Abstract: Methods of conducting thrombectomy procedures and deploying a thrombectomy catheter are disclosed. A thrombectomy procedure is conducted with a thrombectomy catheter deployment system. A drive unit configured to operate an infusion pump is provided. The drive unit is operable according to one or more operating modes. A preconnected and consolidated pump and catheter assembly configured for loading in the drive unit is also provided. The assembly is separate from the drive unit prior to loading. The infusion pump and a catheter of the assembly are in communication prior to loading. The assembly provides one or more digital instructions to the drive unit. The drive unit is operable according to the one or more operating modes referenced by the one or more digital instructions. The assembly is loaded into the drive unit, and the drive unit is engaged to the infusion pump for operation of the infusion pump.

Abstract: A surgical device comprises a housing, a bioprocessing module, an end effector, and a pumping device. The bioprocessing module comprises media reservoirs, fluid conduits in communication with the reservoirs, and a port through which media is expelled. The end effector is configured for insertion into a lumen and delivering a tissue repair composition into that lumen. The end effector has at least one fluid conduit extending therethrough and at least one orifice in communication with the fluid conduit. The fluid conduit in the first end effector is in fluid communication with the port on the bioprocessing module. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the media reservoirs through the fluid conduit of the first end effector such that the tissue repair composition is expelled from the at least one orifice.

Abstract: An injection device including a drive unit, a delivery unit, a dosing unit, a trigger for triggering an injection, a first coupling mechanism between the drive unit and the delivery unit, and a second coupling mechanism between the dosing unit and the drive unit, wherein the drive unit is tensioned by a rotation of the dosing unit and when the drive unit is tensioned the first coupling mechanism is disengaged and the second coupling mechanism is engaged, and wherein when an injection is triggered first the first coupling mechanism is engaged and then the second coupling mechanism is disengaged. In some embodiments, the device may include a third coupling mechanism which only releases the delivery unit after the engagement and disengagement which follow a triggering.

Abstract: An ophthalmic microsurgical system is described for treatment of eye diseases, such as glaucoma, using minimally invasive surgical techniques. The microsurgical system includes a thin walled outer sheath microcannula 1 slidably disposed about an inner member 4, which extends slightly beyond the distal end of the microcannula 1. The inner member 4 may be straight or curved and may optionally include a surgical instrument and/or a sensor or signaling beacon. The microsurgical system is used in a surgical procedure for opening Schlemm's Canal to provide drainage of aqueous fluid in order to relieve excess intraocular pressure that results from glaucoma and other diseases of the eye.

Abstract: A pen injection device designed for use with dual or multi-chamber cartridges 14, is provided with an extended length plunger 24 having a non-drive portion 24? on its forward end and the usual screw-threaded drive portion 24? on its rearward end. This arrangement allows the plunger to be pushed forwardly while the dosing drive mechanism is disengaged to effect a reconstitution movement of the rearward bung 18? in the cartridge. Thereafter the threaded portion on the plunger 24? engages the drive mechanism to allow metered dosing.

Abstract: A balloon of a balloon catheter is inflated with a liquid inflating medium by a syringe through a flow line. Air in the flow line and the balloon is displaced into a return line. The balloon is deflated by drawing the liquid inflating medium from the balloon along with the air in the return line into the syringe where the air is trapped in the syringe. The balloon is reinflated and deflated by the syringe until the level of air in the liquid inflating medium has been reduced to a predefined level. A first non-return valve and a second non-return valve are provided in the flow and return lines, so that the liquid inflating medium is prevented from flowing from the balloon to the syringe in the flow line and from the syringe to the balloon in the return line.

Abstract: A shaft for a balloon dilation catheter comprises a proximal portion wherein a guidewire tubular member is disposed coaxially within an outer tubular member, a shaft transitional portion, wherein the guidewire member is disposed within the outer member, with at least one distal tubular member not present in the proximal portion, a shaft distal portion, wherein the guidewire member and the distal members are disposed side-by-side and encased within a distal body, and fluid-tight barrier within a proximal lumen blocking the flow of fluid in the proximal lumen, but allowing the proximal lumen to remain in fluid communication with a distal lumens.

Abstract: A catheter adapted for ablation, mapping, injection, and directional control by an external magnetic system has a catheter body, an intermediate section, and a tip section having a tip electrode configured with an omnidirectional distal end and a concentric needle port. The tip electrode houses a magnetic device and a position sensor arranged in an integrated configuration, wherein the configuration facilitates a path in the tip section for a component, including an injection needle, to extend through the tip section for extension and retraction with reduced stress and friction. The integrated configuration is an efficient use of space in the tip electrode that allows the tip section to carry both the position sensor for determining location and orientation of the tip section and the necessary volume of magnetic or magnetizable material to accomplish magnetic navigation.

Abstract: Apparatus and methods for generating foam are disclosed. The inventions can be used for generating foam for sclerotherapy. A foaming element can be agitated within a foaming chamber by a drive unit that does not touch the foaming element, but actuates it from outside the foaming chamber. The foaming element and drive unit can be magnetically coupled. A syringe can be used to form a foaming chamber.

