Abstract: A continuous process for the preparation of propylene oxide, comprising (i) providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile, water, optionally propane, and at least one dissolved potassium salt; (ii) passing the feed stream provided in (i) into an epoxidation reactor comprising a catalyst comprising a titanium zeolite of structure type MWW, and subjecting the feed stream to epoxidation reaction conditions in the epoxidation reactor, obtaining a reaction mixture comprising propylene oxide, acetonitrile, water, the at least one potassium salt, optionally propene, and optionally pane; (iii) removing an effluent stream from the epoxidation reactor, the effluent stream comprising propylene oxide, acetonitrile, water, at least a portion of the at least one potassium salt, optionally propene, and optionally propane.
Type:
Grant
Filed:
July 16, 2014
Date of Patent:
August 22, 2017
Assignees:
BASF SE, Dow Global Technologies LLC
Inventors:
Dominic Riedel, Joaquim Henrique Teles, Ulrike Wegerle, Andrei-Nicolae Parvulescu, Alexander Schroeder, Luise Spiske, Daniel Urbanczyk, Ulrich Mueller, Werner Witzl, Meinolf Weidenbach
Abstract: A continuous process for the preparation of propylene oxide, comprising (i) providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile, water, optionally propane, and at least one dissolved potassium salt of a phosphorus oxyacid wherein the molar ratio of potassium relative to phosphorus in the at least one potassium salt of a phosphorus oxyacid is in the range of from 0.6 to 1.
Type:
Grant
Filed:
July 16, 2014
Date of Patent:
August 8, 2017
Assignees:
BASF SE, Dow Global Technologies LLC
Inventors:
Joaquim Henrique Teles, Bianca Seelig, Dominic Riedel, Philip Kampe, Daniel Urbanczyk, Markus Weber, Ulrich Mueller, Andrei-Nicolae Parvulescu, Kai Gumlich, Peter Bassler, Christian Bartosch, Richard Jacubinas, Meinolf Weidenbach, Werner Witzl
Abstract: The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a ?2-adrenergic receptor agonist.
Type:
Grant
Filed:
March 17, 2014
Date of Patent:
August 1, 2017
Assignee:
VERONA PHARMA PLC
Inventors:
Michael J. A. Walker, Mario Cazzola, Luigino Calzetta
Abstract: The present invention relates to a catalyst for the epoxidation of alkenes, comprising silver, rhenium, cesium, lithium, tungsten and sulfur on a support. The present invention further relates to a process for producing the catalyst and the use of the catalyst for the oxidation of alkylenes to alkylene oxides. In addition, the present invention relates to a process for preparing ethylene oxide from ethylene, which comprises the oxidation of ethylene with oxygen in the presence of said catalyst.
Type:
Grant
Filed:
December 1, 2014
Date of Patent:
July 25, 2017
Inventors:
Joseph J. Zakzeski, Marco Bosch, Cornelia Dobner, Christian Bartosch, Jürgen Zühlke
Abstract: Provided are imidazolidinedione compounds of formula (I), processes for preparation, uses and pharmaceutically compositions thereof. Said imidazolidinedione compounds possess androgen receptor antagonist activity and can be used for preventing and treating diseases and disorders related to androgen receptor, such as prostate cancer, alopecia, hair regeneration, acne and adolescent acne.
Abstract: The disclosure relates to a method for forming 2,5-furan dicarboxylic acid (FDCA) from aldaric acids. The aldaric acids are dehydrating and cyclizing via acid catalysis to form the FDCA product. Aldaric acids such as galactaric acid, gularic acid, mannaric acid, and glucaric acid can be used in the disclosed method, and the aldaric acids can be obtained from form renewable biomass sources which contain pectin, alginate, and/or other biomass carbohydrates. The FDCA can be used as a renewable feedstock for consumer product polymeric materials such as polyalkylene furoate polymers.
Type:
Grant
Filed:
November 23, 2016
Date of Patent:
July 11, 2017
Assignee:
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
Inventors:
Dennis J. Miller, Lars Peereboom, Evan Wegener, Matthew Gattinger
Abstract: The invention relates to dronedarone or one of its pharmaceutically acceptable salts for the treatment of leishmaniasis, formulations and associations comprising dronedarone or one of its pharmaceutically acceptable salts for the treatment of leishmaniasis.
Abstract: Methods, catalysts, and reactor systems for producing in high yield aromatic chemicals and liquid fuels from a mixture of oxygenates comprising di- and polyoxygenates are disclosed. Also disclosed are methods, catalysts, and reactor systems for producing aromatic chemicals and liquid fuels from oxygenated hydrocarbons such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like; and methods, catalysts, and reactor systems for producing the mixture of oxygenates from oxygenated hydrocarbons such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like. The disclosed catalysts for preparing the mixture of oxygenates comprise a NinSnm alloy and a crystalline alumina support.
