 1.5 after 2000 hours of heat aging at 130° C., measured according ISO 11664-4:2008(E)/CIE S 014-4/E:2007 using CIE illuminant D65 and a 2.5 mm thick molded plaque of the thermoplastic composition.
Type:
Grant
Filed:
May 28, 2014
Date of Patent:
September 26, 2017
Assignee:
SABIC INNOVATIVE PLASTICS IP B.V.
Inventors:
Joshua Arie van den Bogerd, Johannes de Brouwer
Abstract: A pharmaceutical composition which is Rapidly Dissolved in a mouth, comprising (a) agglomerate units which is consisted of a discontinuous phase comprising the first component; and a continuous phase comprising the second component; and (b) a pharmaceutically acceptable excipient, in which the pharmaceutical composition is characterized in that the first component is an effective ingredient exhibiting the pharmacological activity, and the second component is sugar or sugar alcohol is provided.
Abstract: The present invention relates to an improved process for the preparation of 2,5-dimethylfuran and furfuryl alcohol over ruthenium supported catalysts. Further, the present invention disclosed a process for the selective hydrogenolysis of biomass derived 5-hydroxymethylfurfural (HMF) into 2,5-dimethylfuran (DMF) using Ru nanoparticles supported on NaY zeolite as a catalyst.
Type:
Grant
Filed:
January 21, 2015
Date of Patent:
September 12, 2017
Assignee:
Council of Scientific and Industrial Research
Inventors:
Satyanarayana Vera Venkata Chilukuri, Atul Sopan Nagpure, Nishita Satyendra Lucas
Abstract: The present invention relates to new types of processes for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations with an increased content of (3E,7E)-homofarnesol (also referred to as all E-homofarnesol).
Type:
Grant
Filed:
October 12, 2016
Date of Patent:
September 12, 2017
Assignee:
BASF SE
Inventors:
Melanie Weingarten, Hansgeorg Ernst, Wolfgang Siegel, Ekkehard Winterfeldt, Reinhard W. Hoffmann
Abstract: Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.
Abstract: The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the following steps: Oxidation of 2,3,6-trimethylphenol with oxygen or an oxygen-containing gas in a two- or multi-phase reaction medium in the presence of a catalyst or catalyst system containing at least one copper (II)-halide to a mixture containing 2,3,5-trimethyl benzoquinone, characterized in that the reaction medium contains water and at least one secondary aliphatic acyclic alcohol having 6 or more, preferably 7 or more, carbon atoms.
Type:
Grant
Filed:
June 25, 2014
Date of Patent:
September 12, 2017
Assignee:
BASF SE
Inventors:
Richard Dehn, Michael Kraus, Martine Dehn, Manuel Danz, Joaquim Henrique Teles
Abstract: A catalyst, method of using, and use of a hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support. This in the presence of lithium salts, with salts such as the borates being preferred. This provides hydrogenation of precursors to give rise to a stereoselective, such as diastereoselective bias in the product of alkene hydrogenation using the catalyst.
Type:
Grant
Filed:
September 28, 2015
Date of Patent:
September 5, 2017
Assignee:
Thomas Swan & Co. Ltd
Inventors:
David Dunn, Howard Winston Tyrrell Sutton, John Ing Chuan Daly, Simon Jonathon Grant, Lian Hutchings, Patrice Georges Antonin Ribiere, Matthew Richard Gibbings, Sergio Aaron Gamboa Martinez, Craig Anderson, Yulia Rogan
Abstract: A method of photooxygenating furfural in a photooxygenating system, whereby a liquid mixture comprising furfural, a photosensitizer, and a reaction solvent is passed through a reaction section of the photooxygenating system, wherein the liquid mixture is exposed to solar radiation, while a portion of the furfural is oxidized in presence of the photosensitizer and a furanone compound is produced. Various embodiments of the photocatalytic water splitting reactor, and the water splitting system are also provided.
Type:
Grant
Filed:
December 6, 2016
Date of Patent:
September 5, 2017
Assignee:
King Fahd University of Petroleum and Minerals
Abstract: Dimers of acetyl salicylic acid, including 4,4?-diacetoxy-[1,1?-biphenyl]-3,3?-dicarboxylic acid (DAS-1) and 5,5?-methylenebis(2-acetoxybenzoic acid) (DAS-2) are provided. Methods of blocking the C3 convertase stage of the alternative complement pathway, preventing formation of the membrane attack complex of complement, and preventing or treating a complement-mediated disorder in a mammal including the step of administering dimers of acetyl salicylic acid are also provided.
Type:
Grant
Filed:
November 17, 2014
Date of Patent:
September 5, 2017
Assignee:
Aurin Biotech Inc.
Inventors:
Patrick L. McGeer, Moonhee Lee, Edith G. McGeer
Abstract: The present disclosure generally relates to the production of fuels, gasoline additives, and/or lubricants, and precursors thereof. The compounds used to produce the fuels, gasoline additives, and/or lubricants, and precursors thereof may be derived from biomass. The fuels, gasoline additives, and/or lubricants, and precursors thereof may be produced by a combination of intermolecular and/or intramolecular aldol condensation reactions, Guerbet reactions, hydrogenation reactions, and/or oligomerization reactions.
Type:
Grant
Filed:
June 3, 2014
Date of Patent:
August 22, 2017
Assignees:
The Regents of the University of California, BP Corporation North America Inc.
Inventors:
Eric Sacia, Anbarasan Pazhamalai, Balakrishnan Madhesan, Sanil Sreekumar, F. Dean Toste, Amit A. Gokhale, Martin E. Carrera, Alexis T. Bell, Gorkem Gunbas
Abstract: Disclosed are compositions including a solid dispersion comprising a dispersion polymer, a basic low-water solubility active, and an anionic counterion, as well as methods of making and using the compositions.