Abstract: A rapid exchange balloon dilation catheter includes a catheter shaft with a proximal tubular member defining a proximal inflation/deflation lumen for conveying fluids therethrough with a distal portion of the bore of proximal tubular member filled with a fluid-impervious barrier, a distal body extending from the fluid-impervious barrier to the distal end of the shaft, a plurality of distal tubular members defining distal inflation/deflation lumens in fluid communication with the proximal inflation/deflation lumen and extending through the fluid-impervious barrier and the distal body to the distal end of the shaft distal portion, a guidewire tubular member having a bore extending from a side aperture formed in the distal body through the distal body alongside the distal tubular members in a multi-lumen arrangement, and a plurality of stiffening members extending from within the fluid-impervious barrier into the distal body to a point within the shaft distal portion.

Abstract: A cartridge insertion assembly including apparatus with a pathway formed therein, a cartridge insertable into the pathway, the cartridge including a cartridge coupling element connectable to an activation mechanism disposed in the apparatus operative to cause a substance contained in the cartridge to be metered out of the cartridge, and a door pivoted to the apparatus that includes a door coupling element arranged with respect to the cartridge such that when the door is in a fully closed position, the door coupling element couples the cartridge coupling element with a coupling element of the activation mechanism.

Abstract: Drug delivery devices having non-luer connections and adapters and adaption connectors for providing non-luer connections to drug delivery devices are provided. An exemplary drug delivery device for use with a catheter connection includes a blunt needle component with a non-luer connection and a filter component with a non-luer connection, wherein the non-luer connections of the blunt needle component and filter component are incompatible with standard luer fitting and intravenous route-accessing devices. In one or more embodiments, an adapter having a non-luer connection at one end and a luer connector is provided for use with blunt needle components and filter components wherein one of the blunt needle component and the filter component includes a luer connection and the other of the blunt needle component and the filter component includes a non-luer connection. Methods of delivering liquid medication to a catheter are also provided.

Abstract: A lacrimal drainage manometer includes a syringe, a pressure sensor operably coupled to the syringe, a flow sensor operably coupled to the syringe, and a user feedback unit. The syringe includes a syringe body and a piston. The syringe body defines a fluid cavity in fluid communication with a cannula, which is configured for insertion into at least a portion of a lacrimal drainage system. The piston is for dispensing a fluid from the fluid cavity through the cannula. The user feedback unit is in electrical communication with each of the pressure sensor and the flow sensor. The user feedback unit is operably coupled to the syringe and configured to provide user feedback based on data from the pressure sensor and/or the flow sensor.

Abstract: Apparatus and methods are disclosed for medical treatment comprising bone, tissue or duct dilatation using inflatable dilatation elements together with apparatus and techniques for tensioning, stretching, folding, and/or wrapping the dilatation elements externally as well as in situ to facilitate insertion, positioning and withdrawal procedures.

Abstract: A trocar and cannula assembly with improved conical valve that incorporates a plurality of ribs to restrict and/or otherwise influence valve movement, and a plurality of improved convolutes and bumps to enhance performance characteristics.

Abstract: A method for constructing an instrument with a covered bore for subcutaneous implantation is provided. An incising body is formed by defining a non-circular coaxial bore and sharpening a cutting edge extending from a bottom distal end beyond the opening of the coaxial bore and affixing an attachment point at a top distal end. A plunger is constructed sized to fit within the coaxial bore. The plunger is inserted in the bore of the incising body. A cover is affixed to the attachment point, wherein the cover extends down to the bottom distal end and, when closed, the cover encloses the opening proximal to the cutting edge.

Abstract: A device for applying a lock solution in a catheter or other access system comprises a syringe (302) having an expulsion arrangement (305, 311) for expelling the lock solution from the device, said expulsion arrangement including a plunger (305) arranged in a housing (304), further comprising a sterile connector (303) for connecting the syringe (302) to the catheter. The connector (303) is arranged to engage a tip (307) of the expulsion arrangement (305, 311) tightly when the syringe (302) is inserted in the connector (303). The connector (303) is arranged to prevent the tip (307) of the expulsion arrangement (305, 311) from entering the catheter. The tip (307) is frangible. A method of applying a lock solution in a catheter or other access system is also disclosed.

Abstract: Apparatus and methods are disclosed for medical treatment comprising bone, tissue or duct dilatation using inflatable dilatation elements together with apparatus and techniques for tensioning, stretching, folding, and/or wrapping the dilatation elements externally as well as in situ to facilitate insertion, positioning and withdrawal procedures.

Abstract: An automatic feeding/sputum suction device, which mainly comprises a feeding syringe or sputum suction device, an air pump, a liquid food replenishing drum or oxygen/water supply device, three-way control valve, feeding duct or sputum suction duct, controller and detector strap, wherein the three-way control valve is connected with liquid food replenishing drum (oxygen/water supply device), feeding syringe (sputum suction device) and feeding duct (sputum suction duct).

Abstract: A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. From these values, a coupling index is calculated that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.