Type:
Grant
Filed:
July 22, 2016
Date of Patent:
July 4, 2017
Assignee:
Virent, Inc.
Inventors:
Taylor Beck, Brian Blank, Casey Jones, Elizabeth Woods, Randy Cortright
Abstract: Described herein are ?9-THC prodrugs, methods of making ?9-THC prodrugs, formulations comprising ?9-THC prodrugs and methods of using ?9-THC. One embodiment described herein relates to the transdermal administration of a ?9-THC prodrug for treating and preventing diseases and/or disorders.
Type:
Grant
Filed:
February 11, 2015
Date of Patent:
July 4, 2017
Assignee:
Zynerba Pharmaceuticals, Inc.
Inventors:
Audra Lynn Stinchcomb, Miroslaw Jerzy Golinski, Dana Carmel Hammell, Jeffrey Lynn Howard
Abstract: The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.
Type:
Grant
Filed:
January 23, 2014
Date of Patent:
June 27, 2017
Assignee:
ALDEYRA THERAPEUTICS, INC.
Inventors:
Todd Brady, Scott Young, William A. Kinney, Kenneth J. Mandell
Abstract: A continuous process for the preparation of propylene oxide, comprising (i) providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile, water, dissolved potassium dihydrogen phosphate, and optionally propane; (ii) passing the liquid feed stream provided in (i) into an epoxidation reactor comprising a catalyst comprising a titanium zeolite of structure type MWW, and subjecting the liquid feed stream to epoxidation reaction conditions; (iii) removing an effluent stream from the epoxidation reactor; wherein the concentration of the dissolved potassium dihydrogen phosphate in the liquid feed stream is at least 10% of the solubility limit of the potassium dihydrogen phosphate in the liquid feed stream.
Type:
Grant
Filed:
July 16, 2014
Date of Patent:
June 27, 2017
Assignees:
BASF SE, Dow Global Technologies LLC
Inventors:
Joaquim Henrique Teles, Bianca Seelig, Dominic Riedel, Philip Kampe, Daniel Urbanczyk, Markus Weber, Ulrich Mueller, Andrei-Nicolae Parvulescu, Alexander Schroeder, Meinolf Weidenbach, Werner Witzl
Abstract: Direct epoxidation of propene is carried out on electrochemically tuned mixed oxide catalyst surfaces in a single chamber reactor with mixed reaction gas of hydrocarbon and oxygen. Yield and selectivity improvement compared to platinum- or silver-based noble metal catalysts have been demonstrated for the same reactor set up. Increase in propylene oxide yield has been demonstrated when a cell voltage is applied.
Abstract: The present invention concerns a process for converting biomass into useful organic building blocks for the chemical industry. The process involves the use of molybdenum catalysts of the formula Aa+a(MovXxR1yR2zR3e)a*3?, which may be readily prepared from industrial molybdenum compounds.
Type:
Grant
Filed:
August 29, 2014
Date of Patent:
June 13, 2017
Assignee:
Danmarks Tekniska Universitet
Inventors:
Johannes Rytter Dethlefsen, Peter Fristrup
Abstract: The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.
Type:
Grant
Filed:
February 19, 2016
Date of Patent:
June 13, 2017
Assignee:
Ecolab USA Inc.
Inventors:
Li Junzhong, Richard Staub, David D. McSherry, Keith G. Lascotte, Steven J. Lange, Frank Everts
Abstract: A dysphagia improving composition characterized in that a substance having an inhibitory action on an angiotensin converting enzyme, which is a degrading enzyme of substance P, is administered locally in a dosage not influencing blood pressure, and a pharmaceutical for improving dysphagia containing the composition.
Abstract: Embodiments herein relate to animal feed preservatives including byproducts containing levulinic acid and methods of making and using the same. In an embodiment, a method of making an animal feed preservative is included. The method can include obtaining an acidic byproduct of a manufacturing process. The acidic byproduct can include at least about 1% by weight levulinic acid or a salt thereof. The method can further include mixing the acidic byproduct with a base to form the animal feed preservative. The animal feed preservative can include at least about 5 wt. % of the acid byproduct. In various embodiments, a method of reducing the amount of mycotoxins formed in an animal feed product during storage is included. In various embodiments, an animal feed preservative or supplement is included. Other embodiments are also included herein.
Type:
Grant
Filed:
September 2, 2015
Date of Patent:
June 13, 2017
Assignee:
Hawkins, Inc.
Inventors:
Theodore R. Stern, Stephen G. Campano, Gary Carl Larson
Abstract: The present invention provides a forsythiaside sulfate derivatives as represented by the following formula, the preparation method and antiviral application thereof: